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Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception.

Abstract：

:Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tissue, identify opioid containing cells and demonstrate their functional significance in the inhibition of nociception. In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw. Taken together, these data suggest that endogenous opioid peptides are synthesized and processed within various types of immune cells at the site of inflammation. Immunosuppression abolishes the intrinsic antinociception in inflammatory tissue confirming the functional significance of these cells.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Przewłocki R,Hassan AH,Lason W,Epplen C,Herz A,Stein C

doi

10.1016/0306-4522(92)90509-z

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

491-500

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(92)90509-Z

journal_volume

48

pub_type

杂志文章

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