β₂-adrenergic receptors protect axons during energetic stress but do not influence basal glio-axonal lactate shuttling in mouse white matter.

abstract：:Two major systems of cholinergic projection neurons are found within the centrum of the mammalian brain: the basal nuclear complex, projecting predominantly to the cerebral cortex, amygdala, and hippocampus, and the pontomesencephalotegmental network, innervating primarily the thalamus. Neurons comprising the latter n...

journal_title：Neuroscience

authors： Consolo S,Bertorelli R,Forloni GL,Butcher LL

更新日期：1990-01-01 00:00:00

abstract：:Electrophysiological and anatomical studies were carried out in parallel to investigate the ability of lateral geniculate body neurons to regenerate axons damaged by the removal of the primary visual cortex and to innervate graft neurons functionally after transplantation of fetal neocortical tissue to a lesion cavity...

journal_title：Neuroscience

authors： Girman SV

更新日期：1994-06-01 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00

abstract：:The occurrence of neuropeptide Y-like immunoreactivity in the adrenal gland was investigated by means of radioimmunoassay, chromatography and immunohistochemistry. The adrenal levels of neuropeptide Y-like immunoreactivity varied considerably between species with lowest amounts in the rat and highest in the cow where ...

journal_title：Neuroscience

authors： de Quidt ME,Emson PC

更新日期：1986-11-01 00:00:00

abstract：:Converging evidence in schizophrenia suggests prefrontal cortical neuronal deficits that correlate with exaggerated subcortical dopamine (DA) functions: Excitotoxic lesion of the ventral hippocampus (VH) in neonatal rats is widely considered a putative animal model of schizophrenia as they lead to characteristic post-...

journal_title：Neuroscience

authors： Bhardwaj SK,Beaudry G,Quirion R,Levesque D,Srivastava LK

更新日期：2003-01-01 00:00:00

abstract：:Calmodulin (CaM), a multifunctional intracellular calcium receptor, is a key element in signaling mechanisms. It is encoded in vertebrates by multiple apparently redundant genes (CaM I, II, III). To investigate whether differential expression takes place in the developing rat brain, a quantitative in situ hybridizatio...

journal_title：Neuroscience

authors： Kortvely E,Palfi A,Bakota L,Gulya K

更新日期：2002-01-01 00:00:00

abstract：:The schizophrenia-susceptibility gene, dystrobrevin-binding protein 1 (DTNBP1), encodes the dysbindin protein and mediates neurotransmission and neurodevelopment in normal subjects. Functional studies show that DTNBP1 loss may cause deficient presynaptic vesicle transmission, which is related to multiple psychiatric d...

journal_title：Neuroscience

authors： Hu H,Wang X,Li C,Li Y,Hao J,Zhou Y,Yang X,Chen P,Shen X,Zhang S

更新日期：2021-01-01 00:00:00

abstract：:Protection of CNS white matter tracts in brain and spinal cord is essential for maximizing clinical recovery from disorders such as stroke or spinal cord injury. Central myelinated axons are damaged by anoxia/ischemia in a Ca(2+)-dependent manner. Leakage of Na+ into the axoplasm through Na+ channels causes Ca2+ overl...

journal_title：Neuroscience

authors： Stys PK,Lesiuk H

更新日期：1996-03-01 00:00:00

abstract：:In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presy...

journal_title：Neuroscience

authors： Wang H,Shen S,Zheng T,Bi L,Li B,Wang X,Yang Y,Jen PH

更新日期：2018-10-15 00:00:00

abstract：:In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

journal_title：Neuroscience

authors： Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

更新日期：2016-06-14 00:00:00

abstract：:Diabetes mellitus-induced metabolic disturbances underlie the action of many systems including some higher functions of the brain such as learning and memory. Plenty of evidence supports the effects of probiotics on the function of many systems including the nervous system. Here we report the effect of probiotics trea...

journal_title：Neuroscience

authors： Davari S,Talaei SA,Alaei H,Salami M

更新日期：2013-06-14 00:00:00

abstract：:We have developed a stroke model involving middle cerebral artery occlusion in the rat which elicits changes in cardiac and autonomic variables that are similar to those observed clinically. It is likely that these neurogenic autonomic responses are mediated by changes in neurotransmitter systems subsequent to the str...

journal_title：Neuroscience

authors： Allen GV,Cheung RT,Cechetto DF

更新日期：1995-10-01 00:00:00

abstract：:Cognitive aging affects episodic memory and executive functions, and these vulnerable domains are postulated to be modulated by endogenous and exogenous estrogen exposures. In midlife and late-life women without dementia, estrogen effects on cognition can be examined through associations with concentrations of serum e...

journal_title：Neuroscience

authors： Henderson VW,Popat RA

更新日期：2011-09-15 00:00:00

abstract：:Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...

journal_title：Neuroscience

authors： Rahimi Nedjat M,Wähmann M,Bächli H,Güresir E,Vatter H,Raabe A,Heimann A,Kempski O,Alessandri B

更新日期：2013-05-15 00:00:00

abstract：:Cocaine's multiple pharmacological substrates are ubiquitously present in the peripheral and central nervous system. Thus, upon its administration, cocaine acts in the periphery before directly acting in the brain. We determined whether cocaine alters ventral tegmental area (VTA) neuronal activity via its peripheral a...

journal_title：Neuroscience

authors： Mejías-Aponte CA,Kiyatkin EA

更新日期：2012-04-05 00:00:00

abstract：:Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic. To date, however, a quantitative description of the topographic distribution of GABAergic neurons in the rat's IC and their GABAergic or glyciner...

journal_title：Neuroscience

authors： Merchán M,Aguilar LA,Lopez-Poveda EA,Malmierca MS

更新日期：2005-01-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1), vanilloid 2 (TRPV2) and melastatin 8 (TRPM8) are thermosensitive cation channels expressed on primary sensory neurons. In contrast to TRPV1, which is present on nociceptive primary afferents and keratinocytes in human skin, less is known about the distribution of TRPV2...

journal_title：Neuroscience

authors： Axelsson HE,Minde JK,Sonesson A,Toolanen G,Högestätt ED,Zygmunt PM

更新日期：2009-09-15 00:00:00

abstract：:The caudal anterior cingulate cortex (cAC) is an essential component of the circuitry involved in acquisition of forebrain-dependent trace eyeblink conditioning. Lesions of the cAC prevent trace eyeblink conditioning [Weible AP, McEchron MD, Disterhoft JF (2000) Cortical involvement in acquisition and extinction of tr...

journal_title：Neuroscience

authors： Weible AP,Weiss C,Disterhoft JF

更新日期：2007-03-02 00:00:00

abstract：:The uptake and release of catecholamines was investigated in the isolated perfused adrenal gland of the rat after preloading the preparation with [3H]norepinephrine, and the effects of various agents were examined on the stimulation-evoked secretion of catecholamines and total tritium. Large quantities of tritium were...

journal_title：Neuroscience

authors： Wakade AR,Malhotra RK,Wakade TD,Dixon WR

更新日期：1986-08-01 00:00:00

abstract：:8-oxoguanine DNA glycosylase and Kin17 are proteins widely distributed and phylogenetically conserved in the CNS. 8-oxoguanine DNA glycosylase is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine present in DNA damaged by oxidative stress. Kin17 protein is involved in DNA repair and illegitimate recombination ...

journal_title：Neuroscience

authors： Araneda S,Pelloux S,Radicella JP,Angulo J,Kitahama K,Gysling K,Forray MI

更新日期：2005-01-01 00:00:00

abstract：:Little is known about the projections from the orofacial areas of the secondary somatosensory cortex (S2) to the pons and medulla including the second-order somatosensory neuron pools. To address this in rats, we first examined the distribution of S2 neurons projecting to the trigeminal principal nucleus (Vp) or oral ...

journal_title：Neuroscience

authors： Haque T,Akhter F,Kato T,Sato F,Takeda R,Higashiyama K,Moritani M,Bae YC,Sessle BJ,Yoshida A

更新日期：2012-09-06 00:00:00

abstract：:We have previously shown that the myristoylated alanine-rich C kinase substrate, a primary protein kinase C substrate in brain that binds and cross-links filamentous actin, is enriched in neuronal growth cones and is developmentally regulated in brain. Here we examined myristoylated alanine-rich C kinase substrate exp...

journal_title：Neuroscience

authors： McNamara RK,Jiang Y,Streit WJ,Lenox RH

更新日期：2000-01-01 00:00:00

abstract：:The aim of this study was to assess whether omega conotoxin fraction GVIA, a potent blocker of N- and L-type voltage-sensitive calcium channels, might interfere with reflex responses (micturition, blood pressure rise in spinal rats) produced by activation of capsaicin-sensitive sensory nerves of the rat urinary bladde...

journal_title：Neuroscience

authors： Maggi CA,Giuliani S,Santicioli P,Tramontana M,Meli A

更新日期：1990-01-01 00:00:00

abstract：:Chronic Mountain Sickness (CMS) occurs in high-altitude residents with major neurological symptoms such as migraine headaches, dizziness and cognitive deficits. Recent work demonstrated that highlanders have increased intracellular pH (pHi) in their brain cells, perhaps for the sake of adaptation to hypoxemia and help...

journal_title：Neuroscience

authors： Yao H,Zhao H,Wang J,Haddad GG

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

journal_title：Neuroscience

authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might increase the understanding of sites of action, and mechanisms related to headache therapy. The overall aim of the study was to investigate the presence of migraine targets in the TG with particular emphasis on pituitary adenylate cy...

journal_title：Neuroscience

authors： Frederiksen SD,Warfvinge K,Ohlsson L,Edvinsson L

更新日期：2018-11-21 00:00:00

abstract：:Tetramethylpyrazine (TMP) is an active compound extracted from the traditional Chinese medicinal herb Chuanxiong. Recently, it has been reported that TMP enhances neurogenesis, and promotes neural stem cell differentiation toward neurons. However, its molecular basis remains unknown. Topoisomerase IIβ (TopoIIβ) is a n...

journal_title：Neuroscience

authors： Yan Y,Zhao J,Cao C,Jia Z,Zhou N,Han S,Wang Y,Xu Y,Zhao J,Yan Y,Cui H

更新日期：2014-10-10 00:00:00

abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

journal_title：Neuroscience

authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

更新日期：1999-01-01 00:00:00

abstract：:Neuromedin U is a newly described regulatory peptide, found by radioimmunoassay in significant concentrations in both the brain and gut of the rat. The aim of the present study was to localize this peptide immunoreactivity to discrete structures of the gut and brain and to map its distribution using immunocytochemistr...

journal_title：Neuroscience

authors： Ballesta J,Carlei F,Bishop AE,Steel JH,Gibson SJ,Fahey M,Hennessey R,Domin J,Bloom SR,Polak JM

更新日期：1988-06-01 00:00:00

abstract：:With the six convulsants studied (Soman, intrahippocampal penicillin, bicuculline, pentylenetetrazol, picrotoxin and strychnine), the anatomical distribution of changes in local cerebral glucose utilization was related to the type of seizure observed. Strychnine induced a few very intense motor convulsions during the ...

journal_title：Neuroscience

authors： Pazdernik TL,Cross RS,Giesler M,Samson FE,Nelson SR

更新日期：1985-03-01 00:00:00