Chronic stress impairs acoustic conditioning more than visual conditioning in rats: morphological and behavioural evidence.

abstract：:Resident microglia are involved in immune responses of the central nervous system and may contribute to neuronal degeneration and death. Here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the ...

journal_title：Neuroscience

authors： Lu X,Bing G,Hagg T

更新日期：2000-01-01 00:00:00

abstract：:Subjective tinnitus is a chronic neurological disorder in which phantom sounds are perceived. Recent evidence supports the hypothesis that tinnitus is related to neuronal hyperactivity in auditory brain regions, and consequently drugs that increase GABAergic neurotransmission in the CNS, such as the GABA(B) receptor a...

journal_title：Neuroscience

authors： Zheng Y,McPherson K,Smith PF

更新日期：2014-01-31 00:00:00

abstract：:Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during t...

journal_title：Neuroscience

authors： Hueston CM,Cryan JF,Nolan YM

更新日期：2017-12-04 00:00:00

abstract：:The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...

journal_title：Neuroscience

authors： Loughlin SE,Foote SL,Bloom FE

更新日期：1986-06-01 00:00:00

abstract：:Activity within the mesolimbic dopamine system is associated with the performance of naturally motivated behaviors, one of which is aggression. In male rats, aggressive behavior induces neurochemical changes within the nucleus accumbens, a key structure within the mesolimbic dopamine system. Corresponding studies have...

journal_title：Neuroscience

authors： Staffend NA,Meisel RL

更新日期：2012-12-27 00:00:00

abstract：:Astrocytic endothelin receptors are involved in the appearance of activated astrocytes upon injury of the brain [Ishikawa N. et al. (1997) Eur. J. Neurosci. 9, 895-901; Koyama Y. et al. (1999) Glia 26, 268-271]. To clarify signal transduction triggered by endothelin receptors, we examined the effects of endothelins on...

journal_title：Neuroscience

authors： Koyama Y,Yoshioka Y,Hashimoto H,Matsuda T,Baba A

更新日期：2000-01-01 00:00:00

abstract：:The N-methyl-D-aspartate channel blocker phencyclidine is known to induce psychotic episodes in normal subjects and exacerbate psychosis in schizophrenics; however, its site of action is not clear. The prefrontal cortex, hippocampus, and basal ganglia are brain regions that appear to play a role in the pathophysiology...

journal_title：Neuroscience

authors： O'Donnell P,Grace AA

更新日期：1998-12-01 00:00:00

abstract：:The medial thalamus contains abundant mu-opioid receptors and is activated by acute morphine administration. However, the role of the medial thalamus in the rewarding effects of morphine is unclear. The present study examined whether mu-opioid receptors of the medial thalamus influenced the acquisition and expression ...

journal_title：Neuroscience

authors： Guo N,Garcia MM,Taylor BK,Zadina JE,Harlan RE

更新日期：2008-02-19 00:00:00

abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

journal_title：Neuroscience

authors： Turgeon SM,Albin RL

更新日期：1994-09-01 00:00:00

abstract：:Although neurogenesis in the hippocampus is critical for improvement of depressive behaviors and cognitive functions in neurodegeneration disorders, there is no therapeutic agent available to promote neurogenesis in adult brain following brain ischemic injury. Here we found that i.p. administration of bis(1-oxy-2-pyri...

journal_title：Neuroscience

authors： Shioda N,Han F,Morioka M,Fukunaga K

更新日期：2008-08-26 00:00:00

abstract：:Using in vitro receptor autoradiographic techniques we have analysed the pre- and postnatal development of neurotensin receptors in the rat brain. Receptors were labeled with [3H] or [125I]neurotensin in mounted tissue sections from animals of ages gestational day 14 until the postnatal day 21 as well as young adult a...

journal_title：Neuroscience

authors： Palacios JM,Pazos A,Dietl MM,Schlumpf M,Lichtensteiger W

更新日期：1988-04-01 00:00:00

abstract：:The aim of this study was to assess the effect of blocking the axonal transport of sensory neuropeptides, by local injection of colchicine at pelvic ganglia level, on the sensory and efferent functions mediated by capsaicin-sensitive primary afferent neurons innervating the rat urinary bladder. Bilateral injection of ...

journal_title：Neuroscience

authors： Lecci A,Patacchini R,De Giorgio R,Corinaldesi R,Theodorsson E,Giuliani S,Santicioli P,Maggi CA

更新日期：1996-03-01 00:00:00

abstract：:The effect of intrathecal or intracerebroventricular administration of the GABAB receptor agonist, baclofen, on rhythmic contractions induced by distension of the urinary bladder (micturition reflex) was evaluated in urethane-anesthetized rats. Baclofen inhibited bladder motility acting at central nervous system sites...

journal_title：Neuroscience

authors： Giuliani S,Lecci A,Santicioli P,Del Bianco E,Maggi CA

更新日期：1992-01-01 00:00:00

abstract：:Working memory has often been modeled and conceptualized as a kind of binary (bistable) memory switch, where stimuli turn on plateau-like persistent activity in subsets of cells, in line with many in vivo electrophysiological reports. A potentially related form of bistability, termed up- and down-states, has been stud...

journal_title：Neuroscience

authors： Durstewitz D,Seamans JK

更新日期：2006-04-28 00:00:00

abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

journal_title：Neuroscience

authors： Clarke PG,Nussbaumer JC

更新日期：1987-12-01 00:00:00

abstract：:Since functional imaging of whole body movements is not feasible with functional magnetic resonance imaging (fMRI), the present study presents in vivo functional near-infrared spectroscopy (fNIRS) as a suitable technique to measure body movement effects on fronto-temporo-parietal cortical activation in single- and dua...

journal_title：Neuroscience

authors： Metzger FG,Ehlis AC,Haeussinger FB,Schneeweiss P,Hudak J,Fallgatter AJ,Schneider S

更新日期：2017-02-20 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00

abstract：:Excitotoxic mechanisms involving alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA)/kainate receptors play an important role in mediating cellular damage in spinal cord injury. However, the precise cellular mechanisms of glutamate release from non-synaptic white matter are not well understood. We examined ho...

journal_title：Neuroscience

authors： Li S,Stys PK

更新日期：2001-01-01 00:00:00

abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

journal_title：Neuroscience

authors： Kim JY,Yenari MA,Lee JE

更新日期：2015-02-12 00:00:00

abstract：:The purpose of this study was to examine whether mechanisms, involved during the maintenance of familiar movement information in memory, were influenced by the degree of familiarity of the display in which the movements were embedded. Twelve gymnasts who possessed high visual and motor familiarity with the movements e...

journal_title：Neuroscience

authors： Calmels C,Foutren M,Stam CJ

更新日期：2012-06-14 00:00:00

abstract：:The role of ubiquitin in development of the mammalian brain has been studied using a monoclonal antibody, RHUb1, specific for ubiquitin. Immunodevelopment of western blots of homogenate samples of the cerebral cortex, hippocampus and cerebellum prepared from animals of known postnatal age show marked developmental cha...

journal_title：Neuroscience

authors： Flann S,Hawkes RB,Riederer BM,Rider CC,Beesley PW

更新日期：1997-11-01 00:00:00

abstract：:Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons we...

journal_title：Neuroscience

authors： Varastet M,Riche D,Maziere M,Hantraye P

更新日期：1994-11-01 00:00:00

abstract：:Aberrant, lesion-induced neuroplastic changes in the auditory pathway are believed to give rise to the phantom sound of tinnitus. Noise-induced cochlear damage can induce extensive fiber growth and synaptogenesis in the cochlear nucleus, but it is currently unclear if these changes are linked to tinnitus. To address t...

journal_title：Neuroscience

authors： Kraus KS,Ding D,Jiang H,Lobarinas E,Sun W,Salvi RJ

更新日期：2011-10-27 00:00:00

abstract：:A recent series of studies in rats has demonstrated positively reinforcing and memory enhancing effects following lesions of the nucleus tuberomammillaris, which is the only known source of neuronal histamine. The aim of the present experiments was to assess whether inhibition of histaminergic neurotransmission in the...

journal_title：Neuroscience

authors： Zimmermann P,Privou C,Huston JP

更新日期：1999-01-01 00:00:00

abstract：:Recent studies have demonstrated that astrocytes express a variety of ion channels and neurotransmitter receptors and can modulate the activity of neurons. Since a single astrocyte makes tight contacts with many neighboring neuronal cells, they can provide efficient and wide modulation of neuronal networks. Here, we p...

journal_title：Neuroscience

authors： Yamazaki Y,Hozumi Y,Kaneko K,Li J,Fujii S,Miyakawa H,Kudo Y,Kato H

更新日期：2005-01-01 00:00:00

abstract：:The role of the cerebral cortex in maintaining human standing balance remains unclear. Beta corticomuscular coherence (CMC) provides a measure of communication between the sensory-motor cortex and muscle, but past literature has not demonstrated significant beta CMC during human stance. This study evaluated the effect...

journal_title：Neuroscience

authors： Jacobs JV,Wu G,Kelly KM

更新日期：2015-07-09 00:00:00

abstract：:To elucidate the role and the mechanism of action of nerve growth factor in the adult central nervous system, we investigated the localization of nerve growth factor-like immunoreactivity in adult rat brain, both quantitatively and immunohistochemically, using polyclonal anti-nerve growth factor immunoglobulin G. We r...

journal_title：Neuroscience

authors： Nishio T,Furukawa S,Akiguchi I,Oka N,Ohnishi K,Tomimoto H,Nakamura S,Kimura J

更新日期：1994-05-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1), vanilloid 2 (TRPV2) and melastatin 8 (TRPM8) are thermosensitive cation channels expressed on primary sensory neurons. In contrast to TRPV1, which is present on nociceptive primary afferents and keratinocytes in human skin, less is known about the distribution of TRPV2...

journal_title：Neuroscience

authors： Axelsson HE,Minde JK,Sonesson A,Toolanen G,Högestätt ED,Zygmunt PM

更新日期：2009-09-15 00:00:00

abstract：:Previous studies have shown that pretreatment with neurotrophins can potentiate the vulnerability of cultured neurons to excitotoxic and free radical-induced necrosis, in contrast to their well known neuroprotective effects against apoptosis. Here we tested the hypothesis that this unexpected injury-potentiating effec...

journal_title：Neuroscience

authors： Mcdonald JW,Stefovska VG,Liu XZ,Shin H,Liu S,Choi DW

更新日期：2002-01-01 00:00:00

abstract：:We have investigated effects of letrozole, an aromatase inhibitor, on spatial learning and memory, expression of neural cell adhesion molecules (NCAM) and catecholaminergic neurotransmitters in the hippocampus and cortex of female rats. In the intact model, adult Sprague-Dawley rats were divided into four groups (n=8)...

journal_title：Neuroscience

authors： Aydin M,Yilmaz B,Alcin E,Nedzvetsky VS,Sahin Z,Tuzcu M

更新日期：2008-01-02 00:00:00