Simvastatin increases excitability in the hippocampus via a PI3 kinase-dependent mechanism.

abstract：:Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that this ADX effect on behavioral sensitization in the DBA/2 strain involves changes in midbrain dopamine systems that do not occur in the C57BL/6 strain. For that purpose, w...

journal_title：Neuroscience

authors： de Jong IE,Steenbergen PJ,de Kloet ER

更新日期：2008-05-15 00:00:00

abstract：:Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study ...

journal_title：Neuroscience

authors： Dong J,Lu C,Chen C,Li H,Liu X,Mei L

更新日期：2020-03-15 00:00:00

abstract：:Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an excess of peripheral ailments, OP intoxication induces status epilepticus (SE) which if left untreated may lead to permanent brain damage or d...

journal_title：Neuroscience

authors： Barker BS,Spampanato J,McCarren HS,Smolik M,Jackson CE,Hornung EN,Yeung DT,Dudek FE,McDonough JH

更新日期：2020-01-15 00:00:00

abstract：:In the spinal cord, glycine and γ-amino butyric acid (GABA) are inhibitory neurotransmitters. However, the ontogeny of the glycinergic network remains unclear. To address this point, we examined the developmental formation of glycinergic terminals by immunohistochemistry for glycine transporter 2 (GlyT2), a marker of ...

journal_title：Neuroscience

authors： Sunagawa M,Shimizu-Okabe C,Kim J,Kobayashi S,Kosaka Y,Yanagawa Y,Matsushita M,Okabe A,Takayama C

更新日期：2017-02-20 00:00:00

abstract：:Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. In the present study, the possibility that Arc would be specifically upregulated in rats during the acquisition of a quickly...

journal_title：Neuroscience

authors： Kelly MP,Deadwyler SA

更新日期：2002-01-01 00:00:00

abstract：:The uncrossed retinotectal projection of rats undergoes extensive axonal elimination and subsequent growth of axonal arbors in topographically appropriate territories within the first two/three postnatal weeks. Nitric oxide has been implicated in development and stabilization of synapses in the retinotectal pathway si...

journal_title：Neuroscience

authors： Campello-Costa P,Fosse-Júnior AM,Oliveira-Silva P,Serfaty CA

更新日期：2006-01-01 00:00:00

abstract：:Respiratory disturbances are a primary phenotype of the neurological disorder, Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Mouse models generated with null mutations in Mecp2 mimic respiratory abnormalities in RTT girls. Large deletions, however, are see...

journal_title：Neuroscience

authors： Bissonnette JM,Schaevitz LR,Knopp SJ,Zhou Z

更新日期：2014-05-16 00:00:00

abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...

journal_title：Neuroscience

authors： Torp R,Head E,Milgram NW,Hahn F,Ottersen OP,Cotman CW

更新日期：2000-01-01 00:00:00

abstract：:The clinical course of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) is closely related to hypoxia. The normal response to hypoxia involves two pathways in particular: the hypoxia inducible factor 1α (HIF-1α) pathway (which notably controls the synthesis of vascular endothelial growth fact...

journal_title：Neuroscience

authors： Moreau C,Gosset P,Kluza J,Brunaud-Danel V,Lassalle P,Marchetti P,Defebvre L,Destée A,Devos D

更新日期：2011-01-13 00:00:00

abstract：:The purpose of the present study was to test the respective roles of the intrinsic neurons and of the catecholaminergic fibers in two behaviors elicited by electrical stimulation of the lateral hypothalamus, intracranial self-stimulation and the increase in locomotor activity produced by noncontingent stimulation. One...

journal_title：Neuroscience

authors： Velley L,Verney C,Kempf E,Berger B

更新日期：1988-05-01 00:00:00

abstract：:An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to exa...

journal_title：Neuroscience

authors： Rizzo FR,Federici M,Mercuri NB

更新日期：2018-05-01 00:00:00

abstract：:A histochemical stain to detect cobalt in cells was used to investigate the ionic basis of heat transduction in mammalian primary afferent neurons. Cultured dorsal root ganglion neurons from the adult rat were exposed to 10-min heat stimuli in an extracellular solution containing cobalt ions. When accumulated intracel...

journal_title：Neuroscience

authors： Reichling DB,Barratt L,Levine JD

更新日期：1997-03-01 00:00:00

abstract：:Despite extensive investigations into the mechanisms of aerobic respiration in mitochondria, the spontaneous metabolic activity of individual cells within a whole animal has not been observed in real time. Consequently, little is known about whether and how the level of mitochondrial energy metabolism is regulated in ...

journal_title：Neuroscience

authors： Kazama H,Ichikawa A,Kohsaka H,Morimoto-Tanifuji T,Nose A

更新日期：2008-03-03 00:00:00

abstract：:Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors negatively coupled to adenylyl cyclase, was investigated in vivo by the intraventricular administration in the rat, compared with that of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-C...

journal_title：Neuroscience

authors： Kwak S,Miyamoto M,Ishida M,Shinozaki H

更新日期：1996-08-01 00:00:00

abstract：:Brain ischemia induces a marked response of resident microglia and hematopoietic cells including monocytes/macrophages. The present study was designed to assess the distribution of microglia/macrophages in cerebral ischemia using bone marrow chimera mice known to express enhanced green fluorescent protein (EGFP). At 2...

journal_title：Neuroscience

authors： Tanaka R,Komine-Kobayashi M,Mochizuki H,Yamada M,Furuya T,Migita M,Shimada T,Mizuno Y,Urabe T

更新日期：2003-01-01 00:00:00

abstract：:Field recordings of responses to activation of corticostriatal afferents were made in coronally sectioned rat brain slices. Each recording site was categorized according to its medial to lateral and rostral to caudal position to investigate anatomical differences in synaptic plasticity. Individual responses were highl...

journal_title：Neuroscience

authors： Smith R,Musleh W,Akopian G,Buckwalter G,Walsh JP

更新日期：2001-01-01 00:00:00

abstract：:Small (SK) and intermediate (IK) conductance calcium-activated potassium channels are candidate ion channels for the regulation of excitability in nociceptive neurones. We have used unique peptide-directed antisera to describe the immunocytochemical distribution of the known isoforms of these ion channels in dorsal ro...

journal_title：Neuroscience

authors： Mongan LC,Hill MJ,Chen MX,Tate SN,Collins SD,Buckby L,Grubb BD

更新日期：2005-01-01 00:00:00

abstract：:Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the firs...

journal_title：Neuroscience

authors： Mirdamadi JL,Suzuki LY,Meehan SK

更新日期：2017-09-17 00:00:00

abstract：:Endothelin 1 (ET-1) exerts normally a powerful vasoconstrictor role in the control of the brain microcirculation. In altered states, such as following traumatic brain injury (TBI), it may contribute to the development of ischemia and/or secondary cell injury. Because little is known of ET-1's cellular compartmentaliza...

journal_title：Neuroscience

authors： Petrov T,Steiner J,Braun B,Rafols JA

更新日期：2002-01-01 00:00:00

abstract：:The effect of systemic administration of domoic acid, a potent structural analogue of kainic acid, on the mouse hippocampus has been studied using light and electron microscopic techniques. Intraperitoneal injections of either domoic acid (4 mg/kg) or kainic acid (32 mg/kg) produced a series of behavioural changes inc...

journal_title：Neuroscience

authors： Strain SM,Tasker RA

更新日期：1991-01-01 00:00:00

abstract：:The present study tests the hypothesis that propentofylline, an adenosine re-uptake inhibitor, will reduce free radical generation during cerebral hypoxia. Ten newborn piglets were pretreated with propentofylline (10 mg/kg), five of which were subjected to hypoxia, while the other five were maintained at normoxia. Fiv...

journal_title：Neuroscience

authors： Numagami Y,Marro PJ,Mishra OP,Delivoria-Papadopoulos M

更新日期：1998-06-01 00:00:00

abstract：:The findings in this feline study indicate that the enkephalin-positive subcommissural part of the globus pallidus, which is known to contain GABA and cholinergic cells projecting to the cortex, is innervated by the anterodorsal region of the caudate nucleus, but not by the core. Like stimulation of a particular subcl...

journal_title：Neuroscience

authors： Cools AR,Spooren W,Bezemer R,Cuypers E,Jaspers R,Groenewegen H

更新日期：1989-01-01 00:00:00

abstract：:The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). However, these compounds also inhibit many other enzymes, any of which may play a role in their toxicity. We tested the neurotoxic mechanism of two organophosphorous insecticides, chlorpyrifos a...

journal_title：Neuroscience

authors： Rush T,Liu XQ,Hjelmhaug J,Lobner D

更新日期：2010-03-31 00:00:00

abstract：:A previous study investigating potential adult hippocampal neurogenesis in microchiropteran bats failed to reveal a strong presence of this neural trait. As microchiropterans have a high field metabolic rate and a small body mass, it is possible that capture/handling stress may lead to a decrease in the detectable pre...

journal_title：Neuroscience

authors： Chawana R,Alagaili A,Patzke N,Spocter MA,Mohammed OB,Kaswera C,Gilissen E,Bennett NC,Ihunwo AO,Manger PR

更新日期：2014-09-26 00:00:00

abstract：:This study evaluated Fos-like immunoreactivity in lumbar spinal cord neurons following intense cold stimulation and then the modifications induced by opioid administration. Under urethane anaesthesia, the rat's right foot was stimulated by holding it in a regulated temperature bath at 15, 10, 0, -10, -15, -17.5 or -20...

journal_title：Neuroscience

authors： Abbadie C,Honoré P,Besson JM

更新日期：1994-03-01 00:00:00

abstract：:The activity of 62 antidromically identified prepositus hypoglossi neurons was recorded in 10 alert cats during spontaneous, vestibular or visually induced eye movements. Neurons were antidromically activated from stimulating electrodes implanted in the ipsilateral medial longitudinal fasciculus (n = 24), the ipsilate...

journal_title：Neuroscience

authors： Delgado-García JM,Vidal PP,Gómez C,Berthoz A

更新日期：1989-01-01 00:00:00

abstract：:Arachidonic acid (20:4) is a component of membrane lipids that has been implicated as a messenger both in physiological and pathophysiological processes, including ischemic injury and synaptic plasticity. In order to clarify direct trophic or toxic effects of arachidonic acid on central neurons, primary cultures of ra...

journal_title：Neuroscience

authors： Okuda S,Saito H,Katsuki H

更新日期：1994-12-01 00:00:00

abstract：:Acetylcholine (ACh) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ACh degrading enzyme acetylcholinesterase (AChE). Here we report that physostigmine alone can also dose-dependently induce γ-oscillations in rat hippocampal slices. We ...

journal_title：Neuroscience

authors： Hollnagel JO,Ul Haq R,Behrens CJ,Maslarova A,Mody I,Heinemann U

更新日期：2015-01-22 00:00:00

abstract：:The hypothesis that attention deficits induced by the hypofunction of N-methyl d-aspartate (NMDA) receptors in the prefrontal cortex (PFC) might be associated with increased glutamate release and changes in the phosphorylation of the cyclic adenosine monophosphate response element-binding protein on serine 133 (p-S(13...

journal_title：Neuroscience

authors： Pozzi L,Baviera M,Sacchetti G,Calcagno E,Balducci C,Invernizzi RW,Carli M

更新日期：2011-03-10 00:00:00

abstract：:We have previously described a population of 5-hydroxytryptamine neurons which repetitively fires bursts of usually two (but occasionally three or four) action potentials, with a short (<20 ms) interspike interval within a regular low-frequency firing pattern. Here we used a paradigm of electrical stimulation comprisi...

journal_title：Neuroscience

authors： Gartside SE,Hajós-Korcsok E,Bagdy E,Hársing LG Jr,Sharp T,Hajós M

更新日期：2000-01-01 00:00:00