当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways.

Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways.

Abstract：

:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. Dietary fatty acids, especially polyunsaturated fatty acids, have been shown to enhance learning and memory and prevent memory deficits in various experimental conditions. The present study investigated the effects of fish oil supplementation on the lipid peroxidation, inflammation and neuron apoptosis in the hippocampus of streptozotocin (STZ)-induced diabetes rats. The effects of diabetes and fish oil treatment on the spatial learning and memory were also evaluated using the Morris Water Maze. STZ-induced diabetes impaired spatial learning and memory of rats, which was associated with the inflammation, oxidative stress and apoptosis of hippocampal neurons. Fish oil administration ameliorated cognitive deficit, reduced oxidative stress and tumor necrosis factor α (TNF-α), protected the hippocampal neurons by increasing Protein Kinase B (AKT) phosphorylation and decreasing caspase-9 expression. These results suggested that the principle mechanisms involved in the antidiabetic and neuroprotective effect of fish oil were its antioxidant, anti-inflammatory and anti-apoptosis potential, supporting a potential role for fish oil as an adjuvant therapy for the prevention and treatment of diabetic complications.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Jia D,Heng LJ,Yang RH,Gao GD

doi

10.1016/j.neuroscience.2013.11.016

subject

Has Abstract

pub_date

2014-01-31 00:00:00

pages

228-37

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(13)00956-1

journal_volume

258

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4.

    abstract：:Toll-like receptor 2 (TLR2) and TLR4 belong to a family of highly conserved pattern recognition receptors and are well-known upstream sensors of signaling pathways of innate immunity. TLR2 and TLR4 upregulation is thought to be associated with poor outcome in stroke patients. We currently show that transient focal isc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.01.014

    authors： Nalamolu KR,Smith NJ,Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

    更新日期：2018-03-01 00:00:00

  • Reflex responses of fusimotoneurons to sinusoidal muscle stretching.

    abstract：:Reflex response of fusimotoneurons to sinusoidal muscle stretching were investigated in decerebrated cats. Nerve impulses of single fusimotoneurons were recorded from thin filaments dissected from otherwise intact nerves to triceps surae muscles. Amplitude of the sinusoidal stretching of these muscles was 3 mm peak-to...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90020-5

    authors： Anastasijević R,Jovanović K,Vuco J

    更新日期：1990-01-01 00:00:00

  • Facial motor neuron regeneration induces a unique spatial and temporal pattern of myristoylated alanine-rich C kinase substrate expression.

    abstract：:We have previously shown that the myristoylated alanine-rich C kinase substrate, a primary protein kinase C substrate in brain that binds and cross-links filamentous actin, is enriched in neuronal growth cones and is developmentally regulated in brain. Here we examined myristoylated alanine-rich C kinase substrate exp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00039-7

    authors： McNamara RK,Jiang Y,Streit WJ,Lenox RH

    更新日期：2000-01-01 00:00:00

  • Cortical and Subcortical Neural Interactions Between Trunk and Upper-limb Muscles in Humans.

    abstract：:Activities of daily living require simultaneous and coordinated activation of trunk and upper-limb segments, which involves complex interlimb interaction within the central nervous system. Although many studies have reported associations between activity of trunk and limb muscles during functional tasks, evidence on c...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.10.011

    authors： Sasaki A,Milosevic M,Nakazawa K

    更新日期：2020-12-15 00:00:00

  • Homotransplant of pelvic ganglion into bladder wall in adult rats.

    abstract：:In these experiments a large portion of the pelvic ganglion of adult female rats was transplanted into the wall of the urinary bladder of the same animals. The morphology and fine structure of the transplants were studied in whole-mounts and in sections for light and electron microscopy, from two days up to four month...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00401-6

    authors： Gabella G,Uvelius B

    更新日期：1998-03-01 00:00:00

  • Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice.

    abstract：:Victims of minimal traumatic brain injury (mTBI) do not show clear morphological brain defects, but frequently suffer lasting cognitive deficits, emotional difficulties and behavioral disturbances. In the present study we adopted a non-invasive closed-head weight-drop mouse model to produce mTBI. We examined the effec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00048-4

    authors： Zohar O,Schreiber S,Getslev V,Schwartz JP,Mullins PG,Pick CG

    更新日期：2003-01-01 00:00:00

  • New dopaminergic terminal fields in the motor, visual (area 18b) and retrosplenial cortex in the young and adult rat. Immunocytochemical and catecholamine histochemical analyses.

    abstract：:New dopaminergic terminal fields have been visualized in the rat cerebral neocortex, using two morphological methods based on distinct properties of the dopaminergic system: presence of the first synthetic enzyme, tyrosine hydroxylase, and high-affinity uptake of amines. Tyrosine hydroxylase was used as an immunocytoc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90248-9

    authors： Berger B,Verney C,Alvarez C,Vigny A,Helle KB

    更新日期：1985-08-01 00:00:00

  • Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell.

    abstract：:Microglia, the primary immune cells in the brain, have been implicated as the predominant cells governing inflammation-mediated neuronal damage. In response to immunological challenges such as lipopolysaccharide (LPS), microglia are activated and subsequently inflammatory process is initiated as evidenced by the relea...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.09.034

    authors： Liu F,Zhou R,Yan H,Yin H,Wu X,Tan Y,Li L

    更新日期：2014-12-05 00:00:00

  • Glutamatergic input-output properties of thalamic astrocytes.

    abstract：:Astrocytes in the somatosensory ventrobasal (VB) thalamus of rats respond to glutamatergic synaptic input with metabotropic glutamate receptor (mGluR) mediated intracellular calcium ([Ca²⁺](i)) elevations. Astrocytes in the VB thalamus also release the gliotransmitter (GT) glutamate in a Ca²⁺-dependent manner. The tri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.12.049

    authors： Pirttimaki TM,Parri HR

    更新日期：2012-03-15 00:00:00

  • Glutamic acid decarboxylase and GABA immunoreactivities in the cerebellar cortex of adult rat after prenatal exposure to a low concentration of carbon monoxide.

    abstract：:Glutamic acid decarboxylase and GABA immunoreactivities were qualitatively and quantitatively evaluated in the cerebellar cortex of adult rats prenatally exposed to a low concentration of carbon monoxide (75 parts per million). Carbon monoxide-exposed and control rats were perfused with modified Bouin's fluid and thei...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.06.058

    authors： Benagiano V,Lorusso L,Coluccia A,Tarullo A,Flace P,Girolamo F,Bosco L,Cagiano R,Ambrosi G

    更新日期：2005-01-01 00:00:00

  • Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation.

    abstract：:Oxytocin (OT) levels in plasma increase during sexual response and are significantly lower in patients with depression. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. In this study, we showed that sildenafil had an antidepressant...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.11.001

    authors： Matsushita H,Matsuzaki M,Han XJ,Nishiki TI,Ohmori I,Michiue H,Matsui H,Tomizawa K

    更新日期：2012-01-03 00:00:00

  • Differential efficiency of the endocytic machinery in tonic and phasic synapses.

    abstract：:Efficient synaptic vesicle membrane recycling is one of the key factors required to sustain neurotransmission. We investigated potential differences in the compensatory endocytic machineries in two glutamatergic synapses with phasic and tonic patterns of activity in the lamprey spinal cord. Post-embedding immunocytoch...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.03.038

    authors： Evergren E,Zotova E,Brodin L,Shupliakov O

    更新日期：2006-08-11 00:00:00

  • Electrophysiological, pharmacological and molecular profile of the transient outward rectifying conductance in rat sympathetic preganglionic neurons in vitro.

    abstract：:Transient outward rectifying conductances or A-like conductances in sympathetic preganglionic neurons (SPN) are prolonged, lasting for hundreds of milliseconds to seconds and are thought to play a key role in the regulation of SPN firing frequency. Here, a multidisciplinary electrophysiological, pharmacological and mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.12.061

    authors： Whyment AD,Coderre E,Wilson JM,Renaud LP,O'Hare E,Spanswick D

    更新日期：2011-03-31 00:00:00

  • Feeding-evoked dopamine release in the nucleus, accumbens: regulation by glutamatergic mechanisms.

    abstract：:The extent to which glutamate receptors in the nucleus accumbens and ventral tegmental area regulate feeding-evoked increases in dopamine release in the nucleus accumbens was determined using in vivo brain microdialysis in the rat. In some animals a second dialysis probe was implanted in the ventral tegmental area ips...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00450-2

    authors： Taber MT,Fibiger HC

    更新日期：1997-02-01 00:00:00

  • Altered distribution of dorsal root fibers in the rat following neonatal capsaicin treatment.

    abstract：:Distribution of primary afferent fibers was studied in intact and neonatally capsaicin treated rats by the application of horseradish peroxidase to the central branch of the transected lumbar dorsal roots. Coarse primary afferent fibers entered the spinal cord through the larger medial portion of the rootlet and arbor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90067-9

    authors： Réthelyi M,Salim MZ,Jancsó G

    更新日期：1986-07-01 00:00:00

  • Stimulus exposure duration alters implicit processing of neutral and emotional faces.

    abstract：:Stimulus exposure duration in emotion perception research is often chosen pragmatically; however, little work exists on the consequences of stimulus duration for the processing of emotional faces. We utilized the spatiotemporal resolution capabilities of magnetoencephalography (MEG) to characterize early implicit proc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.11.030

    authors： Kouptsova JE,Leung RC,Taylor MJ

    更新日期：2017-01-26 00:00:00

  • Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm.

    abstract：:The present study investigated the membrane mechanisms underlying the inhibitory influence of melatonin on suprachiasmatic nucleus (SCN) neurones in a hypothalamic slice preparation. Perforated-patch recordings were performed to prevent the rapid rundown of spontaneous firing rate as observed during whole cell recordi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00346-3

    authors： van den Top M,Buijs RM,Ruijter JM,Delagrange P,Spanswick D,Hermes ML

    更新日期：2001-01-01 00:00:00

  • Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers.

    abstract：:Eleven healthy tobacco smoking adult male volunteers of mixed race were tobacco abstinent overnight for this study. In each subject, positron emission tomographic images of regional cerebral metabolism of glucose with [18F]fluorodeoxyglucose were obtained in two conditions in the morning on different days: about 3min ...

    journal_title：Neuroscience

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0306-4522(00)00357-2

    authors： Domino EF,Minoshima S,Guthrie SK,Ohl L,Ni L,Koeppe RA,Cross DJ,Zubieta J

    更新日期：2000-01-01 00:00:00

  • Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: relevance to depression.

    abstract：:Chronic stress, the administration of glucocorticoids and the prolonged activation of glucocorticoid receptors (GRs) are reported to induce affective changes in humans and rodents that resemble a depressive state. However, data concerning the behavioral and molecular effects of the selective activation of specific GRs...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.11.035

    authors： Skupio U,Tertil M,Sikora M,Golda S,Wawrzczak-Bargiela A,Przewlocki R

    更新日期：2015-02-12 00:00:00

  • Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling.

    abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90150-1

    authors： Blight AR

    更新日期：1983-10-01 00:00:00

  • Deep prepiriform cortex modulates kainate-induced hippocampal injury.

    abstract：:As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90404-9

    authors： Shimosaka S,So YT,Simon RP

    更新日期：1994-08-01 00:00:00

  • Neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamic nucleus in the rat.

    abstract：:The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90102-9

    authors： Fukami K,Kiyama H,Shiotani Y,Tohyama M

    更新日期：1988-09-01 00:00:00

  • Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.

    abstract：:Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues from 22 non-familial s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.12.018

    authors： Lonskaya I,Hebron ML,Algarzae NK,Desforges N,Moussa CE

    更新日期：2013-03-01 00:00:00

  • Diurnal pattern of clock gene expression in the hypothalamus of the newborn rabbit.

    abstract：:In the European rabbit (Oryctolagus cuniculus) nursing acts as a strong non-photic synchronizer of circadian rhythmicity in the newborn young. Rabbits only nurse for a few minutes once every 24 h and previous studies have shown that the pups, blind at birth, display endogenous circadian rhythms in behavior and physiol...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.09.020

    authors： Caldelas I,Tejadilla D,González B,Montúfar R,Hudson R

    更新日期：2007-01-19 00:00:00

  • Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala.

    abstract：:Recently, it was reported that stimulation of the infralimbic cortex produces a feedforward inhibition of central amygdala neurons. The interest of this observation comes from the fact that the central nucleus is the main output station of the amygdala for conditioned fear responses and evidence that the infralimbic c...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.01.020

    authors： Berretta S,Pantazopoulos H,Caldera M,Pantazopoulos P,Paré D

    更新日期：2005-01-01 00:00:00

  • Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures.

    abstract：:An inflammatory response in the CNS mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. Using mouse cortical mixed glia cultures, we have previously demonstrated that the bacterial endotoxin lipopolysaccharide induces the activation of microglia and ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00057-9

    authors： Liu B,Du L,Kong LY,Hudson PM,Wilson BC,Chang RC,Abel HH,Hong JS

    更新日期：2000-01-01 00:00:00

  • Opposite effects of neurotensin on dopamine inhibition in different regions of the rat brain: an iontophoretic study.

    abstract：:Anatomical, biochemical and behavioral data suggest functional interactions between dopamine and neurotensin in regions of the brain receiving a co-existent and/or distinct innervation by these two transmitters. We therefore measured and compared the effects of iontophoretically applied dopamine and neurotensin in the...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90170-7

    authors： Beauregard M,Ferron A,Descarries L

    更新日期：1992-01-01 00:00:00

  • Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway.

    abstract：:Development of functional synapses is crucial for the transmission and storage of information in the brain. Post establishment of the initial synaptic contact, synapses are stabilized through neuronal activity-induced signals. Emerging studies have implicated ubiquitination; a reversible posttranslational modification...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.08.057

    authors： Kumari P,Srinivasan B,Banerjee S

    更新日期：2017-11-19 00:00:00

  • Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death.

    abstract：:A dysfunction of noradrenergic mechanisms originating in the locus coeruleus has been hypothesised to be the critical factor underlying the evolution of central neurodegenerative diseases [Colpaert FC (1994) Noradrenergic mechanism Parkinson's disease: a theory. In: Noradrenergic mechanisms in Parkinson's disease (Bri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00757-1

    authors： Bauer S,Moyse E,Jourdan F,Colpaert F,Martel JC,Marien M

    更新日期：2003-01-01 00:00:00

  • Non-invasive visualization of CNS inflammation with nuclear and optical imaging.

    abstract：:Inflammation is crucially involved in many diseases of the CNS. Immune cells may attack the CNS, as in multiple sclerosis, and therefore be responsible for primary damage. Immune cells may also be activated by injury to the CNS, as for example in stroke or brain trauma, secondarily enhancing lesion growth. In general,...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2008.10.005

    authors： Wunder A,Klohs J,Dirnagl U

    更新日期：2009-02-06 00:00:00