Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats.

abstract：:Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...

journal_title：Neuroscience

authors： Chang IA,Kim KJ,Namgung U

更新日期：2018-02-10 00:00:00

abstract：OBJECTIVE:To examine the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. MATERIALS AND METHODS:Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and...

journal_title：Neuroscience

authors： Zhou Y,Zheng H,Ruan F,Chen X,Zheng G,Kang M,Zhang Q,Sun X

更新日期：2012-05-03 00:00:00

abstract：:The development of the catecholaminergic system in the hypothalamus and in the septal region was studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic structures were visualized with pre-embedding immunocytochemistry using antiserum to tyrosine hydroxylase. An intensification of diamin...

journal_title：Neuroscience

authors： Ugrumov MV,Taxi J,Tixier-Vidal A,Thibault J,Mitskevich MS

更新日期：1989-01-01 00:00:00

abstract：:Electrophysiological and anatomical studies were carried out in parallel to investigate the ability of lateral geniculate body neurons to regenerate axons damaged by the removal of the primary visual cortex and to innervate graft neurons functionally after transplantation of fetal neocortical tissue to a lesion cavity...

journal_title：Neuroscience

authors： Girman SV

更新日期：1994-06-01 00:00:00

abstract：:Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...

journal_title：Neuroscience

authors： Jonsson G,Hallman H

更新日期：1982-01-01 00:00:00

abstract：:Pseudoephedrine (PSE) salts (hydrochloride and sulfate) are commonly used as nasal and paranasal decongestants by scuba divers. Anecdotal reports from the Divers Alert Network suggest that taking PSE prior to diving while breathing pure O₂ increases the risk for CNS oxygen toxicity (CNS-OT), which manifests as seizure...

journal_title：Neuroscience

authors： Pilla R,Held HE,Landon CS,Dean JB

更新日期：2013-08-29 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:In situ hybridization was used to measure the levels of proenkephalin mRNA and prodynorphin mRNA in regions of rat striatum and nucleus accumbens. Chronic administration of haloperidol (2.4 mg/kg/day for 7 days) increased the levels of proenkephalin mRNA in both striatum and nucleus accumbens. In contrast, the levels ...

journal_title：Neuroscience

authors： Morris BJ,Höllt V,Herz A

更新日期：1988-05-01 00:00:00

abstract：:Intracellular recordings were made from neurones in the thalamic reticular nucleus (TRN) and ventro-basal (VB) thalamus in slices of rat midbrain in vitro. Electrical stimulation of the medial lemniscus or TRN resulted in the generation of complex synaptic potentials containing disynaptic inhibitory post-synaptic pote...

journal_title：Neuroscience

authors： Turner JP,Salt TE

更新日期：2003-01-01 00:00:00

abstract：:The distribution of CA3 hippocampal axonal terminal fields undergo a period of widespread connectivity-based changes in the early postnatal stages of life. The purpose of the current study was to examine the effect of acute phthalate exposure during this period of hippocampal development (postnatal days 16-22 (p16-p22...

journal_title：Neuroscience

authors： Smith CA,Macdonald A,Holahan MR

更新日期：2011-10-13 00:00:00

abstract：:The distribution of neurotensin-immunoreactive structures in the rat striatum was evaluated after blockade of dopamine neurotransmission by drugs that act presynaptically (6-hydroxydopamine, reserpine) and postsynaptically, preferentially at the D2 (eticlopride, haloperidol) and D1 [(R)-(+)-8-chloro-2,3,4,5-tetrahydro...

journal_title：Neuroscience

authors： Zahm DS

更新日期：1992-01-01 00:00:00

abstract：:Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...

journal_title：Neuroscience

authors： Zhu J,Tsai NP

更新日期：2020-01-21 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00

abstract：:Hepatic encephalopathy is characterized by disturbances of motor and cognitive functions involving the basal ganglia. So far no standards for assessment of neuropsychiatric abnormalities (disorders of sleep, mood, anxiety and personality) in subclinical hepatic encephalopathy have been defined. Using an animal model o...

journal_title：Neuroscience

authors： Sergeeva OA,Schulz D,Doreulee N,Ponomarenko AA,Selbach O,Borsch E,Kircheis G,Huston JP,Häussinger D,Haas HL

更新日期：2005-01-01 00:00:00

abstract：:Histamine, a putative neuromodulator and neurotransmitter, can depolarize supraoptic neurons and enhance depolarizing afterpotentials that play a key role in determining the excitability of these neurons. This study investigated intracellular signal transduction involved in histamine-induced enhancement of depolarizin...

journal_title：Neuroscience

authors： Li Z,Miyata S,Hatton GI

更新日期：1999-01-01 00:00:00

abstract：:Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD specific E3 ubiquitin protein ligase 2 (smurf2). With age smurf2 expression increases and Smurf2...

journal_title：Neuroscience

authors： Sasik MUT,Eravsar ETK,Kinali M,Ergul AA,Adams MM

更新日期：2020-06-01 00:00:00

abstract：:Although neurogenesis in the hippocampus is critical for improvement of depressive behaviors and cognitive functions in neurodegeneration disorders, there is no therapeutic agent available to promote neurogenesis in adult brain following brain ischemic injury. Here we found that i.p. administration of bis(1-oxy-2-pyri...

journal_title：Neuroscience

authors： Shioda N,Han F,Morioka M,Fukunaga K

更新日期：2008-08-26 00:00:00

abstract：:Growth-associated protein-43, an established marker of neuronal plasticity during development and in injury, was used to characterize innervation in the normal human pancreas and changes in chronic alcohol-induced pancreatitis by using light microscopic immunocytochemistry and computer-assisted image analysis. Immunos...

journal_title：Neuroscience

authors： Fink T,Di Sebastiano P,Büchler M,Beger HG,Weihe E

更新日期：1994-11-01 00:00:00

abstract：:This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5Hz) rTMS was pe...

journal_title：Neuroscience

authors： Zhang N,Xing M,Wang Y,Tao H,Cheng Y

更新日期：2015-12-17 00:00:00

abstract：:Environmental enrichment of laboratory animals leads to multi-faceted changes to physiology, health and disease prognosis. An important and under-appreciated factor in enhancing cognition through environmental manipulation may be improved basic sensory function. Previous studies have highlighted changes in cortical se...

journal_title：Neuroscience

authors： Devonshire IM,Dommett EJ,Grandy TH,Halliday AC,Greenfield SA

更新日期：2010-10-13 00:00:00

abstract：:It has recently become clear that the neurotrophic factor, nerve growth factor, interacts specifically with nociceptive sensory neurons during development and maturity. Indeed, it may serve as a critical link between inflammation and the hyperalgesia that ensues in adult animals. Nerve growth factor is normally expres...

journal_title：Neuroscience

authors： Davis BM,Lewin GR,Mendell LM,Jones ME,Albers KM

更新日期：1993-10-01 00:00:00

abstract：:The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signali...

journal_title：Neuroscience

authors： Kramer B,Tropitzsch A,Müller M,Löwenheim H

更新日期：2017-08-15 00:00:00

abstract：:Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner. Therefore, using the lithium-pilocarpine status epilepticus model, we performed a detailed in situ hybridization ti...

journal_title：Neuroscience

authors： Rosell DR,Nacher J,Akama KT,McEwen BS

更新日期：2003-01-01 00:00:00

abstract：:Interactions between dopamine and glutamate receptors are essential for the prefrontal cortical (PFC) and hippocampal cognitive functions. In order to understand the molecular basis of dopamine/glutamate interactions in rat PFC and hippocampus, we investigated (a) the effect of in vitro dopamine D1 receptor stimulatio...

journal_title：Neuroscience

authors： Sarantis K,Matsokis N,Angelatou F

更新日期：2009-11-10 00:00:00

abstract：:In an earlier study we have shown that local application of capsaicin directly to one sciatic nerve induces a decrease of substance P and cholecystokinin octapeptide (CCK8)-like peptide from the dorsal spinal cord using immunocytochemical analysis. Here the effect of locally applied capsaicin on seven peptides known t...

journal_title：Neuroscience

authors： Gibson SJ,McGregor G,Bloom SR,Polak JM,Wall PD

更新日期：1982-01-01 00:00:00

abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

journal_title：Neuroscience

authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

更新日期：2013-04-16 00:00:00

abstract：:Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in childr...

journal_title：Neuroscience

authors： Connolly AJ,Rinehart NJ,Johnson B,Papadopoulos N,Fielding J

更新日期：2016-10-15 00:00:00

abstract：:Intrauterine growth restriction (IUGR) associates with increased preference for palatable foods and altered insulin sensitivity. Insulin modulates the central dopaminergic response and changes behavioral responses to reward. We measured the release of dopamine in the accumbens during palatable food intake in IUGR rats...

journal_title：Neuroscience

authors： Laureano DP,Alves MB,Miguel PM,Machado TD,Reis AR,Mucellini AB,Cunha FS,Lampert C,Salvador APA,Dalle Molle R,Mosca PR,Pokhvisneva I,Desai M,Ross MG,Silveira PP

更新日期：2019-02-21 00:00:00

abstract：:Studies with animal seizure models have indicated that changes in temporal and spatial expression of voltage-gated sodium channels may be important in the pathology of epilepsy. Here, by using in situ hybridisation with previously characterised subtype-selective oligonucleotide probes [Whitaker et al. (2000) J. Comp. ...

journal_title：Neuroscience

authors： Whitaker WR,Faull RL,Dragunow M,Mee EW,Emson PC,Clare JJ

更新日期：2001-01-01 00:00:00

abstract：:Although serotonin has been shown to play an important role in peripheral pain mechanisms, the specific subtypes of serotonin receptors involved in pain and hyperalgesia remain poorly understood. To date, no previous study has attempted to determine the presence of any serotonin receptor subtype in human dorsal root g...

journal_title：Neuroscience

authors： Pierce PA,Xie GX,Meuser T,Peroutka SJ

更新日期：1997-12-01 00:00:00