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p38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,488H-induced conditioned place aversion.

Abstract：

:κ opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible involvement of p38 MAPK in the aversive effects induced by κ opioid receptor activation. We found that the κ opioid receptor agonist trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzenacetamide methanesulfonate salt (U50,488H) produced significant place aversion in mice as measured by the conditioned place preference procedure, accompanied with significant p38 MAPK activation in the amygdala, but not in the nucleus accumbens and hippocampus. Stereotaxic microinjection of the p38 MAPK inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridy-l)-1H-imidazole (SB203580) into amygdala significantly inhibited p38 MAPK activation and completely blocked the conditioned place aversion in mice. Thus, these results suggested that activation of p38 MAPK in the amygdala was required to mediate κ opioid receptor-induced aversive behavior.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Zan GY,Wang Q,Wang YJ,Chen JC,Wu X,Yang CH,Chai JR,Li M,Liu Y,Hu XW,Shu XH,Liu JG

doi

10.1016/j.neuroscience.2016.01.052

subject

Has Abstract

pub_date

2016-04-21 00:00:00

pages

122-8

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(16)00080-4

journal_volume

320

pub_type

杂志文章

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