Freely Chosen Cadence During Cycling Attenuates Intracortical Inhibition and Increases Intracortical Facilitation Compared to a Similar Fixed Cadence.

Abstract:

:In contrast to other rhythmic tasks such as running, the preferred movement rate in cycling does not minimize energy consumption. It is possible that neurophysiological mechanisms contribute to the choice of cadence, however this phenomenon is not well understood. Eleven participants cycled at a fixed workload of 125 W and different cadences including a freely chosen cadence (FCC, ∼72), and fixed cadences of 70, 80, 90 and 100 revolutions per minute (rpm) during which transcranial magnetic stimulation (TMS) was used to measure short interval intracortical inhibition (SICI) and intracortical facilitation (ICF). There was a significant increase in SICI at 70 (P = 0.004), 80 (P = 0.008) and 100 rpm (P = 0.041) compared to FCC. ICF was significantly reduced at 70 rpm compared to FCC (P = 0.04). Inhibition-excitation ratio (SICI divided by ICF) declined (P = 0.014) with an increase in cadence. The results demonstrate that SICI is attenuated during FCC compared to fixed cadences. The outcomes suggest that the attenuation of intracortical inhibition and augmentation of ICF may be a contributing factor for FCC.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Sidhu SK,Lauber B

doi

10.1016/j.neuroscience.2020.06.021

subject

Has Abstract

pub_date

2020-08-10 00:00:00

pages

93-101

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30397-3

journal_volume

441

pub_type

杂志文章
  • Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons.

    abstract::In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00129-3

    authors: Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

    更新日期:1999-01-01 00:00:00

  • A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.

    abstract::Intracellular recordings were made from neurons in a rat locus coeruleus slice preparation in vitro. A postsynaptic potential was evoked by electrical stimulation of afferents to the neurons. CI-977 ([5R-(5a,7a,8b)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec -8-yl[-4-benzofuranacetamide monohydrochloride) cause...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90123-j

    authors: Pinnock RD

    更新日期:1992-01-01 00:00:00

  • Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain.

    abstract::Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion and migration, and neurite outgrowth. Since these processes have been found to be under thyroid control in the developing rat brain, we have investigated the effect of congenital hypothyroidism on tenascin-C expression. At birth, in situ hybr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00511-3

    authors: Alvarez-Dolado M,González-Sancho JM,Bernal J,Muñoz A

    更新日期:1998-05-01 00:00:00

  • Cholinergic excitation from the pedunculopontine tegmental nucleus to the dentate nucleus in the rat.

    abstract::In spite of the existence of pedunculopontine tegmental nucleus (PPTg) projections to cerebellar nuclei, their nature and functional role is unknown. These fibers may play a crucial role in postural control and may be involved in the beneficial effects induced by deep-brain stimulation (DBS) of brainstem structures in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.12.055

    authors: Vitale F,Mattei C,Capozzo A,Pietrantoni I,Mazzone P,Scarnati E

    更新日期:2016-03-11 00:00:00

  • Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.

    abstract::Incubation of the rat sensory neuron-derived cell line ND7 in serum-free medium results in the arrest of mitosis and the appearance of numerous neuronal processes. During this differentiation event, secretory granule components such as chromogranins, neuropeptide Y and the C-flanking peptide of pro-neuropeptide Y move...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90297-f

    authors: Wheatley SC,Suburo AM,Horn DA,Vucicevic V,Terenghi G,Polak JM,Latchman DS

    更新日期:1992-12-01 00:00:00

  • Neural mechanisms of single corrective steps evoked in the standing rabbit.

    abstract::Single steps in different directions are often used for postural corrections. However, our knowledge about the neural mechanisms underlying their generation is scarce. This study was aimed to characterize the corrective steps generated in response to disturbances of the basic body configuration caused by forward, back...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.02.007

    authors: Hsu LJ,Zelenin PV,Lyalka VF,Vemula MG,Orlovsky GN,Deliagina TG

    更新日期:2017-04-07 00:00:00

  • Ultrastructural cytochemical localization of carbonic anhydrase activity in rat peripheral sensory and motor nerves, dorsal root ganglia and dorsal column nuclei.

    abstract::Some of the myelinated axons in rat peripheral nerves possess marked axoplasmic carbonic anhydrase activity [Riley, Ellis and Bain (1982) J. Histochem. Cytochem. 30, 1275-1288; Riley and Lang (1984) J. Hand Surg. 9A, 112-120]. A mixture of reactive and nonreactive neurons was a general observation in cervical, thoraci...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90269-0

    authors: Riley DA,Ellis S,Bain JL

    更新日期:1984-09-01 00:00:00

  • Short increase of BDNF messenger RNA triggers kainic acid-induced neuronal hypertrophy in adult mice.

    abstract::Neurotrophin gene expression in adult brain varies according to physiological activity and following brain injury, suggesting a role in neuronal maintenance and plasticity. However, the exact roles and mechanisms of action of neurotrophins in the adult brain are still poorly understood. We have recently demonstrated t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00005-x

    authors: Guilhem D,Dreyfus PA,Makiura Y,Suzuki F,Onteniente B

    更新日期:1996-06-01 00:00:00

  • Influence of the medial septal nucleus on the excitability of the commissural path-CA1 pyramidal cell synapse in the hippocampus of freely moving mice.

    abstract::Changes in the excitability of the commissural path-CA1 pyramidal cell synapse were studied by varying the interval between the application of a conditioning pulse in the medial septal nucleus and a test pulse in the contralateral hippocampus in freely moving mice. The results showed that septal prestimulation results...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90067-2

    authors: Jeantet Y,Jaffard R

    更新日期:1983-01-01 00:00:00

  • D-1 and D-2 dopaminergic receptors regulate protein phosphorylation in the rat neurohypophysis.

    abstract::Dopamine stimulates the phosphorylation of the neuron-specific synaptic vesicle proteins Synapsin I, Protein IIIa and Protein IIIb in the posterior pituitary gland of the rat [Tsou and Greengard (1982) Proc. natn. Acad. Sci. U.S.A. 79, 6075-6079]. This effect has been characterized in the present investigation. The st...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90073-9

    authors: Treiman M,Greengard P

    更新日期:1985-07-01 00:00:00

  • Monoclonal antibodies to chromaffin cells can distinguish proteins specific to or specifically excluded from chromaffin granules.

    abstract::I have prepared a number of monoclonal antibodies to chromaffin cell membranes. One of these antibodies recognizes a number of antigenically related proteins that are present in all tissues examined. In the adrenal, these proteins are completely excluded from chromaffin granules but are present in other subcellular me...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90204-1

    authors: Pruss RM

    更新日期:1987-07-01 00:00:00

  • Encoding of temporal features of auditory stimuli in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat.

    abstract::Neurons in the superior paraolivary nucleus (SPON) of the rat respond to the offset of pure tones with a brief burst of spikes. Medial nucleus of the trapezoid body (MNTB) neurons, which inhibit the SPON, produce a sustained pure tone response followed by an offset response characterized by a period of suppressed spon...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.11.008

    authors: Kadner A,Berrebi AS

    更新日期:2008-02-06 00:00:00

  • Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.

    abstract::Homer is a postsynaptic density (PSD) scaffold protein that is involved in synaptic plasticity, calcium signaling and neurological disorders. Here, we use pre-embedding immunogold electron microscopy to illustrate the differential localization of three Homer gene products (Homer 1, 2, and 3) in different regions of th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.01.066

    authors: Tao-Cheng JH,Thein S,Yang Y,Reese TS,Gallant PE

    更新日期:2014-04-25 00:00:00

  • Semaphorin4D promotes axon regrowth and swimming ability during recovery following zebrafish spinal cord injury.

    abstract::Semaphorins comprise a family of proteins involved in axon guidance during development. Semaphorin4D (Sema4D) has both neuroregenerative and neurorepressive functions, being able to stimulate both axonal outgrowth and growth cone collapse during development, and therefore could play an important role in neurological r...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.03.030

    authors: Peng SX,Yao L,Cui C,Zhao HD,Liu CJ,Li YH,Wang LF,Huang SB,Shen YQ

    更新日期:2017-05-20 00:00:00

  • Characteristics and specific localization of receptors for atrial natriuretic peptides at non-neuronal cells in cultured mouse spinal cord cells.

    abstract::Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90342-4

    authors: Simonnet G,Allard M,Legendre P,Gabrion J,Vincent JD

    更新日期:1989-01-01 00:00:00

  • Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.

    abstract::In several tauopathies such as Alzheimer's disease (AD), an increased incidence of seizures is observed. Tau, one of the major proteins implicated in AD pathology, is an important regulator of neural network excitability and might participate in the underlying epileptic cascade. However, the mechanisms underlying this...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.11.007

    authors: Van Erum J,Valkenburg F,Van Dam D,De Deyn PP

    更新日期:2020-01-15 00:00:00

  • Lesion-induced transient suppression of inhibitory function in rat neocortex in vitro.

    abstract::The structural and functional consequences of a local thermolesion were examined in rat neocortex with electrophysiological in vitro techniques and immunocytochemistry. Age-matched untreated and sham-operated animals served as controls and were analysed in the same way. The lesions consisted of a core of coagulated ti...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90270-4

    authors: Mittmann T,Luhmann HJ,Schmidt-Kastner R,Eysel UT,Weigel H,Heinemann U

    更新日期:1994-06-01 00:00:00

  • Electrophysiology of the dorsolateral mesopontine reticular formation during Pavlovian conditioning in the rabbit.

    abstract::Extracellular single-unit recording methods were used to study the activity of neurons within a restricted portion of the dorsolateral mesopontine reticular formation, an area which includes the parabrachial, pedunculopontine tegmental and cuneiform nuclei. Recordings were obtained during presentations of unfamiliar a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90245-b

    authors: Pascoe JP,Kapp BS

    更新日期:1993-06-01 00:00:00

  • Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo.

    abstract::GABA neurones in the dorsal raphe nucleus (DRN) influence ascending 5-hydroxytryptamine (5-HT) neurones but are not physiologically or anatomically characterised. Here, in vivo juxtacellular labelling methods in urethane-anaesthetised rats were used to establish the neurochemical and morphological identity of a fast-f...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00518-9

    authors: Allers KA,Sharp T

    更新日期:2003-01-01 00:00:00

  • Cerebellin-like peptide: tissue distribution in rat and guinea-pig and its release from rat cerebellum, hypothalamus and cerebellar synaptosomes in vitro.

    abstract::We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90262-x

    authors: Burnet PW,Bretherton-Watt D,Ghatei MA,Bloom SR

    更新日期:1988-05-01 00:00:00

  • Role of the substantia nigra in the expression of dopamine D1 receptor-mediated and D2 receptor-mediated behaviours.

    abstract::This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90175-8

    authors: Fletcher GH,Starr MS

    更新日期:1987-12-01 00:00:00

  • Ontogeny of cholecystokinin-8 containing neuron system of the rat: an immunohistochemical analysis--II. Lower brain stem.

    abstract::The ontogeny of the cholecystokinin-8 neuron system in the lower brain stem of the rat was investigated by means of indirect immunofluorescence. Cholecystokinin-8-like immunoreactive structures first appeared in the primordium of the ventral tegmental area, ventral tegmental nucleus of Gudden and the area lateral to t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90116-1

    authors: Kiyama H,Shiosaka S,Kubota Y,Cho HJ,Takagi H,Tateishi K,Hashimura E,Hamaoka T,Tohyama M

    更新日期:1983-12-01 00:00:00

  • A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: locus of the sensitive region.

    abstract::Carbachol, a long-acting cholinergic agonist, was microinjected (4 micrograms/250 nl per 90 s) into 90 sites within the anterodorsal pontine tegmentum of four cats and the time to onset and percentage of time spent in a desynchronized sleep-like state during 40 min postinjection were calculated. Compared with more pos...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90267-8

    authors: Yamamoto K,Mamelak AN,Quattrochi JJ,Hobson JA

    更新日期:1990-01-01 00:00:00

  • It Pays to Prepare: Human Motor Preparation Depends on the Relative Value of Potential Response Options.

    abstract::Alternative motor responses can be prepared in parallel. Here, we used electroencephalography (EEG) to test whether the parallel preparation of alternative response options is modulated by their relative value. Participants performed a choice response task with three potential actions: isometric contraction of the lef...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.01.055

    authors: Reuter EM,Marinovic W,Beikoff J,Carroll TJ

    更新日期:2018-03-15 00:00:00

  • Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.

    abstract::Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.12.065

    authors: Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

    更新日期:2015-03-19 00:00:00

  • Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective degeneration and death of motoneurons in the spinal cord, brainstem and motor cortex which causes progressive muscle weakness and paralysis. Although the molecular mechanisms causing the disease remain unknown, excitotoxi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.10.060

    authors: Tolosa L,Mir M,Olmos G,Lladó J

    更新日期:2009-02-18 00:00:00

  • Double orientation tuning in the cat visual cortex units.

    abstract::Orientation tuning of 271 neurons of the cat visual cortex (area 17) was studied with a light bar flashing in the receptive field. Under different conditions, 27-57% of units were found to have double-orientation tuning: they demonstrated the main preferred orientation and an additional preferred orientation. The stat...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90416-2

    authors: Shevelev IA,Lazareva NA,Novikova BV,Tikhomirov AS,Sharaev GA

    更新日期:1994-08-01 00:00:00

  • Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex.

    abstract::Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.04.070

    authors: Luo F,Tang H,Cheng ZY

    更新日期:2015-08-06 00:00:00

  • Triiodothyronine enhances the morphological maturation of dopaminergic neurons from fetal mouse hypothalamus cultured in serum-free medium.

    abstract::In dissociated hypothalamic cell cultures of 16-day mouse embryos, growing in chemically defined medium, the catecholaminergic neurons were identified by autoradiography after labelling with [3H]dopamine and by immunocytochemistry with an anti-tyrosine hydroxylase antibody. Using selective inhibitors of amine transpor...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90217-8

    authors: Puymirat J,Barret A,Picart R,Vigny A,Loudes C,Faivre-Bauman A,Tixier-Vidal A

    更新日期:1983-11-01 00:00:00

  • Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors.

    abstract::In the present autoradiographic study, we took advantage of 5-hydroxytryptamine(7) (5-HT(7)) receptor knockout mice to analyze the brain distribution of 5-HT(7) receptor binding sites using [(3)H]5-carboxamidotryptamine (5-CT; a 5-HT(1A/1B/1D/5/7) receptor ligand) and [(3)H]8-hydroxy-2-(di-n-propylamino)tetralin (8-OH...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.01.014

    authors: Bonaventure P,Nepomuceno D,Hein L,Sutcliffe JG,Lovenberg T,Hedlund PB

    更新日期:2004-01-01 00:00:00