Abstract:
:Electrophysiological and anatomical studies were carried out in parallel to investigate the ability of lateral geniculate body neurons to regenerate axons damaged by the removal of the primary visual cortex and to innervate graft neurons functionally after transplantation of fetal neocortical tissue to a lesion cavity in the brain of adult rats. In electrophysiological experiments neurons of a large portion of the transplants (14/35) displayed visual responses with characteristics resembling closely those of normal primary visual cortex; these transplants also displayed a different degree of restoration of topographically organized visual field representations on them. To demonstrate anatomical regeneration of inputs from the host lateral geniculate body to the graft, injections of FluoroGold were made before grafting into the intact visual cortex for retrograde labeling of the lateral geniculate body neurons. After completion of the microelectrode recordings from the transplants a second dye, Bisbenzimide, was injected into the transplants. The rats with transplants whose neurons displayed responses to visual stimulations contained in the lateral geniculate body neurons with FluoroGold-labeled cytoplasm and Bisbenzimide-labeled nuclei. The presence of double-labeled neurons suggests that the same neurons, the axons of which have terminated in area 17 of the cortex, innervated the transplants functionally through the regeneration of damaged axons.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Girman SVdoi
10.1016/0306-4522(94)90278-xsubject
Has Abstractpub_date
1994-06-01 00:00:00pages
989-97issue
4eissn
0306-4522issn
1873-7544pii
0306-4522(94)90278-Xjournal_volume
60pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Astrocytes in the somatosensory ventrobasal (VB) thalamus of rats respond to glutamatergic synaptic input with metabotropic glutamate receptor (mGluR) mediated intracellular calcium ([Ca²⁺](i)) elevations. Astrocytes in the VB thalamus also release the gliotransmitter (GT) glutamate in a Ca²⁺-dependent manner. The tri...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.12.049
更新日期:2012-03-15 00:00:00
abstract::The distribution of N-methyl-D-aspartate- (NMDA) and kainic acid- (KA) sensitive ionotropic glutamate receptors (iGluR) in the zebrafish olfactory bulb was assessed using an activity-dependent labeling method. Olfactory bulbs were incubated with an ion channel permeant probe, agmatine (AGB), and iGluR agonists in vitr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00544-x
更新日期:2003-01-01 00:00:00
abstract::Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the righ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.06.011
更新日期:2017-08-15 00:00:00
abstract::The effect of the intrathecal administration of the catecholaminergic neurotoxin 6-hydroxydopamine, or of hemisection of the spinal cord at the Cl level, on the density of alpha 2-adrenoceptors and on the norepinephrine, dopamine, and serotonin content in the cat lumbar spinal enlargement was determined 2, 7 or 21 day...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90128-x
更新日期:1987-05-01 00:00:00
abstract::It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90044-3
更新日期:1987-06-01 00:00:00
abstract::During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.03.050
更新日期:2005-01-01 00:00:00
abstract::In addition to triggering vasoconstriction of peripheral blood vessels, which led to its discovery as a circulating neurohormone 50 years ago, serotonin (5-hydroxytryptamine) acts as a neurotransmitter/ modulator in the central nervous system and regulates local cerebral blood flow and vascular permeability through di...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00196-1
更新日期:1998-10-01 00:00:00
abstract::Brainstem networks generating the respiratory rhythm in lampreys are still not fully characterized. In this study, we described the patterns of respiratory activities and we identified the general location of underlying neural networks. In a semi-intact preparation including the brain and gills, rhythmic discharges we...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.05.023
更新日期:2007-08-10 00:00:00
abstract::The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.06.043
更新日期:2017-09-17 00:00:00
abstract::Intracellular recordings were made from neurones in myenteric ganglia of the guinea-pig ileum in vitro. Synaptic potentials were evoked by electrically stimulating presynaptic fibres as they entered the ganglion, using a small focal electrode. Slow synaptic depolarizations (excitatory postsynaptic potentials) were evo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90317-3
更新日期:1985-02-01 00:00:00
abstract::For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2015.08.035
更新日期:2015-11-19 00:00:00
abstract::Our previous results obtained by lesioning or stimulating the ventrolateral part of the lateral septum and the bed nuclei of the stria terminalis suggested that this area is involved in the control of milk ejection pattern in rats. The present study was undertaken with the aim of testing ventrolateral part of the late...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90258-h
更新日期:1993-05-01 00:00:00
abstract::Astrocytic endothelin receptors are involved in the appearance of activated astrocytes upon injury of the brain [Ishikawa N. et al. (1997) Eur. J. Neurosci. 9, 895-901; Koyama Y. et al. (1999) Glia 26, 268-271]. To clarify signal transduction triggered by endothelin receptors, we examined the effects of endothelins on...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00330-4
更新日期:2000-01-01 00:00:00
abstract::Interactions of acoustic and somatosensory evoked potentials were studied in the anterior suprasylvian gyrus of the cat. Two kinds of interaction could be observed: occlusion or facilitation. In most cases occlusion was observed. The interactions showed dynamic changes and were susceptible to different kinds of influe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90084-8
更新日期:1984-11-01 00:00:00
abstract::Recent studies have shown that tachykinins mediate slow synaptic transmission to myenteric AH (afterhyperpolarising) neurons via neurokinin-3 receptors (NK(3)R). This study investigated a similar role for neurokinin-1 receptors (NK(1)R) and compared the effect of selective receptor antagonists on non-cholinergic slow ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.03.021
更新日期:2004-01-01 00:00:00
abstract::Acute stress is known to evoke a discrete pattern of c-fos expression in the brain. The work reported here shows that this pattern is modified in regionally specific ways following repeated stress, and that this can be correlated with changes in telemetered heart rate, core temperature and corticosterone output that o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00532-a
更新日期:1995-02-01 00:00:00
abstract::The effects of the dopamine D(3) receptor, a putative autoreceptor, have been investigated by comparing behavioral and neurochemical properties of wild-type mice and mice with a genetic deletion of the D(3) receptor. The D(3) knock-out mice were modestly hyper-responsive to a novel environment relative to wild-type mi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00067-2
更新日期:2002-01-01 00:00:00
abstract::The cerebellum is organized into parasagittal zones with respect to the topography of climbing fiber (CF) afferents and the expression of molecular markers such as zebrin II. Zebrin is expressed by a subset of Purkinje cells that are distributed as a parasagittal array of immunopositive and immunonegative stripes. Sev...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.08.062
更新日期:2008-11-11 00:00:00
abstract::Prolonged stress triggers neuroinflammation, which plays a significant role in the development of depression; however, stressed people do not always suffer from depression because of individual differences in stress vulnerability. Negative cognitive bias (NCB) toward pessimistic judgment often underlies depressive epi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.07.023
更新日期:2020-09-01 00:00:00
abstract::Tob (transducer of ErbB2) is a negative cell cycle regulator with anti-proliferative activity in the periphery. Using a behavioral screening paradigm to look for novel gene functions in the brain, we identified Tob as a brain-expressed protein involved in learning and memory. Behavioral training of fear-conditioning t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.10.044
更新日期:2005-01-01 00:00:00
abstract::Involvement of the local angiotensin receptor system in the central nervous system is well documented, yet its cellular localization and role in the glial cells have remained elusive. This study reports expression of angiotensin II and its receptors namely, angiotensin II receptor type 1 (AT(1)) and angiotensin II rec...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.11.046
更新日期:2009-02-18 00:00:00
abstract::Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.09.072
更新日期:2009-12-29 00:00:00
abstract::Estrogens influence neuronal activity and are important for normal brain functions. Effects of estrogens on seizures are contradictory. It is commonly accepted that estrogens may increase neuronal excitability and thus mediate proconvulsant effects. However, clinical and animal data show that estrogen may also have no...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2005.07.005
更新日期:2006-01-01 00:00:00
abstract::An antibody recognizing all ankyrin isoforms was employed to localize ankyrin in the cerebellum by light and electron microscopy. White matter (myelinated fiber tracts) did not contain ankyrin. Granule cell bodies and axons contained ankyrin which extended into the parallel fibers and their synapses. Purkinje cells co...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90596-8
更新日期:1993-06-01 00:00:00
abstract::Rats receiving a complete spinal cord transection (ST) at a neonatal stage spontaneously can recover significant stepping ability, whereas minimal recovery is attained in rats transected as adults. In addition, neonatally spinal cord transected rats trained to step more readily improve their locomotor ability. We hypo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.12.010
更新日期:2010-03-10 00:00:00
abstract::Subjects with Parkinson's disease exhibit abnormally short compensatory steps in response to external postural perturbations. We examined whether: (1) Parkinson's disease subjects exhibit short compensatory steps due to abnormal central proprioceptive-motor integration, (2) this proprioceptive-motor deficit can be ove...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.04.014
更新日期:2006-08-25 00:00:00
abstract::Cocaine's multiple pharmacological substrates are ubiquitously present in the peripheral and central nervous system. Thus, upon its administration, cocaine acts in the periphery before directly acting in the brain. We determined whether cocaine alters ventral tegmental area (VTA) neuronal activity via its peripheral a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.01.026
更新日期:2012-04-05 00:00:00
abstract::Adolescence is a period of progressive changes in brain that likely contribute to the maturation of behavior. Human adolescents consume large amounts of ethanol. To investigate the effects of ethanol on adolescent neural progenitor cells, male rats (35-40 days old) were treated with an acute dose of ethanol (1.0, 2.5 ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.08.090
更新日期:2006-01-01 00:00:00
abstract::Astrocyte hypertrophy and swelling occur in a variety of pathophysiological conditions, including diseases associated with hyperammonemia. Ammonia is rapidly incorporated into glutamine by glutamine synthetase localized in astrocytes. We tested the hypotheses that (1) 6 h of hyperammonemia (500-600 microM) is adequate...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00462-9
更新日期:1996-03-01 00:00:00
abstract::Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.02.031
更新日期:2019-05-21 00:00:00