Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death.

abstract：:In addition to triggering vasoconstriction of peripheral blood vessels, which led to its discovery as a circulating neurohormone 50 years ago, serotonin (5-hydroxytryptamine) acts as a neurotransmitter/ modulator in the central nervous system and regulates local cerebral blood flow and vascular permeability through di...

journal_title：Neuroscience

authors： Riad M,Tong XK,el Mestikawy S,Hamon M,Hamel E,Descarries L

更新日期：1998-10-01 00:00:00

abstract：:The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...

journal_title：Neuroscience

authors： Marks WN,Greba Q,Cain SM,Snutch TP,Howland JG

更新日期：2016-09-22 00:00:00

abstract：:Immunohistochemistry for the somatostatin sst2A receptor was performed on the rat trigeminal ganglion to know its function in the trigeminal nervous system. The immunoreactivity was detected in 9.4% of primary sensory neurons in the ganglion. These neurons were small to medium-sized (range=106.5-1123.2 microm(2); mean...

journal_title：Neuroscience

authors： Ichikawa H,Schulz S,Höllt V,Sugimoto T

更新日期：2003-01-01 00:00:00

abstract：:The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signali...

journal_title：Neuroscience

authors： Kramer B,Tropitzsch A,Müller M,Löwenheim H

更新日期：2017-08-15 00:00:00

abstract：:Excitotoxicity plays an important role in the pathogenesis of developing brain injury. The neuropeptide secretoneurin (SN) has neuroprotective potential. The aim of this study was to investigate SN plasma concentrations following excitotoxicity and to evaluate the effect of SN as therapeutic strategy in excitotoxic ne...

journal_title：Neuroscience

authors： Posod A,Wechselberger K,Schmid A,Huber E,Urbanek M,Kiechl-Kohlendorfer U,Griesmaier E

更新日期：2019-07-01 00:00:00

abstract：:Neurodegeneration in fetal development of Down syndrome (DS) patients is proposed to result in apparent neuropathological abnormalities and to contribute to the phenotypic characteristics of mental retardation and premature development of Alzheimer disease. In order to identify the aberrant and specific genes involved...

journal_title：Neuroscience

authors： Kadota M,Nishigaki R,Wang CC,Toda T,Shirayoshi Y,Inoue T,Gojobori T,Ikeo K,Rogers MS,Oshimura M

更新日期：2004-01-01 00:00:00

abstract：:Noninvasive functional imaging holds great promise for the future of translational research, due to the ability to directly compare between preclinical and clinical models of psychiatric disorders. Despite this potential, concerns have been raised regarding the necessity to anesthetize rodent and monkey subjects durin...

journal_title：Neuroscience

authors： Smith ML,Li J,Cote DM,Ryabinin AE

更新日期：2016-03-01 00:00:00

abstract：:Nerve growth factor (NGF) can augment transmitter release in sensory neurons by acutely sensitizing sensory neurons and by increasing the expression of calcitonin gene-related peptide (CGRP) over time. The current study examined the intracellular signaling pathways that mediate these two temporally distinct effects of...

journal_title：Neuroscience

authors： Park KA,Fehrenbacher JC,Thompson EL,Duarte DB,Hingtgen CM,Vasko MR

更新日期：2010-12-15 00:00:00

abstract：:One week after injection of L-[35S]methionine into the dorsal motor nuclei of the guinea-pig, labelled tubulin carried down the vagal nerve by the slow phase of axonal transport was analysed by one- and two-dimensional gel electrophoresis. Transported tubulin showed a much stronger labelling of the beta-subunit. Isoel...

journal_title：Neuroscience

authors： Tashiro T,Komiya Y

更新日期：1983-08-01 00:00:00

abstract：:The functional changes of astrocytes are deeply involved in neurodegenerating processes of various CNS diseases. ATP is released during various neuronal damages such as brain ischemia and may control astrocyte functions. We examined the effect of ATP on the production of nitric oxide in the cultured astrocytes from ra...

journal_title：Neuroscience

authors： Murakami K,Nakamura Y,Yoneda Y

更新日期：2003-01-01 00:00:00

abstract：:While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Withi...

journal_title：Neuroscience

authors： Alvarez P,Chen X,Hendrich J,Irwin JC,Green PG,Giudice LC,Levine JD

更新日期：2012-12-06 00:00:00

abstract：:The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight an...

journal_title：Neuroscience

authors： Ishihara A,Ohira Y,Roy RR,Nagaoka S,Sekiguchi C,Hinds WE,Edgerton VR

更新日期：1997-11-01 00:00:00

abstract：:The existence of a sex difference in several chronic pain syndromes and the fluctuation of symptoms during the menstrual cycle strongly suggest sex hormones are involved in pain processing. The mechanisms underlying these changes are not well understood. Using the colorectal distention model in the rat, we previously ...

journal_title：Neuroscience

authors： Ji Y,Tang B,Traub RJ

更新日期：2008-07-17 00:00:00

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:The development of chronic pain is associated with activity-dependent plastic changes in neuronal structures in the peripheral and central nervous system. In order to investigate the time-dependent processing of afferent noxious stimuli in the spinal cord we employed the quantitative autoradiographic 2-deoxyglucose te...

journal_title：Neuroscience

authors： Schadrack J,Neto FL,Ableitner A,Castro-Lopes JM,Willoch F,Bartenstein P,Zieglgänsberger W,Tölle TR

更新日期：1999-01-01 00:00:00

abstract：:Recent studies have shown that tachykinins mediate slow synaptic transmission to myenteric AH (afterhyperpolarising) neurons via neurokinin-3 receptors (NK(3)R). This study investigated a similar role for neurokinin-1 receptors (NK(1)R) and compared the effect of selective receptor antagonists on non-cholinergic slow ...

journal_title：Neuroscience

authors： Johnson PJ,Bornstein JC

更新日期：2004-01-01 00:00:00

abstract：:Several lines of evidence suggest that integrin receptors play a pivotal role in consolidation of long-term potentiation (LTP), but which of the many integrin dimers are involved remains to be discovered. The present study used an LTP reversal paradigm to test if alpha3 integrins make an important contribution. Functi...

journal_title：Neuroscience

authors： Kramár EA,Bernard JA,Gall CM,Lynch G

更新日期：2002-01-01 00:00:00

abstract：:The modulation of neurotransmitter release by calcium channels is well established, yet, sodium channels were regarded mainly as charge carriers. Many lines of evidence suggest a more fine-tuning role played by sodium channels. Using rat cerebrocortical isolated nerve endings (synaptosomes) and two toxins that have se...

journal_title：Neuroscience

authors： Bicalho AF,Guatimosim C,Prado MA,Gomez MV,Romano-Silva MA

更新日期：2002-01-01 00:00:00

abstract：:The pattern of expression of p75, the low affinity nerve growth factor receptor, in the adult rat cerebellum and its fate after a traumatic lesion were analysed using immunohistochemical localization of this receptor. A subset of Purkinje cells was immunoreactive for low affinity nerve growth factor receptor in the in...

journal_title：Neuroscience

authors： Dusart I,Morel MP,Sotelo C

更新日期：1994-11-01 00:00:00

abstract：:Recent in vivo electrophysiological studies suggest that chronic dopamine depletion alters profoundly the firing pattern of basal ganglia neurons. These changes may disrupt the processing of cortical information flow from the striatum to the output nuclei, and presumably underlie the clinical manifestations of Parkins...

journal_title：Neuroscience

authors： Tseng KY,Riquelme LA,Murer MG

更新日期：2004-01-01 00:00:00

abstract：:Extracellular signal-regulated kinases and activator protein 1 transcription factor have been functionally linked to addiction. It has also been shown that extracellular signal-regulated kinase activation can regulate cocaine-induced expression of c-Fos and FosB, two possible components of activator protein 1. A direc...

journal_title：Neuroscience

authors： Radwanska K,Valjent E,Trzaskos J,Caboche J,Kaczmarek L

更新日期：2006-01-01 00:00:00

abstract：:Antisera raised against protein-glutaraldehyde-amino acid conjugates were used to study the light and electron microscopic distribution of GABA, glutamate, glutamine and taurine in organotypic slice cultures of rat hippocampi. In the stratum oriens and radiatum, glutamate-like immunoreactivity was particularly concent...

journal_title：Neuroscience

authors： Torp R,Haug FM,Tønder N,Zimmer J,Ottersen OP

更新日期：1992-01-01 00:00:00

abstract：:The transport of excitatory amino acids (EAA) in CNS is performed by a family of high affinity, sodium dependent carriers. One of these transporters, excitatory amino acid carrier 1 (EAAC1), is known to be regulated by several mechanisms that modify carrier abundance on the plasma membrane. Much less is known on EAAC1...

journal_title：Neuroscience

authors： Bianchi MG,Gazzola GC,Tognazzi L,Bussolati O

更新日期：2008-02-19 00:00:00

abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

journal_title：Neuroscience

authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

更新日期：2013-02-12 00:00:00

abstract：:Little is known about the G protein-coupled receptor desensitization process during pregnancy. Wistar pregnant rats were treated with (-)N(6)-phenylisopropyladenosine (R-PIA), an adenosine A(1) receptor (A(1)R) agonist, in their drinking water during pregnancy, and the effect on A(1)R/adenylyl cyclase system was studi...

journal_title：Neuroscience

authors： León DA,Castillo CA,Albasanz JL,Martín M

更新日期：2009-10-06 00:00:00

abstract：:NESP55 (neuroendocrine secretory protein of M(r) 55000) is a novel member of the chromogranin family. In the present study, we have investigated the distribution, axonal transport and proteolytic processing of NESP55 in the peripheral nervous system. The amount of NESP55 immunoreactivity in adrenal gland was more than...

journal_title：Neuroscience

authors： Li JY,Lovisetti-Scamihorn P,Fischer-Colbrie R,Winkler H,Dahlström A,Department of Anatomy and Cell Biology, University of Göteborg, Sweden. jiayi.li@anatcell.gu.se.

更新日期：2002-01-01 00:00:00

abstract：:The function of N-methyl-d-aspartate (NMDA) receptors in primary afferents remains controversial, in particular regarding their ability to evoke substance P release in the spinal cord. The objective of this study was, first, to confirm that substance P release evoked by NMDA is mediated by NMDA receptors in primary af...

journal_title：Neuroscience

authors： Chen W,Zhang G,Marvizón JC

更新日期：2010-03-31 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

journal_title：Neuroscience

authors： van Vliet EA,Aronica E,Gorter JA

更新日期：2014-09-26 00:00:00

abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

journal_title：Neuroscience

authors： Clarke PG,Nussbaumer JC

更新日期：1987-12-01 00:00:00

abstract：:Dopamine (DA) axons and receptors have recently been identified in the primate thalamus, including the mediodorsal thalamic nucleus (MD). In order to determine whether the DA innervation of the primate MD shares the anatomical features of the mesocortical or nigrostriatal DA projections, we performed tract-tracing and...

journal_title：Neuroscience

authors： Melchitzky DS,Erickson SL,Lewis DA

更新日期：2006-12-28 00:00:00