Abstract：
:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated microglia, or microglia stimulated with pro- or anti-inflammatory agents. NSC survival, proliferation, migration, and differentiation were investigated thereafter. We found that NSCs kept in conditioned medium from the anti-inflammatory microglial subtype had better survival, increased migration, and lower astrocytic differentiation compared to NSCs grown in conditioned medium collected from the pro-inflammatory subtype. Finally, we found that NSCs differentiated in microglial conditioned media generated cells expressing the pro-inflammatory chemokine CCL2, most pronounced when differentiated in medium from the pro-inflammatory microglia subtype. Our results show that microglial subtypes regulate NSCs differently and induce generation of cells with inflammatory properties.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren Kdoi
10.1016/j.neuroscience.2017.10.034subject
Has Abstractpub_date
2019-05-01 00:00:00pages
92-102eissn
0306-4522issn
1873-7544pii
S0306-4522(17)30762-5journal_volume
405pub_type
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