Effect of prolonged in vitro lithium treatment on calcium transients in frog twitch muscle fibres and its reversal by exogenous myo-inositol.

Abstract:

:Using arsenazo III as an intracellular indicator to monitor the calcium transients elicited by voltage-clamp depolarizing pulse, the effect of prolonged in vitro lithium treatment on excitation--contraction coupling in frog twitch muscle fibres was investigated. Incubation in 10 mM Li+ Ringer's solution for 2 days caused a 46% increase in the amplitude of the calcium transients, while treatment with 30 mM Li+ for 2 days produced a depression of 44%. Shortening the bathing time to 1 day, the decrease of calcium transients caused by 30 mM Li+ was reversed to a small increase. For the 2-day incubation, both the increase in the amplitude with 10 mM and the decrease with 30 mM Li+ were abolished by the presence of 1 mM myo-inositol in the bathing medium. These results imply that the turnover of inositol phospholipids is involved in regulating excitation-contraction coupling in skeletal muscle fibres.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Zhu PH,Fu DX

doi

10.1016/0306-4522(90)90240-5

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

271-8

issue

1

eissn

0306-4522

issn

1873-7544

pii

0306-4522(90)90240-5

journal_volume

39

pub_type

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