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Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture.

Abstract：

:The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane conductance. In the sensitive neurons capsaicin inhibited voltage-activated calcium current to an extent that depended on the size and duration of the capsaicin-induced inward current. Calcium channels were protected from the long-lasting inhibitory action of capsaicin by substituting extracellular Ca with Mg or Ba when capsaicin was applied, which suggests that the inhibition was dependent on the presence of extracellular Ca. Substituting Ca with Co did not prevent the prolonged block of calcium channels. It is concluded that the inhibition of voltage-activated calcium currents by capsaicin is secondary to increased intracellular Ca levels due to calcium entry through capsaicin-activated cation-specific ion channels in the plasma membrane. Long-lasting inhibition of voltage-activated calcium channels may contribute to the mechanism of the analgesic and anti-inflammatory effects of capsaicin through inhibition of neurotransmitter release from central and peripheral terminals of primary afferent nociceptive neurons.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Docherty RJ,Robertson B,Bevan S

doi

10.1016/0306-4522(91)90137-d

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

513-21

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(91)90137-D

journal_volume

40

pub_type

杂志文章

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