Abstract：
:Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signaling activation, leading to repression of proneural factors such as Mash1 and Ngn2/3, which are essential for neuronal differentiation and neurogenesis. Thus, we aimed to investigate the effects of maternal HFD consumption during gestation and lactation on the Notch1/Mash1 pathway in the hypothalamus and arcuate nucleus (ARC) of mouse offspring (neonates and 28 days old). Our results showed that maternal HFD consumption increases body weight and adiposity of mouse offspring, accompanied by increased levels of Il-1β mRNA compared to those in control offspring. We noticed high mRNA levels of Hes5 accompanied by diminished mRNA levels of Ascl1 (Mash1). The number of Mash1-labeled cells in the ARC was diminished in HFD-O. Additionally, the population of NPY neurons was increased in these animals. Mash1 is important for the development of POMC and NPY neurons in the ARC. Therefore, the reduction in Mash1-labeled cells could be related to modification of the NPY neuron population in the ARC. This scenario favors hyperphagia and weight gain, and could be responsible for the development of obesity in adulthood.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Lemes SF,de Souza ACP,Payolla TB,Versutti MD,de Fátima da Silva Ramalho A,Mendes-da-Silva C,Souza CM,Milanski M,Torsoni AS,Torsoni MAdoi
10.1016/j.neuroscience.2017.11.043subject
Has Abstractpub_date
2018-02-10 00:00:00pages
1-15eissn
0306-4522issn
1873-7544pii
S0306-4522(17)30846-1journal_volume
371pub_type
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