Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors.

abstract：:Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression and drug abuse. Both serotonin-2A (5-HT2A) and -2C (5-HT2C) receptors are known t...

journal_title：Neuroscience

authors： Nocjar C,Alex KD,Sonneborn A,Abbas AI,Roth BL,Pehek EA

更新日期：2015-06-25 00:00:00

abstract：:Invertebrate microvillar photoreceptors utilize the phosphoinositide cascade to transduce light stimuli and inositol 1,4,5-trisphosphate is thought to be one of the messengers that triggers the electrical response by mobilizing intracellular stored calcium. To further characterize the role of the phosphoinositide sign...

journal_title：Neuroscience

authors： Ukhanov K,Ukhanova M,Taylor CW,Payne R

更新日期：1998-09-01 00:00:00

abstract：:Capsaicin, a neurotoxin which depletes substance P from primary afferent nerve fibres, was injected systematically into adult guinea pigs. The effects of capsaicin were studied by immunohistochemistry, electron microscopy and radioimmunoassay at times from 5 min to 1 year. Within 5 min after a single injection of caps...

journal_title：Neuroscience

authors： Papka RE,Furness JB,Della NG,Murphy R,Costa M

更新日期：1984-08-01 00:00:00

abstract：:Synthesis of phosphatidylcholine, the most abundant brain membrane phosphatide, requires three circulating precursors: choline; a pyrimidine (e.g. uridine); and a polyunsaturated fatty acid. Supplementing a choline-containing diet with the uridine source uridine-5'-monophosphate (UMP) or, especially, with UMP plus the...

journal_title：Neuroscience

authors： Cansev M,Wurtman RJ

更新日期：2007-08-24 00:00:00

abstract：:Single steps in different directions are often used for postural corrections. However, our knowledge about the neural mechanisms underlying their generation is scarce. This study was aimed to characterize the corrective steps generated in response to disturbances of the basic body configuration caused by forward, back...

journal_title：Neuroscience

authors： Hsu LJ,Zelenin PV,Lyalka VF,Vemula MG,Orlovsky GN,Deliagina TG

更新日期：2017-04-07 00:00:00

abstract：:Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the striatum. We have previously reported that cocaine inhibits the DAT within 4-5 s of i.v. injection, matching the temporal profile of the behavior...

journal_title：Neuroscience

authors： Yorgason JT,Jones SR,España RA

更新日期：2011-05-19 00:00:00

abstract：:Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). Howeve...

journal_title：Neuroscience

authors： Amritraj A,Rauw G,Baker GB,Kar S

更新日期：2010-10-27 00:00:00

abstract：:Neonatal posterior cingulate cortex lesions spare the spatial deficits that characterize adult lesions. The present experiments examined the possibility that the anterior cingulate cortex mediates the spared spatial behavior. Rats were given bilateral lesions of the posterior cingulate cortex or anterior plus posterio...

journal_title：Neuroscience

authors： Gonzalez CL,Whishaw IQ,Kolb B

更新日期：2003-01-01 00:00:00

abstract：:Sensory input from female reproductive structures is paramount for the co-ordination of neuroendocrine changes at parturition. Using a retrograde tracer (fluorescent latex microspheres) in combination with Fos (as an indicator of neuronal activation) and tyrosine hydroxylase (to identify catecholaminergic neurons) imm...

journal_title：Neuroscience

authors： Meddle SL,Leng G,Selvarajah JR,Bicknell RJ,Russell JA

更新日期：2000-01-01 00:00:00

abstract：:The effect of muscarinic agonists on the spontaneous release of [3H]GABA was investigated in vitro on rat substantia nigra slices. Acetylcholine (5 x 10(-5) M) in the presence of eserine (5 x 10(-5) M) induced a 12.3% increase of the spontaneous release of [3H]GABA. Similarly, carbachol (5 x 10(-4) M) enhanced by 9% t...

journal_title：Neuroscience

authors： Kayadjanian N,Gioanni H,Ménetrey A,Besson MJ

更新日期：1994-12-01 00:00:00

abstract：:Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behavioral sensitization, vulnerability to compulsive relapse, and high mortality. In laboratory animals, the potential effect of opiate drugs to induce cell death by apoptosis is a controversial topic. This postmortem human...

journal_title：Neuroscience

authors： García-Fuster MJ,Ramos-Miguel A,Rivero G,La Harpe R,Meana JJ,García-Sevilla JA

更新日期：2008-11-11 00:00:00

abstract：:In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...

journal_title：Neuroscience

authors： Kosaka K,Toida K,Margolis FL,Kosaka T

更新日期：1997-02-01 00:00:00

abstract：:Receptor-associated protein appears to play an important role in low-density lipoprotein receptor-related protein trafficking. Since ligands for the low-density lipoprotein receptor-related protein have been implicated in Alzheimer's disease and normal functioning of this protein is indispensable for central nervous s...

journal_title：Neuroscience

authors： Van Uden E,Veinbergs I,Mallory M,Orlando R,Masliah E

更新日期：1999-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) was investigated in the present study to examine whether it could affect the activation status of microglia under microenvironment of spinal cord injury and provide a potential therapeutic treatment for spinal cord injury. We established mouse spinal cord hemisection model...

journal_title：Neuroscience

authors： Guo Y,Zhang H,Yang J,Liu S,Bing L,Gao J,Hao A

更新日期：2013-05-15 00:00:00

abstract：:We have examined the effect of acrolein, an aldehyde product of lipid peroxidation, on axons in isolated guinea-pig spinal cord white matter. We found that 200 microM acrolein, but not 50 microM, induced a time-dependent loss of compound action potential conduction. Such conduction loss was irreversible within 1 h aft...

journal_title：Neuroscience

authors： Shi R,Luo J,Peasley M

更新日期：2002-01-01 00:00:00

abstract：:Estrogens influence neuronal activity and are important for normal brain functions. Effects of estrogens on seizures are contradictory. It is commonly accepted that estrogens may increase neuronal excitability and thus mediate proconvulsant effects. However, clinical and animal data show that estrogen may also have no...

journal_title：Neuroscience

authors： Velísková J

更新日期：2006-01-01 00:00:00

abstract：:To localize glycinergic cell bodies and fibers in the rat brain, we developed a sensitive immunohistochemical method combining the use of specific glycine antibodies (Campistron G. et al. (1986) Brain Res. 376, 400-405; Wenthold R. J. et al. (1987) Neuroscience 22, 897-912) with the streptavidin-horseradish peroxidase...

journal_title：Neuroscience

authors： Rampon C,Luppi PH,Fort P,Peyron C,Jouvet M

更新日期：1996-12-01 00:00:00

abstract：:Rapid eye movement (REM) sleep deprivation elevates noradrenaline level, which upon acting on alpha1-adrenoceptors increases Na-K-ATPase activity; however, the detailed intracellular mechanism of action was unknown. Since membrane integrity is crucial for maintaining Na-K-ATPase activity as well as ionic exchange and ...

journal_title：Neuroscience

authors： Das G,Gopalakrishnan A,Faisal M,Mallick BN

更新日期：2008-07-31 00:00:00

abstract：:The fact that neurobiological research is reliant upon laboratory-reared rodents is well known. The following paper discusses this topic broadly, but also aims to highlight other species used in the study of the nervous system and the evolution of animal species usage from the end of World War II through recent invest...

journal_title：Neuroscience

authors： Żakowski W

更新日期：2020-05-01 00:00:00

abstract：:We have shown that transgenic transient axonal glycoprotein (TAG)/F3 mice, in which the mouse axonal glycoprotein F3/contactin was misexpressed from a regulatory region of the gene encoding the transient axonal glycoprotein TAG-1, exhibit a transient disruption of cerebellar granule and Purkinje cell development [Deve...

journal_title：Neuroscience

authors： Coluccia A,Tattoli M,Bizzoca A,Arbia S,Lorusso L,De Benedictis L,Buttiglione M,Cuomo V,Furley A,Gennarini G,Cagiano R

更新日期：2004-01-01 00:00:00

abstract：:The rapid eye movement dreaming sleep stage and schizophrenia are both characterized by common intracerebral disconnections, disturbed responsiveness and sensory deafferentation processes. Moreover, in both states, there is dorsolateral prefrontal deactivation as shown by the decrease of blood flow. Finally, identical...

journal_title：Neuroscience

authors： Gottesmann C

更新日期：2006-07-21 00:00:00

abstract：:Here we investigate the temporal properties of recurrent seizure-like events (SLEs) in a low-[Mg(2+)] model of experimental epilepsy. Simultaneous intra- and extracellular electric signals were recorded in the CA3 region of rat hippocampal slices whereby cytosolic [Ca(2+)] transients were imaged by fluorescence detect...

journal_title：Neuroscience

authors： Nyikos L,Lasztóczi B,Antal K,Kovács R,Kardos J

更新日期：2003-01-01 00:00:00

abstract：:Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...

journal_title：Neuroscience

authors： Johnson MD,Yee AG

更新日期：1995-08-01 00:00:00

abstract：:The blockade of the central nucleus of the amygdala (CeA) with the GABAA receptor agonist muscimol significantly reduces hypertonic NaCl and water intake by sodium-depleted rats. In the present study we investigated the effects of previous injection of losartan, an angiotensin II type-1 (AT1) receptor antagonist, into...

journal_title：Neuroscience

authors： Hu B,Qiao H,Sun B,Jia R,Fan Y,Wang N,Lu B,Yan JQ

更新日期：2015-10-29 00:00:00

abstract：:In the nervous system, the aminoacylhistidine dipeptide carnosine (beta-alanyl-L-histidine) has been shown to be expressed in the olfactory receptor neurons and in brain astrocytes. Using immunocytochemical techniques, we report here a dense carnosine-like immunoreactivity in the subependymal layer of the rodent foreb...

journal_title：Neuroscience

authors： Peretto P,Bonfanti L,Merighi A,Fasolo A

更新日期：1998-07-01 00:00:00

abstract：:Trigeminal neurogenic inflammation is one explanation for the development of vascular migraine. The triggers for this inflammation and pain are not well understood, but are probably vasoactive components acting on the blood vessel wall. Migraine-related inner ear symptoms like phonophobia, tinnitus, fluctuation in hea...

journal_title：Neuroscience

authors： Vass Z,Steyger PS,Hordichok AJ,Trune DR,Jancsó G,Nuttall AL

更新日期：2001-01-01 00:00:00

abstract：:Free radicals have been implicated in a number of pathological conditions. To evaluate the neurophysiological consequences of free radical exposure, slices of hippocampus isolated from guinea-pigs were exposed to hydrogen peroxide which reacts with tissue iron to generate hydroxyl free radicals. Long-term potentiation...

journal_title：Neuroscience

authors： Pellmar TC,Hollinden GE,Sarvey JM

更新日期：1991-01-01 00:00:00

abstract：:The uptake and transport of basic and acidic horseradish peroxidase isoenzymes was compared in the neuromuscular, visual and olfactory systems of Xenopus larvae and postmetamorphic frogs. The concentration (w/v) of the two preparations was corrected to compensate for their difference in enzymatic activity (unit/w), wh...

journal_title：Neuroscience

authors： Key B,Giorgi PP

更新日期：1987-09-01 00:00:00

abstract：:Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement ther...

journal_title：Neuroscience

authors： Smith ES,Hardy GA,Schallert T,Lee HJ

更新日期：2016-11-19 00:00:00

abstract：:When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of t...

journal_title：Neuroscience

authors： Woolf CJ,Reynolds ML,Molander C,O'Brien C,Lindsay RM,Benowitz LI

更新日期：1990-01-01 00:00:00