Ectopic sympathetic preganglionic neurons maintain proper connectivity in the reeler mutant mouse.

abstract：:Reg-2 is a secreted protein that is expressed de novo in motoneurons, sympathetic neurons, and dorsal root ganglion (DRG) neurons after nerve injury and which can act as a Schwann cell mitogen. We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat mo...

journal_title：Neuroscience

authors： Averill S,Inglis JJ,King VR,Thompson SW,Cafferty WB,Shortland PJ,Hunt SP,Kidd BL,Priestley JV

更新日期：2008-09-09 00:00:00

abstract：:Oxidative stress is central to the pathology of several neurodegenerative diseases, including Parkinson's disease (PD), and therapeutics designed to enhance antioxidant potential could have clinical value. In this study, we investigated whether dimethyl fumarate (DMF) has therapeutic effects in cellular and animal mod...

journal_title：Neuroscience

authors： Jing X,Shi H,Zhang C,Ren M,Han M,Wei X,Zhang X,Lou H

更新日期：2015-02-12 00:00:00

abstract：:In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat model of Parkinson's disease, animals with unilateral 6-hydroxydopamine lesions of the median forebrain bundle received dopamine-rich ventral mesencephalic grafts derived...

journal_title：Neuroscience

authors： Torres EM,Monville C,Gates MA,Bagga V,Dunnett SB

更新日期：2007-06-08 00:00:00

abstract：:The unilateral application of GABA (10(-5) M; 30 min) into thalamic motor nuclei of the cat increases the release of dopamine in both caudate nuclei. This effect has been suggested to be related to an activation of the bilateral corticostriatal glutamatergic projection, glutamate exerting a presynaptic facilitatory in...

journal_title：Neuroscience

authors： Barbeito L,Girault JA,Godeheu G,Pittaluga A,Glowinski J,Cheramy A

更新日期：1989-01-01 00:00:00

abstract：:Resident microglia are involved in immune responses of the central nervous system and may contribute to neuronal degeneration and death. Here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the ...

journal_title：Neuroscience

authors： Lu X,Bing G,Hagg T

更新日期：2000-01-01 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00

abstract：:The effects of treatment with the antidepressant drug imipramine on neuropeptide Y immunoreactivity were studied immunocytochemically in the rat brain cortex and hypothalamus. It was found that the level of neuropeptide Y immunoreactivity in the cortex was significantly lowered three and 24 h after the last dose of ch...

journal_title：Neuroscience

authors： Smiałowska M,Legutko B

更新日期：1991-01-01 00:00:00

abstract：:The calcium binding protein, Calbindin-D28k, is known to be localized within spiny neurons of the matrix of the dorsal striatum, caudate-putamen nuclei. This compartment is also known to contain an abundance of GABAergic neurons and to receive extensive input from excitatory limbic and cortical afferents whose activat...

journal_title：Neuroscience

authors： Pickel VM,Heras A

更新日期：1996-03-01 00:00:00

abstract：:The hippocampus maintains the remarkable ability to generate new neurons throughout the lifespan. Progenitor cells in the subgranular zone give rise mainly to granule cells that migrate to the granule cell layer and become mature, functionally integrated neurons. Numerous factors are capable of regulating the prolifer...

journal_title：Neuroscience

authors： Spanswick SC,Epp JR,Sutherland RJ

更新日期：2011-09-08 00:00:00

abstract：:Cerebellar granule cells in culture develop survival requirements which can be met either by chronic membrane depolarization (25 mM K+) or by stimulation of ionotropic excitatory amino acid receptors. We observed previously that this trophic effect is mediated via Ca2+ influx, either through dihydropyridine-sensitive,...

journal_title：Neuroscience

authors： Hack N,Hidaka H,Wakefield MJ,Balázs R

更新日期：1993-11-01 00:00:00

abstract：:The nicotinic antagonists d-tubocurarine and trimethaphan camsylate competitively inhibit GABA-induced currents. Hexamethonium, mecamylamine and dihydro-beta-erythroidine, other nicotinic antagonists, do not affect GABA-elicited currents. The trimethaphan effect is completely reversed by a putative convulsant receptor...

journal_title：Neuroscience

authors： Wotring VE,Yoon KW

更新日期：1995-07-01 00:00:00

abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

journal_title：Neuroscience

authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

更新日期：2002-01-01 00:00:00

abstract：:Ghrelin induces orexigenic behavior by activation of growth hormone secretagogue 1 receptors (GHSRs) in the ventral tegmental area (VTA) as well as hypothalamus, suggesting the involvement of mesolimbic dopamine system in the action of ghrelin. The present study aimed to identify neuronal mechanisms by which periphera...

journal_title：Neuroscience

authors： Kawahara Y,Kawahara H,Kaneko F,Yamada M,Nishi Y,Tanaka E,Nishi A

更新日期：2009-07-07 00:00:00

abstract：:Recently, we reported that erythropoietin attenuates neonatal brain injury caused by focal cerebral ischemia. The long-term effects of erythropoietin on focal cerebral ischemia-induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The cu...

journal_title：Neuroscience

authors： Wen TC,Rogido M,Peng H,Genetta T,Moore J,Sola A

更新日期：2006-01-01 00:00:00

abstract：:We have demonstrated the formation of entorhinodentate projections by axons arising from explants of embryonic mouse entorhinal cortex or slices of postnatal rat entorhinal area co-cultured in contact with slices of postnatal rat hippocampus in roller tube and static culture. Species-specific markers (Thy-1 alleles an...

journal_title：Neuroscience

authors： Li D,Field PM,Starega U,Li Y,Raisman G

更新日期：1993-02-01 00:00:00

abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

journal_title：Neuroscience

authors： Sershen H,Balla A,Lajtha A,Vizi ES

更新日期：1997-03-01 00:00:00

abstract：:Seizures produced by pilocarpine given i.p. to rats provide an animal model for studying the initiation, spread and generalisation of convulsive activity within the forebrain. Pilocarpine, 380 mg/kg, produces a sequence of behavioural and electroencephalographic alterations indicative of motor limbic seizures and stat...

journal_title：Neuroscience

authors： Turski L,Cavalheiro EA,Turski WA,Meldrum BS

更新日期：1986-05-01 00:00:00

abstract：:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connec...

journal_title：Neuroscience

authors： Zahm DS,Brog JS

更新日期：1992-10-01 00:00:00

abstract：:The possible irreversible blockade of 5-hydroxytryptamine1 receptor subtypes 5-hydroxytryptamine1A, 5-hydroxytryptamine1B/5-hydroxytryptamine1D and 5-hydroxytryptamine1C by the chloramine 8-methoxy-2-(N-2'-chloropropyl,N-propyl)aminotetralin (8-MeO-2'-chloro-PAT) was investigated in rat brain sections by quantitative ...

journal_title：Neuroscience

authors： Radja F,Daval G,Emerit MB,Gallissot MC,Hamon M,Vergé D

更新日期：1989-01-01 00:00:00

abstract：:The present study was designed to elucidate the distribution, time-course and mechanism(s) of status epilepticus-induced neuronal damage in the rat amygdaloid complex. Status epilepticus was induced with kainate (9 mg/kg, i.p.), and the behavioral and electrographic seizure activity of each rat was monitored via corti...

journal_title：Neuroscience

authors： Tuunanen J,Lukasiuk K,Halonen T,Pitkänen A

更新日期：1999-01-01 00:00:00

abstract：:Peripheral nerve injury in a limb usually causes functional reorganization of the contralateral motor cortex. However, a dynamic process of the novel transhemispheric functional reorganization in the motor cortex was found in adult rats after transferring the seventh cervical nerve root from the contralateral healthy ...

journal_title：Neuroscience

authors： Lou L,Shou T,Li Z,Li W,Gu Y

更新日期：2006-01-01 00:00:00

abstract：:Microelectrode recordings were made from 5-10 micron dia axons of adult rat spinal cord in vitro. Action potentials in response to electrical stimulation were recorded intracellularly and electrical characteristics of the axons were examined by injecting current pulses through a bridge circuit. All action potentials l...

journal_title：Neuroscience

authors： Blight AR,Someya S

更新日期：1985-05-01 00:00:00

abstract：:Tg2576 transgenic mice (mice overexpressing the "Swedish" mutation in the human amyloid precursor protein 695) demonstrated a decreased capacity for cell proliferation in the dentate gyrus of the hippocampus compared with non-transgenic littermates at 3 months, 6 months and 9 months of age. Isolation stress induced by...

journal_title：Neuroscience

authors： Dong H,Goico B,Martin M,Csernansky CA,Bertchume A,Csernansky JG

更新日期：2004-01-01 00:00:00

abstract：:Scratching inhibits pruritogen-evoked responses of neurons in the superficial dorsal horn, implicating a spinal site for scratch inhibition of itch. We investigated if scratching differentially affects neurons depending on whether they are activated by itchy vs. painful stimuli, and if the degree of inhibition depends...

journal_title：Neuroscience

authors： Nishida K,Takechi K,Akiyama T,Carstens MI,Carstens E

更新日期：2013-10-10 00:00:00

abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

journal_title：Neuroscience

authors： Lowe G,Buerk DG,Ma J,Gelperin A

更新日期：2008-05-15 00:00:00

abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

journal_title：Neuroscience

authors： Pickel VM,Chan J

更新日期：1991-01-01 00:00:00

abstract：:Intersegmental interneurons with relatively short axons perform an important role in the coordination of limb movement but surprisingly little is known about their organization and how they contribute to neuronal networks in the adult rat. We undertook a series of anatomical tract-tracing studies to label cell bodies ...

journal_title：Neuroscience

authors： Liu TT,Bannatyne BA,Maxwell DJ

更新日期：2010-12-01 00:00:00

abstract：:Noradrenergic neurons from the locus coeruleus innervate several brain regions, such as hippocampus and cortex. The hippocampus exhibits the highest concentration of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the brain. To study the role of the noradrenergic system i...

journal_title：Neuroscience

authors： Hutter P,Johansson M,Saria A,Humpel C

更新日期：1996-01-01 00:00:00

abstract：:In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...

journal_title：Neuroscience

authors： Hunter JC,Birchmore B,Woodruff R,Hughes J

更新日期：1989-01-01 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and the increased risk of developing Parkinson's disease. Previously we have reported that Dichlorvos exposure can induce oxidative stress, resulting in over-expression of pro-apoptotic genes and finally caspase-dependent nigrostriat...

journal_title：Neuroscience

authors： Wani WY,Sunkaria A,Sharma DR,Kandimalla RJ,Kaushal A,Gerace E,Chiarugi A,Gill KD

更新日期：2014-01-31 00:00:00