Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.

Abstract:

:Dopamine-mediated behaviors and certain biochemical and molecular events associated with these behaviors were examined following continuous infusion of the D1 dopamine agonist SKF38393 or the D2 dopamine agonist quinpirole into mice for six days. SKF38393 produced a transient grooming behavior while quinpirole initially induced stereotypy, which was followed by an increased locomotor behavior. Continuous infusion of quinpirole caused a significant down-regulation of striatal D2 dopamine receptors without significantly changing the density of D1 receptors. This was accompanied by a decrease in the level of D2 receptor messenger RNA in striatum as measured by Northern analysis. The down-regulation of dopamine receptors was selective for D2 dopamine receptors, since treatment with SKF38393 had no significant effects on either D1 or D2 dopamine receptors, nor did it alter the messenger RNAs for the D1 and D2 receptors. Continuous treatment with quinpirole resulted in a significant increase in striatal mu opioid receptor levels without significant changing delta opioid receptors. This treatment also induced a significant decrease in proenkephalin messenger RNA in striatum. Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin. They suggest further that the biochemical and molecular changes that take place in dopaminergic and enkephalinergic systems following continuous treatment with dopamine agonists may underlie the mechanisms by which certain dopamine-mediated behaviors occur.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Chen JF,Aloyo VJ,Weiss B

doi

10.1016/0306-4522(93)90238-b

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

669-80

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(93)90238-B

journal_volume

54

pub_type

杂志文章
  • A novel SDS-stable dimer of a heterogeneous nuclear ribonucleoprotein at presynaptic terminals of squid neurons.

    abstract::The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.05.040

    authors: Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

    更新日期:2015-08-06 00:00:00

  • The optic tectum of gymnotiform teleosts Eigenmannia virescens and Apteronotus leptorhynchus: a Golgi study.

    abstract::Golgi, Nissl, Bielschowsky and cholinesterase techniques have been used to analyze the optic tectum of the weakly electric teleost fish Eigenmannia virescens and Apteronotus leptorhynchus. Six layers are readily distinguished: a fairly thick stratum marginale, a narrow stratum opticum and stratum fibrosum et griseum s...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(86)90190-9

    authors: Sas E,Maler L

    更新日期:1986-05-01 00:00:00

  • Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy.

    abstract::Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Altho...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.12.027

    authors: Alvaro AR,Martins J,Costa AC,Fernandes E,Carvalho F,Ambrósio AF,Cavadas C

    更新日期:2008-03-03 00:00:00

  • Role of the axodendritic tree in the functioning of helix bursting neurons: generation of pacemaker activity and propagation of action potentials along the axon.

    abstract::The purpose of this study was to determine the role of the axodendritic tree in the generation of bursting pacemaker activity in the identified Helix RPa1 neuron, which is homologous to the Aplysia R15 cell, and propagation of action potentials along the axons. In doing so, I used recording of RPa1 neuron electrical a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00543-6

    authors: Kononenko NI

    更新日期:2000-01-01 00:00:00

  • Modulation of local field potential power of the subthalamic nucleus during isometric force generation in patients with Parkinson's disease.

    abstract::Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance ima...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.02.043

    authors: Florin E,Dafsari HS,Reck C,Barbe MT,Pauls KA,Maarouf M,Sturm V,Fink GR,Timmermann L

    更新日期:2013-06-14 00:00:00

  • Respiratory rhythms generated in the lamprey rhombencephalon.

    abstract::Brainstem networks generating the respiratory rhythm in lampreys are still not fully characterized. In this study, we described the patterns of respiratory activities and we identified the general location of underlying neural networks. In a semi-intact preparation including the brain and gills, rhythmic discharges we...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.05.023

    authors: Martel B,Guimond JC,Gariépy JF,Gravel J,Auclair F,Kolta A,Lund JP,Dubuc R

    更新日期:2007-08-10 00:00:00

  • Cholinergic stimulation of rostral and caudal substantia nigra pars compacta produces opposite effects on circling behavior and striatal dopamine release measured by brain microdialysis.

    abstract::Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López e...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90378-6

    authors: Hernández-López S,Góngora-Alfaro JL,Martínez-Fong D,Rosales MG,Aceves J

    更新日期:1994-09-01 00:00:00

  • Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury.

    abstract::A satisfactory management to ensure a full restoration of peripheral nerve after trauma is not yet available. Using an experimental protocol, in which crush injury was applied 1 cm above the bifurcation of the rat sciatic nerve for 20 s, we here demonstrate that the levels of neuroactive steroids, such as pregnenolone...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.06.034

    authors: Roglio I,Bianchi R,Gotti S,Scurati S,Giatti S,Pesaresi M,Caruso D,Panzica GC,Melcangi RC

    更新日期:2008-08-26 00:00:00

  • Double-label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization.

    abstract::A new double-label autoradiographic glucose analog method for the sequential measurement of altered regional cerebral metabolic rates for glucose in the same animal is presented. This method is based on the sequential injection of two boluses of glucose tracer labeled with two different isotopes (short-lived 18F and l...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90357-5

    authors: Redies C,Diksic M,Evans AC,Gjedde A,Yamamoto YL

    更新日期:1987-08-01 00:00:00

  • 11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids.

    abstract::11beta-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives. As 11beta-hydroxysteroid dehydrogenase type 2 is highly expressed in the developing brain, but not in the adult CNS, we hypothesized that it ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.09.037

    authors: Holmes MC,Sangra M,French KL,Whittle IR,Paterson J,Mullins JJ,Seckl JR

    更新日期:2006-02-01 00:00:00

  • Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.

    abstract::The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90400-a

    authors: Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

    更新日期:1993-02-01 00:00:00

  • Extrinsic origins of the somatostatin and neuropeptide Y innervation of the rat basolateral amygdala.

    abstract::The amygdalar basolateral nuclear complex (BLC) is a cortex-like structure that receives inputs from many cortical areas. It has long been assumed that cortico-amygdalar projections, as well as inter-areal intracortical connections, arise from cortical pyramidal cells. However, recent studies have shown that GABAergic...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.03.004

    authors: McDonald AJ,Zaric V

    更新日期:2015-05-21 00:00:00

  • Ethanol blocks cytosolic Ca2+ responses triggered by activation of GABA(A) receptor/Cl- channels in cultured proliferating rat neuroepithelial cells.

    abstract::GABA(A) receptor/Cl- channels and voltage-gated Ca2+ channels are believed to be important sites of ethanol action in the CNS. Acute exposure of ethanol potentiates GABA(A) receptor/Cl- channel activity and inhibits voltage-gated Ca2+ channels in a number of preparations, mostly post-mitotic neurons. The effects of et...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00084-7

    authors: Ma W,Pancrazio JJ,Andreadis JD,Shaffer KM,Stenger DA,Li BS,Zhang L,Barker JL,Maric D

    更新日期:2001-01-01 00:00:00

  • Fine structural alteration in target-deprived axonal terminals in the rat thalamus.

    abstract::Lesioning of thalamic target neurons in the adult rat provokes a resorption of terminal axonal branches of afferent neurons from the dorsal column nuclei. There is, however, no massive neuronal loss in the dorsal column nuclei. In the adult, therefore, the thalamic post synaptic target cells influence primarily the ex...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90348-4

    authors: Marty S,Peschanski M

    更新日期:1994-10-01 00:00:00

  • Basic fibroblast growth factor stimulates functional recovery after neonatal lesions of motor cortex in rats.

    abstract::Rats were given bilateral lesions of the motor cortex on the tenth day of life, and then received a daily subcutaneously injection of either basic fibroblast growth factor (FGF-2) or vehicle for 7 consecutive days. In adulthood, they were trained and assessed on a skilled forelimb reaching task. Although all lesion gr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.04.006

    authors: Monfils MH,Driscoll I,Vandenberg PM,Thomas NJ,Danka D,Kleim JA,Kolb B

    更新日期:2005-01-01 00:00:00

  • Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants.

    abstract::Solid pieces of cerebellar primordia taken from 12-day-old C57BL embryos were implanted into the cerebellar parenchyma of 3- to 4-month-old "Purkinje cell degeneration" mutant mice and analysed 2-3 months later. Purkinje cell replacement was followed by means of immunocytochemistry with antisera against either cyclic ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90002-9

    authors: Sotelo C,Alvarado-Mallart RM

    更新日期:1987-01-01 00:00:00

  • Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat.

    abstract::Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex. In this study, experiments were done in Sprague-Dawley rats initially to provide a detailed mapping within the NTS co...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.10.065

    authors: Ciriello J,Moreau JM

    更新日期:2013-01-15 00:00:00

  • Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.

    abstract::Increased levels of preproenkephalin mRNA in spinal cord neurons induced by peripheral tissue inflammation were examined using in situ hybridization histochemistry. In addition, in situ hybridization histochemistry was combined with immunocytochemistry to determine whether increases in preproenkephalin mRNA were co-lo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90144-q

    authors: Noguchi K,Dubner R,Ruda MA

    更新日期:1992-01-01 00:00:00

  • Early Postnatal Ethanol Exposure in Mice Induces Sex-Dependent Memory Impairment and Reduction of Hippocampal NMDA-R2B Expression in Adulthood.

    abstract::Drinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.11.045

    authors: Ieraci A,Herrera DG

    更新日期:2020-02-10 00:00:00

  • Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells.

    abstract::The aim of the present work was to investigate the mechanism by which the diffusible factor nitric oxide regulates GABAA receptor function in the brain. The effect of nitric oxide on GABAA receptor function has been studied in two different neuronal preparations: rat cerebral cortex microsacs and rat cerebellum granul...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00110-8

    authors: Robello M,Amico C,Bucossi G,Cupello A,Rapallino MV,Thellung S

    更新日期:1996-09-01 00:00:00

  • Ectopic sympathetic preganglionic neurons maintain proper connectivity in the reeler mutant mouse.

    abstract::The location of sympathetic preganglionic neurons (SPN) in the spinal cord of the reeler mouse mutant is abnormal. Instead of their normal location in the intermediolateral column, the majority of SPN in the reeler cluster around the central canal. To determine whether ectopically located SPN in the reeler form approp...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00945-4

    authors: Yip YP,Rinaman L,Capriotti C,Yip JW

    更新日期:2003-01-01 00:00:00

  • Differential efficiency of the endocytic machinery in tonic and phasic synapses.

    abstract::Efficient synaptic vesicle membrane recycling is one of the key factors required to sustain neurotransmission. We investigated potential differences in the compensatory endocytic machineries in two glutamatergic synapses with phasic and tonic patterns of activity in the lamprey spinal cord. Post-embedding immunocytoch...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.03.038

    authors: Evergren E,Zotova E,Brodin L,Shupliakov O

    更新日期:2006-08-11 00:00:00

  • Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine, a potent agonist for class II metabotropic glutamate receptors, in the rat.

    abstract::Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors negatively coupled to adenylyl cyclase, was investigated in vivo by the intraventricular administration in the rat, compared with that of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-C...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00043-7

    authors: Kwak S,Miyamoto M,Ishida M,Shinozaki H

    更新日期:1996-08-01 00:00:00

  • Input-selective potentiation and rebalancing of primary sensory cortex afferents by endogenous acetylcholine.

    abstract::Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.06.026

    authors: Kuo MC,Rasmusson DD,Dringenberg HC

    更新日期:2009-09-29 00:00:00

  • Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression.

    abstract::The aim of the present study was to identify potential biomarkers for depression in the search for novel disease targets and treatment regimens. Furthermore, the study includes a search for biomarkers involved in treatment resistance and stress resilience in order to investigate mechanisms underlying antidepressant dr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.08.024

    authors: Christensen T,Bisgaard CF,Wiborg O

    更新日期:2011-11-24 00:00:00

  • Immunohistochemical localization of GABAA receptors in comparison with GABA-immunoreactive structures in the nucleus tractus solitarii of the rat.

    abstract::The localization of GABAA receptors was studied by immunohistochemistry in the nucleus tractus solitarii of the rat using a monoclonal antibody (bd17) against the beta-subunit. The pattern of distribution was compared with that of GABA-immunoreactive axons and nerve terminals. Positive staining for GABAA receptors was...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00238-8

    authors: Terai K,Tooyama I,Kimura H

    更新日期:1998-02-01 00:00:00

  • Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress.

    abstract::In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral sclerosis that, in its bulbar form, is manifested...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.10.019

    authors: Ghezzi F,Monni L,Corsini S,Rauti R,Nistri A

    更新日期:2017-12-26 00:00:00

  • The localization of nitric oxide synthase in the rat eye and related cranial ganglia.

    abstract::Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90393-t

    authors: Yamamoto R,Bredt DS,Snyder SH,Stone RA

    更新日期:1993-05-01 00:00:00

  • Role of myelin plasticity in oscillations and synchrony of neuronal activity.

    abstract::Conduction time is typically ignored in computational models of neural network function. Here we consider the effects of conduction delays on the synchrony of neuronal activity and neural oscillators, and evaluate the consequences of allowing conduction velocity (CV) to be regulated adaptively. We propose that CV vari...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.11.007

    authors: Pajevic S,Basser PJ,Fields RD

    更新日期:2014-09-12 00:00:00

  • Time-dependent neuroplasticity in mesostriatal projections after unilateral removal of vibrissae in the adult rat: compartment-specific effects on horseradish peroxidase transport and cell size.

    abstract::In adult rats the mystacial vibrissae were clipped on one side of the snout, and the influence of this sensory deprivation on crossed and uncrossed striatal afferents from the substantia nigra, ventral tegmental area, and retrorubral area was examined with the horseradish peroxidase tract tracing technique. Unilateral...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90030-6

    authors: Steiner H,Weiler HT,Morgan S,Huston JP

    更新日期:1992-01-01 00:00:00