Abstract:
:The effects of excitatory amino acid antagonists on extracellular field potentials in the olfactory bulb produced by lateral olfactory tract stimulation were analysed in vivo. The compounds tested D-2-amino-5-phosphonovalerate, L-(+)2-amino-4-phosphonobutyrate, gamma-D-glutamylglycine, L-glutamic acid diethylester and cis-2,3-piperidine dicarboxylic acid, were administered by brain dialysis. Of the compounds tested, only cis-2,3 piperidine-dicarboxylic acid and gamma-D-glutamylglycine were able to suppress the synaptic excitation of granule cells. This pharmacological profile suggests the involvement of non-N-methyl-D-aspartate receptors. However, the suppression was accompanied by a reduction in the amplitude of the presynaptic volley. A second finding was that D-2-amino-5-phosphono-valerate and gamma-D-glutamyl glycine attenuated granule cell mediated inhibition of mitral cells, suggesting the involvement of N-methyl-D-aspartate-sensitive receptors. The possibility that mitral cells and that either centrifugal fibres, or an intrinsic olfactory bulb feedback loop might use an excitatory amino acid as its neurotransmitter is therefore discussed.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Jacobson I,Butcher S,Hamberger Adoi
10.1016/0306-4522(86)90020-5subject
Has Abstractpub_date
1986-09-01 00:00:00pages
267-73issue
1eissn
0306-4522issn
1873-7544pii
0306-4522(86)90020-5journal_volume
19pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::The tectofugal pathway in birds consists of four stations, the retina, optic tectum, rotundal nucleus, and entopallium, and it conveys visual information via three ascending pathways. These pathways consist of retino-tectal, tecto-rotundal and rotundo-entopallial cells, all of which are glutamatergic. The present stud...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.12.032
更新日期:2016-03-01 00:00:00
abstract::[3H]Bremazocine, in the presence of saturating concentrations of mu and delta receptor blocking agents, was used to label putative kappa opiate binding sites in rat brain. The binding of [3H]bremazocine under these conditions was completely displaced with high affinity by U-50488H and dynorphin1-17, and the potency of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90302-7
更新日期:1986-11-01 00:00:00
abstract::Astrocytes perform several functions that are essential for normal neuronal activity. They play a critical role in neuronal survival during ischemia and other degenerative injuries and also modulate neuronal recovery by influencing neurite outgrowth. In this study, we investigated the neuroprotective effects of astroc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.07.045
更新日期:2012-10-25 00:00:00
abstract::Calmodulin (CaM), a multifunctional intracellular calcium receptor, is a key element in signaling mechanisms. It is encoded in vertebrates by multiple apparently redundant genes (CaM I, II, III). To investigate whether differential expression takes place in the developing rat brain, a quantitative in situ hybridizatio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00317-2
更新日期:2002-01-01 00:00:00
abstract::Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90330-5
更新日期:1992-11-01 00:00:00
abstract::Maturation of the visual cortex is a visual experience-dependent process. It has been shown that visual input triggers changes in N-methyl-D-aspartate receptor (NMDAR) subunit expression in the visual cortex. However, no data are available on the layer distribution of these molecular changes. Here we describe the lami...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00196-9
更新日期:2003-01-01 00:00:00
abstract::We have examined by immunoassay and immunohistochemistry, the expression of nerve growth factor in the rat hippocampus, one to 28 days after transient forebrain ischemia. In the CA1 area, the overall level of nerve growth factor expression remained constant over the first three days of reperfusion while it increased b...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00612-5
更新日期:1999-01-01 00:00:00
abstract::Zinc plays an important role in synaptic signaling in the mammalian cerebral cortex. Zinc is sequestered into presynaptic vesicles of subpopulations of glutamatergic neurons and is released by depolarization, in a calcium-dependent manner. As the majority of mechanisms that have been suggested to participate in experi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00292-6
更新日期:2003-01-01 00:00:00
abstract::A diet high in total fat (HF) reduces hippocampal levels of brain-derived neurotrophic factor (BDNF), a crucial modulator of synaptic plasticity, and a predictor of learning efficacy. We have evaluated the capacity of voluntary exercise to interact with the effects of diet at the molecular level. Animal groups were ex...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2003.09.020
更新日期:2004-01-01 00:00:00
abstract::A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to crit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00403-2
更新日期:2003-01-01 00:00:00
abstract::Electrical stimulation of the distal stump of cut peripheral nerves is a commonly accepted way to evoke neurogenic inflammation. Nevertheless, the modulatory effect of biogenic amines and vasoactive peptides released from efferent fibres can be excluded only if the dorsal roots are stimulated. The present study was fo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00104-q
更新日期:1995-09-01 00:00:00
abstract::Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00080-5
更新日期:2002-01-01 00:00:00
abstract::Eleven healthy tobacco smoking adult male volunteers of mixed race were tobacco abstinent overnight for this study. In each subject, positron emission tomographic images of regional cerebral metabolism of glucose with [18F]fluorodeoxyglucose were obtained in two conditions in the morning on different days: about 3min ...
journal_title:Neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4522(00)00357-2
更新日期:2000-01-01 00:00:00
abstract::The presence of subgroups in vomeronasal sensory neurons has been known in various animals. To elucidate possible functional subdivisions in the guinea-pig accessory olfactory bulb, the combined studies with GTP-binding protein immunohistochemistry, electrophysiological and optical recordings were carried out. Gi2 alp...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00690-2
更新日期:1997-08-01 00:00:00
abstract::Mesopontine cholinergic neurons have been implicated in the initiation and maintenance of rapid eye movement sleep via their efferent connections to the thalamus and the medial pontine reticular formation. As a first step toward understanding how these modulatory neurons integrate synaptic input, we have investigated ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(96)00139-x
更新日期:1996-09-01 00:00:00
abstract::It is well established that chronic food restriction enhances sensitivity to the rewarding and motor-activating effects of abused drugs. However, neuroadaptations underlying these behavioral effects have not been characterized. The purpose of the present study was to explore the possibility that food restriction produ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00227-6
更新日期:2003-01-01 00:00:00
abstract::We studied whether interactions between the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic neurons of the mouse brain cortex occur. Cerebral cortex slices from the mouse (and, in few experiments, from the rat) were preincubated with [3H]noradrenaline and then superfused with a physiologi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00685-9
更新日期:1997-07-01 00:00:00
abstract::The location of sympathetic preganglionic neurons (SPN) in the spinal cord of the reeler mouse mutant is abnormal. Instead of their normal location in the intermediolateral column, the majority of SPN in the reeler cluster around the central canal. To determine whether ectopically located SPN in the reeler form approp...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00945-4
更新日期:2003-01-01 00:00:00
abstract::The cerebellum is known to be involved in temporal information processing. However, the underlying neuronal mechanisms remain unclear. In our previous study, monkeys were trained to make a saccade in response to a single omission of periodically presented visual stimuli. To detect stimulus omission, animals had to pre...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.01.023
更新日期:2017-03-27 00:00:00
abstract::Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.03.062
更新日期:2019-06-01 00:00:00
abstract::Hyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system thes...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.11.038
更新日期:2020-02-01 00:00:00
abstract::Environmental enrichment of laboratory animals leads to multi-faceted changes to physiology, health and disease prognosis. An important and under-appreciated factor in enhancing cognition through environmental manipulation may be improved basic sensory function. Previous studies have highlighted changes in cortical se...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.07.029
更新日期:2010-10-13 00:00:00
abstract::Animal models of diabetes do not reach the severity of human diabetic neuropathy but relatively mild neurophysiological deficits and minor morphometric changes. The lack of degenerative neuropathy in diabetic rodent models seems to be a consequence of the shorter length of the axons or the shorter animal life span. Di...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.05.015
更新日期:2014-08-22 00:00:00
abstract::Rett syndrome (RTT), a disorder caused almost exclusively by mutations in the X-linked gene, MECP2, has a phenotype thought to be primarily of neurological origin. Disruption of Mecp2 in mice results in a prominent RTT-like phenotype. One of the consequences of MeCP2 absence in the brain is altered functional and stru...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.01.061
更新日期:2011-04-28 00:00:00
abstract::The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functioning, and the oxidant and antioxidant capacity of plasma. We recruited 52 healthy s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.09.046
更新日期:2018-02-01 00:00:00
abstract::Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Studies have shown that the circadian clock gene Period in Drosophila melanogaster could influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate co...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.01.009
更新日期:2007-04-25 00:00:00
abstract::The finding that endogenous tetrahydroisoquinolines may be involved in the etiology of Parkinson's disease suggests that their administration may cause changes resembling those observed in parkinsonian brain. We tested, using a high-performance liquid chromatography method, how single and chronic administration of 1,2...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00533-3
更新日期:2000-01-01 00:00:00
abstract::The pontine micturition center or Barrington's nucleus (BN) - besides regulating micturition - co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular importance due to: (i) recent findings of α-synuclein in BN, (ii) known urinary dysfunction in pa...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2014.02.002
更新日期:2014-04-25 00:00:00
abstract::Drinking alcohol in moderation is often considered a health-conscious behavior, associated with improved cardiovascular and brain health. However, "moderate" amounts of alcohol include drinking 3-4 alcohol beverages in a day, which is closer to binge drinking and may do more harm than good. Here we examined how daily ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.08.018
更新日期:2012-11-08 00:00:00
abstract::Co-localization of neurotensin and cholecystokinin in tyrosine hydroxylase-containing neurons in the nucleus tractus solitarius of the rat was demonstrated by immunocytochemistry with fluorescent double-staining combined with the peroxidase-antiperoxidase method. Co-localization of neurotensin/tyrosine hydroxylase or ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90326-0
更新日期:1988-01-01 00:00:00