当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Kainic acid induces apoptosis in neurons.

Kainic acid induces apoptosis in neurons.

Abstract：

:Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainic acid neurotoxicity using cerebellar granule cell neurons in vitro and we sought to determine the mechanism of kainic acid-induced neuronal degeneration. We found DNA laddering by agarose gel electrophoresis, cellular DNA fragmentation by in situ end labeling of DNA, and chromatin condensation using a fluorescent DNA intercalating dye, in cerebellar granule cells following exposure to kainic acid (100 microM). Aurintricarboxylic acid protected cerebellar granule cells from kainic acid-induced death. While the morphological and biochemical features of neuronal death induced by kainic acid resembled low K(+)-induced apoptosis in cerebellar granule cells, the time interval from the institution of the death promoting condition to neuronal death was shorter with kainic acid and did not require new protein or RNA synthesis. These results demonstrate that kainic acid receptor activation can induce transcription-independent apoptosis in neurons. This in vitro model should be useful in identifying the intracellular pathways that link kainic acid receptor activation with apoptosis.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Simonian NA,Getz RL,Leveque JC,Konradi C,Coyle JT

doi

10.1016/0306-4522(96)00326-0

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1047-55

issue

4

eissn

0306-4522

issn

1873-7544

pii

0306452296003260

journal_volume

75

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • The Role of Task Complexity on Frontal Event-related Potentials and Evidence in Favour of the Epiphenomenal Interpretation of the Go/No-Go N2 Effect.

    abstract：:It is well established that task complexity can affect both performance and brain processing. Event-related potentials (ERPs) studies have shown modulation of the well-known N2 and P3 components. However, limited information is available on the recently described frontal components associated with processing within th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.09.042

    authors： Mussini E,Berchicci M,Bianco V,Perri RL,Quinzi F,Di Russo F

    更新日期：2020-11-21 00:00:00

  • Excitatory projections from the amygdala to neurons in the nucleus pontis oralis in the rat: an intracellular study.

    abstract：:There is a consensus that active (REM) sleep (AS) is controlled by cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei (LDT/PPT) to neurons in the nucleus pontis oralis (NPO) that generate AS (i.e. AS-Generator neurons). The present study was designed to provide evidence that other proj...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.09.029

    authors： Xi M,Fung SJ,Sampogna S,Chase MH

    更新日期：2011-12-01 00:00:00

  • Improving spatial updating accuracy in absence of external feedback.

    abstract：:Updating the position of an earth-fixed target during whole-body rotation seems to rely on cognitive processes such as the utilization of external feedback. According to perceptual learning models, improvement in performance can also occur without external feedback. The aim of this study was to assess spatial updating...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.05.024

    authors： Mackrous I,Simoneau M

    更新日期：2015-08-06 00:00:00

  • Gender differences in long-term beneficial effects of erythropoietin given after neonatal stroke in postnatal day-7 rats.

    abstract：:Recently, we reported that erythropoietin attenuates neonatal brain injury caused by focal cerebral ischemia. The long-term effects of erythropoietin on focal cerebral ischemia-induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The cu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.057

    authors： Wen TC,Rogido M,Peng H,Genetta T,Moore J,Sola A

    更新日期：2006-01-01 00:00:00

  • Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons.

    abstract：:GABAA-receptors in the brain display a striking structural heterogeneity, which is based on a multiplicity of diverse subunits. The allocation of GABAA-receptor subtypes to identified neurons is essential for an analysis of the functional significance of receptor heterogeneity. Among GABA-receptive neurons, well-chara...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90582-z

    authors： Gao B,Fritschy JM,Benke D,Mohler H

    更新日期：1993-06-01 00:00:00

  • Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress.

    abstract：:Tg2576 transgenic mice (mice overexpressing the "Swedish" mutation in the human amyloid precursor protein 695) demonstrated a decreased capacity for cell proliferation in the dentate gyrus of the hippocampus compared with non-transgenic littermates at 3 months, 6 months and 9 months of age. Isolation stress induced by...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.040

    authors： Dong H,Goico B,Martin M,Csernansky CA,Bertchume A,Csernansky JG

    更新日期：2004-01-01 00:00:00

  • Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex.

    abstract：:Basic fibroblast growth factor is a potent trophic factor with a wide spectrum of activity at various stages of neuronal development. In our studies on the effects of select lesions on the expression of growth factors, we observed that neurons of layer VIb of the rat cerebral cortex developed immunoreactivity for basi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90355-6

    authors： Gómez-Pinilla F,Cotman CW

    更新日期：1992-08-01 00:00:00

  • Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain.

    abstract：:Neuronal loss is the most common and critical feature of a spectrum of brain traumas and neurodegenerative disorders such as Alzheimer's disease (AD). The capacity to generate new neurons in the central nervous system diminishes early during brain development and is restricted mainly to two brain areas in the mature b...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.054

    authors： Yeung ST,Myczek K,Kang AP,Chabrier MA,Baglietto-Vargas D,Laferla FM

    更新日期：2014-02-14 00:00:00

  • Tonic and stimulus-evoked nitric oxide production in the mouse olfactory bulb.

    abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.003

    authors： Lowe G,Buerk DG,Ma J,Gelperin A

    更新日期：2008-05-15 00:00:00

  • Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses.

    abstract：:Activity-regulated, cytoskeletal-associated protein (Arc) is an immediate early gene induced in excitatory circuits following behavioral episodes. Arc mRNA is targeted to activated regions of the dendrite after long-term potentiation (LTP) of the dentate gyrus, a process dependent on NMDA receptor activation. We used ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.02.004

    authors： Moga DE,Calhoun ME,Chowdhury A,Worley P,Morrison JH,Shapiro ML

    更新日期：2004-01-01 00:00:00

  • α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury.

    abstract：:Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.11.046

    authors： Chang IA,Kim KJ,Namgung U

    更新日期：2018-02-10 00:00:00

  • Membrane specializations and extracellular material associated with host astrocytes in peripheral neural transplants.

    abstract：:The work of Aguayo and colleagues [Aguayo, David and Bray (1981) J. Exp. Biol. 95, 231-240] demonstrates that grafts of peripheral neural tissue are able to induce regenerative elongation of cut axons in the adult central nervous system. Elucidation of the mechanism of this response requires an understanding of the ce...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90261-2

    authors： Lawrence JM,Raisman G

    更新日期：1987-03-01 00:00:00

  • Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats.

    abstract：:Intraspecific confrontation has been used to study effect of depleting central serotonin on the adaptation of male rats to repeated social stress (social defeat). Four groups of adult male rats were used (serotonin depletion/sham: stressed; serotonin depletion/sham: non-stressed). Central serotonin was reduced (by 59-...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00028-7

    authors： Chung KK,Martinez M,Herbert J

    更新日期：1999-01-01 00:00:00

  • Monocular deprivation of Fourier phase information boosts the deprived eye's dominance during interocular competition but not interocular phase combination.

    abstract：:Ocular dominance has been extensively studied, often with the goal to understand neuroplasticity, which is a key characteristic within the critical period. Recent work on monocular deprivation, however, demonstrates residual neuroplasticity in the adult visual cortex. After deprivation of patterned inputs by monocular...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.03.053

    authors： Bai J,Dong X,He S,Bao M

    更新日期：2017-06-03 00:00:00

  • Ventral tegmental area neurons are either excited or inhibited by cocaine's actions in the peripheral nervous system.

    abstract：:Cocaine's multiple pharmacological substrates are ubiquitously present in the peripheral and central nervous system. Thus, upon its administration, cocaine acts in the periphery before directly acting in the brain. We determined whether cocaine alters ventral tegmental area (VTA) neuronal activity via its peripheral a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.01.026

    authors： Mejías-Aponte CA,Kiyatkin EA

    更新日期：2012-04-05 00:00:00

  • Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms.

    abstract：:The present study was designed to elucidate the distribution, time-course and mechanism(s) of status epilepticus-induced neuronal damage in the rat amygdaloid complex. Status epilepticus was induced with kainate (9 mg/kg, i.p.), and the behavioral and electrographic seizure activity of each rat was monitored via corti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00251-1

    authors： Tuunanen J,Lukasiuk K,Halonen T,Pitkänen A

    更新日期：1999-01-01 00:00:00

  • Vesicle recycling revisited: rapid endocytosis may be the first step.

    abstract：:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(97)00453-3

    authors： Palfrey HC,Artalejo CR

    更新日期：1998-04-01 00:00:00

  • The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep.

    abstract：:Sleep mechanisms and synaptic plasticity are thought to interact to regulate homeostasis and memory formation. However, the influences of molecules that mediate synaptic plasticity on sleep are not well understood. In this study we demonstrate that mice lacking Rab3 interacting molecule 1 alpha (RIM1 alpha) (Rim1 alph...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.047

    authors： Lonart G,Tang X,Simsek-Duran F,Machida M,Sanford LD

    更新日期：2008-06-23 00:00:00

  • Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons.

    abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00141-x

    authors： Ma D,Connors T,Nothias F,Fischer I

    更新日期：2000-01-01 00:00:00

  • Developmental patterns of somatostatin-receptors and somatostatin-immunoreactivity during early neurogenesis in the rat.

    abstract：:The temporal pattern of distribution of somatostatin receptor was investigated using the somatostatin analogue [125I]Tyr0-DTrp8-somatostatin14 as a ligand and compared with that of somatostatin immunoreactivity during early developmental stages in the spinal cord and the sensory derivatives in rat fetuses. Qualitative...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90335-2

    authors： Maubert E,Slama A,Ciofi P,Viollet C,Tramu G,Dupouy JP,Epelbaum J

    更新日期：1994-09-01 00:00:00

  • Emotional Impairments and Neuroinflammation are Induced in Male Mice Invulnerable to Repeated Social Defeat Stress.

    abstract：:Prolonged stress triggers neuroinflammation, which plays a significant role in the development of depression; however, stressed people do not always suffer from depression because of individual differences in stress vulnerability. Negative cognitive bias (NCB) toward pessimistic judgment often underlies depressive epi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.07.023

    authors： Ito N,Sasaki K,Takemoto H,Kobayashi Y,Isoda H,Odaguchi H

    更新日期：2020-09-01 00:00:00

  • Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling.

    abstract：:Orexins (OX), also called hypocretins, are bioactive peptides secreted from glucose-sensitive neurons in the lateral hypothalamus linking appetite, arousal and neuroendocrine-autonomic control. Here, OX-A was found to cause a slow-onset long-term potentiation of synaptic transmission (LTPOX) in the hippocampus of youn...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.012

    authors： Selbach O,Doreulee N,Bohla C,Eriksson KS,Sergeeva OA,Poelchen W,Brown RE,Haas HL

    更新日期：2004-01-01 00:00:00

  • Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat.

    abstract：:We previously showed that magnesium sulfate (MS) has systemic antinociceptive and local peripheral pronociceptive effects. The role of transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs) in the mechanism of action of MS has not been investigated in detail. The aim of this study was to exp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.09.032

    authors： Srebro D,Vučković S,Prostran M

    更新日期：2016-12-17 00:00:00

  • Neuronal interactions are higher in the cortex than thalamus in the somatosensory pathway.

    abstract：:Previous studies have shown significant correlated discharges (noise correlation) and synergistic information coding among adjacent cortical neurons. In order to investigate whether such interactions are present at an earlier stage of sensory processing, we compared noise correlation and synergistic information transm...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00813-8

    authors： Kim MJ,Kim YB,Kang KJ,Huh N,Oh JH,Kim Y,Jung MW

    更新日期：2003-01-01 00:00:00

  • Opposite modulation of cortical N-methyl-D-aspartate receptor-mediated responses by low and high concentrations of dopamine.

    abstract：:To examine whether dopamine modulates cortical N-methyl-D-aspartate receptor-mediated glutamate transmission, whole-cell recordings were made from identified pyramidal cells located in layers V and VI of the medial prefrontal cortex of the rat using a slice preparation. In the presence of tetrodotoxin and the absence ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00604-6

    authors： Zheng P,Zhang XX,Bunney BS,Shi WX

    更新日期：1999-01-01 00:00:00

  • Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats.

    abstract：:Androgens are known to affect cognitive and mnemonic aspects of spatial processing. The cholinergic system is thought to play an important role in cognition and memory, but little is known about the interaction between androgen and cholinergic neurons. The present study focused on the effects of testosterone on the ch...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00513-9

    authors： Nakamura N,Fujita H,Kawata M

    更新日期：2002-01-01 00:00:00

  • Acquisition of a palatable-food-sustained appetitive behavior in satiated rats is dependent on the dopaminergic response to this food in limbic areas.

    abstract：:Rats exposed to repeated unavoidable stress show decreased dopamine output in the nucleus accumbens shell (NAcS) and do not acquire vanilla sugar (VS)-sustained appetitive behavior (VAB). Rats treated with lithium for 3 weeks also show decreased NAcS dopamine output, yet they acquire VAB. Feeding a novel palatable foo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00383-x

    authors： Gambarana C,Masi F,Leggio B,Grappi S,Nanni G,Scheggi S,De Montis MG,Tagliamonte A

    更新日期：2003-01-01 00:00:00

  • Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities.

    abstract：:Chronic stress and spatial training have been proposed to affect hippocampal structure and function in opposite ways. Previous morphological studies that addressed structural changes after chronic restraint stress and spatial training were based on two-dimensional morphometry which does not allow a complete morphometr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.10.031

    authors： Stewart MG,Davies HA,Sandi C,Kraev IV,Rogachevsky VV,Peddie CJ,Rodriguez JJ,Cordero MI,Donohue HS,Gabbott PL,Popov VI

    更新日期：2005-01-01 00:00:00

  • Selective expression of protein F1/(GAP-43) mRNA in pyramidal but not granule cells of the hippocampus.

    abstract：:Protein F1/GAP-43 is a protein kinase C substrate associated with axonal growth and synaptic plasticity. We used in situ hybridization in rat brain to determine the cellular distribution of its gene expression. Throughout the septotemporal axis of the adult hippocampus, pyramidal cells express F1/GAP-43 mRNA, but gran...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90284-u

    authors： Meberg PJ,Routtenberg A

    更新日期：1991-01-01 00:00:00

  • Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury.

    abstract：:Cannabinoid receptor activation has been shown to modulate both neurotransmission (CB(1)) and neuroinflammatory (CB(2)) responses. There are conflicting reports in the literature describing the influence of cannabinoid receptor activation on ischemic/reperfusion injury. The goal of this study was to evaluate how chang...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.01.022

    authors： Zhang M,Martin BR,Adler MW,Razdan RK,Ganea D,Tuma RF

    更新日期：2008-03-27 00:00:00