The spinal transmission of nociceptive information: modulation by the caudal medulla.


:Multiple descending systems for pain control originate from the rostral medulla and midbrain. These systems are involved in the antinociceptive action produced by opioids. One category of descending inhibitory controls is activated specifically by noxious stimuli and has been termed diffuse noxious inhibitory controls. These controls have been described in both animal and man, but their supraspinal circuitry has not been fully localized. To determine the supraspinal level of integration of nociceptor activated controls and hence their potential relationships with previously described descending controls, we studied in halothane-anesthetized rats the effects of transections performed at various levels in the brainstem. The physiological properties of dorsal horn convergent neurons, including supraspinally-mediated inhibitory processes elicited by heterotopic noxious stimuli, i.e. diffuse noxious inhibitory controls, were not altered in rats in which the brainstem had been completely transected up to 200 microns caudal to the caudal end of the rostral ventromedial medulla. In contrast, the spontaneous activity of these neurons was significantly enhanced and the inhibitory phenomena significantly reduced in animals with transections more than 500 microns caudal to the caudal end of the rostral ventromedial medulla. These effects were not related to cardiovascular changes induced by the transections. These data indicate that some tonic descending inhibitory controls and diffuse noxious inhibitory controls depend upon connections in the caudal medulla. It is proposed that this area constitutes another level from which the transmission of nociceptive information can be modulated and that it acts co-operatively with previously described modulatory systems in the spinal cord and at more rostral levels of the brainstem.






Bouhassira D,Chitour D,Villaneuva L,Le Bars D




Has Abstract


1995-12-01 00:00:00














  • Pyramidal input to the intracerebellar nuclei of the cat.

    abstract::In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...


    pub_type: 杂志文章


    authors: Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

    更新日期:1983-06-01 00:00:00

  • Adrenergic mechanisms of the Kölliker-Fuse/A7 area on the control of water and sodium intake.

    abstract::The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present study we investigated the effect...


    pub_type: 杂志文章


    authors: Gasparini S,de Luca LA Jr,Colombari DS,de Paula PM,Barbosa SP,Menani JV

    更新日期:2009-12-01 00:00:00

  • Depolarization of rat locus coeruleus neurons by adenosine 5'-triphosphate.

    abstract::Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following ...


    pub_type: 杂志文章


    authors: Harms L,Finta EP,Tschöpl M,Illes P

    更新日期:1992-06-01 00:00:00

  • Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments.

    abstract::The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provi...


    pub_type: 杂志文章


    authors: Bassareo V,Di Chiara G

    更新日期:1999-03-01 00:00:00

  • The Impact of Perineuronal Net Digestion Using Chondroitinase ABC on the Intrinsic Physiology of Cortical Neurons.

    abstract::Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNN expression around somas, proximal d...


    pub_type: 杂志文章


    authors: Chu P,Abraham R,Budhu K,Khan U,De Marco Garcia N,Brumberg JC

    更新日期:2018-09-15 00:00:00

  • Activity of deep dorsal horn neurons in the anaesthetized rat during hyperalgesia of the hindpaw induced by ultraviolet irradiation.

    abstract::Thermal hyperalgesia was induced by UV irradiation of the glabrous skin of the hindpaw of adult female Sprague-Dawley rats. We have recorded single cell activity and studied excitability changes in wide dynamic range neurons in the lumbar spinal segments during the early phase (days 1-3) and late phase (days 5-7) of t...


    pub_type: 杂志文章


    authors: Urban L,Perkins MN,Campbell E,Dray A

    更新日期:1993-11-01 00:00:00

  • Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury.

    abstract::A diet consisting of high levels of saturated fat has been linked to a dramatic rise in obesity, type II diabetes, and metabolic syndrome. The effect of these co-morbidities on stroke outcome has not been examined in detail in human or animal studies. In this study we hypothesized that maintaining animals on a high fa...


    pub_type: 杂志文章


    authors: Langdon KD,Clarke J,Corbett D

    更新日期:2011-05-19 00:00:00

  • Role of blood-brain barrier in temporal lobe epilepsy and pharmacoresistance.

    abstract::Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...


    pub_type: 杂志文章,评审


    authors: van Vliet EA,Aronica E,Gorter JA

    更新日期:2014-09-26 00:00:00

  • Identification of dynorphin a from zebrafish: a comparative study with mammalian dynorphin A.

    abstract::We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin...


    pub_type: 杂志文章


    authors: Gonzalez-Nuñez V,Marrón Fernández de Velasco E,Arsequell G,Valencia G,Rodríguez RE

    更新日期:2007-01-19 00:00:00

  • White matter differences between multiple system atrophy (parkinsonian type) and Parkinson's disease: A diffusion tensor image study.

    abstract::The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...


    pub_type: 杂志文章


    authors: Ji L,Wang Y,Zhu D,Liu W,Shi J

    更新日期:2015-10-01 00:00:00

  • The effects of acoustic trauma that can cause tinnitus on spatial performance in rats.

    abstract::Previous studies have shown that acoustic trauma can disrupt the firing of place cells in the hippocampus and also inhibit hippocampal neurogenesis, suggesting that such trauma might impair spatial memory. In this study, we investigated performance in the alternating T maze and Morris water maze of rats exposed to aco...


    pub_type: 杂志文章


    authors: Zheng Y,Hamilton E,Begum S,Smith PF,Darlington CL

    更新日期:2011-07-14 00:00:00

  • Glutamate receptor antagonism in inferior colliculus attenuates elevated startle response of high anxiety diazepam-withdrawn rats.

    abstract::Rats segregated according to low (LA) or high (HA) anxiety levels have been used as an important tool in the study of fear and anxiety. Since the efficacy of an anxiolytic compound is a function of the animal's basal anxiety level, it is possible that chronic treatment with a benzodiazepine (Bzp) affects LA and HA ani...


    pub_type: 杂志文章


    authors: Cabral A,De Ross J,Castilho VM,Brandão ML,Nobre MJ

    更新日期:2009-07-07 00:00:00

  • 1H-MRS can monitor metabolites changes of lateral intraventricular BDNF infusion into a mouse model of Alzheimer's disease in vivo.

    abstract::Proton magnetic resonance spectroscopy (1H-MRS) can provide noninvasive detection of brain metabolite changes in vivo in Alzheimer's disease (AD). AD is a prevalent neurodegenerative disorder characterized by deposition of β-amyloid peptides (Aβ) in multiple brain regions. Brain-derived neurotrophic factor (BDNF) is a...


    pub_type: 杂志文章,收录出版


    authors: Zhang W,Wang PJ,Li MH,Gao XL,Gu GJ,Shao ZH

    更新日期:2013-08-15 00:00:00

  • Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.

    abstract::We investigated the electrophysiology of morphologically identified human granule cells with conventional current-clamp recordings. Slices were prepared from 14 human epileptic sclerotic hippocampi. Granule cells appeared to have a diverse electrophysiology. Each cell was distinguished by the shape of the afterhyperpo...


    pub_type: 杂志文章


    authors: Dietrich D,Clusmann H,Kral T,Steinhäuser C,Blümcke I,Heinemann U,Schramm J

    更新日期:1999-01-01 00:00:00

  • Neonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.

    abstract::Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...


    pub_type: 杂志文章


    authors: Bakker J,Baum MJ,Slob AK

    更新日期:1996-09-01 00:00:00

  • GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour.

    abstract::The role of GABA(A) receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABA(A) receptor agonist muscimol (50 ng) nor the antagonist bicuculline (200 ng) unilaterally injected into the mdT elicited any behavioural change. Unilateral injection of the acetylcholine receptor ...


    pub_type: 杂志文章


    authors: Ikeda H,Kotani A,Lee J,Koshikawa N,Cools AR

    更新日期:2009-04-10 00:00:00

  • Functional differences between D(1) and D(5) revealed by high resolution imaging on live neurons.

    abstract::The interaction between the dopaminergic and glutamatergic systems governs normal behavior and is perturbed in many psychiatric disorders including schizophrenia. Hypofunction of the D1 family of receptors, to which the D(1) and D(5) subtypes belong, is a typical feature of schizophrenia. Here we have used confocal li...


    pub_type: 杂志文章


    authors: Kruusmägi M,Kumar S,Zelenin S,Brismar H,Aperia A,Scott L

    更新日期:2009-12-01 00:00:00

  • Efferent projections of nucleus locus coeruleus: topographic organization of cells of origin demonstrated by three-dimensional reconstruction.

    abstract::The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...


    pub_type: 杂志文章


    authors: Loughlin SE,Foote SL,Bloom FE

    更新日期:1986-06-01 00:00:00

  • Involvement of SMAp in the intention-related long latency stretch reflex modulation: a TMS study.

    abstract::When our movement is perturbed by environmental forces, the Long Latency Stretch Reflex (LLSR), generated by a transcortical loop through the primary motor cortex (M1), is the fastest reaction adapted according to our prior intent. We investigated the involvement of the caudal part of the Supplementary Motor Area (SMA...


    pub_type: 杂志文章


    authors: Spieser L,Aubert S,Bonnard M

    更新日期:2013-08-29 00:00:00

  • Mutual interactions of the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic terminals in the mouse brain.

    abstract::We studied whether interactions between the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic neurons of the mouse brain cortex occur. Cerebral cortex slices from the mouse (and, in few experiments, from the rat) were preincubated with [3H]noradrenaline and then superfused with a physiologi...


    pub_type: 杂志文章


    authors: Schlicker E,Marr I

    更新日期:1997-07-01 00:00:00

  • Working memory and the homeostatic control of brain adenosine by adenosine kinase.

    abstract::The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...


    pub_type: 杂志文章


    authors: Singer P,McGarrity S,Shen HY,Boison D,Yee BK

    更新日期:2012-06-28 00:00:00

  • Synaptic excitation in the dorsal nucleus of the lateral lemniscus: whole-cell patch-clamp recordings from rat brain slice.

    abstract::The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...


    pub_type: 杂志文章


    authors: Fu XW,Brezden BL,Kelly JB,Wu SH

    更新日期:1997-06-01 00:00:00

  • Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord.

    abstract::Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...


    pub_type: 杂志文章


    authors: Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

    更新日期:2002-01-01 00:00:00

  • Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats.

    abstract::The forced swim test (FST) has been considered as a pharmacologically valid test of the depressive syndrome in rodents. However, few studies have focused on neurochemical and behavioral responses during FST in both male and female rats. Thus, we investigated certain behavioral and neuroendocrine responses as well as t...


    pub_type: 杂志文章


    authors: Drossopoulou G,Antoniou K,Kitraki E,Papathanasiou G,Papalexi E,Dalla C,Papadopoulou-Daifoti Z

    更新日期:2004-01-01 00:00:00

  • Plasticity of tyrosine hydroxylase and vasoactive intestinal peptide messenger RNAs in visceral afferent neurons of the nodose ganglion upon axotomy-induced deafferentation.

    abstract::The nodose ganglion contains placode-derived visceral sensory neurons of the vagus nerve. Previous study showed that axotomy-induced deafferentation reduced the number of tyrosine hydroxylase-immunoreactive and increased the number of vasoactive intestinal peptide-immunoreactive neurons in the ganglion. The present st...


    pub_type: 杂志文章


    authors: Zhuo H,Sinclair C,Helke CJ

    更新日期:1994-11-01 00:00:00

  • Topographical representation of vestibulo-ocular reflexes in rabbit cerebellar flocculus.

    abstract::In anaesthetized albino rabbits, the cerebellar flocculus was systematically mapped with a glass microelectrode to identify the location of Purkinje cells that inhibit specific vestibulo-ocular reflex pathways. The effects of microstimulation of the flocculus Purkinje cell layer on vestibular nerve-evoked reflexes to ...


    pub_type: 杂志文章


    authors: Ito M,Orlov I,Yamamoto M

    更新日期:1982-07-01 00:00:00

  • The visceral sector of the thalamic reticular nucleus in the rat.

    abstract::Visceral sensory perception is subjected to modulation by attention or distraction, like other sensory systems. The thalamic reticular nucleus is a key region in selective attention, effecting a change in the mode of thalamocortical transmission. Each major thalamocortical system is connected with a particular sector ...


    pub_type: 杂志文章


    authors: Stehberg J,Acuña-Goycolea C,Ceric F,Torrealba F

    更新日期:2001-01-01 00:00:00

  • Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures.

    abstract::The transmembrane isoform of agrin (Tm-agrin) is the predominant form expressed in the brain but its putative roles in brain development are not well understood. Recent reports have implicated Tm-agrin in the formation and stabilization of filopodia on neurites of immature central and peripheral neurons in culture. In...


    pub_type: 杂志文章


    authors: McCroskery S,Bailey A,Lin L,Daniels MP

    更新日期:2009-09-29 00:00:00

  • Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.

    abstract::The nicotinic receptor proteins and gene transcripts for the different nicotinic receptor subunits exist in human prenatal brain already at 4-5 weeks of gestation. The early presence of nicotinic receptors suggests an important role for these receptors in modulating dendritic outgrowth, establishment of neuronal conne...


    pub_type: 杂志文章


    authors: Hellström-Lindahl E,Seiger A,Kjaeldgaard A,Nordberg A

    更新日期:2001-01-01 00:00:00

  • Directed axonal growth towards axolotl limb blastemas in vitro.

    abstract::Limb amputation in urodele amphibia is followed by formation of a blastema, which subsequently develops into a complete limb with normal pattern of innervation. In this study, we investigated the effects of axolotl limb blastemas on axonal growth in gels of collagen and extracellular matrix (matrigel). When peripheral...


    pub_type: 杂志文章


    authors: Tonge DA,Leclere PG

    更新日期:2000-01-01 00:00:00