Differential efficiency of the endocytic machinery in tonic and phasic synapses.

abstract：:Ghrelin is a peptide produced in the gut with a wide range of physiological functions. Recent studies have suggested it may have potential as a neuroprotective agent in models of Parkinson's disease, reducing the impact of toxic challenges on the survival of nigral dopaminergic neurons. The presence of the ghrelin rec...

journal_title：Neuroscience

authors： Elabi OF,Duskova K,Davies JS,Lane EL

更新日期：2018-12-15 00:00:00

abstract：:Histamine H(3) autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca(2+)/CaMKII transduction pathways mediate H(3) effects on histamine synthesis, the pathways regulating neuronal histamine release are poorly known. Given the...

journal_title：Neuroscience

authors： Moreno-Delgado D,Gómez-Ramírez J,Torrent-Moreno A,González-Sepúlveda M,Blanco I,Ortiz J

更新日期：2009-12-15 00:00:00

abstract：:Wnt proteins have been implicated in regulating a variety of developmental processes in the CNS. Secreted Frizzled-related protein 3 (sFRP3) is a member of the sFRP family that can inhibit the Wnt signaling by binding directly to Wnts via their regions of homology to the Wnt-binding domain of Frizzleds. Recent studies...

journal_title：Neuroscience

authors： Zhao X,Huang H,Chen Y,Liu Y,Zhang Z,Ma Q,Qiu M

更新日期：2013-09-17 00:00:00

abstract：:Remyelination is common under physiological conditions and usually occurs as a response to a pathological demyelinating event. Its potentiation is an important goal for the development of therapies against pathologies such as multiple sclerosis and white matter injury. Visualization and quantification in vivo of demye...

journal_title：Neuroscience

authors： Cisneros-Mejorado AJ,Garay E,Ortiz-Retana J,Concha L,Moctezuma JP,Romero S,Arellano RO

更新日期：2020-07-15 00:00:00

abstract：:We have recently reported on the efficacy of an NK1 tachykinin receptor antagonist in improving outcome following stroke, including reduced blood-brain barrier (BBB) disruption, reduced cerebral edema and improved functional outcome. The clinically approved stroke treatment, tissue plasminogen activator (tPA), has bee...

journal_title：Neuroscience

authors： Turner RJ,Vink R

更新日期：2012-09-18 00:00:00

abstract：:The cholinergic agonist nicotine facilitates detection of invalidly cued trials in location-cueing paradigms and reduces the associated neural activity in human inferior parietal cortex. By using functional magnetic resonance imaging we test the hypothesis that the nicotinic modulation of attentional reorienting may r...

journal_title：Neuroscience

authors： Thiel CM,Fink GR

更新日期：2008-03-18 00:00:00

abstract：:Early life adversity or parental neglect is linked to the development of a number of psychiatric illnesses, including major depression and substance use disorder. These two disorders are often comorbid and characterized by anhedonia, defined as the reduced ability to experience pleasure or reward. The aim of the prese...

journal_title：Neuroscience

authors： Der-Avakian A,Markou A

更新日期：2010-11-10 00:00:00

abstract：:Monoclonal antibodies to rat striatal choline acetyltransferase were produced by fusion of sensitized mouse lymphocytes with murine plasmacytoma (NS1) cells. Two stable anti-choline acetyltransferase lines were established by limiting dilution cloning. Specificity of antibody was established by the following criteria:...

journal_title：Neuroscience

authors： Ross ME,Park DH,Teitelman G,Pickel VM,Reis DJ,Joh TH

更新日期：1983-11-01 00:00:00

abstract：:A qualitative and quantitative immunohistochemical study of cholinergic systems in the human hippocampal formation was performed with an antibody against choline acetyltransferase. Four control subjects and six patients with Alzheimer's disease, matched for age and post-mortem delay, were examined. Immunoreactive nerv...

journal_title：Neuroscience

authors： Ransmayr G,Cervera P,Hirsch E,Ruberg M,Hersh LB,Duyckaerts C,Hauw JJ,Delumeau C,Agid Y

更新日期：1989-01-01 00:00:00

abstract：:The effects of excitatory amino acid antagonists on extracellular field potentials in the olfactory bulb produced by lateral olfactory tract stimulation were analysed in vivo. The compounds tested D-2-amino-5-phosphonovalerate, L-(+)2-amino-4-phosphonobutyrate, gamma-D-glutamylglycine, L-glutamic acid diethylester and...

journal_title：Neuroscience

authors： Jacobson I,Butcher S,Hamberger A

更新日期：1986-09-01 00:00:00

abstract：:The mirror neuron system (MNS) is currently one of the most prominent areas of research in neuroscience. Some of the work has focused on the identification of factors that modulate its activity, but until now, no one has tried to identify the effect of motor ability on the MNS regions. The aim of the present work is t...

journal_title：Neuroscience

authors： Plata Bello J,Modroño C,Marcano F,González-Mora JL

更新日期：2014-09-05 00:00:00

abstract：:Astrocytes perform several functions that are essential for normal neuronal activity. They play a critical role in neuronal survival during ischemia and other degenerative injuries and also modulate neuronal recovery by influencing neurite outgrowth. In this study, we investigated the neuroprotective effects of astroc...

journal_title：Neuroscience

authors： Terashvili M,Sarkar P,Nostrand MV,Falck JR,Harder DR

更新日期：2012-10-25 00:00:00

abstract：:Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either development...

journal_title：Neuroscience

authors： Zagrebelsky M,Korte M

更新日期：2014-12-26 00:00:00

abstract：:GABA(A) functioning has been implicated in anxiety and depressive disorders. In this regard, we suggested that in addition to analyzing GABA(A) and the subunits that comprise the GABA(A) receptor, it might be profitable to assess the coordinated expression of subunits that comprise the GABA(A) receptor cassette. We de...

journal_title：Neuroscience

authors： Poulter MO,Du L,Zhurov V,Merali Z,Anisman H

更新日期：2010-02-17 00:00:00

abstract：:It is well established that chronic food restriction enhances sensitivity to the rewarding and motor-activating effects of abused drugs. However, neuroadaptations underlying these behavioral effects have not been characterized. The purpose of the present study was to explore the possibility that food restriction produ...

journal_title：Neuroscience

authors： Carr KD,Tsimberg Y,Berman Y,Yamamoto N

更新日期：2003-01-01 00:00:00

abstract：:Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of slowly adapting type I mechanoreceptors. Using an isolated rat sinus hair follicle preparation we tested a range of compounds. Surprisingly, only non-competitive mGlu1 receptor antagonists pr...

journal_title：Neuroscience

authors： Cahusac PM,Mavulati SC

更新日期：2009-10-20 00:00:00

abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

journal_title：Neuroscience

authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

更新日期：2003-01-01 00:00:00

abstract：:Electrical stimulation of the distal stump of cut peripheral nerves is a commonly accepted way to evoke neurogenic inflammation. Nevertheless, the modulatory effect of biogenic amines and vasoactive peptides released from efferent fibres can be excluded only if the dorsal roots are stimulated. The present study was fo...

journal_title：Neuroscience

authors： Pintér E,Szolcsányi J

更新日期：1995-09-01 00:00:00

abstract：:Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule. The SNr receives one of the highest densit...

journal_title：Neuroscience

authors： Threlfell S,Greenfield SA,Cragg SJ

更新日期：2010-01-13 00:00:00

abstract：:Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood. It is known that vascular endothelial growth factor A (VEGF) has neuroprotective effects. The objective of this study was to evaluate the role of the ...

journal_title：Neuroscience

authors： Feng Y,Rhodes PG,Bhatt AJ

更新日期：2011-04-14 00:00:00

abstract：:It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first...

journal_title：Neuroscience

authors： Helmeke C,Poeggel G,Braun K

更新日期：2001-01-01 00:00:00

abstract：:Novel approaches are required in the clinical management of peripheral nerve injuries because current surgical techniques result in deficient sensory recovery. Microsurgery alone fails to address extensive cell death in the dorsal root ganglia (DRG), in addition to poor axonal regeneration. Incorporation of cultured c...

journal_title：Neuroscience

authors： Reid AJ,Sun M,Wiberg M,Downes S,Terenghi G,Kingham PJ

更新日期：2011-12-29 00:00:00

abstract：:Scratching inhibits pruritogen-evoked responses of neurons in the superficial dorsal horn, implicating a spinal site for scratch inhibition of itch. We investigated if scratching differentially affects neurons depending on whether they are activated by itchy vs. painful stimuli, and if the degree of inhibition depends...

journal_title：Neuroscience

authors： Nishida K,Takechi K,Akiyama T,Carstens MI,Carstens E

更新日期：2013-10-10 00:00:00

abstract：:Cervical or high thoracic spinal cord injury often results in autonomic dysreflexia, a condition characterized by exaggerated spinal reflexes and episodic hypertension, that may be caused by reorganization of synapses on sympathetic preganglionic neurons after loss of supraspinal input. To assess remodelling of synapt...

journal_title：Neuroscience

authors： Weaver LC,Cassam AK,Krassioukov AV,Llewellyn-Smith IJ

更新日期：1997-11-01 00:00:00

abstract：:Although serotonin has been shown to play an important role in peripheral pain mechanisms, the specific subtypes of serotonin receptors involved in pain and hyperalgesia remain poorly understood. To date, no previous study has attempted to determine the presence of any serotonin receptor subtype in human dorsal root g...

journal_title：Neuroscience

authors： Pierce PA,Xie GX,Meuser T,Peroutka SJ

更新日期：1997-12-01 00:00:00

abstract：:Longevity genes attenuate the aging process, but their expression in the brain during aging remains unknown. Loss of the majority of heteromeric brain nicotinic acetylcholine receptors (nAChRs) results in premature brain aging, and altered regulation of longevity genes could be involved. Using in situ hybridization, t...

journal_title：Neuroscience

authors： Huang PS,Son JH,Abbott LC,Winzer-Serhan UH

更新日期：2011-11-24 00:00:00

abstract：:Brain structural connectivity is known to be altered in cases of intrauterine growth restriction and premature birth, although the specific effect of maternal nutritional restriction, a common burden in human populations, has not been assessed yet. Here we analyze the effects of maternal undernutrition during pregnanc...

journal_title：Neuroscience

authors： Barbeito-Andrés J,Gleiser PM,Bernal V,Hallgrímsson B,Gonzalez PN

更新日期：2018-06-01 00:00:00

abstract：:The effects of L-glutamate on the potency of kainate for stimulating guanosine 3',5'-cyclic monophosphate (cyclic GMP) accumulation and for killing neurones in incubated slices of immature (8-day) and adult rat cerebellum were investigated. L-glutamate did not potentiate the cyclic GMP responses to kainate in either t...

journal_title：Neuroscience

authors： Garthwaite J,Gilligan GJ

更新日期：1984-01-01 00:00:00

abstract：:The distribution of gene expression domains during development constitutes a novel tool for the identification of distinct brain regions. This is particularly useful in the brain of amphibians where cell migration is very limited and most neurons organize in a periventricular layer. Here we report the expression patte...

journal_title：Neuroscience

authors： González A,López JM,Sánchez-Camacho C,Marín O

更新日期：2002-01-01 00:00:00

abstract：:The acute self-stimulation of the medial forebrain bundle was reported to induce the expression of c-Fos, the protein product of c-fos, an immediate early gene, in the central nervous system. In the present study, we examined regional changes in c-Fos expression in several reward-related areas of rat brain in response...

journal_title：Neuroscience

authors： Nakahara D,Ishida Y,Nakamura M,Kuwahara I,Todaka K,Nishimori T

更新日期：1999-03-01 00:00:00