Abstract:
:The effects of L-glutamate on the potency of kainate for stimulating guanosine 3',5'-cyclic monophosphate (cyclic GMP) accumulation and for killing neurones in incubated slices of immature (8-day) and adult rat cerebellum were investigated. L-glutamate did not potentiate the cyclic GMP responses to kainate in either the adult or the immature tissue (in contrast to a recent report), nor did it alter the pharmacological characteristics of this postsynaptic action of kainate in the immature cerebellum. Slices incubated for 2 h in the presence of L-glutamate displayed pronounced glial swelling and neuronal damage. These effects were concentration-dependent and neurones in the immature cerebellum proved to be about 10 times more susceptible than in the adult. None of the neuronal cell types appeared to be selectively vulnerable to the toxicity of glutamate. At the lower concentrations tested (300 microM in the immature tissue, 3 mM in the adult), neurotoxicity was largely restricted to regions near the cut edges of the slices, indicating that very effective mechanisms limit the diffusion of glutamate within the cerebellum. Kainate caused selective necrosis of Purkinje cells and inhibitory interneurones in slices of adult cerebellum at concentrations between 5 and 20 microM; 30 microM kainate, however, also affected granule cells. The neurotoxic potency of kainate towards all neuronal cell types was significantly lower in the immature cerebellum and was not enhanced by including glutamate in the incubation medium. Similarly, glutamate did not potentiate the neurotoxicity of kainate towards Purkinje cells and inhibitory interneurones or or towards granule cells in adult slices. It is concluded that the availability of glutamate is unlikely to be a factor which limits the neurotoxicity of kainate either in the immature or in the adult cerebellum. The increase in the neurotoxic potency of kainate with cerebellar maturation can be ascribed, more readily, to be developmentally-related appearance of kainate receptors.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Garthwaite J,Gilligan GJdoi
10.1016/0306-4522(84)90218-5subject
Has Abstractpub_date
1984-01-01 00:00:00pages
125-38issue
1eissn
0306-4522issn
1873-7544pii
0306-4522(84)90218-5journal_volume
11pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::The electrophysiological, biochemical and behavioral responses produced by administration of haloperidol were studied in intact rats and in rats with 6-hydroxydopamine-induced partial lesions of the nigrostriatal dopamine pathway. In both control rats and rates tested four to 10 days postlesion, the electrophysiologic...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90168-2
更新日期:1992-01-01 00:00:00
abstract::The aim of this study is to characterize calbindin-positive photoreceptors and their opsin content in the retina of nocturnal prosimians (Microcebus murinus), New World monkeys (Callithrix jacchus), Old World monkeys (Macaca fascicularis), and humans. To identify the calbindin and opsin content of cones, combined mult...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00327-5
更新日期:2002-01-01 00:00:00
abstract::Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.01.067
更新日期:2013-05-15 00:00:00
abstract::Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.08.016
更新日期:2018-10-15 00:00:00
abstract::The extent to which glutamate receptors in the nucleus accumbens and ventral tegmental area regulate feeding-evoked increases in dopamine release in the nucleus accumbens was determined using in vivo brain microdialysis in the rat. In some animals a second dialysis probe was implanted in the ventral tegmental area ips...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00450-2
更新日期:1997-02-01 00:00:00
abstract::AMPA-type glutamate receptor (GluR) channels provide fast excitatory synaptic transmission in the CNS, but mediate also cytotoxic insults. It could be shown that AMPA-type GluR channel-mediated chronic excitotoxicity leads to an increased intracellular calcium concentration and plays an important role in neurodegenera...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.07.034
更新日期:2006-11-03 00:00:00
abstract::Central GABA(A) receptors mediate GABAergic phasic and tonic inhibition. While synaptic αβγ GABA(A) receptors primarily mediate phasic inhibition, extrasynaptic αβδ receptors play an important role in mediating tonic inhibition. Etomidate is a general anesthetic that produces its effects by enhancing GABA(A) receptor ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.05.051
更新日期:2015-08-06 00:00:00
abstract::Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.09.007
更新日期:2009-12-15 00:00:00
abstract::The aim of this study was to determine whether the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin (NT)-3 could act as endogenous target-derived trophic factors for erection-inducing, i.e. penis-projecting major pelvic ganglion (MPG) neurons, and/or penile sensory ne...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.01.019
更新日期:2005-01-01 00:00:00
abstract::The development of mechanisms of neurotransmitter release is an important component in the formation of functional synaptic connections. Synaptic neurotransmitter release can be modulated by nitric oxide, a compound shown to have a variety of physiologic functions in the nervous system. The goal of this study was to d...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00152-8
更新日期:1997-10-01 00:00:00
abstract::This study examined the age-related subsequent memory effect (SME) in perceptual and semantic encoding using event-related potentials (ERPs). Seventeen younger adults and 17 older adults studied a series of Chinese characters either perceptually (by inspecting orthographic components) or semantically (by determining w...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.12.036
更新日期:2014-03-07 00:00:00
abstract::Toll-like receptor 2 (TLR2) and TLR4 belong to a family of highly conserved pattern recognition receptors and are well-known upstream sensors of signaling pathways of innate immunity. TLR2 and TLR4 upregulation is thought to be associated with poor outcome in stroke patients. We currently show that transient focal isc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.01.014
更新日期:2018-03-01 00:00:00
abstract::Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90103-5
更新日期:1987-02-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory pro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.11.060
更新日期:2016-02-09 00:00:00
abstract::Some of the myelinated axons in rat peripheral nerves possess marked axoplasmic carbonic anhydrase activity [Riley, Ellis and Bain (1982) J. Histochem. Cytochem. 30, 1275-1288; Riley and Lang (1984) J. Hand Surg. 9A, 112-120]. A mixture of reactive and nonreactive neurons was a general observation in cervical, thoraci...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90269-0
更新日期:1984-09-01 00:00:00
abstract::The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00583-1
更新日期:1999-03-01 00:00:00
abstract::Steroid hormones, especially estradiol, facilitate reproductive behaviors in male and female rodents and birds. In green anole lizards estradiol facilitates receptivity in females but, unlike in some other species, is not the activating hormone for courtship and copulatory behavior in males. Instead, testicular androg...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.02.060
更新日期:2009-05-19 00:00:00
abstract::In rodents, reproductively relevant pheromonal cues are detected by receptors in the vomeronasal organ, which in turn transmit this information centrally via the accessory olfactory bulb, the medial nucleus of the amygdala, the posterior medial bed nucleus of the stria terminalis and the medial preoptic area. In the r...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00493-9
更新日期:1996-04-01 00:00:00
abstract::The central projections of the rat superior sagittal sinus (SSS) sensory innervation were studied by transganglionic tract tracing techniques. Cholera toxin subunit b (CTb) or wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) was applied on the overlying dura of the SSS and labeled terminations in the b...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.07.045
更新日期:2004-01-01 00:00:00
abstract::Cerebral ischemia/reperfusion (I/R) usually leads to the exacerbation of brain injury. In the present research, the effect of BTB and CNC homology 1 (BACH1) on cerebral I/R injury was studied. Mice model of middle cerebral artery occlusion/reperfusion (MCAO/R) and Neuro-2a (N2a) cell model of oxygen-glucose deprivatio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.04.014
更新日期:2020-06-01 00:00:00
abstract::The role of the primary somatosensory cortex in thermal pain perception has been established. However, the cortical circuitry that mediates the thermo-nociceptive information processing has not been elucidated. The aim of present study was to investigate the intracortical synaptic currents in primary somatosensory cor...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.03.018
更新日期:2006-07-21 00:00:00
abstract::We showed that hypothermic preconditioning (HPC) increased survival of Purkinje neurons in rat cerebellar slices after oxygen-glucose deprivation (OGD). HPC also reduced the OGD-increased expression of high mobility group I (Y) proteins, a transcription factor that can enhance inducible nitric oxide synthase (iNOS) ex...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.06.053
更新日期:2006-10-13 00:00:00
abstract::Resilience, a personality construct that reflects capacities to persevere, maintain a positive outlook and/or thrive despite ongoing stressors, has emerged as an important focus of research on chronic pain (CP). Although behavior studies have found more resilient persons with CP experience less pain-related dysfunctio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2021.01.019
更新日期:2021-01-21 00:00:00
abstract::Calcium permeabilities were examined in large cerebellar neurons maintained in culture, and morphologically identified as Purkinje cells. When cells were supplied with a Dulbecco Minimum Eagle's Medium with 10% horse serum added (5-10 days), somatic recordings revealed complex spikes and these were shown to be generat...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90155-3
更新日期:1989-01-01 00:00:00
abstract::Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.07.019
更新日期:2015-09-10 00:00:00
abstract::Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.07.047
更新日期:2020-12-01 00:00:00
abstract::The C57BL/Wld s mouse is a mutant strain of mouse that shows greatly slowed Wallerian degeneration both in the central and peripheral nervous system. Using immunohistochemistry, immunofluorescence and Western blotting, we have investigated the distribution of the chimeric Wld s protein and its different components in ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.06.078
更新日期:2005-01-01 00:00:00
abstract::Intracellular recordings were made from neurones in the thalamic reticular nucleus (TRN) and ventro-basal (VB) thalamus in slices of rat midbrain in vitro. Electrical stimulation of the medial lemniscus or TRN resulted in the generation of complex synaptic potentials containing disynaptic inhibitory post-synaptic pote...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2003.08.014
更新日期:2003-01-01 00:00:00
abstract::Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission by targeting the most redox-sensitive presynaptic compartment (Ginia...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.12.027
更新日期:2019-02-10 00:00:00
abstract::During periods of high-frequency stimulation the maintenance of synaptic transmission depends on a continued supply of synaptic vesicles. Local recycling in the terminals ensures synaptic vesicle replenishment, but the intermediate steps are still a matter of debate. We analyzed changes in synaptic vesicle pools and e...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00450-x
更新日期:2002-01-01 00:00:00