Abstract：
:Fetal alcohol spectrum disorder is associated with defects in neuronal generation, migration, and differentiation. The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Wild-type and Bax knockout mice were given a pair of injections (two hours apart) of ethanol (2.5 g/kg) or saline on postnatal day (P) 4, P7, P10, or P13. Mean blood ethanol concentration was 435 mg/dl one hour after the second injection. The total numbers of neurons in individual layers of somatosensory cortex were stereologically determined in 30-day-old mice and the expressions of active caspase 3 immunopositivity and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) were determined 2-36 h after the first injection. On P30, ethanol caused up to 36% neuronal loss in cortical laminae of wild-type mice. In contrast, no ethanol-induced loss was detected in Bax knockout mice. Ethanol also caused an acute bilaminar (layers II/III and V) increase in caspase 3 immunoexpression and TUNEL in wild-type mice. The changes in the expression of these markers were age- and lamina-dependent. No ethanol-induced expression of caspase 3 or TUNEL was detected in Bax knockout animals. Thus, ethanol-induced death of cortical neurons is Bax-dependent, occurs concurrently in all layers, but does not correspond to lamina- and age-dependent expression of DNA fragmentation. Both ethanol-induced and naturally occurring death of cortical neurons rely on caspase 3-dependent and independent mechanisms.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Britton SM,Miller MWdoi
10.1016/j.neuroscience.2017.11.013subject
Has Abstractpub_date
2018-01-15 00:00:00pages
278-291eissn
0306-4522issn
1873-7544pii
S0306-4522(17)30800-Xjournal_volume
369pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00494-1
更新日期：1999-01-01 00:00:00
abstract：:Previous studies found that prostaglandins in skeletal muscle play a role in evoking the exercise pressor reflex; however the role played by prostaglandins in the spinal transmission of the reflex is not known. We determined, therefore, whether or not spinal blockade of cyclooxygenase (COX) activity and/or spinal bloc...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.06.061
更新日期：2014-09-26 00:00:00
abstract：:The metabotropic glutamate receptor 4 is highly expressed presynaptically on thalamocortical neurons that are involved in the pathogenesis of generalized absence seizures. Mutant mice devoid of metabotropic glutamate receptor 4 are completely resistant to absence seizures induced by low doses of GABA type A receptor a...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.05.033
更新日期：2005-01-01 00:00:00
abstract：:Increased energy food consumption during early-life has been associated with memory impairment. Swimming training has been reported to improve memory processes in rodent models. This study aimed to evaluate whether moderate-intensity swimming training counteracts learning and memory impairment in young mice fed a high...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.11.023
更新日期：2021-01-01 00:00:00
abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00271-1
更新日期：1999-01-01 00:00:00
abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.05.039
更新日期：2011-08-25 00:00:00
abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(86)90140-5
更新日期：1986-12-01 00:00:00
abstract：:Unlike mammals, adult urodele amphibians can regenerate their spinal cord and associated ganglia, but the molecular mechanisms controlling regeneration are not fully understood. We have recently shown that expression of FGF2, a member of the fibroblast growth factor family, is induced in the progenitor cells of the re...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00321-4
更新日期：2002-01-01 00:00:00
abstract：:In rats anaesthetized with ketamine, rhythmic jaw-opening and jaw-closing movements were induced by palatal stimulation. The two masseter muscles (jaw-closing) and the four digastric muscles (jaw-opening) were fitted with electrodes, which could be used either for electrical stimulation or for recording electromyograp...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(86)90273-3
更新日期：1986-10-01 00:00:00
abstract：:Rat cerebellar granule cells, when subjected to a glucose-free environment for 4 h, developed extensive degeneration of neuronal cell bodies and their associated neurite network over the following 24 h. This neuronal damage was quantitated with a colorimetric assay using the metabolic dye 3-(4,5-dimethylthiazol-2-yl)-...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(90)90101-9
更新日期：1990-01-01 00:00:00
abstract：:Calpain-mediated tau cleavage into the neurotoxic tau45-230 fragment plays an important role in Alzheimer's disease (AD). This tau fragment accumulates mainly in the cytoplasm of degenerating neurons. However, subcellular localization studies indicated that a pool of tau45-230 associates with the cytoskeleton in hippo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.05.046
更新日期：2019-08-01 00:00:00
abstract：:Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/s0306-4522(00)00401-2
更新日期：2000-01-01 00:00:00
abstract：:The primary somatosensory cortex (S1) projects to the thalamus and brainstem somatosensory nuclei and modulates somatosensory information ascending to the S1 itself. However, the projections from the S1 to the brainstem second-order somatosensory neuron pools have not been fully studied. To address this in rats, we fi...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.10.048
更新日期：2012-01-03 00:00:00
abstract：:The monoclonal antibody PAC 1 (postsynaptic density and cytoskeleton enriched) recognizes an epitope present on two postsynaptic density-enriched glycoproteins of 130,000 (postsynaptic density-enriched glycoprotein 130) and 117,000 mol. wt (postsynaptic density-enriched glycoprotein 117), and a cytoskeleton-enriched p...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90159-7
更新日期：1994-01-01 00:00:00
abstract：:A previous study in our laboratory, involving early stage, amyloid pathology in 8-month-old transgenic mice, demonstrated a selective loss of cholinergic terminals in the cerebral and hippocampal cortices of doubly transgenic (APP(K670N,M671L)+PSl(M146L)) mice, an up-regulation in the single mutant APP(K670N,M671L) mi...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00394-4
更新日期：2003-01-01 00:00:00
abstract：:The amygdala is a temporal lobe region that is implicated in emotional information processing. The amygdala also is associated with the processing and modulation of pain sensation. Recently, we demonstrated that in nonhuman primates, the amygdala is necessary for the full expression of cannabinoid-induced antinocicept...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00356-7
更新日期：2003-01-01 00:00:00
abstract：:The action of mastoparan (a wasp venom peptide) on "maxi" Ca(2+)-activated K+ channels was studied in excised inside-out patch recordings from cultured bovine chromaffin cells, under normal conditions (160 mM K+ inside, 154 mM Na+ outside). Mastoparan, when applied on the intracellular side of the membrane reduced the...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90456-c
更新日期：1992-10-01 00:00:00
abstract：:Antisera produced in rabbits against pure fractions of cholinergic vesicles from Narcine brasiliensis were used to study cholinergic organelles in rat motor neurons. The indirect immunofluorescence method was used on perfusion-fixed material. The rats were surgically sympathectomized to remove sympathetic adrenergic a...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(85)90314-8
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:Myoclonus dystonia syndrome (MDS) is a hyperkinetic movement disorder caused, in a proportion of cases, by mutations of the maternally imprinted epsilon-sarcoglycan gene (SGCE). SGCE mutation rates vary between cohorts, suggesting genetic heterogeneity. E- and ζ-sarcoglycan are both expressed in brain tissue...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.04.034
更新日期：2014-07-11 00:00:00
abstract：:The amygdalar basolateral nuclear complex (BLC) is a cortex-like structure that receives inputs from many cortical areas. It has long been assumed that cortico-amygdalar projections, as well as inter-areal intracortical connections, arise from cortical pyramidal cells. However, recent studies have shown that GABAergic...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.03.004
更新日期：2015-05-21 00:00:00
abstract：:Isolated neurointermediate lobes or neural lobes of the rat pituitary gland attached to the pituitary stalk were incubated in vitro and the spontaneous or electrically (pituitary stalk stimulation, 5 Hz, 1,500 pulses) evoked release of 5-hydroxytryptamine was determined. The evoked release of 5-hydroxytryptamine from ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90085-6
更新日期：1987-11-01 00:00:00
abstract：:Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.03.020
更新日期：2016-06-02 00:00:00
abstract：:Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel superfamily composed of alpha and beta subunits with specific structural, functional and pharmacological properties. In this study we have used immunohistochemistry to investigate the presence of nicotinic acetylcholine receptor sub...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00223-3
更新日期：2002-01-01 00:00:00
abstract：:The calcium binding protein, Calbindin-D28k, is known to be localized within spiny neurons of the matrix of the dorsal striatum, caudate-putamen nuclei. This compartment is also known to contain an abundance of GABAergic neurons and to receive extensive input from excitatory limbic and cortical afferents whose activat...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00441-6
更新日期：1996-03-01 00:00:00
abstract：:Nucleotide-activated P2X channels and P2Y metabotropic receptors participate in nociceptive signaling. Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y agonist) and AMP. They provide...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.07.044
更新日期：2011-10-13 00:00:00
abstract：:I have prepared a number of monoclonal antibodies to chromaffin cell membranes. One of these antibodies recognizes a number of antigenically related proteins that are present in all tissues examined. In the adrenal, these proteins are completely excluded from chromaffin granules but are present in other subcellular me...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90204-1
更新日期：1987-07-01 00:00:00
abstract：:High densities of mRNAs for three rhythm-related genes, rPeriod1 (rPer1), rPer2, and rClock, which share high homology in Drosophila and mice, were found in the hypothalamic suprachiasmatic nucleus (SCN). The SCN, however, is not the only brain region that expresses these genes. To understand the distributions and pos...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00004-6
更新日期：2003-01-01 00:00:00
abstract：:Stress affects brain activity and promotes long-term changes in multiple neural systems. Exposure to stressors causes substantial effects on the perception and response to pain. In several animal models, chronic stress produces lasting hyperalgesia. The insular (IC) and anterior cingulate cortices (ACC) are the region...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2013.11.045
更新日期：2014-02-14 00:00:00
abstract：:Substance P is known to elicit diverse actions via activating multiple subtypes of tachykinin receptors, and these actions appear to be involved not only in synaptic transmission but also in synaptic plasticity during development of the mammalian central nervous system. The availability of sensitive quantitation of in...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(96)00198-4
更新日期：1996-10-01 00:00:00
abstract：:Flies acquire information about self-rotation via Coriolis forces detected by their moving halteres. Information processing in the haltere system was analysed by exploiting the method of simulating rotational stimuli by vibrating the fly's body and simultaneously observing compensatory head and wing reactions. Althoug...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90068-x
更新日期：1994-07-01 00:00:00
