当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Monoclonal antibodies to chromaffin cells can distinguish proteins specific to or specifically excluded from chromaffin granules.

Monoclonal antibodies to chromaffin cells can distinguish proteins specific to or specifically excluded from chromaffin granules.

Abstract：

:I have prepared a number of monoclonal antibodies to chromaffin cell membranes. One of these antibodies recognizes a number of antigenically related proteins that are present in all tissues examined. In the adrenal, these proteins are completely excluded from chromaffin granules but are present in other subcellular membrane fractions. This non-granule membrane-specific antibody has been designated NG3. A second antibody, CG7, binds to a single protein which segregates specifically into chromaffin granules. The protein recognized by CG7 is cytochrome b561, or chromomembrin B, one of the major protein components of chromaffin granule membranes. CG7 also labels a protein (the identical cytochrome b561) in bovine posterior pituitary neurosecretory vesicle membranes indicating that it functions in both peptidergic and catecholaminergic secretory granules. These two monoclonal antibodies provide useful probes of both granule and extra-granule membrane proteins for studies of membrane trafficking in chromaffin cells.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Pruss RM

doi

10.1016/0306-4522(87)90204-1

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

141-7

issue

1

eissn

0306-4522

issn

1873-7544

pii

0306-4522(87)90204-1

journal_volume

22

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Modulation of botulinum toxin-induced changes in neuromuscular function with antibodies directed against recombinant polypeptides or fragments.

    abstract：:Botulinum toxin is an agent that is typically encountered in two settings: as an agent that can cause disease (e.g. botulism), and as an agent that can be used to treat disease (i.e., a variety of neurologic disorders). In both cases it would be advantageous to develop a sound understanding of the mechanisms by which ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.01.033

    authors： Joshi SG,Elias M,Singh A,Al-Saleem FH,Ancharski D,Nasser Z,Takahashi T,Simpson LL

    更新日期：2011-04-14 00:00:00

  • Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions.

    abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2019.07.036

    authors： Pizzarelli R,Griguoli M,Zacchi P,Petrini EM,Barberis A,Cattaneo A,Cherubini E

    更新日期：2020-07-15 00:00:00

  • The Positional Logic of Sensory-Motor Reflex Circuit Assembly.

    abstract：:Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2020.04.038

    authors： Balaskas N,Ng D,Zampieri N

    更新日期：2020-12-01 00:00:00

  • Overexpression of SIRT1 Inhibits Corticosterone-Induced Autophagy.

    abstract：:Individuals continuously confronted with various stresses in modern life generate high levels of cortisol (corticosterone in rodents), the major glucocorticoid secreted by adrenal gland when hypothalamic-pituitary-adrenal axis is activated. Chronic stress can induce constant release of glucocorticoid and cause many se...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.05.035

    authors： Jiang Y,Botchway BOA,Hu Z,Fang M

    更新日期：2019-07-15 00:00:00

  • Impaired release of beta-endorphin in response to serotonin in a rat model of depression.

    abstract：:Involvement of both the serotonergic and the endogenous opioid systems in the onset of depressive behavior has been suggested. Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc). Herein, the microdialysis method was used to assess in vivo the ef...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00612-1

    authors： Zangen A,Nakash R,Roth-Deri I,Overstreet DH,Yadid G

    更新日期：2002-01-01 00:00:00

  • Effects of Intramuscular Heating-needle Stimulation in Controlling Adjuvant-induced Muscle Nociception in Rats: Differential Roles of Thalamic Purinergic P2X3 Receptors.

    abstract：:Here we investigated effects of intramuscular (i.m.) heating-needle stimulation on persistent muscle nociception evoked by i.m. injection of different doses (50-200 µl) of complete Freund's adjuvant (CFA) in rats. Paw withdrawal reflexes evoked by noxious mechanical and heat stimulation as well as hind limb swelling w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.039

    authors： Lei J,Ye G,Pertovaara A,You HJ

    更新日期：2020-05-01 00:00:00

  • Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling.

    abstract：:Interactions between dopamine and glutamate receptors are essential for the prefrontal cortical (PFC) and hippocampal cognitive functions. In order to understand the molecular basis of dopamine/glutamate interactions in rat PFC and hippocampus, we investigated (a) the effect of in vitro dopamine D1 receptor stimulatio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.07.056

    authors： Sarantis K,Matsokis N,Angelatou F

    更新日期：2009-11-10 00:00:00

  • Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission.

    abstract：:The nucleus accumbens is considered to be critically involved in the control of complex motivated behaviors. By modulating its glutamatergic excitatory input, mesolimbic dopaminergic afferents have been implicated in the reinforcing properties of drugs of abuse. However, they might not represent the only path for infl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00372-4

    authors： d'Alcantara P,Ledent C,Swillens S,Schiffmann SN

    更新日期：2001-01-01 00:00:00

  • Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.

    abstract：:Sleep is strongly implicated in learning, especially in the reprocessing of recently acquired memory. Children with intellectual disability (ID) tend to have sleep-wake disturbances, which may contribute to the pathophysiology of the disease. Given that sleep is partly controlled by the circadian clock, we decided to ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.08.066

    authors： Renaud J,Dumont F,Khelfaoui M,Foisset SR,Letourneur F,Bienvenu T,Khwaja O,Dorseuil O,Billuart P

    更新日期：2015-11-12 00:00:00

  • Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia.

    abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.06.014

    authors： Kagan R,Kainz V,Burstein R,Noseda R

    更新日期：2013-09-17 00:00:00

  • Growth-associated protein-43 and protein gene-product 9.5 innervation in human pancreas: changes in chronic pancreatitis.

    abstract：:Growth-associated protein-43, an established marker of neuronal plasticity during development and in injury, was used to characterize innervation in the normal human pancreas and changes in chronic alcohol-induced pancreatitis by using light microscopic immunocytochemistry and computer-assisted image analysis. Immunos...

    journal_title：Neuroscience

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4522(94)90020-5

    authors： Fink T,Di Sebastiano P,Büchler M,Beger HG,Weihe E

    更新日期：1994-11-01 00:00:00

  • Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata.

    abstract：:The loss of dopamine neurons combined or not with the subsequent administration of L-DOPA in patients with Parkinson's disease or in experimental models of the disease results in altered GABAergic signaling throughout the basal ganglia, including the striatum and the substantia nigra, pars reticulata. However, the mol...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.12.001

    authors： Wang H,Katz J,Dagostino P,Soghomonian JJ

    更新日期：2007-03-16 00:00:00

  • Effects of basic fibroblast growth factor on the development of GABAergic neurons in culture.

    abstract：:Six-day-old neuronal cultures derived from 14-day-old embryonic rat cerebral hemispheres were highly enriched in GABAergic neurons, as was demonstrated by immunocytochemistry using an anti-glutamate decarboxylase antiserum. They contained about 64% glutamate decarboxylase-positive neurons. About 8% of these neurons pr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90398-8

    authors： Deloulme JC,Gensburger C,Sarhan S,Seiler N,Sensenbrenner M

    更新日期：1991-01-01 00:00:00

  • Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain.

    abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00494-1

    authors： Carpintero P,Anadón R,Díaz-Regueira S,Gómez-Márquez J

    更新日期：1999-01-01 00:00:00

  • Detection of putative dopamine receptors in neurites outgrowing from locust central nervous system explants using anti-idiotypic dopamine antibodies.

    abstract：:Organotypic cultures established from the third thoracic ganglion of locust embryo have been used to investigate dopamine receptors. In this in vitro system, neurites emerge directly from the explants and form a dense network around the explants, presenting cell surface freely exposed for experimental labelling. Polyc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90088-4

    authors： Vanhems E,Delbos M,Geffard M,Viellemaringe J

    更新日期：1994-02-01 00:00:00

  • Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro.

    abstract：:During spinal cord maturation neuronal excitability gradually differentiates to meet different functional demands. Spontaneous activity, appearing early during spinal development, is regulated by the expression pattern of ion channels in individual neurons. While emerging excitability of embryonic motoneurons has been...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.06.040

    authors： Furlan F,Guasti L,Avossa D,Becchetti A,Cilia E,Ballerini L,Arcangeli A

    更新日期：2005-01-01 00:00:00

  • Specificity of attachment and neurite outgrowth of dissociated basal forebrain cholinergic neurons seeded on to organotypic slice cultures of forebrain.

    abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00067-5

    authors： Robertson RT,Baratta J,Kageyama GH,Ha DH,Yu J

    更新日期：1997-10-01 00:00:00

  • Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

    abstract：:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.02.004

    authors： Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

    更新日期：2008-04-22 00:00:00

  • Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.

    abstract：:Early degeneration of pedunculopontine nucleus (PPN) is considered part of changes that characterize premotor stages of Parkinson's disease (PD). In this paper, the effects of unilateral neurotoxic lesion of the PPN in motor execution and in the development of oxidative stress events in striatal and nigral tissues in ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.12.056

    authors： Jimenez-Martin J,Blanco-Lezcano L,González-Fraguela ME,Díaz-Hung ML,Serrano-Sánchez T,Almenares JL,Francis-Turner L

    更新日期：2015-03-19 00:00:00

  • Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.

    abstract：:Application of N-methyl-D-aspartate on to the dendrites of hippocampal granule cells dramatically decreased prodynorphin messenger RNA levels in the affected cells while increasing proenkephalin messenger RNA levels. Sin-1 molsidomine (an agent which releases nitric oxide) and 8-bromo-cyclic GMP were similarly effecti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90423-5

    authors： Johnston HM,Morris BJ

    更新日期：1994-08-01 00:00:00

  • Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes.

    abstract：:Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.09.072

    authors： Moeller HB,Fenton RA,Zeuthen T,Macaulay N

    更新日期：2009-12-29 00:00:00

  • Oxytocin/vasopressin-like immunoreactivity is present in the nervous system of hydra.

    abstract：:Nerve cells have been found in hydra, which react with antisera to oxytocin, vasopressin and mesotocin. These nerve cells have a high density in the ectoderm of basal disk and tentacles and lower density in the ectoderm of peduncle, gastric region and hypostome. A very small number of nerve cells occur also in the end...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90241-x

    authors： Grimmelikhuijzen CJ,Dierickx K,Boer GJ

    更新日期：1982-01-01 00:00:00

  • Plasmalemmal appositions between cholinergic and non-cholinergic neurons in rat caudate-putamen nuclei.

    abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90341-k

    authors： Pickel VM,Chan J

    更新日期：1991-01-01 00:00:00

  • Nicotinic acetylcholine receptors in the rat and primate nucleus tractus solitarius and on rat and human inferior vagal (nodose) ganglia: evidence from in vivo microdialysis and [125I]alpha-bungarotoxin autoradiography.

    abstract：:The nucleus tractus solitarius is a key brain centre involved in the regulation of numerous autonomic functions. The present study has employed in vitro autoradiography and in vivo microdialysis to investigate the presence and function of nicotinic acetylcholine receptors located in the medial nucleus tractus solitari...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00476-4

    authors： Ashworth-Preece M,Jarrott B,Lawrence AJ

    更新日期：1998-04-01 00:00:00

  • Stimulus exposure duration alters implicit processing of neutral and emotional faces.

    abstract：:Stimulus exposure duration in emotion perception research is often chosen pragmatically; however, little work exists on the consequences of stimulus duration for the processing of emotional faces. We utilized the spatiotemporal resolution capabilities of magnetoencephalography (MEG) to characterize early implicit proc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.11.030

    authors： Kouptsova JE,Leung RC,Taylor MJ

    更新日期：2017-01-26 00:00:00

  • Dopaminergic activation excites rat lateral habenular neurons in vivo.

    abstract：:The lateral habenular complex (LHb) of the epithalamus is part of a dorsal diencephalic conduction system connecting basal forebrain with regulatory midbrain nuclei. The LHb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. Here, we hav...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.04.026

    authors： Kowski AB,Veh RW,Weiss T

    更新日期：2009-07-21 00:00:00

  • Cellular localization of type II Ca2+/calmodulin-dependent protein kinase in the rat basal ganglia and intrastriatal grafts derived from fetal striatal primordia, in comparison with that of Ca2+/calmodulin-regulated protein phosphatase, calcineurin.

    abstract：:We investigated immunohistochemically the cellular localization of multifunctional type II Ca2+/calmodulin-dependent protein kinase in the rat basal ganglia and intrastriatal grafts derived from fetal striatal primordia, in comparison with that of calcineurin, a reliable marker for striatal medium-sized spinous neuron...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90470-7

    authors： Goto S,Yamada K,Oyama T,Korematsu K,Nagahiro S,Ushio Y,Fukunaga K,Miyamoto E,Hofer W

    更新日期：1994-10-01 00:00:00

  • Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice.

    abstract：:The sodium-activated potassium channel Slack (Slo2.2) is widely expressed in central and peripheral neurons where it is supposed to shape firing properties important for neuronal excitability. Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.05.040

    authors： Bausch AE,Ehinger R,Straubinger J,Zerfass P,Nann Y,Lukowski R

    更新日期：2018-08-01 00:00:00

  • Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture.

    abstract：:The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90137-d

    authors： Docherty RJ,Robertson B,Bevan S

    更新日期：1991-01-01 00:00:00

  • Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: implications for schizophrenia.

    abstract：:Prenatal exposures to a variety of infections have been associated with an increased incidence of schizophrenia. We have reported that a single injection of the synthetic cytokine releaser PolyI:C to pregnant mice produced offspring that exhibited multiple schizophrenia-related behavioral deficits in adulthood. Here, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.07.029

    authors： Nyffeler M,Meyer U,Yee BK,Feldon J,Knuesel I

    更新日期：2006-11-17 00:00:00