Abstract:
:Spontaneous activity in medial vestibular nucleus (MVN) neurons is modulated by synaptic inputs. These inputs are crucial for maintaining gaze and posture and contribute to vestibular compensation after lesions of peripheral vestibular organs. We investigated how chronically attenuated glycinergic input affects excitability of MVN neurons. To this end we used three mouse strains (spastic, spasmodic, and oscillator), with well-characterized naturally occurring mutations in the inhibitory glycine receptor (GlyR). First, using whole-cell patch-clamp recordings, we demonstrated that the amplitude of the response to rapidly applied glycine was dramatically reduced by 25 to 90% in MVN neurons from mutant mice. We next determined how reduced GlyR function affected MVN neuron output. Neurons were classified using two schemas: (1) the shape of their action potential afterhyperpolarization (AHP); and (2) responses to hyperpolarizing current injection. In the first schema, neurons were classified as types A, B and C. The prevalence of type C neurons in the mutant strains was significantly increased. In the second schema, the proportion of neurons lacking post inhibitory rebound firing (PRF-deficient) was increased. In both schemas an increase in AHP amplitude was a common feature of the augmented neuron group (type C, PRF-deficient) in the mutant strains. We suggest increased AHP amplitude reduces overall excitability in the MVN and thus maintains network function in an environment of reduced glycinergic input.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Camp AJ,Lim R,Anderson WB,Schofield PR,Callister RJ,Brichta AMdoi
10.1016/j.neuroscience.2010.06.040subject
Has Abstractpub_date
2010-09-29 00:00:00pages
348-60issue
1eissn
0306-4522issn
1873-7544pii
S0306-4522(10)00887-0journal_volume
170pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Within the dorsomedial hypothalamus (DMH), cholecystokinin (CCK) has been proposed to modulate neuropeptide Y (NPY) signaling to affect food intake. However, the neural circuitry underlying the actions of this CCK-NPY signaling system in the controls of food intake has yet to be determined. We sought to characterize t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.12.004
更新日期:2008-03-03 00:00:00
abstract::The in vivo effects of [D-Pen2,D-Pen5]enkephalin, a cyclic peptide agonist with high affinity and selectivity for the delta opioid receptors, on the endogenous aluminum content of selected areas of rat brain and spinal cord were studied by means of atomic absorption spectrophotometry. Intracerebroventricular injection...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00575-p
更新日期:1995-05-01 00:00:00
abstract::In order to develop a rodent model displaying a progressive degeneration of the dopamine neurons of the substantia nigra, we bilaterally injected the tracer substance FluoroGold into the terminal field of the nigrostriatal projection, i.e. the striatum. One week later, rats received unilateral injections of 20 microgr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90605-x
更新日期:1994-03-01 00:00:00
abstract::Acoustic trauma is the major cause of hearing loss in industrialised nations. We show in guinea-pigs that sound exposure (6 kHz, 120 dB sound pressure level for 30 min) leads to sensory cell death and subsequent permanent hearing loss. Ultrastructural analysis reveals that degeneration of the noise-damaged hair cells ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00004-0
更新日期:2002-01-01 00:00:00
abstract::Our previous studies on olfactory bulbar responses in salmonid fishes suggest that pheromone signals might be processed by a mechanism distinct from that of other odorants. Using in vivo single-unit and electroencephalographic recordings, we investigated response characteristics of olfactory neurons in lake whitefish,...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00717-0
更新日期:2003-01-01 00:00:00
abstract::The distribution and origin of nerves with calcitonin gene-related peptide, substance P or neurokinin A immunoreactivity in the walls of the cerebral arteries were investigated in three microchiropteran species. The supply of nerves immunoreactive for substance P and neurokinin A to the bat cerebral arteries is confin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90002-5
更新日期:1990-01-01 00:00:00
abstract::Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.02.017
更新日期:2017-04-21 00:00:00
abstract::Eider duck (Somateria mollissima) cerebellar neurons are highly tolerant toward hypoxia in vitro, which in part is due to a hypoxia-induced depression of their spontaneous activity. We have studied whether this response involves ATP-sensitive potassium (KATP) channels, which are known to be involved in the hypoxic/isc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.10.046
更新日期:2015-01-22 00:00:00
abstract::It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90044-3
更新日期:1987-06-01 00:00:00
abstract::Changes in the distribution of muscarinic acetylcholine receptor-immunoreactive neurons were examined in the amygdaloid complex at different time-intervals following a single training session of active shock avoidance in a two-way shuttle-box. Muscarinic acetylcholine receptors were visualized using M35, a monoclonal ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00360-0
更新日期:1997-01-01 00:00:00
abstract::Estrogen exerts many of its receptor-mediated neuroprotective functions through the activation of various intracellular signal transduction pathways including the mitogen activating protein kinase (MAPK), phospho inositol-3 kinase and protein kinase C pathways. Here we have used a hippocampal slice culture model of ka...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.12.029
更新日期:2005-01-01 00:00:00
abstract::Our recent data suggest that noradrenaline (NA) regulates expression of Per1 mRNA in rat C6 cells, as a model of brain astrocytes, by two distinct NA-mediating pathways. Although C6 cells possess potential astrocyte-type characteristics, we hypothesize that astrocytes located in a distinct tissue or organ play specifi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.04.024
更新日期:2011-06-30 00:00:00
abstract::As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90404-9
更新日期:1994-08-01 00:00:00
abstract::The hypothalamic paraventricular nucleus (PVN), a site for the integration of both the neuroendocrine and autonomic systems, has heterogeneous cell composition. These neurons are classified into type I and type II neurons based on their electrophysiological properties. In the present study, we investigated the molecul...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.12.031
更新日期:2012-03-15 00:00:00
abstract::Dephosphorylation by the Ca2+/calmodulin-dependent phosphatase calcineurin has been suggested as an important mechanism of Ca2+-dependent inactivation of voltage-gated Ca2+ channels. We have tested whether calcineurin plays a role in the inactivation process of two types of high-voltage-activated Ca2+ channels (L and ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00434-0
更新日期:2000-01-01 00:00:00
abstract::The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.04.067
更新日期:2006-09-01 00:00:00
abstract::Affective states, such as anticipatory anxiety, critically influence speech communication behavior in adults who stutter. However, there is currently little evidence regarding the involvement of the limbic system in speech disfluency during interpersonal communication. We designed this neuroimaging study and experimen...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.01.037
更新日期:2018-03-15 00:00:00
abstract::Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainic acid neurotoxicity...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(96)00326-0
更新日期:1996-12-01 00:00:00
abstract::Rett syndrome (RTT), a disorder caused almost exclusively by mutations in the X-linked gene, MECP2, has a phenotype thought to be primarily of neurological origin. Disruption of Mecp2 in mice results in a prominent RTT-like phenotype. One of the consequences of MeCP2 absence in the brain is altered functional and stru...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.01.061
更新日期:2011-04-28 00:00:00
abstract::[3H]Bremazocine, in the presence of saturating concentrations of mu and delta receptor blocking agents, was used to label putative kappa opiate binding sites in rat brain. The binding of [3H]bremazocine under these conditions was completely displaced with high affinity by U-50488H and dynorphin1-17, and the potency of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90302-7
更新日期:1986-11-01 00:00:00
abstract::Central GABA(A) receptors mediate GABAergic phasic and tonic inhibition. While synaptic αβγ GABA(A) receptors primarily mediate phasic inhibition, extrasynaptic αβδ receptors play an important role in mediating tonic inhibition. Etomidate is a general anesthetic that produces its effects by enhancing GABA(A) receptor ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.05.051
更新日期:2015-08-06 00:00:00
abstract::People commonly synchronize taps to rhythmic sounds and can continue tapping after the sounds stop, indicating that time intervals between sounds can be internalized. Here, we investigate what happens in the brain after simply listening to auditory beats in order to understand more about the automatic internalization ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.06.010
更新日期:2019-08-10 00:00:00
abstract::Foetal mouse hippocampal primordia from mice homozygous for the Thy-1.1 allele were transplanted into the hippocampal region of adult histocompatible mice, homozygous for the Thy-1.2 allele. After survival periods of two months to one year the transplants consisted of a discrete tissue mass, well fused with the host, ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90096-x
更新日期:1985-12-01 00:00:00
abstract::Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2019.07.046
更新日期:2019-10-01 00:00:00
abstract::In a natural acoustic environment, sound stimuli often occur in a contextual acoustic stream. The aim of the present study was to determine how the frequency tuning of auditory cortical neurons is affected by an acoustic context. A forward masking paradigm was used to determine the frequency receptive fields of rat au...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.05.047
更新日期:2010-09-01 00:00:00
abstract::Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00259-8
更新日期:2003-01-01 00:00:00
abstract::The steroid hormone vitamin D has important biological roles in calcium transport, cell growth, and cell differentiation. Its cellular activities are mediated by high affinity interaction with the vitamin D receptor. In brain, autoradiographic, immunohistologic, and messenger RNA expression studies implicate a number ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00049-5
更新日期:2001-01-01 00:00:00
abstract::MicroRNA (miRNA) is a small non-coding RNA that regulates gene expression by degrading target mRNAs or inhibiting translation. Although many miRNAs play important roles in various conditions, it is unclear whether miRNAs are involved in motor nerve regeneration. In this study, we identified the possible implication of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.10.055
更新日期:2014-01-03 00:00:00
abstract::The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria m...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2007.01.059
更新日期:2007-04-14 00:00:00
abstract::Cellular distribution of creatine kinase BB-isoenzyme and tubulin was investigated immunohistochemically with tissue sections from various areas of the gerbil brain. Both the reaction for creatine kinase BB-isoenzyme and tubulin visualized nerve cell bodies, dendrites and axons. While the reaction for tubulin was simi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90183-0
更新日期:1984-07-01 00:00:00