Abstract:
:The pattern of expression of p75, the low affinity nerve growth factor receptor, in the adult rat cerebellum and its fate after a traumatic lesion were analysed using immunohistochemical localization of this receptor. A subset of Purkinje cells was immunoreactive for low affinity nerve growth factor receptor in the intact adult cerebellum. These cells were arranged in alternating positive and negative parasagittal compartments along the cerebellar cortex. This pattern of expression had 90% homology with zebrin I. After a traumatic lesion, the specific pattern of expression of zebrin I remained unchanged, whereas the low affinity nerve growth factor receptor pattern changed as early as one day: Purkinje cells near the lesion site, independent of zebrin I staining, became immunoreactive. During the first week, the increase in immunoreactivity remained high. Thereafter, there was a short, fast decrease followed by a long period in which a faint immunostaining on lesioned Purkinje cells is maintained for up to one year. The increase in the expression of the low affinity nerve growth factor receptor by all traumatically affected Purkinje cells suggests a correlation between this specific up-regulation and the high resistance of these neurons to axotomy or other traumatic injuries.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Dusart I,Morel MP,Sotelo Cdoi
10.1016/0306-4522(94)90534-7subject
Has Abstractpub_date
1994-11-01 00:00:00pages
351-6issue
2eissn
0306-4522issn
1873-7544pii
0306-4522(94)90534-7journal_volume
63pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::We used whole-cell patch recording to study 102 local interneurons in the rat dorsal lateral geniculate nucleus in vitro. Input impedance with this technique (607.0+/-222.4 MOhm) was far larger than that measured with sharp electrode techniques, suggesting that interneurons may be more electrotonically compact than pr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00665-4
更新日期:1999-01-01 00:00:00
abstract::Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90078-3
更新日期:1986-04-01 00:00:00
abstract::The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+. The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid or release of Ca2+ from intracellular stores such as mitochondria. Whether Ca2+ utilized in transmitter release ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00509-6
更新日期:2000-01-01 00:00:00
abstract::Astrocytes in the somatosensory ventrobasal (VB) thalamus of rats respond to glutamatergic synaptic input with metabotropic glutamate receptor (mGluR) mediated intracellular calcium ([Ca²⁺](i)) elevations. Astrocytes in the VB thalamus also release the gliotransmitter (GT) glutamate in a Ca²⁺-dependent manner. The tri...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.12.049
更新日期:2012-03-15 00:00:00
abstract::Resting state functional connectivity can be leveraged to investigate bilingual individual differences in cognitive control of language; however, thus far no report is provided on how the connectivity profiles of brain functional networks at rest point to different language control behavior in bilinguals. In order to ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.08.032
更新日期:2020-10-15 00:00:00
abstract::Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.05.019
更新日期:2016-08-04 00:00:00
abstract::Oscillatory activity is a prominent characteristic of electrophysiological recordings in the olfactory system and has been proposed to play a key role in encoding olfactory representations. Studies in several systems have shown that some aspects of information coding involve characteristics that intertwine spikes and ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.07.077
更新日期:2008-10-15 00:00:00
abstract::The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid beta (Abeta) deposition in the brain. We studied electroencephalographically defined sleep and the circadian regulation of waking activities in Tg2576 mice to determine whether these animals exhibit sleep abnormalities akin to those in A...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.11.018
更新日期:2005-01-01 00:00:00
abstract::Some neural mechanism must prevent the full expression of the baroreceptor reflex during static exercise because arterial blood pressure increases even though the baroreceptors are functioning. Two likely candidates are central command and input from the thin fiber muscle afferents evoking the exercise pressor reflex....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.02.050
更新日期:2006-07-07 00:00:00
abstract::The topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and lateral portions of the bed nucleus of the stria terminalis and central amygdaloid nucleus was investigated, in the rat, using the retrograde transport of wheat germ agglutinin-conjugated horseradish peroxidase. Alth...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90248-m
更新日期:1991-01-01 00:00:00
abstract::Aging is associated with disturbances in autonomic cardiovascular control. The purpose of this study was to test the hypothesis that changes in nitric oxide occur with aging in brainstem nuclei involved in autonomic cardiovascular control. The principal and unexpected finding in this study was that NADPH-diaphorase re...
journal_title:Neuroscience
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to minute quantities of GABAA receptor agonists, induces a state of general anesthesia. In addition to immobility and analgesia this state is accompanied by widespread suppression of neural activity in the cerebral cortex ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.02.022
更新日期:2020-04-15 00:00:00
abstract::Purkinje cell maturation during thyroxine-induced metamorphosis in premetamorphic bullfrog tadpoles was studied using electron microscopy and Golgi (silver-impregnated) preparations. Cerebella from tadpoles were examined following 1, 2, or 3 weeks of thyroxine treatment. Particular attention was paid to possible diffe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90219-7
更新日期:1984-01-01 00:00:00
abstract::The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90148-x
更新日期:1986-12-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is triggered by exposure to traumatic events, but not everyone who experiences trauma develops this disorder. Like humans, PTSD-like symptoms develop in some laboratory rodents (susceptible individuals), while others express less or no symptoms (resilient individuals). Here, consi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.08.018
更新日期:2019-10-15 00:00:00
abstract::The glucocorticoid-induced receptor (GIR) is an orphan G-protein-coupled receptor awaiting pharmacological characterization. GIR was originally identified in murine thymoma cells, and shows a widespread, yet not completely complementary distribution in mouse and human brain. Expression of the mouse GIR gene is modulat...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.01.066
更新日期:2005-01-01 00:00:00
abstract::The effect of systemic administration of domoic acid, a potent structural analogue of kainic acid, on the mouse hippocampus has been studied using light and electron microscopic techniques. Intraperitoneal injections of either domoic acid (4 mg/kg) or kainic acid (32 mg/kg) produced a series of behavioural changes inc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90059-w
更新日期:1991-01-01 00:00:00
abstract::Rats were given bilateral lesions of the motor cortex on the tenth day of life, and then received a daily subcutaneously injection of either basic fibroblast growth factor (FGF-2) or vehicle for 7 consecutive days. In adulthood, they were trained and assessed on a skilled forelimb reaching task. Although all lesion gr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.04.006
更新日期:2005-01-01 00:00:00
abstract::The ultrastructure of rat neurohypophyses incubated in vitro was studied to investigate secretion-related changes that may be intrinsic to the isolated neurohypophysis and to establish the morphological integrity of this preparation. Neurohypophyses were incubated for 2 h in an in vitro chamber in medium of low (290 m...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90069-1
更新日期:1984-06-01 00:00:00
abstract::Subjects with Parkinson's disease exhibit abnormally short compensatory steps in response to external postural perturbations. We examined whether: (1) Parkinson's disease subjects exhibit short compensatory steps due to abnormal central proprioceptive-motor integration, (2) this proprioceptive-motor deficit can be ove...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.04.014
更新日期:2006-08-25 00:00:00
abstract::In rats under urethane anaesthesia gamma-aminobutyric acid agonists and uptake blockers were microiontophoretically applied in the pyramidal layer of CA1 and in the apical dendrites using a twin set of multibarrelled micropipettes. Thus, the somatic and dendritic field potentials elicited by commissural stimulation we...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90072-1
更新日期:1984-06-01 00:00:00
abstract::The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.09.036
更新日期:2012-12-27 00:00:00
abstract::Stimulus-induced pattern of bioelectric activity in human neocortical tissue was investigated by use of the voltage sensitive dye RH795 and a fast optical recording system. During control conditions stimulation of layer I evoked activity predominantly in supragranular layers showing a spatial extent of up to 3000 micr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00530-x
更新日期:2003-01-01 00:00:00
abstract::Methyl-CpG-binding protein 2 is a characteristic member of the methyl-CpG-binding protein family of transcription regulators. In conjunction with Sin3, MeCP2 recruits class I histone deacetylases to methyl-CpG regions to suppress transcription. Rett syndrome, a disorder characterized by mental retardation and autistic...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00586-9
更新日期:2003-01-01 00:00:00
abstract::In vitro studies have demonstrated that β2-adrenergic receptor activation stimulates glycogen degradation in astrocytes, generating lactate as a potential energy source for neurons. Using in vivo microdialysis in mouse cerebellar white matter we demonstrate continuous axonal lactate uptake and glial-axonal metabolic c...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.07.022
更新日期:2014-09-26 00:00:00
abstract::Delta opioid receptor (DOR) is essential for neuronal survival against hypoxic/ischemic damages. However, current understanding on how DOR activation affects astrocytic functions under ischemia remains incomplete. The present study investigated the astroglial responses to [d-Ala2, d-Leu5] enkephalin (DADLE) (a selecti...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.06.067
更新日期:2011-09-29 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.07.013
更新日期:2013-10-10 00:00:00
abstract::The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90137-d
更新日期:1991-01-01 00:00:00
abstract::Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00459-6
更新日期:2002-01-01 00:00:00
abstract::Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.12.041
更新日期:2008-03-18 00:00:00