当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors.

Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors.

Abstract：

:The regional distribution of the specific D1 agonist [3H]SKF 38393 (SKF 38393, 2,3,4,5-tetra-hydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) has been studied autoradiographically in the rat CNS. The binding of [3H]SKF 38393 to striatal sections was saturable, stereospecific, reversible, of high affinity (Kd = 9.9 nM) and partly sodium sensitive; it occurred at a single population of sites and possessed the pharmacological characteristics of the dopamine D1 receptor. The highest levels of [3H]SKF 38393 binding sites were found in the caudate-putamen, nucleus accumbens, olfactory tubercle and substantia nigra. Moderately high concentrations of the [3H]ligand were observed in the amygdala, endopyriform nucleus, nucleus olfactorius anterior, lateral septum, primary olfactory cortex, cerebellum (molecular layer) and spinal cord. An intermediate labelling was found in the thalamus, habenula, subthalamic nucleus, hypothalamus, ventral tegmental area, superior colliculus, hippocampus and cerebral cortex. Moderate levels of [3H]SKF 38393 binding were observed in the globus pallidus and arcuate nucleus. The autoradiographic distribution of [3H]SKF 38393 overlapped with that of [3H]N,n-propylnorapomorphine, a radioligand which labels the D2 dopamine receptors, in a number of dopamine-rich brain areas but there were several areas which exhibited a high density of [3H]SKF 38393 binding sites but undetectable concentrations of [3H]N,n-propylnorapomorphine. Moreover, in the spinal cord, the subregional localization of these [3H]ligands clearly differed. Intrastriatal injection of ibotenic acid caused a large decrease in [3H]SKF 38393 and [3H]N,n-propylnorapomorphine binding in the striatum and provoked a reduction of [3H]SKF 38393 but not [3H]N,n-propylnorapomorphine binding in the substantia nigra confirming the view that nigral D1 but not D2 receptors are located on striatonigral fibres.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Dubois A,Savasta M,Curet O,Scatton B

doi

10.1016/0306-4522(86)90010-2

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

125-37

issue

1

eissn

0306-4522

issn

1873-7544

pii

0306-4522(86)90010-2

journal_volume

19

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Two-stage model of memory trace formation: a role for "noisy" brain states.

    abstract：:Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4522(89)90423-5

    authors： Buzsáki G

    更新日期：1989-01-01 00:00:00

  • Mapping of perineuronal nets in the rat brain stained by colloidal iron hydroxide histochemistry and lectin cytochemistry.

    abstract：:Net-like structures, visualized with the Golgi technique and several histochemical and immunocytochemical methods, have been described to ensheath somata, parts of dendrites and axon initial segments of various types of neurons. The origin and function of these perineuronal nets have been controversially discussed. Re...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90044-2

    authors： Seeger G,Brauer K,Härtig W,Brückner G

    更新日期：1994-01-01 00:00:00

  • The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.

    abstract：:The disturbance of the insulin-signaling pathway plays an important role in Alzheimer's disease. Resistance to insulin signaling renders neurons energy-deficient and vulnerable to oxidization or other metabolic insults and impairs synaptic plasticity. In search of neuroprotective drugs, we synthesized a peptide analog...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.10.069

    authors： Wang P,Jiang S,Cui Y,Yue Z,Su C,Sun J,Sheng S,Tian J

    更新日期：2011-01-26 00:00:00

  • Ventral subiculum regulates hypothalamo-pituitary-adrenocortical and behavioural responses to cognitive stressors.

    abstract：:The hippocampus plays an important role in central stress integration. The present study tests the hypothesis that the ventral subiculum, as a principal source of hippocampal efferents, is involved in co-ordination of hypothalamo-pituitary-adrenocortical and behavioural responses to cognitively-processed information. ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00055-4

    authors： Herman JP,Dolgas CM,Carlson SL

    更新日期：1998-09-01 00:00:00

  • GABAA and GABAB receptor-mediated inhibition of release of 5-hydroxytryptamine in the intermediate lobe of the rat pituitary gland.

    abstract：:Isolated neurointermediate lobes or neural lobes of the rat pituitary gland attached to the pituitary stalk were incubated in vitro and the spontaneous or electrically (pituitary stalk stimulation, 5 Hz, 1,500 pulses) evoked release of 5-hydroxytryptamine was determined. The evoked release of 5-hydroxytryptamine from ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90085-6

    authors： Racké K,Holzbauer M,Sharman DF,Cooper TR

    更新日期：1987-11-01 00:00:00

  • Immunohistochemical localization of creatine kinase BB-isoenzyme and tubulin in gerbil brain.

    abstract：:Cellular distribution of creatine kinase BB-isoenzyme and tubulin was investigated immunohistochemically with tissue sections from various areas of the gerbil brain. Both the reaction for creatine kinase BB-isoenzyme and tubulin visualized nerve cell bodies, dendrites and axons. While the reaction for tubulin was simi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90183-0

    authors： Yoshimine T,Morimoto K,Homburger HA,Yanagihara T

    更新日期：1984-07-01 00:00:00

  • MALAT1 Protected the Angiogenesis Function of Human Brain Microvascular Endothelial Cells (HBMECs) Under Oxygen Glucose Deprivation/re-oxygenation (OGD/R) Challenge by Interacting with miR-205-5p/VEGFA Pathway.

    abstract：:Long non-coding RNA MALAT1 was previously revealed to express abnormally in animal and cellular models of stroke, suggesting its indispensable role in stroke. The aims of the present study were to further investigate the functions of MALAT1 and to elucidate the underlying molecular mechanisms. Oxygen glucose deprivati...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.03.027

    authors： Gao C,Zhang CC,Yang HX,Hao YN

    更新日期：2020-05-21 00:00:00

  • Quantitative study of neuronal degeneration induced by Ricinus toxin and crush of postganglionic nerves in the ciliary ganglion of quail.

    abstract：:The effects of Ricinus toxin on the neurons of the ciliary ganglia were investigated in the quail. The neuronal death and the morphological alterations of the ganglionic cells were assessed following injection of the toxin in the anterior chamber of the eye or after application of the toxin on the postganglionic nerve...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90052-p

    authors： Ciofi Luzzatto A,De Stefano ME,Guidolin D,Paggi P,Toschi G

    更新日期：1991-01-01 00:00:00

  • A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways.

    abstract：:Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.07.019

    authors： Tang G,Dong X,Huang X,Huang XJ,Liu H,Wang Y,Ye WC,Shi L

    更新日期：2015-09-10 00:00:00

  • Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease.

    abstract：:In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat model of Parkinson's disease, animals with unilateral 6-hydroxydopamine lesions of the median forebrain bundle received dopamine-rich ventral mesencephalic grafts derived...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.037

    authors： Torres EM,Monville C,Gates MA,Bagga V,Dunnett SB

    更新日期：2007-06-08 00:00:00

  • Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivity.

    abstract：:Striatal dopamine receptors become supersensitive when dopaminergic input is removed through either surgical denervation or pharmacological depletion. Although alterations such as increased D2 receptor binding and increased receptor-G protein coupling have been described in supersensitive striatal tissue, their roles ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.017

    authors： Harrison LM,LaHoste GJ

    更新日期：2006-01-01 00:00:00

  • Deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson's disease.

    abstract：OBJECTIVES:The aim of this study was to investigate whether an objective measure of freezing of gait (FOG) using a validated alternating stepping in place (SIP) task, is related to executive and/or visuospatial cognitive impairment in Parkinson's disease (PD). METHODS:We studied prospectively 30 PD subjects with the U...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.007

    authors： Nantel J,McDonald JC,Tan S,Bronte-Stewart H

    更新日期：2012-09-27 00:00:00

  • Excitotoxic lesions of the pedunculopontine differentially mediate morphine- and d-amphetamine-evoked striatal dopamine efflux and behaviors.

    abstract：:Cholinergic and glutamatergic cells in the pedunculopontine tegmental nucleus are a principal source of excitatory input to midbrain dopamine neurons projecting to the striatum. Disruption of these brainstem inputs has been shown to respectively enhance and reduce psychostimulant and opiate self-administration in rats...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00595-4

    authors： Miller AD,Forster GL,Metcalf KM,Blaha CD

    更新日期：2002-01-01 00:00:00

  • Neuropeptide Y in the adrenal gland: characterization, distribution and drug effects.

    abstract：:The occurrence of neuropeptide Y-like immunoreactivity in the adrenal gland was investigated by means of radioimmunoassay, chromatography and immunohistochemistry. The adrenal levels of neuropeptide Y-like immunoreactivity varied considerably between species with lowest amounts in the rat and highest in the cow where ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90313-1

    authors： de Quidt ME,Emson PC

    更新日期：1986-11-01 00:00:00

  • Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain.

    abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00494-1

    authors： Carpintero P,Anadón R,Díaz-Regueira S,Gómez-Márquez J

    更新日期：1999-01-01 00:00:00

  • Imaging genetics and the power of combined technologies: a perspective from neuroethics.

    abstract：:Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2009.01.052

    authors： Tairyan K,Illes J

    更新日期：2009-11-24 00:00:00

  • Potassium ion- and nitric oxide-induced exocytosis from populations of hippocampal synapses during synaptic maturation in vitro.

    abstract：:The development of mechanisms of neurotransmitter release is an important component in the formation of functional synaptic connections. Synaptic neurotransmitter release can be modulated by nitric oxide, a compound shown to have a variety of physiologic functions in the nervous system. The goal of this study was to d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00152-8

    authors： Sporns O,Jenkinson S

    更新日期：1997-10-01 00:00:00

  • Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotrophic factor and the induction of neuronal cell death.

    abstract：:Neurotrophic factors are known to promote neuronal survival during development and after acute brain injury. Recent data suggest that some neuropeptides also exhibit neurotrophic activities, as shown for the pituitary adenylate cyclase activating polypeptide, which increases the survival of various neuronal population...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00414-x

    authors： Skoglösa Y,Lewén A,Takei N,Hillered L,Lindholm D

    更新日期：1999-04-01 00:00:00

  • The Secretome of Microglia Regulate Neural Stem Cell Function.

    abstract：:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.10.034

    authors： Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren K

    更新日期：2019-05-01 00:00:00

  • Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring.

    abstract：:Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signaling activation, leading to repression of proneural factors such as Mash1 and Ngn2/3, which are essential for neuronal different...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.11.043

    authors： Lemes SF,de Souza ACP,Payolla TB,Versutti MD,de Fátima da Silva Ramalho A,Mendes-da-Silva C,Souza CM,Milanski M,Torsoni AS,Torsoni MA

    更新日期：2018-02-10 00:00:00

  • Electrophysiology of the dorsolateral mesopontine reticular formation during Pavlovian conditioning in the rabbit.

    abstract：:Extracellular single-unit recording methods were used to study the activity of neurons within a restricted portion of the dorsolateral mesopontine reticular formation, an area which includes the parabrachial, pedunculopontine tegmental and cuneiform nuclei. Recordings were obtained during presentations of unfamiliar a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90245-b

    authors： Pascoe JP,Kapp BS

    更新日期：1993-06-01 00:00:00

  • Reduced expression and desensitization of adenosine A1 receptor/adenylyl cyclase pathway after chronic (-)N6-phenylisopropyladenosine intake during pregnancy.

    abstract：:Little is known about the G protein-coupled receptor desensitization process during pregnancy. Wistar pregnant rats were treated with (-)N(6)-phenylisopropyladenosine (R-PIA), an adenosine A(1) receptor (A(1)R) agonist, in their drinking water during pregnancy, and the effect on A(1)R/adenylyl cyclase system was studi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.06.050

    authors： León DA,Castillo CA,Albasanz JL,Martín M

    更新日期：2009-10-06 00:00:00

  • Zinc chelation during non-lesioning overexcitation results in neuronal death in the mouse hippocampus.

    abstract：:In the hippocampus, chelatable zinc is accumulated in vesicles of glutamatergic presynaptic terminals, abounding specially in the mossy fibers, from where it is released with activity and can exert a powerful inhibitory action upon N-methyl-D-aspartate receptors. Zinc is therefore in a strategic situation to control o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00731-5

    authors： Domínguez MI,Blasco-Ibáñez JM,Crespo C,Marqués-Marí AI,Martínez-Guijarro FJ

    更新日期：2003-01-01 00:00:00

  • Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons.

    abstract：:The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00097-3

    authors： Ishihara A,Ohira Y,Roy RR,Nagaoka S,Sekiguchi C,Hinds WE,Edgerton VR

    更新日期：1997-11-01 00:00:00

  • Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.

    abstract：:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to tr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.10.005

    authors： Kemp SWP,Szynkaruk M,Stanoulis KN,Wood MD,Liu EH,Willand MP,Morlock L,Naidoo J,Williams NS,Ready JM,Mangano TJ,Beggs S,Salter MW,Gordon T,Pieper AA,Borschel GH

    更新日期：2015-01-22 00:00:00

  • Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.

    abstract：:The mechanism of action of conventional antidepressants (e.g. imipramine) has been linked to modulation of central monoamine systems. Substance P (NK1) receptor antagonists may have antidepressant and anxiolytic effects in patients with major depressive disorder and high anxiety but, unlike conventional antidepressant...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00467-5

    authors： Maubach KA,Martin K,Chicchi G,Harrison T,Wheeldon A,Swain CJ,Cumberbatch MJ,Rupniak NM,Seabrook GR

    更新日期：2002-01-01 00:00:00

  • Long-lasting potentiation in the secondary somatosensory cortex affects motor control: assessment by H-reflex.

    abstract：:We investigated descending projections from the secondary somatosensory cortex to the feline spinal cord and the effects of long-lasting potentiation in secondary somatosensory cortex on the activities of motoneurons of the cat. Electrophysiological examinations revealed that the low-intensity subthreshold secondary s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00191-1

    authors： Kawakami Y,Oshima T

    更新日期：1996-10-01 00:00:00

  • Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats.

    abstract：:Hindbrain dorsal vagal complex A2 noradrenergic signaling represses the pre-ovulatory luteinizing hormone (LH) surge in response to energy deficiency. Insulin-induced hypoglycemia augments A2 neuron adenosine 5'-monophosphate-activated protein kinase (AMPK) activity and estrogen receptor-beta (ERβ) expression, coincid...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.06.014

    authors： Briski KP,Shrestha PK

    更新日期：2016-09-07 00:00:00

  • The extracellular signal-regulated kinase signaling pathway is involved in the modulation of morphine-induced reward by mPer1.

    abstract：:Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Studies have shown that the circadian clock gene Period in Drosophila melanogaster could influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate co...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.009

    authors： Liu Y,Wang Y,Jiang Z,Wan C,Zhou W,Wang Z

    更新日期：2007-04-25 00:00:00

  • Differential effects of acute and regular physical exercise on cognition and affect.

    abstract：:The effects of regular exercise versus a single bout of exercise on cognition, anxiety, and mood were systematically examined in healthy, sedentary young adults who were genotyped to determine brain-derived neurotrophic factor (BDNF) allelic status (i.e., Val-Val or Val66Met polymorphism). Participants were evaluated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.04.056

    authors： Hopkins ME,Davis FC,Vantieghem MR,Whalen PJ,Bucci DJ

    更新日期：2012-07-26 00:00:00