Dark-rearing decreases NR2A N-methyl-D-aspartate receptor subunit in all visual cortical layers.

abstract：:Brain responses to discrete short sounds have been studied intensively using the event-related potential (ERP) method, in which the electroencephalogram (EEG) signal is divided into epochs time-locked to stimuli of interest. Here we introduce and apply a novel technique which enables one to isolate ERPs in human elici...

journal_title：Neuroscience

authors： Poikonen H,Alluri V,Brattico E,Lartillot O,Tervaniemi M,Huotilainen M

更新日期：2016-01-15 00:00:00

abstract：:Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited detailed investigation of cellular behaviour f...

journal_title：Neuroscience

authors： Balaratnasingam C,Morgan WH,Bass L,Kang M,Cringle SJ,Yu DY

更新日期：2011-03-17 00:00:00

abstract：:It has recently been demonstrated that alpha-bungarotoxin receptors, which behave as functional nicotinic receptors, are present in chick CNS. In this paper, we report the purification and characterization of a functional alpha-bungarotoxin receptor from chick cerebellum, a nervous tissue in which a clear inhibition o...

journal_title：Neuroscience

authors： Gotti C,Hanke W,Schlue WR,Briscini L,Moretti M,Clementi F

更新日期：1992-09-01 00:00:00

abstract：:Ketamine is a dissociative anesthetic with complex actions on the CNS. We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique. Unanesthetized or ketamine-anesthetized male Sprague...

journal_title：Neuroscience

authors： Porro CA,Cavazzuti M,Giuliani D,Vellani V,Lui F,Baraldi P

更新日期：2004-01-01 00:00:00

abstract：:Mice provide a highly valuable resource for investigating learning and memory processes; however, many of the established tasks for evaluating learning and memory were developed for rats. Behaviors of mice in these tasks appear to be driven by different motivational factors, and as a result, they often do not perform ...

journal_title：Neuroscience

authors： Pistell PJ,Ingram DK

更新日期：2010-03-10 00:00:00

abstract：:The enzyme choline-O-acetyltransferase catalyses the biosynthesis of acetylcholine from acetyl coenzyme A and choline and is considered as one of the best markers for cholinergic nerve endings. The distribution of this enzymatic activity was analysed during the purification of plasma membranes of purely cholinergic ne...

journal_title：Neuroscience

authors： Eder-Colli L,Amato S

更新日期：1985-06-01 00:00:00

abstract：:Food restriction has been shown to be beneficial for a number of brain processes. In the current study, we characterized the impact of food restriction on hippocampal damage 70 days following ischemia. We assessed memory and cognitive flexibility of ad libitum fed (AL) and food-restricted (FR) animals using complex de...

journal_title：Neuroscience

authors： Roberge MC,Messier C,Staines WA,Plamondon H

更新日期：2008-09-22 00:00:00

abstract：:Leptin and somatostatin (SRIF) have opposite effects on food seeking and ingestive behaviors, functions partially regulated by the frontoparietal cortex and hippocampus. Although it is known that the acute suppression of food intake mediated by leptin decreases with time, the counter-regulatory mechanisms remain uncle...

journal_title：Neuroscience

authors： Perianes-Cachero A,Burgos-Ramos E,Puebla-Jiménez L,Canelles S,Frago LM,Hervás-Aguilar A,de Frutos S,Toledo-Lobo MV,Mela V,Viveros MP,Argente J,Chowen JA,Arilla-Ferreiro E,Barrios V

更新日期：2013-11-12 00:00:00

abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

journal_title：Neuroscience

authors： Blight AR

更新日期：1983-10-01 00:00:00

abstract：:It is well established that physical exercise can exert neuroprotection both in clinical settings and animal experiments. A series of studies have demonstrated that physical exercise may be a promising preconditioning method to induce brain ischemic tolerance through the promotion of angiogenesis, mediation of the inf...

journal_title：Neuroscience

authors： Zhang F,Wu Y,Jia J

更新日期：2011-03-17 00:00:00

abstract：BACKGROUND AND PURPOSE:Peptide analog of thymulin (PAT) has been shown to have anti-hyperalgesic and anti-inflammatory properties in animal models of inflammation. Recent reports suggest that the peripheral cholinergic system has an anti-inflammatory role mediated by α7-nicotinic acetylcholine receptor (α7-nAChR). Our ...

journal_title：Neuroscience

authors： Safieh-Garabedian B,Oz M,Bey RM,Shamaa F,Ashoor A,El-Agnaf OM,Saadé NE

更新日期：2013-10-10 00:00:00

abstract：:The binding of the GABAA/benzodiazepine receptor agonist [3H]flunitrazepam was studied in the hippocampus of rats kindled by daily stimulation of the Schaffer collaterals, using semi-quantitative autoradiography. Two kindled stages were investigated: (i) 24 h after the last generalized tonic-clonic seizure (fully kind...

journal_title：Neuroscience

authors： Titulaer MN,Kamphuis W,Lopes da Silva FH

更新日期：1995-09-01 00:00:00

abstract：:Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical ...

journal_title：Neuroscience

authors： Lam YW,Sherman SM

更新日期：2013-07-09 00:00:00

abstract：:The purpose of the present study was to examine whether the rostroventral portion of the medulla oblongata (RVM) exerts descending modulation on the cardiosomatic motor reflex (CMR) in rats. Capsaicin (1 μg/ml, 0.2 ml) was injected into the pericardial sac as an algesic substance to induce the CMR, which was monitored...

journal_title：Neuroscience

authors： Sun N,Liu XH,Du JQ,Zhu JX,Tang JS,Li Q

更新日期：2011-06-30 00:00:00

abstract：:Activation of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM) can facilitate pain transmission in conditions such as inflammation, and thereby contribute to hyperalgesia. Since blockade of NK-1 receptors in the RVM can attenuate hyperalgesia produced by prolonged inflammation, we examined the r...

journal_title：Neuroscience

authors： Khasabov SG,Brink TS,Schupp M,Noack J,Simone DA

更新日期：2012-11-08 00:00:00

abstract：:The regional distribution of the specific D1 agonist [3H]SKF 38393 (SKF 38393, 2,3,4,5-tetra-hydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) has been studied autoradiographically in the rat CNS. The binding of [3H]SKF 38393 to striatal sections was saturable, stereospecific, reversible, of high affinity (Kd = 9.9 nM) a...

journal_title：Neuroscience

authors： Dubois A,Savasta M,Curet O,Scatton B

更新日期：1986-09-01 00:00:00

abstract：:PSD-95/SAP90, a molecular scaffold protein, attaches the N-methyl-D-aspartate receptor to cellular signaling pathways through PSD-95/DLG/Z0-1 domain interactions at neuronal synapses.(5,9) This suggests that PSD-95/SAP90 might be involved in many physiological and pathophysiological actions triggered via the N-methyl-...

journal_title：Neuroscience

authors： Tao YX,Huang YZ,Mei L,Johns RA

更新日期：2000-01-01 00:00:00

abstract：:Substance P is known to elicit diverse actions via activating multiple subtypes of tachykinin receptors, and these actions appear to be involved not only in synaptic transmission but also in synaptic plasticity during development of the mammalian central nervous system. The availability of sensitive quantitation of in...

journal_title：Neuroscience

authors： Taoka M,Song SY,Kubota M,Minegishi A,Yamakuni T,Konishi S

更新日期：1996-10-01 00:00:00

abstract：:Undifferentiated PC12 cells undergo apoptosis, via a calcium-induced calcium release mechanism, when the calcium-binding protein purified from bovine brain (native S100) is present in micromolar concentration in the medium. This process begins when S100 binds to specific membrane binding sites and involves up to 50% o...

journal_title：Neuroscience

authors： Fulle S,Mariggiò MA,Belia S,Petrelli C,Ballarini P,Guarnieri S,Fanò G

更新日期：1999-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron loss and gliosis in the spinal cord, brain stem and cortex. The Notch signaling pathway has been reported to be dysfunctional in neurodegenerative diseases, including ALS. However, the exact mechanism is still uncle...

journal_title：Neuroscience

authors： Liu C,Li D,Lv C,Gao Z,Qi Y,Wu H,Tian Y,Guo Y

更新日期：2020-04-15 00:00:00

abstract：:Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition...

journal_title：Neuroscience

authors： Shakya Shrestha S,Bannatyne BA,Jankowska E,Hammar I,Nilsson E,Maxwell DJ

更新日期：2012-12-13 00:00:00

abstract：:We applied randomized double pulse stimulation for assessing the effects of GABA and a GABAA antagonist on compound action potentials in dorsal column axons isolated from adult rat. We stimulated the axons with double pulses at 0.2 Hz and randomly varied interpulse intervals between 3, 4, 5, 8, 10, 20, 30, 50 and 80 m...

journal_title：Neuroscience

authors： Saruhashi Y,Young W,Sugimori M,Abrahams J,Sakuma J

更新日期：1999-01-01 00:00:00

abstract：:Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene...

journal_title：Neuroscience

authors： Lee WH,Michels KM,Bondy CA

更新日期：1993-03-01 00:00:00

abstract：:I.c.v. injection of L-ornithine has been shown to have sedative and hypnotic effects on neonatal chicks exposed to acute stressful conditions. To clarify the mechanism, we conducted three experiments under strengthened stressful conditions with corticotropin-releasing factor (CRF). In Experiment 1, the effect of i.c.v...

journal_title：Neuroscience

authors： Kurata K,Shigemi K,Tomonaga S,Aoki M,Morishita K,Denbow DM,Furuse M

更新日期：2011-01-13 00:00:00

abstract：:Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phosph...

journal_title：Neuroscience

authors： Yoshida R,Takai S,Sanematsu K,Margolskee RF,Shigemura N,Ninomiya Y

更新日期：2018-01-15 00:00:00

abstract：:The localization of GABA and parvalbumin was studied in the developing cerebellum of human fetuses from 16 to 28 weeks of gestation. The avidin-biotin complex immunohistochemical method combined with silver staining were used to reveal the presence of GABA- and parvalbumin-positive neurons and nerve fibres. As early a...

journal_title：Neuroscience

authors： Yu MC,Cho E,Luo CB,Li WW,Shen WZ,Yew DT

更新日期：1996-01-01 00:00:00

abstract：:While the effects of progesterone in the CNS, like those of estrogen, have generally been considered within the context of reproductive function, growing evidence supports its importance in regulating non-reproductive functions including cognition and affect. In addition, progesterone has well-described protective eff...

journal_title：Neuroscience

authors： Singh M,Su C

更新日期：2013-06-03 00:00:00

abstract：:Electron probe X-ray microanalysis was used to measure water content and concentrations of elements (i.e. Na, K, Cl and Ca) in selected morphological compartments of rat optic nerve myelinated axons. Transaxolemmal movements of Na+ and Ca2+ were modified experimentally and corresponding effects on axon element and wat...

journal_title：Neuroscience

authors： Stys PK,Lopachin RM

更新日期：1998-01-01 00:00:00

abstract：:Nitric oxide (NO) is a neurotransmitter of the autonomic nerves in the urogenital tract, in particular the release of NO in the cavernous tissue is of importance for maintaining erection. However, the regulation of NO formation in neurons of the corpus cavernosum is poorly understood. Here, we report, that upon electr...

journal_title：Neuroscience

authors： Hallén K,Gustafsson LE,Wiklund NP

更新日期：2005-01-01 00:00:00

abstract：:We have investigated effects of letrozole, an aromatase inhibitor, on spatial learning and memory, expression of neural cell adhesion molecules (NCAM) and catecholaminergic neurotransmitters in the hippocampus and cortex of female rats. In the intact model, adult Sprague-Dawley rats were divided into four groups (n=8)...

journal_title：Neuroscience

authors： Aydin M,Yilmaz B,Alcin E,Nedzvetsky VS,Sahin Z,Tuzcu M

更新日期：2008-01-02 00:00:00