Abstract：
:Neuronal gap junctions in the brain, providing intercellular electrotonic signal transfer, have been implicated in physiological and behavioral correlates of learning and memory. In connexin31.1 (Cx31.1) knockout (KO) mice the coding region of the Cx31.1 gene was replaced by a LacZ reporter gene. We investigated the impact of Cx31.1 deficiency on open-field exploration, the behavioral response to an odor, non-selective attention, learning and memory performance, and the levels of memory-related proteins in the hippocampus, striatum and the piriform cortex. In terms of behavior, the deletion of the Cx31.1 coding DNA in the mouse led to increased exploratory behaviors in a novel environment, and impaired one-trial object recognition at all delays tested. Despite strong Cx31.1 expression in the peripheral and central olfactory system, Cx31.1 KO mice exhibited normal behavioral responses to an odor. We found increased levels of acetylcholine esterase (AChE) and cAMP response element-binding protein (CREB) in the striatum of Cx31.1 KO mice. In the piriform cortex the Cx31.1 KO mice had an increased heterogeneity of CREB expression among neurons. In conclusion, gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of AChE and CREB in the striatum and piriform cortex.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Dere E,Zheng-Fischhöfer Q,Viggiano D,Gironi Carnevale UA,Ruocco LA,Zlomuzica A,Schnichels M,Willecke K,Huston JP,Sadile AGdoi
10.1016/j.neuroscience.2008.01.077subject
Has Abstractpub_date
2008-05-02 00:00:00pages
396-405issue
2eissn
0306-4522issn
1873-7544pii
S0306-4522(08)00104-8journal_volume
153pub_type
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