Activation of the Notch Signaling Pathway and Cellular Localization of Notch Signaling Molecules in the Spinal Cord of SOD1-G93A ALS Model Mice.

abstract：:The findings reported in this work show that pretreatment with polyunsaturated fatty acids, particularly linolenic acid, present in vegetable oils, can provide a potent tolerance against neurodegeneration in two models of neuronal death-generating treatments such as kainic acid injection and global ischemia. Rats were...

journal_title：Neuroscience

authors： Blondeau N,Widmann C,Lazdunski M,Heurteaux C

更新日期：2002-01-01 00:00:00

abstract：:Motor effects of bilateral lesions of the globus pallidus induced by quinolinic acid (30 and 60 nmol in 0.5 microl) were investigated in rats. Globus pallidus lesions with 60 nmol quinolinic acid produced a significant reduction of spontaneous motor activity measured by a reduced locomotor activity in an open field an...

journal_title：Neuroscience

authors： Hauber W,Lutz S,Münkle M

更新日期：1998-09-01 00:00:00

abstract：:Effective information transmission for open skill performance requires fine-scale coordination of distributed networks of brain regions linked by white matter tracts. However, how patterns of connectivity in these anatomical pathways may improve global efficiency remains unclear. In this study, we hypothesized that th...

journal_title：Neuroscience

authors： Zhu H,Pi YL,Qiu FH,Wang FJ,Liu K,Ni Z,Wu Y,Zhang J

更新日期：2019-04-15 00:00:00

abstract：:Chronic ethanol consumption increases oxidative stress, which accounts for the striking neurological changes seen in this condition. Notwithstanding, there is well-documented evidence that polyphenols, present in grape skin and seeds, exhibit a strong antioxidant activity. As red wine is rich in polyphenols, the aim o...

journal_title：Neuroscience

authors： Assunção M,Santos-Marques MJ,de Freitas V,Carvalho F,Andrade JP,Lukoyanov NV,Paula-Barbosa MM

更新日期：2007-06-08 00:00:00

abstract：:Deep brain stimulation of the anterior nucleus of the thalamus has been proposed as novel therapy to treat intractable epilepsy. To optimize this approach, we proposed to study the involvement of this nucleus in a non-human primate model of mesial temporal lobe seizure. Two macaques were implanted with one chronic ele...

journal_title：Neuroscience

authors： Sherdil A,Coizet V,Pernet-Gallay K,David O,Chabardès S,Piallat B

更新日期：2019-10-15 00:00:00

abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

journal_title：Neuroscience

authors： Michels KM,Heemskerk FM,Saavedra JM

更新日期：1994-02-01 00:00:00

abstract：:A reappraisal of the relationship between length summation and receptive field length assessed by the minimum response field method, was made in complex cells recorded from the lightly anaesthetized feline striate cortex. This relationship has previously been proposed by Gilbert [(1977) J. Physiol., Lond. 268, 391-421...

journal_title：Neuroscience

authors： Hammond P,Ahmed B

更新日期：1985-07-01 00:00:00

abstract：:We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger...

journal_title：Neuroscience

authors： Ma YL,Wang HL,Wu HC,Wei CL,Lee EH

更新日期：1998-02-01 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of the channels containing the NR2B subunit and voltage-independent inhibition of those containing NR2A. Thus, it may represent a f...

journal_title：Neuroscience

authors： Gavazzo P,Tedesco M,Chiappalone M,Zanardi I,Marchetti C

更新日期：2011-03-17 00:00:00

abstract：:Following injection of horseradish peroxidase-labeled wheat germ agglutinin or of rhodamine-labeled microspheres as non-selective tracers into the rat red nucleus, the origins of the corticorubral and cerebellorubral pathways, as well as a considerable number of other brain structures including dorsal raphé nucleus, z...

journal_title：Neuroscience

authors： Bernays RL,Heeb L,Cuenod M,Streit P

更新日期：1988-08-01 00:00:00

abstract：:We have previously shown that the myristoylated alanine-rich C kinase substrate, a primary protein kinase C substrate in brain that binds and cross-links filamentous actin, is enriched in neuronal growth cones and is developmentally regulated in brain. Here we examined myristoylated alanine-rich C kinase substrate exp...

journal_title：Neuroscience

authors： McNamara RK,Jiang Y,Streit WJ,Lenox RH

更新日期：2000-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which more than 70% of patients experience visual disturbance as the earliest symptoms. Lysolecithin (LPC)-induced focal demyelination model has been developed to evaluate the effects of different therapies on myelin repair improvement. In this study, the effects of ...

journal_title：Neuroscience

authors： Daneshdoust D,Khalili-Fomeshi M,Ghasemi-Kasman M,Ghorbanian D,Hashemian M,Gholami M,Moghadamnia A,Shojaei A

更新日期：2017-03-06 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:Blocking activity with intraocular tetrodotoxin prevents the sharpening of the retinotectal map formed during regeneration of the optic nerve. If (under normal conditions) the initially diffuse map sharpens because of correlated activity in neighboring but not distant ganglion cells, then sharpening should also be pre...

journal_title：Neuroscience

authors： Schmidt JT,Eisele LE

更新日期：1985-02-01 00:00:00

abstract：:The present studies were conducted to test the hypothesis that systemically inactive doses of cannabinoids suppress inflammation-evoked neuronal activity in vivo via a peripheral mechanism. We examined peripheral cannabinoid modulation of spinal Fos protein expression, a marker of neuronal activity, in a rat model of ...

journal_title：Neuroscience

authors： Nackley AG,Suplita RL 2nd,Hohmann AG

更新日期：2003-01-01 00:00:00

abstract：:The possible neuroprotective effect of physical exercise was investigated in rats after middle cerebral artery occlusion (MCAO), a focal stroke model. It was found that physical exercise in the form of a 12-week treadmill running programme reduced the volume of infarction caused by MCAO. At the molecular level, revers...

journal_title：Neuroscience

authors： Ang ET,Wong PT,Moochhala S,Ng YK

更新日期：2003-01-01 00:00:00

abstract：:About 7.5million adults in Germany cannot read and write properly despite attending school for several years. They are considered to be functional illiterates. Since the ability to read and write is crucial for being employed and socially accepted, we developed a literacy training to overcome these deficits. In this s...

journal_title：Neuroscience

authors： Boltzmann M,Mohammadi B,Samii A,Münte TF,Rüsseler J

更新日期：2017-03-06 00:00:00

abstract：:We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific nucleotide probes and antisera. The distribution of VGLUT3 protein was compared ...

journal_title：Neuroscience

authors： Herzog E,Gilchrist J,Gras C,Muzerelle A,Ravassard P,Giros B,Gaspar P,El Mestikawy S

更新日期：2004-01-01 00:00:00

abstract：:Repeated microinjections of morphine into the ventrolateral periaqueductal gray produce antinociceptive tolerance. This tolerance may be a direct effect of morphine on cells within the ventrolateral periaqueductal gray or may require activation of downstream structures such as the rostral ventromedial medulla or spina...

journal_title：Neuroscience

authors： Lane DA,Patel PA,Morgan MM

更新日期：2005-01-01 00:00:00

abstract：:We describe the immunocytochemical distribution of adenosine A1 receptors in the rat hippocampus. Adenosine A1 receptor-like immunoreactivity was seen on the cell soma and dendrites of pyramidal cells and the cell soma and proximal part of dendrites of granule cells, but not on glial cells. Developmentally, adenosine ...

journal_title：Neuroscience

authors： Ochiishi T,Saitoh Y,Yukawa A,Saji M,Ren Y,Shirao T,Miyamoto H,Nakata H,Sekino Y

更新日期：1999-01-01 00:00:00

abstract：:The periaqueductal gray (PAG) is part of a descending pain modulatory system that, when activated, produces widespread and profound antinociception. Microinjection of either opioids or cannabinoids into the PAG elicits antinociception. Moreover, microinjection of the cannabinoid 1 (CB1) receptor agonist HU-210 into th...

journal_title：Neuroscience

authors： Wilson-Poe AR,Morgan MM,Aicher SA,Hegarty DM

更新日期：2012-06-28 00:00:00

abstract：:Orexins (OX), also called hypocretins, are bioactive peptides secreted from glucose-sensitive neurons in the lateral hypothalamus linking appetite, arousal and neuroendocrine-autonomic control. Here, OX-A was found to cause a slow-onset long-term potentiation of synaptic transmission (LTPOX) in the hippocampus of youn...

journal_title：Neuroscience

authors： Selbach O,Doreulee N,Bohla C,Eriksson KS,Sergeeva OA,Poelchen W,Brown RE,Haas HL

更新日期：2004-01-01 00:00:00

abstract：:Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...

journal_title：Neuroscience

authors： Smyk MK,van Luijtelaar G,Huysmans H,Drinkenburg WH

更新日期：2019-06-01 00:00:00

abstract：:Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

journal_title：Neuroscience

authors： Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

更新日期：2015-03-19 00:00:00

abstract：:The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathophysiology of this disease. This is commonly modeled in rodents via treatment with NMDAr antagonists, which causes a range of behavioral effects that represent endophenotypes related to schi...

journal_title：Neuroscience

authors： Lee J,Hudson MR,O'Brien TJ,Nithianantharajah J,Jones NC

更新日期：2017-09-01 00:00:00

abstract：:Adrenomedullin (AM) belongs to a calcitonin gene-related peptide (CGRP) family and has been demonstrated to recruit CGRP following chronic use of morphine and neuronal nitric oxide synthase (nNOS) in inflammation. The present study investigated the possibility that AM initiates the changes of other molecules contribut...

journal_title：Neuroscience

authors： Wang D,Li J,Chen P,Hong Y

更新日期：2014-11-07 00:00:00

abstract：:Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to A-type current in cultured cerebellar granule neurons exposed to thiamine deficiency in vitro. A-t...

journal_title：Neuroscience

authors： Cruz JS,Kushmerick C,Moreira-Lobo DC,Oliveira FA

更新日期：2012-09-27 00:00:00

abstract：:Extensive studies have shown that a sports expert is superior to a sports novice in visually perceptual-cognitive processes of sports scene information, however the attentional and neural basis of it has not been thoroughly explored. The present study examined whether a sport expert has the attentional superiority on ...

journal_title：Neuroscience

authors： He M,Qi C,Lu Y,Song A,Hayat SZ,Xu X

更新日期：2018-05-21 00:00:00

abstract：:A previously developed model of exercise-induced muscle contracture using iodoacetate to inhibit glyceraldehyde-3-phosphate dehydrogenase in rat hindlimb muscles produced selective type II myofiber damage. Utilizing a modification of the same model system, rats were given intra-aortic ortho-iodosobenzoic acid (700 nmo...

journal_title：Neuroscience

authors： Locklear I,Feeback DL,Brumback RA

更新日期：1990-01-01 00:00:00