Aggressive experience increases dendritic spine density within the nucleus accumbens core in female Syrian hamsters.

Abstract:

:Activity within the mesolimbic dopamine system is associated with the performance of naturally motivated behaviors, one of which is aggression. In male rats, aggressive behavior induces neurochemical changes within the nucleus accumbens, a key structure within the mesolimbic dopamine system. Corresponding studies have not been done in females. Female Syrian hamsters live as isolates and when not sexually responsive are aggressive toward either male or female intruders, making them an excellent model for studying aggression in females. We took advantage of this naturally expressed behavior to examine the effects of repeated aggressive experience on the morphology of medium spiny neurons in the nucleus accumbens and caudate nucleus, utilizing a DiOlistic labeling approach. We found that repeated aggressive experience significantly increased spine density within the nucleus accumbens core, with no significant changes in any other brain region examined. At the same time, significant changes in spine morphology were observed in all brain regions following repeated aggressive experience. These data are significant in that they demonstrate that repeated exposure to behaviors that form part of an animal's life history will alter neuronal structure in a way that may shift neurobiological responses to impact future social interactions.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Staffend NA,Meisel RL

doi

10.1016/j.neuroscience.2012.09.064

subject

Has Abstract

pub_date

2012-12-27 00:00:00

pages

163-9

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(12)00991-8

journal_volume

227

pub_type

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