Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling.

abstract：:Serotonin (5-HT) is a key regulator of mood and sexual behaviors. 5-HT reuptake inhibitors have been used as antidepressants. Really interesting new gene (RING) finger proteins have been associated with 5-HT regulation but their role remains largely unknown. Some RING finger proteins are involved in the serotonergic s...

journal_title：Neuroscience

authors： Moriya S,Khel NB,Parhar IS

更新日期：2015-05-21 00:00:00

abstract：:Distributions of somata and neurites of cholinergic neurons were studied after seeding dissociated cells onto organotypic slice cultures. Slice cultures were made from hippocampal formation and adjacent cortical regions from rats or mice. Dissociated cell suspensions of basal forebrain tissue from rat or mouse fetuses...

journal_title：Neuroscience

authors： Tsai ES,Haraldson SJ,Baratta J,Lander AD,Yu J,Robertson RT

更新日期：2002-01-01 00:00:00

abstract：:The function of N-methyl-d-aspartate (NMDA) receptors in primary afferents remains controversial, in particular regarding their ability to evoke substance P release in the spinal cord. The objective of this study was, first, to confirm that substance P release evoked by NMDA is mediated by NMDA receptors in primary af...

journal_title：Neuroscience

authors： Chen W,Zhang G,Marvizón JC

更新日期：2010-03-31 00:00:00

abstract：:Coordinated activity in different sets of widely-projecting neurochemical systems characterize waking (W) and sleep (S). How and when this coordination is achieved during development is not known. We used embryos and newborns of a precocial bird species (chickens) to assess developmental activation in different neuroc...

journal_title：Neuroscience

authors： Chan A,Li S,Lee AR,Leung J,Yip A,Bird J,Godden KE,Martinez-Gonzalez D,Rattenborg NC,Balaban E,Pompeiano M

更新日期：2016-12-17 00:00:00

abstract：:Chronic psychosocial stress is an important environmental risk factor for the development of psychiatric diseases. However, studying the impact of chronic psychosocial stress in mice is time consuming and thus not optimally suited to 'screen' increasing numbers of genetically manipulated mouse models for psychiatric e...

journal_title：Neuroscience

authors： Brzózka MM,Unterbarnscheidt T,Schwab MH,Rossner MJ

更新日期：2016-02-09 00:00:00

abstract：:This study investigates the pattern of axonal projections of single corticothalamic neurons from the rat primary visual cortex. Microiontophoretic injections of biocytin were made in cortical laminae V and VI to label small pools of corticothalamic cells and their intrathalamic axonal projections. After a survival per...

journal_title：Neuroscience

authors： Bourassa J,Deschênes M

更新日期：1995-05-01 00:00:00

abstract：:GABAergic neurons are coextensive with cholinergic neurons in the medial septum-diagonal band complex. Serial sectioning, sequential staining and double immunofluorescence techniques employing antibodies to glutamate decarboxylase and choline acetyltransferase revealed the distribution of these transmitter-specific ne...

journal_title：Neuroscience

authors： Brashear HR,Zaborszky L,Heimer L

更新日期：1986-02-01 00:00:00

abstract：:We have recently reported on the efficacy of an NK1 tachykinin receptor antagonist in improving outcome following stroke, including reduced blood-brain barrier (BBB) disruption, reduced cerebral edema and improved functional outcome. The clinically approved stroke treatment, tissue plasminogen activator (tPA), has bee...

journal_title：Neuroscience

authors： Turner RJ,Vink R

更新日期：2012-09-18 00:00:00

abstract：:The interaction between the dopaminergic and glutamatergic systems governs normal behavior and is perturbed in many psychiatric disorders including schizophrenia. Hypofunction of the D1 family of receptors, to which the D(1) and D(5) subtypes belong, is a typical feature of schizophrenia. Here we have used confocal li...

journal_title：Neuroscience

authors： Kruusmägi M,Kumar S,Zelenin S,Brismar H,Aperia A,Scott L

更新日期：2009-12-01 00:00:00

abstract：:The rat pineal gland is an attractive system for studies on the capacity of neural systems to recover following partial injury, allowing both for the creation of precise subtotal lesions and for the measurement of recovery of function at the cellular level. The pineal gland receives overlapping sympathetic innervation...

journal_title：Neuroscience

authors： Kuchel GA,Sherman RL,Zigmond RE

更新日期：1990-01-01 00:00:00

abstract：:Extensive evidences now suggest that an association between inducible nitric oxide synthase and oxidative stress takes place during aging. Since the part played by inducible nitric oxide synthase in the sleep impairments associated with aging still remains unexplored, we compared its involvement in old rats (20-24 mon...

journal_title：Neuroscience

authors： Clément P,Sarda N,Cespuglio R,Gharib A

更新日期：2005-01-01 00:00:00

abstract：:Considerable effort has been directed toward the development of methods to selectively activate specific subtypes of neurons. Focus has been placed on the heterologous expression of proteins that are capable of exciting neurons in which they are expressed. Here we describe the heterologous expression of the invertebra...

journal_title：Neuroscience

authors： Schanuel SM,Bell KA,Henderson SC,McQuiston AR

更新日期：2008-08-13 00:00:00

abstract：:Conductive hearing loss is a prevalent condition globally. It remains unclear whether conductive hearing loss that occurs during early development disrupts auditory peripheral systems. In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal ...

journal_title：Neuroscience

authors： Qi Y,Yu S,Du Z,Qu T,He L,Xiong W,Wei W,Liu K,Gong S

更新日期：2019-05-15 00:00:00

abstract：:Age-dependent, neuronal apoptosis following N-methyl-D-aspartate receptor blockade has been linked to loss of calcium. To further explore this relationship, we examined expression of activated caspase-3, as well as the calcium binding proteins, calbindin-D 28K, calretinin and parvalbumin, following injection of vehicl...

journal_title：Neuroscience

authors： Lema Tomé CM,Bauer C,Nottingham C,Smith C,Blackstone K,Brown L,Hlavaty C,Nelson C,Daker R,Sola R,Miller R,Bryan R,Turner CP

更新日期：2006-09-01 00:00:00

abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...

journal_title：Neuroscience

authors： Hata R,Matsumoto M,Hatakeyama T,Ohtsuki T,Handa N,Niinobe M,Mikoshiba K,Sakaki S,Nishimura T,Yanagihara T

更新日期：1993-09-01 00:00:00

abstract：:Cultured neurons offer many advantages over a slice preparation for whole-cell patch-clamp studies, such as better control over the environment and space clamp control. However, heterogeneous cultures of neurons present problems in distinguishing the cell type from which recordings are made. The present study uses cor...

journal_title：Neuroscience

authors： Mynlieff M

更新日期：1999-01-01 00:00:00

abstract：:[3H]Bremazocine, in the presence of saturating concentrations of mu and delta receptor blocking agents, was used to label putative kappa opiate binding sites in rat brain. The binding of [3H]bremazocine under these conditions was completely displaced with high affinity by U-50488H and dynorphin1-17, and the potency of...

journal_title：Neuroscience

authors： Morris BJ,Herz A

更新日期：1986-11-01 00:00:00

abstract：:NADPH-diaphorase histochemical staining demonstrated a distinct neural group that might synthesize nitric oxide in the lower brainstem of rats. The NADPH-diaphorase stain revealed a Golgi-like network in the dorsomedial spinal trigeminal nucleus oralis and rostrolateral solitary tract nucleus, whereas this network was...

journal_title：Neuroscience

authors： Takemura M,Wakisaka S,Yoshida A,Nagase Y,Bae YC,Shigenaga Y

更新日期：1994-08-01 00:00:00

abstract：:Progesterone (PROG) shows neuroprotective effects in numerous lesion models, including a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, the possible beneficial effects of PROG on the behavioral and neurochemical impairments incurred in the hemiparkinson...

journal_title：Neuroscience

authors： Chao OY,Huston JP,von Bothmer A,Pum ME

更新日期：2011-11-24 00:00:00

abstract：:Stereotaxic injections of a dopamine D1 receptor agonist (SKF 38393) into different regions of the supersensitive striatum of rats with a unilateral 6-hydroxydopamine-induced lesion duplicated the systemic effects of the drug in a topographical manner. Although there was considerable overlap, it was possible to recogn...

journal_title：Neuroscience

authors： Fletcher GH,Starr MS

更新日期：1987-02-01 00:00:00

abstract：:In Parkinson's disease, subthalamic nucleus (STN) neurons burst fire with increased periodicity and synchrony. This may entail abnormal release of glutamate, the major source of which in STN is cortical afferents. Indeed, the cortico-subthalamic pathway is implicated in the emergence of excessive oscillations, which a...

journal_title：Neuroscience

authors： Yamawaki N,Magill PJ,Woodhall GL,Hall SD,Stanford IM

更新日期：2012-02-17 00:00:00

abstract：:Brain injury can often result in the subsequent appearance of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibitio...

journal_title：Neuroscience

authors： Ding MC,Lo EH,Stanley GB

更新日期：2008-06-23 00:00:00

abstract：:The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate...

journal_title：Neuroscience

authors： Espeseth T,Endestad T,Rootwelt H,Reinvang I

更新日期：2007-07-29 00:00:00

abstract：:GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS). The gene encodes a highly conserved protein with an essential role in mRNA export. The mechanism linking Gle1 ...

journal_title：Neuroscience

authors： Seytanoglu A,Alsomali NI,Valori CF,McGown A,Kim HR,Ning K,Ramesh T,Sharrack B,Wood JD,Azzouz M

更新日期：2016-05-13 00:00:00

abstract：:Synapse formation in CNS neurons requires appropriate sorting and clustering of neurotransmitter receptors and associated proteins at postsynaptic sites. In GABAergic synapses, clustering of GABA(A) receptors requires gephyrin, but it is not known whether presynaptic signals are also involved in this process. To inves...

journal_title：Neuroscience

authors： Studler B,Fritschy JM,Brünig I

更新日期：2002-01-01 00:00:00

abstract：:The purpose of the present study was to investigate, by use of in vivo microdialysis technique, the regulatory role of galanin on acetylcholine (ACh) release in the CA1, CA3, and dentate gyrus (DG) subregions of rat dorsal and ventral hippocampus. In the ventral hippocampus, local infusions of galanin (1.5 nmol) into ...

journal_title：Neuroscience

authors： Yoshitake T,Yoshitake S,Savage S,Elvander-Tottie E,Ogren SO,Kehr J

更新日期：2011-12-01 00:00:00

abstract：:In order to investigate neural mechanisms by which the prefrontal cortex adaptively modifies its activities based on past experience, we examined whether or not sensory cortical projections to the medial prefrontal cortex support long-term potentiation (LTP) in rats. Monosynaptic projections from the secondary visual ...

journal_title：Neuroscience

authors： Kim MJ,Chun SK,Kim YB,Mook-Jung I,Jung MW

更新日期：2003-01-01 00:00:00

abstract：:During spinal cord maturation neuronal excitability gradually differentiates to meet different functional demands. Spontaneous activity, appearing early during spinal development, is regulated by the expression pattern of ion channels in individual neurons. While emerging excitability of embryonic motoneurons has been...

journal_title：Neuroscience

authors： Furlan F,Guasti L,Avossa D,Becchetti A,Cilia E,Ballerini L,Arcangeli A

更新日期：2005-01-01 00:00:00

abstract：:Stimulus-induced pattern of bioelectric activity in human neocortical tissue was investigated by use of the voltage sensitive dye RH795 and a fast optical recording system. During control conditions stimulation of layer I evoked activity predominantly in supragranular layers showing a spatial extent of up to 3000 micr...

journal_title：Neuroscience

authors： Straub H,Kuhnt U,Höhling JM,Köhling R,Gorji A,Kuhlmann D,Tuxhorn I,Ebner A,Wolf P,Pannek HW,Lahl R,Speckmann EJ

更新日期：2003-01-01 00:00:00

abstract：:The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...

journal_title：Neuroscience

authors： Moreno-Flores MT,Wandosell F

更新日期：1999-01-01 00:00:00