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Mastoparan blockade of currents through Ca(2+)-activated K+ channels in bovine chromaffin cells.

Abstract：

:The action of mastoparan (a wasp venom peptide) on "maxi" Ca(2+)-activated K+ channels was studied in excised inside-out patch recordings from cultured bovine chromaffin cells, under normal conditions (160 mM K+ inside, 154 mM Na+ outside). Mastoparan, when applied on the intracellular side of the membrane reduced the open channel probability in a concentration dependent manner. Changes in the channel kinetics were complex. The histograms of the open dwell times were all described by either one or two exponentials. Mastoparan shortened the mean duration of the major (long) component and to a lesser extent the minor (short) component. Closed dwell times, were described by three exponentials. While the short (major) component was prolonged by mastoparan, and the intermediate component was unaffected, the long component was shortened. Overall mean closed times were prolonged. The changes in channel kinetics could only partly be explained by a channel-blocking mechanism, even when assuming that mastoparan acts as both an intermediate and a slow channel blocker suggesting that it affects gating mechanism. The fact that mastoparan is a calmodulin inhibitor and a G-protein activator raises the possibility that in bovine chromaffin cells, either the membrane-bound calmodulin or a G-protein, plays a role in the modulation of Ca(2+)-activated K+ channels.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Glavinović MI,Joshi A,Trifaró JM

doi

10.1016/0306-4522(92)90456-c

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

675-84

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(92)90456-C

journal_volume

50

pub_type

杂志文章

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