当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Microglia and astrocyte activation in the frontal cortex of rats with experimental autoimmune encephalomyelitis.

Microglia and astrocyte activation in the frontal cortex of rats with experimental autoimmune encephalomyelitis.

Abstract：

:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory process that leads to a set of motor, sensory, and cognitive symptoms. In MS, gray matter atrophy is related to the emergence of cognitive deficits and contributes to clinical progression. In particular, injury and dysfunction in certain areas of the frontal cortex (FrCx) have been related to the development of cognitive impairments with high incidence, like central fatigue and executive dysfunction. In the present work we show the presence of region-specific microglia and astrocyte activation in the FrCx, during the first hours of acute EAE onset. It is accompanied by the production of the pro-inflammatory cytokines IL-6 and TNF-α, in the absence of detectable leukocyte infiltration. These findings expand previous studies showing presynaptic neural dysfunction occurring at the FrCx and might contribute to the understanding of the mechanisms involved in the genesis and prevalence of common MS symptoms.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Chanaday NL,Roth GA

doi

10.1016/j.neuroscience.2015.11.060

subject

Has Abstract

pub_date

2016-02-09 00:00:00

pages

160-9

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(15)01059-3

journal_volume

314

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Targeted electrophysiological analysis of viscerofugal neurons in the myenteric plexus of guinea-pig colon.

    abstract：:Enteric viscerofugal neurons are mechanosensory interneurons that form the afferent limb of intestino-intestinal reflexes involving prevertebral sympathetic neurons. Fast synaptic inputs to viscerofugal neurons arise from other enteric neurons, but their sources are unknown. We aimed to describe the origins of synapti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.04.066

    authors： Hibberd TJ,Spencer NJ,Zagorodnyuk VP,Chen BN,Brookes SJ

    更新日期：2014-09-05 00:00:00

  • Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain.

    abstract：:This study aimed to determine the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a non-invasive means of detecting effects of increased 5-HT release in brain. Changes in blood-oxygenation level-dependent (BOLD) contrast induced by administration of the 5-HT-releasing agent, fenfluramine, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.12.032

    authors： Preece MA,Taylor MJ,Raley J,Blamire A,Sharp T,Sibson NR

    更新日期：2009-03-17 00:00:00

  • Modulation of presumed cholinergic mesopontine tegmental neurons by acetylcholine and monoamines applied iontophoretically in unanesthetized cats.

    abstract：:The mesopontine tegmentum, which contains both cholinergic and non-cholinergic neurons, plays a crucial role in behavioral state control. Using microiontophoresis in unanesthetized cats, we have examined the effect of cholinergic and monoaminergic drugs on two putative cholinergic neurons located mostly in the laterod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00004-x

    authors： Koyama Y,Sakai K

    更新日期：2000-01-01 00:00:00

  • Novel mRNA isoforms of the sodium channels Na(v)1.2, Na(v)1.3 and Na(v)1.7 encode predicted two-domain, truncated proteins.

    abstract：:The expression of voltage-gated sodium channels is regulated at multiple levels, and in this study we addressed the potential for alternative splicing of the Na(v)1.2, Na(v)1.3, Na(v)1.6 and Na(v)1.7 mRNAs. We isolated novel mRNA isoforms of Na(v)1.2 and Na(v)1.3 from adult mouse and rat dorsal root ganglia (DRG), Na(...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.04.060

    authors： Kerr NC,Holmes FE,Wynick D

    更新日期：2008-08-26 00:00:00

  • The subcortical afferents to caudate nucleus and putamen in primate: a fluorescence retrograde double labeling study.

    abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90104-5

    authors： Parent A,Mackey A,De Bellefeuille L

    更新日期：1983-12-01 00:00:00

  • N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia.

    abstract：INTRODUCTION:Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in psychiatric disorders. Deficits in gating during paired-click tasks and lack of mismatch negativity following deviant stimuli have been well characterized in patients with ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.10.031

    authors： Ehrlichman RS,Gandal MJ,Maxwell CR,Lazarewicz MT,Finkel LH,Contreras D,Turetsky BI,Siegel SJ

    更新日期：2009-01-23 00:00:00

  • Exocytotic release from neuronal cell bodies, dendrites and nerve terminals in sympathetic ganglia of the rat, and its differential regulation.

    abstract：:Stimulant-induced exocytosis has been demonstrated in sympathetic ganglia of the rat by in vitro incubation of excised ganglia in the presence of tannic acid, which stabilizes vesicle cores after their exocytotic release. Sites of exocytosis were observed along non-synaptic regions of the surfaces of neuron somata and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00664-1

    authors： Zaidi ZF,Matthews MR

    更新日期：1997-10-01 00:00:00

  • Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy.

    abstract：:Animal models of diabetes do not reach the severity of human diabetic neuropathy but relatively mild neurophysiological deficits and minor morphometric changes. The lack of degenerative neuropathy in diabetic rodent models seems to be a consequence of the shorter length of the axons or the shorter animal life span. Di...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.05.015

    authors： Ariza L,Pagès G,García-Lareu B,Cobianchi S,Otaegui PJ,Ruberte J,Chillón M,Navarro X,Bosch A

    更新日期：2014-08-22 00:00:00

  • Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites.

    abstract：:The peculiar shape and disposition of Purkinje cell (PC) dendrites, planar and highly branched, offers an optimal model to analyze cellular and molecular regulators for the acquisition of neuronal dendritic trees. During the first 2 weeks after the end of the proliferation period, PCs undergo a 2-phase remodeling proc...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2008.12.035

    authors： Sotelo C,Dusart I

    更新日期：2009-09-01 00:00:00

  • The telencephalic vesicles are innervated by olfactory placode-derived cells: a possible mechanism to induce neocortical development.

    abstract：:During early embryonic development, the olfactory placode is the source of different cell types migrating toward the telencephalic vesicle. Among these cell types are the ensheathing cells, the luteinizing hormone-releasing hormone-producing cells and the olfactory marker protein-immunoreactive cells. We have identifi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00199-s

    authors： De Carlos JA,López-Mascaraque L,Valverde F

    更新日期：1995-10-01 00:00:00

  • Sustained depolarization decreases calcium/calmodulin-dependent protein kinase II activity and gene expression in dopamine neurons.

    abstract：:Altered gene expression mediated by calcium/calmodulin-dependent protein kinase II (CaMKII) and other intracellular signaling molecules plays an important role in activity-dependent neuroplasticity. We discovered that sustained depolarization induced by KCl, a commonly used paradigm for studying activity-dependent gen...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.06.041

    authors： Padmanabhan S,Prasad BM

    更新日期：2009-09-29 00:00:00

  • Delayed axonal degeneration in slow Wallerian degeneration mutant mice detected using diffusion tensor imaging.

    abstract：:Previous studies have shown the feasibility of using diffusion tensor imaging (DTI) as a noninvasive imaging modality to evaluate neurodegeneration in humans and animals. The axial and radial diffusivities derived from DTI were demonstrated to be sensitive markers for axonal and myelin damage, respectively. This study...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.09.042

    authors： Xie M,Wang Q,Wu TH,Song SK,Sun SW

    更新日期：2011-12-01 00:00:00

  • Calretinin immunoreactivity in the monkey hippocampal formation--II. Intrinsic GABAergic and hypothalamic non-GABAergic systems: an experimental tracing and co-existence study.

    abstract：:Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90442-i

    authors： Nitsch R,Leranth C

    更新日期：1993-08-01 00:00:00

  • Transneuronal labeling in hamster brainstem following lingual injections with herpes simplex virus-1.

    abstract：:Brainstem projections to hypoglossal motoneurons innervating the intrinsic and extrinsic muscles of the tongue were determined using the transneuronal transfer of Herpes simplex virus-1. Injections of Herpes simplex virus-1 into the intrinsic muscles of the anterior tongue, the geniohyoid and styloglossus muscles each...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00203-u

    authors： Travers JB,Montgomery N,Sheridan J

    更新日期：1995-10-01 00:00:00

  • Synaptic abnormalities of mice lacking toll-like receptor (TLR)-9.

    abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.03.001

    authors： Patel V,Patel AM,McArdle JJ

    更新日期：2016-06-02 00:00:00

  • Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain.

    abstract：:An antisense oligonucleotide probe was used to examine the expression of gene encoding the obligatory NMDAR1 subunit of the N-methyl-D-aspartate receptor in the hippocampus and adjacent cortical areas (entorhinal and perirhinal cortices) of seven Alzheimer patients and in the same brain regions of seven control indivi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00023-7

    authors： Ulas J,Cotman CW

    更新日期：1997-08-01 00:00:00

  • Benzodiazepines block long-term potentiation in slices of hippocampus and piriform cortex.

    abstract：:The effects of two benzodiazepines, diazepam and triazolam, on long-term potentiation were tested in slices of hippocampus and piriform cortex. The drugs had little influence on baseline synaptic responses but both were very effective in blocking LTP elicited by theta pattern stimulation. The effects were fully revers...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90071-9

    authors： del Cerro S,Jung M,Lynch G

    更新日期：1992-07-01 00:00:00

  • Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice.

    abstract：:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.058

    authors： Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

    更新日期：2004-01-01 00:00:00

  • When a line is a number: color yields magnitude information in a digit-color synesthete.

    abstract：:The phenomenon of synesthesia has received a great deal of interest recently in the scientific literature. Many previous studies stressed the unidirectional nature of this phenomenon. For example, color-grapheme synesthetes automatically perceive achromatic numbers as colored (e.g. 7 is turquoise). Conversely, colors ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.057

    authors： Cohen Kadosh R,Henik A

    更新日期：2006-01-01 00:00:00

  • Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance.

    abstract：:Melatonin, an indoleamine hormone secreted into circulation at night primarily by the brain's pineal gland, has been shown to have a wide variety of actions on the development and physiology of neurons in the CNS. Acting via two G-protein-coupled membrane receptors (MT1 and MT2), melatonin modulates neurogenesis, syna...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.07.018

    authors： O'Neal-Moffitt G,Pilli J,Kumar SS,Olcese J

    更新日期：2014-09-26 00:00:00

  • Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.

    abstract：:Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.082

    authors： Dipietrantonio HJ,Dymecki SM

    更新日期：2009-09-01 00:00:00

  • A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats.

    abstract：:Neurones in the lumbosacral spinal cord are known to play a significant role in ejaculation. In these same areas neurones containing nitric oxide synthase (NOS) have been described. This raised the question as to whether there is a physiological role for nitrous oxide (NO) in the spinal cord in sexual behavior. We fir...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.09.010

    authors： Brack KE,Watkins N,Pyner S,Coote JH

    更新日期：2007-12-05 00:00:00

  • Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons.

    abstract：:The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00097-3

    authors： Ishihara A,Ohira Y,Roy RR,Nagaoka S,Sekiguchi C,Hinds WE,Edgerton VR

    更新日期：1997-11-01 00:00:00

  • Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions.

    abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2019.07.036

    authors： Pizzarelli R,Griguoli M,Zacchi P,Petrini EM,Barberis A,Cattaneo A,Cherubini E

    更新日期：2020-07-15 00:00:00

  • Environmental enrichment selectively increases glutamatergic responses in layer II/III of the auditory cortex of the rat.

    abstract：:Prolonged exposure to environmental enrichment (EE) induces behavioral adaptation accompanied by detectable morphological and physiological changes. Auditory EE is associated with an increased auditory evoked potential (AEP) and increased auditory gating in the primary auditory cortex. We sought physiological correlat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.12.061

    authors： Nichols JA,Jakkamsetti VP,Salgado H,Dinh L,Kilgard MP,Atzori M

    更新日期：2007-03-30 00:00:00

  • Spatial organization of cofilin in dendritic spines.

    abstract：:Synaptic plasticity is associated with morphological changes in dendritic spines. The actin-based cytoskeleton plays a key role in regulating spine structure, and actin reorganization in spines is critical for the maintenance of long term potentiation. To test the hypothesis that a stable pool of F-actin rests in the ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.025

    authors： Racz B,Weinberg RJ

    更新日期：2006-01-01 00:00:00

  • Growth factor regulation of neurogenesis in adult olfactory epithelium.

    abstract：:Neurogenesis continues throughout adult life in the mammalian olfactory epithelium. This process is a dynamic state of proliferation, differentiation and cell death, probably regulated by autocrine and paracrine signals such as peptide growth factors. Previous investigations have demonstrated roles for some growth fac...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00194-9

    authors： Newman MP,Féron F,Mackay-Sim A

    更新日期：2000-01-01 00:00:00

  • Effect of omega conotoxin on reflex responses mediated by activation of capsaicin-sensitive nerves of the rat urinary bladder and peptide release from the rat spinal cord.

    abstract：:The aim of this study was to assess whether omega conotoxin fraction GVIA, a potent blocker of N- and L-type voltage-sensitive calcium channels, might interfere with reflex responses (micturition, blood pressure rise in spinal rats) produced by activation of capsaicin-sensitive sensory nerves of the rat urinary bladde...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90318-x

    authors： Maggi CA,Giuliani S,Santicioli P,Tramontana M,Meli A

    更新日期：1990-01-01 00:00:00

  • The Secretome of Microglia Regulate Neural Stem Cell Function.

    abstract：:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.10.034

    authors： Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren K

    更新日期：2019-05-01 00:00:00

  • Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells.

    abstract：:Mast cells are involved in allergic reactions, but may also participate in neurogenic inflammation. The morphology of mast cells in rat dura mater and tongue was evaluated by histochemistry, as well as by scanning and transmission electron microscopy following unilateral trigeminal ganglion stimulation (5 min, 5 Hz, 5...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90253-k

    authors： Dimitriadou V,Buzzi MG,Moskowitz MA,Theoharides TC

    更新日期：1991-01-01 00:00:00