Animal Use in Neurobiological Research.

abstract：:Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. ...

journal_title：Neuroscience

authors： Bick J,Fox N,Zeanah C,Nelson CA

更新日期：2017-02-07 00:00:00

abstract：:Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested...

journal_title：Neuroscience

authors： Dekker AJ,Gage FH,Thal LJ

更新日期：1992-01-01 00:00:00

abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

journal_title：Neuroscience

authors： Ding Q,Ying Z,Gómez-Pinilla F

更新日期：2011-09-29 00:00:00

abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

journal_title：Neuroscience

authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

更新日期：2003-01-01 00:00:00

abstract：:The role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit usin...

journal_title：Neuroscience

authors： Shirhan MD,Moochhala SM,Ng PY,Lu J,Ng KC,Teo AL,Yap E,Ng I,Hwang P,Lim T,Sitoh YY,Rumpel H,Jose R,Ling E

更新日期：2004-01-01 00:00:00

abstract：:The hyperpolarization-activated h channel current (Ih) reported to be present in acutely isolated rat dorsal root ganglion (DRG) neurons is inhibited by Cs+ and ZD7288. It was recently reported that lead (Pb2+) inhibits voltage-gated Ca2+ and K+ channels in DRG neurons but the effect of Pb2+ on Ih has so far not been ...

journal_title：Neuroscience

authors： Dai XQ,Karpinski E,Chen XZ

更新日期：2003-01-01 00:00:00

abstract：:8-oxoguanine DNA glycosylase and Kin17 are proteins widely distributed and phylogenetically conserved in the CNS. 8-oxoguanine DNA glycosylase is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine present in DNA damaged by oxidative stress. Kin17 protein is involved in DNA repair and illegitimate recombination ...

journal_title：Neuroscience

authors： Araneda S,Pelloux S,Radicella JP,Angulo J,Kitahama K,Gysling K,Forray MI

更新日期：2005-01-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent factor for the ventral mesencephalic dopamine neurons. However, studies on the Gdnf gene deleted (Gdnf(-/-)) mouse have been limited to fetal tissue since these mice die prematurely. To evaluate long-term effects of Gdnf gene deletion, this study involves ...

journal_title：Neuroscience

authors： Nevalainen N,Chermenina M,Rehnmark A,Berglöf E,Marschinke F,Strömberg I

更新日期：2010-12-29 00:00:00

abstract：:Cortical pyramidal neurons are considered to be less excitable in the immature cortex than in adults. Our previous report revealed that a negative feedback regulation of membrane excitability is highly correlated with a novel form of calcium release from inositol-1,4,5-trisphosphate (IP(3))-sensitive calcium stores (I...

journal_title：Neuroscience

authors： Yamamoto K,Nakano M,Hashimoto K,Shimohama S,Kato N

更新日期：2002-01-01 00:00:00

abstract：:Neural injury triggers changes in the expression of a large number of gene families. Particularly interesting are those encoding proteins involved in the generation, propagation or restoration of electric potentials. The expression of the Na+, K+-ATPase subunit isoforms (alpha, beta and gamma) was studied in dorsal ro...

journal_title：Neuroscience

authors： Arteaga MF,Gutiérrez R,Avila J,Mobasheri A,Díaz-Flores L,Martín-Vasallo P

更新日期：2004-01-01 00:00:00

abstract：:Distribution of primary afferent fibers was studied in intact and neonatally capsaicin treated rats by the application of horseradish peroxidase to the central branch of the transected lumbar dorsal roots. Coarse primary afferent fibers entered the spinal cord through the larger medial portion of the rootlet and arbor...

journal_title：Neuroscience

authors： Réthelyi M,Salim MZ,Jancsó G

更新日期：1986-07-01 00:00:00

abstract：:The proto-oncogene bcl-2 and its family members, bcl-x and bax are recognized as major regulators of cell death and survival. Although Bcl-2 and Bcl-x are expressed in brain, little is known how they are regulated in neurons. Here we have studied the expression of bcl-2, bcl-xL and bax mRNA in rat cerebellar granule n...

journal_title：Neuroscience

authors： Ohga Y,Zirrgiebel U,Hamnér S,Michaelidis TM,Cooper J,Thoenen H,Lindholm D

更新日期：1996-08-01 00:00:00

abstract：:The present study tests the hypothesis that propentofylline, an adenosine re-uptake inhibitor, will reduce free radical generation during cerebral hypoxia. Ten newborn piglets were pretreated with propentofylline (10 mg/kg), five of which were subjected to hypoxia, while the other five were maintained at normoxia. Fiv...

journal_title：Neuroscience

authors： Numagami Y,Marro PJ,Mishra OP,Delivoria-Papadopoulos M

更新日期：1998-06-01 00:00:00

abstract：:The resting and reflex-evoked activities of single postganglionic sympathetic neurons with axons in the right thoracic vagus were tested in chloralose-anaesthetized cats. The properties of a majority of neurons were found to be similar. Cardiac- and inspiration-related rhythmicities were present in the resting activit...

journal_title：Neuroscience

authors： Bałkowiec A,Szulczyk P

更新日期：1992-01-01 00:00:00

abstract：:In this study, the nonlinear prediction method combined with Gaussian-scaled surrogate data was used to quantify, as a first goal, the chaotic behavior of the interspike interval of ventral tegmental area dopaminergic neurons, extracellularly recorded in vivo, in anesthetized rats. The second goal was to determine the...

journal_title：Neuroscience

authors： Di Mascio M,Di Giovanni G,Di Matteo V,Esposito E

更新日期：1999-01-01 00:00:00

abstract：:Astrocytes perform several functions that are essential for normal neuronal activity. They play a critical role in neuronal survival during ischemia and other degenerative injuries and also modulate neuronal recovery by influencing neurite outgrowth. In this study, we investigated the neuroprotective effects of astroc...

journal_title：Neuroscience

authors： Terashvili M,Sarkar P,Nostrand MV,Falck JR,Harder DR

更新日期：2012-10-25 00:00:00

abstract：:Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...

journal_title：Neuroscience

authors： Moeller HB,Fenton RA,Zeuthen T,Macaulay N

更新日期：2009-12-29 00:00:00

abstract：:Acute ambient hypoxia interacts with the ventilatory and cardiocirculatory control systems, via the concomitant activation of arterial chemoreceptors and tissue oxygen-sensing mechanisms. Whether these latter mechanisms may trigger a specific pathway had not yet been elucidated. We addressed this issue, mapping Fos ex...

journal_title：Neuroscience

authors： Bodineau L,Larnicol N

更新日期：2001-01-01 00:00:00

abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...

journal_title：Neuroscience

authors： Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

更新日期：2006-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase and haem oxygenase-2 are postulated to be important enzymes involved in neuronal transmission and modulation of free radical levels in neurons. Hippocampal and cortical neuronal nitric oxide synthase and haem oxygenase-2 expressions were compared in young adult (6 months) and aged (24-26...

journal_title：Neuroscience

authors： Law A,Doré S,Blackshaw S,Gauthier S,Quirion R

更新日期：2000-01-01 00:00:00

abstract：:Central neuropathic pain (CNP) in the spinal cord, such as chronic pain after spinal cord injury (SCI), is an incurable ailment. However, little is known about the spinal cord mechanisms underlying CNP. Recently, reactive oxygen species (ROS) have been recognized to play an important role in CNP of the spinal cord. Ho...

journal_title：Neuroscience

authors： Nishio N,Taniguchi W,Sugimura YK,Takiguchi N,Yamanaka M,Kiyoyuki Y,Yamada H,Miyazaki N,Yoshida M,Nakatsuka T

更新日期：2013-09-05 00:00:00

abstract：:Puberty is a critical period of development during which the reemergence of gonadotropin-releasing hormone secretion from the hypothalamus triggers a cascade of hormone-dependent processes. Maturation of specific brain regions including the prefrontal cortex occurs during this window, but the complex mechanisms underl...

journal_title：Neuroscience

authors： Morrison KE,Rodgers AB,Morgan CP,Bale TL

更新日期：2014-04-04 00:00:00

abstract：:X-linked forms of non-specific mental retardation are complex disorders, for which mutations in several genes have recently been identified. These include OPHN1, GDI1, PAK3, IL1RAPL, TM4SF2, FMR2 and RSK2. To investigate the mechanisms through which alterations of these gene products could result in cognitive impairme...

journal_title：Neuroscience

authors： Boda B,Mas C,Muller D

更新日期：2002-01-01 00:00:00

abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

journal_title：Neuroscience

authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

更新日期：1999-01-01 00:00:00

abstract：:Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditio...

journal_title：Neuroscience

authors： Takai Y,Kawai M,Ogo T,Ichinose T,Furuya S,Takaki N,Tone Y,Udo H,Furuse M,Yasuo S

更新日期：2018-03-15 00:00:00

abstract：:The consequences of excessive fructose intake extend beyond those of metabolic disorder to changes in emotional regulation and cognitive function. Long-term consumption of fructose, particularly common when begun in adolescence, is more likely to lead to deleterious consequences than acute consumption. These long-term...

journal_title：Neuroscience

authors： Kloster A,Hyer MM,Dyer S,Salome-Sanchez C,Neigh GN

更新日期：2021-02-01 00:00:00

abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

journal_title：Neuroscience

authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

更新日期：2018-10-15 00:00:00

abstract：:A variety of neurological diseases are characterized by disturbances of the blood-brain barrier (BBB) and its transporters. We recently introduced fibroblast growth factor treated cortical organotypic slice cultures of mice as a model for in vitro studies of the blood-brain barrier and have now further characterized t...

journal_title：Neuroscience

authors： Camenzind RS,Chip S,Gutmann H,Kapfhammer JP,Nitsch C,Bendfeldt K

更新日期：2010-09-29 00:00:00

abstract：:Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...

journal_title：Neuroscience

authors： Tang G,Dong X,Huang X,Huang XJ,Liu H,Wang Y,Ye WC,Shi L

更新日期：2015-09-10 00:00:00

abstract：:Neuronal oscillations are important for information processing. The entorhinal cortex is one of the structures which is involved in generation of theta rhythm. The major role of the entorhinal cortex is to feed diverse sources of information both to and from the hippocampus. Far from simply being a funnel for this inf...

journal_title：Neuroscience

authors： Schmitz D,Gloveli T,Behr J,Dugladze T,Heinemann U

更新日期：1998-08-01 00:00:00