Abstract：
:Animal models of diabetes do not reach the severity of human diabetic neuropathy but relatively mild neurophysiological deficits and minor morphometric changes. The lack of degenerative neuropathy in diabetic rodent models seems to be a consequence of the shorter length of the axons or the shorter animal life span. Diabetes-induced demyelination needs many weeks or even months before it can be evident by morphometrical analysis. In mice myelination of the peripheral nervous system starts at the prenatal period and it is complete several days after birth. Here we induced experimental diabetes to neonatal mice and we evaluated its effect on the peripheral nerve 4 and 8 weeks after diabetes induction. Neurophysiological values showed a decline in sensory nerve conduction velocity at both time-points. Morphometrical analysis of the tibial nerve demonstrated a decrease in the number of myelinated fibers, fiber size and myelin thickness at both time-points studied. Moreover, aldose reductase and poly(ADP-ribose) polymerase activities were increased even if the amount of the enzyme was not affected. Thus, type 1 diabetes in newborn mice induces early peripheral neuropathy and may be a good model to assay pharmacological or gene therapy strategies to treat diabetic neuropathy.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Ariza L,Pagès G,García-Lareu B,Cobianchi S,Otaegui PJ,Ruberte J,Chillón M,Navarro X,Bosch Adoi
10.1016/j.neuroscience.2014.05.015subject
Has Abstractpub_date
2014-08-22 00:00:00pages
250-9eissn
0306-4522issn
1873-7544pii
S0306-4522(14)00407-2journal_volume
274pub_type
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