当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

Abstract：

:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1, the primary astroglial glutamate transporter. To test this hypothesis, we administered ceftriaxone, a beta-lactam antibiotic known to elevate GLT1 expression (200 mg/kg, i.p., for 5 days), to symptomatic R6/2 mice, a widely studied transgenic model of HD. Relative to vehicle, ceftriaxone attenuated several HD behavioral signs: paw clasping and twitching were reduced, while motor flexibility, as measured in a plus maze, and open-field climbing were increased. Assessment of GLT1 expression in striatum confirmed a ceftriaxone-induced increase relative to vehicle. To determine if the change in behavior and GLT1 expression represented a change in striatal glutamate handling, separate groups of behaving mice were evaluated with no-net-flux microdialysis. Vehicle treatment revealed a glutamate uptake deficit in R6/2 mice relative to wild-type controls that was reversed by ceftriaxone. Vehicle-treated animals, however, did not differ in GLT1 expression, suggesting that the glutamate uptake deficit in R6/2 mice reflects dysfunctional rather than missing GLT1. Our results indicate that impaired glutamate uptake is a major factor underlying HD pathophysiology and symptomology. The glutamate uptake deficit, moreover, is present in symptomatic HD mice and reversal of this deficit by up-regulating the functional expression of GLT1 with ceftriaxone attenuates the HD phenotype.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

doi

10.1016/j.neuroscience.2008.02.004

subject

Has Abstract

pub_date

2008-04-22 00:00:00

pages

329-37

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(08)00216-9

journal_volume

153

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Dopamine regulates synaptic transmission mediated by cholinergic neurons of the rat retina.

    abstract：:The purpose of this study was to investigate the effect of dopamine on the function of synapses formed by cholinergic neurons derived from the rat retina. We used an experimental culture system in which rat striated muscle cells served as postsynaptic targets for cholinergic neurons of the retina. This culture system ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90104-0

    authors： Yeh HH,Battelle BA,Puro DG

    更新日期：1984-11-01 00:00:00

  • Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis.

    abstract：BACKGROUND:Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase are transiently phosphorylated (activated) in the spinal cord and trigeminal nucleus by acute noxious stimuli. Acute stimulation of dental pulp induces short-lived ERK activation in trigeminal subnucleus caudalis (Vc), and p...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.03.056

    authors： Worsley MA,Allen CE,Billinton A,King AE,Boissonade FM

    更新日期：2014-06-06 00:00:00

  • Dual Function of Primary Somatosensory Cortex in Cognitive Control of Language: Evidence from Resting State fMRI.

    abstract：:Resting state functional connectivity can be leveraged to investigate bilingual individual differences in cognitive control of language; however, thus far no report is provided on how the connectivity profiles of brain functional networks at rest point to different language control behavior in bilinguals. In order to ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.08.032

    authors： Tabassi Mofrad F,Jahn A,Schiller NO

    更新日期：2020-10-15 00:00:00

  • Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.

    abstract：:Dopamine-mediated behaviors and certain biochemical and molecular events associated with these behaviors were examined following continuous infusion of the D1 dopamine agonist SKF38393 or the D2 dopamine agonist quinpirole into mice for six days. SKF38393 produced a transient grooming behavior while quinpirole initial...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90238-b

    authors： Chen JF,Aloyo VJ,Weiss B

    更新日期：1993-06-01 00:00:00

  • Different voltage-dependent potassium conductances regulate action potential repolarization and excitability in frog myelinated axon.

    abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00139-a

    authors： Poulter MO,Padjen AL

    更新日期：1995-09-01 00:00:00

  • Intense cold noxious stimulation of the rat hindpaw induces c-fos expression in lumbar spinal cord neurons.

    abstract：:This study evaluated Fos-like immunoreactivity in lumbar spinal cord neurons following intense cold stimulation and then the modifications induced by opioid administration. Under urethane anaesthesia, the rat's right foot was stimulated by holding it in a regulated temperature bath at 15, 10, 0, -10, -15, -17.5 or -20...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90609-2

    authors： Abbadie C,Honoré P,Besson JM

    更新日期：1994-03-01 00:00:00

  • Ocular surface-evoked Fos-like immunoreactivity is enhanced in trigeminal subnucleus caudalis by prior exposure to endotoxin.

    abstract：:Endotoxin-induced uveitis (EIU) is a common animal model for anterior uveitis in humans that causes long-term changes in trigeminal brain stem neurons. This study used c-fos immunohistochemistry to assess the effects of different routes of administration of endotoxin on activation of trigeminal brain stem neurons prod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.12.015

    authors： Okamoto K,Bereiter DF,Tashiro A,Bereiter DA

    更新日期：2009-03-17 00:00:00

  • 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats.

    abstract：:7beta-Hydroxycholesterol has been previously demonstrated to inhibit astrocytosis in injured cortex or spinal cord of rats. In this study, we explored the inhibitory effects of the liposome containing 7beta-hydroxycholesterol on the reactive astrocytosis caused by the injection of iron into the hippocampus of rats and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.011

    authors： Yao Y,Sun S,Kong Q,Tong E

    更新日期：2006-01-01 00:00:00

  • Sex comparison of neuronal Fos immunoreactivity in the rat vomeronasal projection circuit after chemosensory stimulation.

    abstract：:In rodents, reproductively relevant pheromonal cues are detected by receptors in the vomeronasal organ, which in turn transmit this information centrally via the accessory olfactory bulb, the medial nucleus of the amygdala, the posterior medial bed nucleus of the stria terminalis and the medial preoptic area. In the r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00493-9

    authors： Bressler SC,Baum MJ

    更新日期：1996-04-01 00:00:00

  • Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats.

    abstract：:The primary somatosensory cortex (S1) projects to the thalamus and brainstem somatosensory nuclei and modulates somatosensory information ascending to the S1 itself. However, the projections from the S1 to the brainstem second-order somatosensory neuron pools have not been fully studied. To address this in rats, we fi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.10.048

    authors： Tomita A,Kato T,Sato F,Haque T,Oka A,Yamamoto M,Ono T,Bae YC,Maeda Y,Sessle BJ,Yoshida A

    更新日期：2012-01-03 00:00:00

  • Time acts as a conditioned stimulus to control behavioral sensitization to amphetamine in rats.

    abstract：:Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(00)00401-2

    authors： Arvanitogiannis A,Sullivan J,Amir S

    更新日期：2000-01-01 00:00:00

  • Dendritic arborization and axon trajectory of neurons in the hypothalamic arcuate nucleus of the rat--updated.

    abstract：:Neurons in the hypothalamic arcuate nucleus (arcuate neurons) were traced on Golgi-impregnated sections. Dendrites of arcuate neurons showed characteristic orientation patterns. Dendrites along the lateral side follow the convex border of the nucleus by running parallel to the tanycyte processes. Neurons located in th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90005-3

    authors： Réthelyi M

    更新日期：1985-10-01 00:00:00

  • Single cell analysis of voltage-gated potassium channels that determines neuronal types of rat hypothalamic paraventricular nucleus neurons.

    abstract：:The hypothalamic paraventricular nucleus (PVN), a site for the integration of both the neuroendocrine and autonomic systems, has heterogeneous cell composition. These neurons are classified into type I and type II neurons based on their electrophysiological properties. In the present study, we investigated the molecul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.12.031

    authors： Lee SK,Lee S,Shin SY,Ryu PD,Lee SY

    更新日期：2012-03-15 00:00:00

  • Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.

    abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.059

    authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

    更新日期：2009-06-16 00:00:00

  • Modulation of local field potential power of the subthalamic nucleus during isometric force generation in patients with Parkinson's disease.

    abstract：:Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance ima...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.02.043

    authors： Florin E,Dafsari HS,Reck C,Barbe MT,Pauls KA,Maarouf M,Sturm V,Fink GR,Timmermann L

    更新日期：2013-06-14 00:00:00

  • Improving spatial updating accuracy in absence of external feedback.

    abstract：:Updating the position of an earth-fixed target during whole-body rotation seems to rely on cognitive processes such as the utilization of external feedback. According to perceptual learning models, improvement in performance can also occur without external feedback. The aim of this study was to assess spatial updating...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.05.024

    authors： Mackrous I,Simoneau M

    更新日期：2015-08-06 00:00:00

  • Aging-Related Oxidative Stress: Positive Effect of Memory Training.

    abstract：:The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functioning, and the oxidant and antioxidant capacity of plasma. We recruited 52 healthy s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.09.046

    authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Patruno A,Ballerini P,De Lutiis MA,Felaco M,Grilli A

    更新日期：2018-02-01 00:00:00

  • Development of the suprachiasmatic nucleus in rats during ontogenesis: serotonin-immunopositive fibers.

    abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90163-5

    authors： Ugrumov MV,Popov AP,Vladimirov SV,Kasmambetova S,Novodjilova AP,Tramu G

    更新日期：1994-01-01 00:00:00

  • Long-term changes of ionotropic glutamate and GABA receptors after unilateral permanent focal cerebral ischemia in the mouse brain.

    abstract：:Long-term hyperexcitability was found after unilateral, permanent middle cerebral artery occlusion in exofocal neocortical areas of the adult mouse [Mittmann et al. (1998) Neuroscience 85, 15-27]. The aim of the present study was to test the hypothesis in an identical paradigm of ischemia. whether alterations in the d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00656-8

    authors： Qü M,Mittmann T,Luhmann HJ,Schleicher A,Zilles K

    更新日期：1998-07-01 00:00:00

  • GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways.

    abstract：UNLABELLED:GABA is an important inhibitory transmitter in the CNS. In the enteric nervous system, however, both excitatory and inhibitory actions have been reported. Here, we investigated the effects of GABA on the intracellular Ca2+ concentration of guinea-pig myenteric neurons (at 35 degrees C) using Fura-2-AM. Neuro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.023

    authors： Reis HJ,Vanden Berghe P,Romano-Silva MA,Smith TK

    更新日期：2006-05-12 00:00:00

  • Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system.

    abstract：:The peripheral sympathetic and parasympathetic cholinergic innervation was investigated with antibodies directed against the C-terminus of the rat vesicular acetylcholine transporter. Immunohistochemistry for the vesicular acetylcholine transporter resulted in considerably more detailed visualization of cholinergic te...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)80196-0

    authors： Schäfer MK,Eiden LE,Weihe E

    更新日期：1998-05-01 00:00:00

  • Complete sparing of spatial learning following posterior and posterior plus anterior cingulate cortex lesions at 10 days of age in the rat.

    abstract：:Neonatal posterior cingulate cortex lesions spare the spatial deficits that characterize adult lesions. The present experiments examined the possibility that the anterior cingulate cortex mediates the spared spatial behavior. Rats were given bilateral lesions of the posterior cingulate cortex or anterior plus posterio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00295-1

    authors： Gonzalez CL,Whishaw IQ,Kolb B

    更新日期：2003-01-01 00:00:00

  • Role of blood-brain barrier in temporal lobe epilepsy and pharmacoresistance.

    abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.07.030

    authors： van Vliet EA,Aronica E,Gorter JA

    更新日期：2014-09-26 00:00:00

  • The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord.

    abstract：:Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, su...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.05.042

    authors： Meyer M,Lara A,Hunt H,Belanoff J,de Kloet ER,Gonzalez Deniselle MC,De Nicola AF

    更新日期：2018-08-01 00:00:00

  • Estradiol influences oxytocin-immunoreactive brain systems.

    abstract：:The rat brain was examined immunocytochemically for estrogen-dependent changes of oxytocin immunoreactivity at the light microscopical level. Ovariectomized rats were treated with subcutaneous silastic implants with estradiol, or empty implants as controls for 2 days (short term treatment). Another group of rats was i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90022-x

    authors： Jirikowski GF,Caldwell JD,Pedersen CA,Stumpf WE

    更新日期：1988-04-01 00:00:00

  • Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics.

    abstract：:A newly developed benzoylpyrrolidine drug (BDP-20) that increases the size of fast, excitatory synaptic responses was examined for its effects on the kinetic properties of alpha-amino-3-hydroxy-5-methyl-4-isoxalepropionic acid (AMPA)-type glutamate receptors. When long pulses of glutamate were applied to excised hippo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00263-1

    authors： Arai A,Kessler M,Ambros-Ingerson J,Quan A,Yigiter E,Rogers G,Lynch G

    更新日期：1996-11-01 00:00:00

  • Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons.

    abstract：:The aim of this study was to determine whether the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin (NT)-3 could act as endogenous target-derived trophic factors for erection-inducing, i.e. penis-projecting major pelvic ganglion (MPG) neurons, and/or penile sensory ne...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.01.019

    authors： Hiltunen JO,Laurikainen A,Klinge E,Saarma M

    更新日期：2005-01-01 00:00:00

  • Cell survival or cell death: differential vulnerability of long descending and thoracic propriospinal neurons to low thoracic axotomy in the adult rat.

    abstract：:Previous studies show that most short thoracic propriospinal (TPS; T5-T7) and long descending propriospinal tract (LDPT; C4-C6) neurons are lost following low-thoracic spinal cord contusion injury (cSCI), as assessed by retrograde labeling with fluorogold (FG). Gene microarray and terminal deoxynucleotidyl transferase...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.05.052

    authors： Conta Steencken AC,Smirnov I,Stelzner DJ

    更新日期：2011-10-27 00:00:00

  • Overexpression of SIRT1 Inhibits Corticosterone-Induced Autophagy.

    abstract：:Individuals continuously confronted with various stresses in modern life generate high levels of cortisol (corticosterone in rodents), the major glucocorticoid secreted by adrenal gland when hypothalamic-pituitary-adrenal axis is activated. Chronic stress can induce constant release of glucocorticoid and cause many se...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.05.035

    authors： Jiang Y,Botchway BOA,Hu Z,Fang M

    更新日期：2019-07-15 00:00:00

  • An immunocytochemical and autoradiographic investigation of the serotoninergic innervation of trigeminal mesencephalic and motor nuclei in the rabbit.

    abstract：:The results of a previous experiment suggest that the cell bodies of many jaw closing muscle spindle afferents in the trigeminal mesencephalic nucleus of the rabbit are phasically inhibited during fictive mastication. The aim of this study was to investigate one possible neurotransmitter system that could be involved ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90494-z

    authors： Kolta A,Dubuc R,Lund JP

    更新日期：1993-04-01 00:00:00