当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Significance of slow synaptic potentials for transmission of excitation in guinea-pig myenteric plexus.

Significance of slow synaptic potentials for transmission of excitation in guinea-pig myenteric plexus.

Abstract：

:Intracellular recordings were made from neurones in myenteric ganglia of the guinea-pig ileum in vitro. Synaptic potentials were evoked by electrically stimulating presynaptic fibres as they entered the ganglion, using a small focal electrode. Slow synaptic depolarizations (excitatory postsynaptic potentials) were evoked in most myenteric neurones of both types. A single stimulus was more likely to evoke a slow excitatory postsynaptic potential in cells with nicotinic synaptic input (S cells; 50%) than in cells with long-lasting after-hyperpolarizations following the soma action potential (AH cells; 20%). Two pulses often evoked a slow excitatory postsynaptic potential in AH cells when one pulse was ineffective. The optimally effective time between the pulses was about 100 ms. Ten pulses resulted in slow excitatory postsynaptic potentials even when delivered at frequencies as low as 0.5 Hz. For the same frequency of presynaptic stimulation, the duration of the slow excitatory postsynaptic potential was greater in AH cells than in S cells and the amplitude of the slow excitatory postsynaptic potential was slightly greater in S than AH cells. Spontaneous depolarizations were observed which had time-courses and amplitudes similar to the evoked slow excitatory postsynaptic potential. They were not blocked by tetrodotoxin or atropine. The calcium-dependent after-hyperpolarization which follows one or more action potentials in AH cells was reduced or even abolished during the slow excitatory postsynaptic potential. Presynaptic nerve stimulation at intensities lower than those required to cause a slow excitatory postsynaptic potential caused a reduction in the calcium dependent after-hyperpolarization. It is concluded that the slow excitatory postsynaptic potential is generated by an intracellular intermediate process which is sensitive to the intracellular calcium concentration. The results suggest that the postsynaptic action of the synaptic transmitter is to interfere with the intracellular process which couples the entry of calcium to the increase in potassium conductance.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Morita K,North RA

doi

10.1016/0306-4522(85)90317-3

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

661-72

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(85)90317-3

journal_volume

14

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake.

    abstract：:Inhibitory serotonergic and cholecystokinergic mechanisms in the lateral parabrachial nucleus and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. In the present study we investigated if the GABA(A) receptors in the lateral parabrachial nucleus are involved in the control of water,...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.05.009

    authors： Callera JC,Oliveira LB,Barbosa SP,Colombari DS,De Luca LA Jr,Menani JV

    更新日期：2005-01-01 00:00:00

  • Thyroid hormone regulates excitability in central neurons from postnatal rats.

    abstract：:A lack of thyroid hormone in the postnatal period causes an irreversible mental retardation, characterized by a slowing of thoughts and movements accompanied by prolonged latencies of several evoked potentials and slowed electroencephalographic rhythms. Here we show that in cultured hippocampal and cortical neurons fr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.01.047

    authors： Hoffmann G,Dietzel ID

    更新日期：2004-01-01 00:00:00

  • Expression of N-methyl-D-aspartate receptor-dependent long-term potentiation in the neostriatal neurons in an in vitro slice after ethanol withdrawal of the rat.

    abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00611-3

    authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

    更新日期：1999-01-01 00:00:00

  • Functional role of Barrington's nucleus in the micturition reflex: relevance in the surgical treatment of Parkinson's disease.

    abstract：:The pontine micturition center or Barrington's nucleus (BN) - besides regulating micturition - co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular importance due to: (i) recent findings of α-synuclein in BN, (ii) known urinary dysfunction in pa...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.02.002

    authors： Blanco L,Ros CM,Tarragón E,Fernández-Villalba E,Herrero MT

    更新日期：2014-04-25 00:00:00

  • Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats.

    abstract：:Intraspecific confrontation has been used to study effect of depleting central serotonin on the adaptation of male rats to repeated social stress (social defeat). Four groups of adult male rats were used (serotonin depletion/sham: stressed; serotonin depletion/sham: non-stressed). Central serotonin was reduced (by 59-...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00028-7

    authors： Chung KK,Martinez M,Herbert J

    更新日期：1999-01-01 00:00:00

  • 11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids.

    abstract：:11beta-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives. As 11beta-hydroxysteroid dehydrogenase type 2 is highly expressed in the developing brain, but not in the adult CNS, we hypothesized that it ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.09.037

    authors： Holmes MC,Sangra M,French KL,Whittle IR,Paterson J,Mullins JJ,Seckl JR

    更新日期：2006-02-01 00:00:00

  • MK-801 pretreatment enhances N-methyl-D-aspartate-mediated brain injury and increases brain N-methyl-D-aspartate recognition site binding in rats.

    abstract：:Direct intracerebral administration of N-methyl-D-aspartate typically produces focal brain injury. (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-immi ne maleate (MK-801), a non-competitive N-methyl-D-aspartate antagonist, can protect against N-methyl-D-aspartate-mediated brain injury when administered sho...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90377-g

    authors： McDonald JW,Silverstein FS,Johnston MV

    更新日期：1990-01-01 00:00:00

  • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.

    abstract：:The present studies were conducted to test the hypothesis that systemically inactive doses of cannabinoids suppress inflammation-evoked neuronal activity in vivo via a peripheral mechanism. We examined peripheral cannabinoid modulation of spinal Fos protein expression, a marker of neuronal activity, in a rat model of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00870-9

    authors： Nackley AG,Suplita RL 2nd,Hohmann AG

    更新日期：2003-01-01 00:00:00

  • Nerve growth factor affects uninjured, adult rat septohippocampal cholinergic neurons.

    abstract：:The effect of nerve growth factor on the intact versus injured septohippocampal cholinergic system of adult rats was studied. Nerve growth factor was continuously infused into the lateral ventricle of adult uninjured rats or rats that had received unilateral partial transection of the fimbria. Controls (operated and u...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90309-6

    authors： Fusco M,Oderfeld-Nowak B,Vantini G,Schiavo N,Gradkowska M,Zaremba M,Leon A

    更新日期：1989-01-01 00:00:00

  • Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus.

    abstract：:Developmental or degenerative damage of the neuronal architecture in the entorhinal cortex may disintegrate a functional part of hippocampal input since the entorhinal cortex provides a major source of neocortical and subcortical input to the hippocampus. These alterations, such as seen in Alzheimer's disease, schizop...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90034-d

    authors： Falkenberg T,Metsis M,Timmusk T,Lindefors N

    更新日期：1993-12-01 00:00:00

  • Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes.

    abstract：:Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production. The present study examined the effects of endothelins on production of neurotrophin-3, a member of the neurotrophin family of neurotrophic factors, in cultured astrocytes and r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.004

    authors： Koyama Y,Baba A,Matsuda T

    更新日期：2005-01-01 00:00:00

  • Patterns of activation and de-activation associated with cue-guided spatial navigation: A whole-brain, voxel-based study.

    abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.06.029

    authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

    更新日期：2017-09-01 00:00:00

  • Feeding-evoked dopamine release in the nucleus, accumbens: regulation by glutamatergic mechanisms.

    abstract：:The extent to which glutamate receptors in the nucleus accumbens and ventral tegmental area regulate feeding-evoked increases in dopamine release in the nucleus accumbens was determined using in vivo brain microdialysis in the rat. In some animals a second dialysis probe was implanted in the ventral tegmental area ips...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00450-2

    authors： Taber MT,Fibiger HC

    更新日期：1997-02-01 00:00:00

  • Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats.

    abstract：:Maternal separation (MS) during the first postnatal weeks induces alcohol intake and a reduction in the expression of glucocorticoid receptors (GR). Adults' alcohol consumption may depend on changes in the endocannabinoid system (eCBs). Our goal was to evaluate the status of the eCBs before the exposition to alcohol t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.071

    authors： Romano-López A,Méndez-Díaz M,Ruiz-Contreras AE,Carrisoza R,Prospéro-García O

    更新日期：2012-10-25 00:00:00

  • Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia.

    abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.12.039

    authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

    更新日期：2016-03-01 00:00:00

  • gamma-Aminobutyric acid and 5-hydroxytryptamine interrelationship in the rat nucleus raphe dorsalis: combination of radioautographic and immunocytochemical techniques at light and electron microscopy levels.

    abstract：:Serotonin and gamma-aminobutyric acid (GABA) neurons in the nucleus raphe dorsalis were identified by immunocytochemistry using antibodies to 5-hydroxytryptamine or GABA. The pattern of the 5-hydroxytryptamine and GABA immunostaining presented similar features: 5-hydroxytryptamine or GABA immunoreactive somata were fu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90336-8

    authors： Harandi M,Aguera M,Gamrani H,Didier M,Maitre M,Calas A,Belin MF

    更新日期：1987-04-01 00:00:00

  • Immunohistochemical evidence for a spinothalamic pathway co-containing cholecystokinin- and galanin-like immunoreactivities in the rat.

    abstract：:Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90103-5

    authors： Ju G,Melander T,Ceccatelli S,Hökfelt T,Frey P

    更新日期：1987-02-01 00:00:00

  • Involvement of brain protein kinase C in nitrous oxide-induced antinociception in mice.

    abstract：:Exposure of mice to the anesthetic gas nitrous oxide (N(2)O) produces a marked antinociceptive effect. Protein kinase C is a key regulatory enzyme that may be targeted by general anesthetics. However, a relationship between N(2)O-induced antinociception and protein kinase C has yet to be established. The present study...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.001

    authors： Ishikawa M,Matsushita Y,Abe K,Utsunomiya I,Hoshi K,Quock RM,Taguchi K

    更新日期：2006-06-19 00:00:00

  • Different voltage-dependent potassium conductances regulate action potential repolarization and excitability in frog myelinated axon.

    abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00139-a

    authors： Poulter MO,Padjen AL

    更新日期：1995-09-01 00:00:00

  • Early Postnatal Ethanol Exposure in Mice Induces Sex-Dependent Memory Impairment and Reduction of Hippocampal NMDA-R2B Expression in Adulthood.

    abstract：:Drinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.11.045

    authors： Ieraci A,Herrera DG

    更新日期：2020-02-10 00:00:00

  • An immunohistochemical study of the gonadotrophin-releasing hormone 1 system in solitary Cape mole-rats, Georychus capensis, and social Natal mole-rats, Cryptomys hottentotus natalensis.

    abstract：:Mole-rat species within the family Bathyergidae exhibit a wide range of reproductive strategies and social systems. Various forms of reproductive suppression are displayed within this family: in the solitary species, breeding is suspended for part of the year and in the social species, reproduction is suppressed in su...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.08.054

    authors： Oosthuizen MK,Bennett NC,Coen CW

    更新日期：2008-11-11 00:00:00

  • High resolution immunogold analysis reveals distinct subcellular compartmentation of protein kinase C gamma and delta in rat Purkinje cells.

    abstract：:High resolution immunogold cytochemistry was used to investigate the subcellular distribution of protein kinase C gamma and delta in Purkinje cells of the rat cerebellum. Postembedding incubation with an antibody raised to a peptide sequence near the C-terminus of protein kinase C gamma resulted in strong labelling al...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00305-9

    authors： Cardell M,Landsend AS,Eidet J,Wieloch T,Blackstad TW,Ottersen OP

    更新日期：1998-02-01 00:00:00

  • Dopaminergic modulation of striatal neurons, circuits, and assemblies.

    abstract：:In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2011.08.051

    authors： Surmeier DJ,Carrillo-Reid L,Bargas J

    更新日期：2011-12-15 00:00:00

  • Identification of motoneurons supplying multiply- or singly-innervated extraocular muscle fibers in the rat.

    abstract：:In mammals, the extraocular muscle fibers can be categorized in singly-innervated and multiply-innervated muscle fibers. In the monkey oculomotor, trochlear and abducens nucleus the motoneurons of multiply-innervated muscle fibers lie separated from those innervating singly-innervated muscle fibers and show different ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.10.038

    authors： Eberhorn AC,Büttner-Ennever JA,Horn AK

    更新日期：2006-02-01 00:00:00

  • High doses of pseudoephedrine hydrochloride accelerate onset of CNS oxygen toxicity seizures in unanesthetized rats.

    abstract：:Pseudoephedrine (PSE) salts (hydrochloride and sulfate) are commonly used as nasal and paranasal decongestants by scuba divers. Anecdotal reports from the Divers Alert Network suggest that taking PSE prior to diving while breathing pure O₂ increases the risk for CNS oxygen toxicity (CNS-OT), which manifests as seizure...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.04.035

    authors： Pilla R,Held HE,Landon CS,Dean JB

    更新日期：2013-08-29 00:00:00

  • Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways.

    abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. Dietary fatty acids, especially polyunsaturated fatty acids, have been shown to enhance learning and memory and prevent memory deficits in various...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.016

    authors： Jia D,Heng LJ,Yang RH,Gao GD

    更新日期：2014-01-31 00:00:00

  • Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons.

    abstract：:The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00097-3

    authors： Ishihara A,Ohira Y,Roy RR,Nagaoka S,Sekiguchi C,Hinds WE,Edgerton VR

    更新日期：1997-11-01 00:00:00

  • Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.

    abstract：:Adenosine has been proposed as a homeostatic "sleep factor" that promotes the transition from waking to sleep by affecting several sleep-wake regulatory systems. In the basal forebrain, adenosine accumulates during wakefulness and, when locally applied, suppresses neuronal activity and promotes sleep. However, the neu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.010

    authors： Arrigoni E,Chamberlin NL,Saper CB,McCarley RW

    更新日期：2006-06-30 00:00:00

  • Nuclear factor-kappa β regulates Notch signaling in production of proinflammatory cytokines and nitric oxide in murine BV-2 microglial cells.

    abstract：:Microglial cells exhibit Notch-1 signaling expression which is enhanced upon activation. We reported previously that enhanced Notch-1 expression in activated microglia modulates production of proinflammatory cytokines and nitric oxide (NO). Furthermore, Notch-1 modulates transcription factor nuclear factor-kappa B (NF...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.060

    authors： Cao Q,Kaur C,Wu CY,Lu J,Ling EA

    更新日期：2011-09-29 00:00:00

  • Structural and quantitative analysis of astrocytes in the mouse hippocampus.

    abstract：:We revealed the structural features of astrocytes by means of light microscopy, confocal laser scanning microscopy and high voltage electron microscopy, and estimated their numerical densities in the mouse hippocampus. The high voltage electron microscope examinations of Golgi-impregnated astrocytes clearly disclosed ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00041-6

    authors： Ogata K,Kosaka T

    更新日期：2002-01-01 00:00:00