Etomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.

abstract：:Effects of L-arginine in the nervous system are often attributed to nitric oxide. Using whole-cell patch pipettes to record membrane currents in voltage-clamp from dopamine neurons in the rat midbrain slice, the present studies found that L-arginine potentiates GABA-dependent membrane currents via a nitric oxide-indep...

journal_title：Neuroscience

authors： Shen KZ,Cox BA,Johnson SW

更新日期：1997-08-01 00:00:00

abstract：:The expression pattern of pannexin1, a gene coding for a protein that forms gap junction channels, was studied as both mRNA and protein in the CNS of adult mouse. Pannexin1 was widely expressed in the CNS by neuronal cell types but not glial cells, except for Bergmann glial cells of the cerebellar cortex. Cells positi...

journal_title：Neuroscience

authors： Zappalà A,Cicero D,Serapide MF,Paz C,Catania MV,Falchi M,Parenti R,Pantò MR,La Delia F,Cicirata F

更新日期：2006-08-11 00:00:00

abstract：:The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...

journal_title：Neuroscience

authors： Fu XW,Brezden BL,Kelly JB,Wu SH

更新日期：1997-06-01 00:00:00

abstract：:It is well established that syntaxin 1A, synaptosomal-associated protein of 25 kDa (SNAP-25) and synaptotagmin either alone or in combination, modulate the kinetic properties of voltage-gated Ca(2+) channels Ca(v)1.2 (Lc-channel) Ca(v)2.2 (N-type) and Ca(v)2.1 (P/Q-type). The interaction interface was found to reside ...

journal_title：Neuroscience

authors： Cohen R,Atlas D

更新日期：2004-01-01 00:00:00

abstract：:Using in vitro autoradiography, we investigated [3H] alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, [3H]kainate and [3H]N-methyl-D-aspartate binding in two forebrain regions, the hippocampus and striatum, of young (four months of age) and aged (24-25 months of age) Long-Evans rats that had previously been teste...

journal_title：Neuroscience

authors： Nicolle MM,Bizon JL,Gallagher M

更新日期：1996-10-01 00:00:00

abstract：:Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes in...

journal_title：Neuroscience

authors： Barnett JH,Smoller JW

更新日期：2009-11-24 00:00:00

abstract：:Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex. In this study, experiments were done in Sprague-Dawley rats initially to provide a detailed mapping within the NTS co...

journal_title：Neuroscience

authors： Ciriello J,Moreau JM

更新日期：2013-01-15 00:00:00

abstract：:In order to determine which neurotransmitters and neuropeptides are utilized by the neurons of the mesencephalic trigeminal nucleus and by the fibres making synaptic contact with these primary sensory cells, we have set up an immunohistochemical study using antibodies against 17 major neurotransmitters and neuropeptid...

journal_title：Neuroscience

authors： Copray JC,Ter Horst GJ,Liem RS,van Willigen JD

更新日期：1990-01-01 00:00:00

abstract：:Secretogranin II (chromogranin C), originally described as tyrosine sulfated protein of the anterior pituitary, is present in large dense core vesicles of several endocrine cells and neurons. We raised antisera in rabbits to conjugates of two synthetic peptides (bovine secretogranin 133-151 and rat secretogranin 154-1...

journal_title：Neuroscience

authors： Kirchmair R,Hogue-Angeletti R,Gutierrez J,Fischer-Colbrie R,Winkler H

更新日期：1993-03-01 00:00:00

abstract：:The identification of leptin and a range of novel anorectic and orexigenic peptides has focussed attention on the neural circuitry involved in the genesis of food intake and the reflex control of thermogenesis. Here, the neurotropic virus pseudorabies has been utilised in conjunction with the immunocytochemical locali...

journal_title：Neuroscience

authors： Oldfield BJ,Giles ME,Watson A,Anderson C,Colvill LM,McKinley MJ

更新日期：2002-01-01 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:Lack of dystrophin in mdx mice leads to muscle fibre degeneration followed by the formation of new myofibres. This degeneration-regeneration event occurs in clusters. It is accompanied by inflammation and remodelling of the intramuscular terminal nerve fibres. Since the growth-associated protein B-50/GAP-43 has been s...

journal_title：Neuroscience

authors： Verzè L,Buffo A,Rossi F,Oestreicher AB,Gispen WH,Strata P

更新日期：1996-02-01 00:00:00

abstract：:Remyelination is common under physiological conditions and usually occurs as a response to a pathological demyelinating event. Its potentiation is an important goal for the development of therapies against pathologies such as multiple sclerosis and white matter injury. Visualization and quantification in vivo of demye...

journal_title：Neuroscience

authors： Cisneros-Mejorado AJ,Garay E,Ortiz-Retana J,Concha L,Moctezuma JP,Romero S,Arellano RO

更新日期：2020-07-15 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:Extracellular nucleotides exert their actions via two subfamilies of purinoceptors: P2X and P2Y. Eight mammalian P2Y receptor subtypes (P2Y(1,2,4,6,11,12,13,14)) have been identified. In this work, the localization of P2Y(6) was studied in rat retina using double immunofluorescence labeling and confocal scanning micro...

journal_title：Neuroscience

authors： Zhang PP,Yang XL,Zhong YM

更新日期：2012-09-18 00:00:00

abstract：:Brain responses to discrete short sounds have been studied intensively using the event-related potential (ERP) method, in which the electroencephalogram (EEG) signal is divided into epochs time-locked to stimuli of interest. Here we introduce and apply a novel technique which enables one to isolate ERPs in human elici...

journal_title：Neuroscience

authors： Poikonen H,Alluri V,Brattico E,Lartillot O,Tervaniemi M,Huotilainen M

更新日期：2016-01-15 00:00:00

abstract：:Transgenic mice with overexpression of the caspase-inhibitor, X-chromosome-linked inhibitor of apoptosis protein (XIAP) in Purkinje cell (PC) and in retinal bipolar cells (RBCs) were produced to study the regulation of cell death. Unexpectedly, an increased neurodegeneration was observed in the PCs in these L7-XIAP mi...

journal_title：Neuroscience

authors： Korhonen L,Hansson I,Maugras C,Wehrle R,Kairisalo M,Borgkvist A,Jokitalo E,Sotelo C,Fisone G,Dusart I,Lindholm D

更新日期：2008-10-15 00:00:00

abstract：:Membrane currents evoked by iontophoretically applied acetylcholine were recorded from non-dissociated neurons of rat superior cervical ganglion using the whole-cell patch-clamp recording method. Blocking effects produced by a series of specially synthesized organic compounds, the blockers of the open channel of gangl...

journal_title：Neuroscience

authors： Skok VI,Voitenko SV,Kurenniy DE,Brovtsyna NB,Gmiro VE,Kertcer SL

更新日期：1995-08-01 00:00:00

abstract：:The effect of nerve growth factor on the intact versus injured septohippocampal cholinergic system of adult rats was studied. Nerve growth factor was continuously infused into the lateral ventricle of adult uninjured rats or rats that had received unilateral partial transection of the fimbria. Controls (operated and u...

journal_title：Neuroscience

authors： Fusco M,Oderfeld-Nowak B,Vantini G,Schiavo N,Gradkowska M,Zaremba M,Leon A

更新日期：1989-01-01 00:00:00

abstract：:Nerve cells have been found in hydra, which react with antisera to oxytocin, vasopressin and mesotocin. These nerve cells have a high density in the ectoderm of basal disk and tentacles and lower density in the ectoderm of peduncle, gastric region and hypostome. A very small number of nerve cells occur also in the end...

journal_title：Neuroscience

authors： Grimmelikhuijzen CJ,Dierickx K,Boer GJ

更新日期：1982-01-01 00:00:00

abstract：:Substance P-like immunoreactivity was localized by an indirect immunohistochemical technique in whole mounts and sections of blood vessels from the guinea-pig. There was a widespread association of nerve fibres that had substance P-like immunoreactivity with blood vessels, extending into all vascular beds. The relativ...

journal_title：Neuroscience

authors： Furness JB,Papka RE,Della NG,Costa M,Eskay RL

更新日期：1982-02-01 00:00:00

abstract：:Recent studies have shown that tachykinins mediate slow synaptic transmission to myenteric AH (afterhyperpolarising) neurons via neurokinin-3 receptors (NK(3)R). This study investigated a similar role for neurokinin-1 receptors (NK(1)R) and compared the effect of selective receptor antagonists on non-cholinergic slow ...

journal_title：Neuroscience

authors： Johnson PJ,Bornstein JC

更新日期：2004-01-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory pro...

journal_title：Neuroscience

authors： Chanaday NL,Roth GA

更新日期：2016-02-09 00:00:00

abstract：:The present paper looks for kinematic similarities between whole-body and arm movements executed in the sagittal plane. Eight subjects performed sit-to-stand (STS) and back-to-sit (BTS) movements at their preferred speed in the sagittal plane. Kinematics analysis focused on shoulder motion revealed that STS was compos...

journal_title：Neuroscience

authors： Papaxanthis C,Dubost V,Pozzo T

更新日期：2003-01-01 00:00:00

abstract：:The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+. The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid or release of Ca2+ from intracellular stores such as mitochondria. Whether Ca2+ utilized in transmitter release ...

journal_title：Neuroscience

authors： Brailoiu E,Miyamoto MD

更新日期：2000-01-01 00:00:00

abstract：:Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the sur...

journal_title：Neuroscience

authors： Andrioli A,Alonso-Nanclares L,Arellano JI,DeFelipe J

更新日期：2007-10-12 00:00:00

abstract：:The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathophysiology of this disease. This is commonly modeled in rodents via treatment with NMDAr antagonists, which causes a range of behavioral effects that represent endophenotypes related to schi...

journal_title：Neuroscience

authors： Lee J,Hudson MR,O'Brien TJ,Nithianantharajah J,Jones NC

更新日期：2017-09-01 00:00:00

abstract：:Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced ne...

journal_title：Neuroscience

authors： Nicolini C,Michalski B,Toepp SL,Turco CV,D'Hoine T,Harasym D,Gibala MJ,Fahnestock M,Nelson AJ

更新日期：2020-06-15 00:00:00

abstract：:The midbrain is essential for prepulse inhibition (PPI) of the startle reflex, but the exact neural circuits for PPI are not yet determined. Electrical stimulation of the superior colliculus (SC) or pedunculopontine tegmentum was used to characterize the neurons and pathways that mediate PPI and the activation of star...

journal_title：Neuroscience

authors： Yeomans JS,Lee J,Yeomans MH,Steidl S,Li L

更新日期：2006-11-03 00:00:00

abstract：:The responses in T3-4, T10-11 and L2-3 white rami to stimulation of different zones of the bulbar ventrolateral surface were maximal when the region of about 4 mm laterally to the midline was stimulated. A weak surface stimulation of all these zones elicited only a long latency response consisting of three waves. A sh...

journal_title：Neuroscience

authors： Lebedev VP,Krasyukov AV,Nikitin SA

更新日期：1986-01-01 00:00:00