Opposite effects of ibotenic acid and 6-hydroxydopamine lesions of the lateral hypothalamus on intracranial self-stimulation and stimulation-induced locomotion.

abstract：:Intracellular recording and staining was applied to study non-pyramidal neurons in the guinea-pig hippocampus. To avoid accidental impalement of pyramidal or granule cells, two hippocampal regions known to be devoid of pyramidal or granule cells were chosen. In transverse and longitudinal slices, neurons of the deep h...

journal_title：Neuroscience

authors： Misgeld U,Frotscher M

更新日期：1986-09-01 00:00:00

abstract：:The role of serotonin1A and serotonin4 receptors in the modulation of synaptic inhibition in the dentate gyrus of guinea-pig hippocampal slices was studied. The effects of serotonin (5-hydroxytryptamine) on hilar neurons and on inhibitory postsynaptic potentials in granule cells were compared using intracellular recor...

journal_title：Neuroscience

authors： Bijak M,Misgeld U

更新日期：1997-06-01 00:00:00

abstract：:Vascular endothelial cells were activated during acute ischemic brain injury, which could induce neural progenitor cell proliferation and migration. However, the mechanism was still unknown. In the current study, we explored whether vascular endothelial cells promoted neural progenitor cell proliferation and whether m...

journal_title：Neuroscience

authors： Zhou S,Gao B,Sun C,Bai Y,Cheng D,Zhang Y,Li X,Zhao J,Xu D

更新日期：2020-08-10 00:00:00

abstract：:Environmental enrichment of laboratory animals leads to multi-faceted changes to physiology, health and disease prognosis. An important and under-appreciated factor in enhancing cognition through environmental manipulation may be improved basic sensory function. Previous studies have highlighted changes in cortical se...

journal_title：Neuroscience

authors： Devonshire IM,Dommett EJ,Grandy TH,Halliday AC,Greenfield SA

更新日期：2010-10-13 00:00:00

abstract：:A significant decline in executive system function mediated by the prefrontal cortex (PFC) often occurs with normal aging. In vitro slice studies have shown that layer 2/3 pyramidal cells in the monkey PFC exhibit increased action potential (AP) firing rates which may, in part, contribute to this decline. Given that l...

journal_title：Neuroscience

authors： Luebke JI,Chang YM

更新日期：2007-12-12 00:00:00

abstract：:The transforming growth factor beta-activated kinase 1 (TAK1), a member of the Mitogen-activated protein kinase kinase kinase family, is characterized as a key regulator in inflammatory and apoptosis signaling pathways. The aim of the present study was to evaluate the role of the TAK1 pathway in experimental traumatic...

journal_title：Neuroscience

authors： Zhang D,Hu Y,Sun Q,Zhao J,Cong Z,Liu H,Zhou M,Li K,Hang C

更新日期：2013-05-15 00:00:00

abstract：:Puberty is a critical period of development during which the reemergence of gonadotropin-releasing hormone secretion from the hypothalamus triggers a cascade of hormone-dependent processes. Maturation of specific brain regions including the prefrontal cortex occurs during this window, but the complex mechanisms underl...

journal_title：Neuroscience

authors： Morrison KE,Rodgers AB,Morgan CP,Bale TL

更新日期：2014-04-04 00:00:00

abstract：:Neuronal apoptosis plays important roles in the early brain injury after subarachnoid hemorrhage (SAH). This study first showed that inhibition of activating transcription factor 6 (ATF6) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-mediated apoptosis and blood-brain-barrier (BBB) disruption after SAH. ...

journal_title：Neuroscience

authors： Xu W,Gao L,Li T,Zheng J,Shao A,Zhang J

更新日期：2018-09-15 00:00:00

abstract：:The hippocampus is a multifaceted, complex brain structure considered to be the learning center. The use of primary hippocampal cell cultures has uncovered important cellular mechanisms involved in overall physiological function. Yet, the use of primary culture is inherently difficult, and the lack of immortalized cel...

journal_title：Neuroscience

authors： Gingerich S,Kim GL,Chalmers JA,Koletar MM,Wang X,Wang Y,Belsham DD

更新日期：2010-09-29 00:00:00

abstract：:Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainic acid neurotoxicity...

journal_title：Neuroscience

authors： Simonian NA,Getz RL,Leveque JC,Konradi C,Coyle JT

更新日期：1996-12-01 00:00:00

abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

journal_title：Neuroscience

authors： Lowe G,Buerk DG,Ma J,Gelperin A

更新日期：2008-05-15 00:00:00

abstract：:Chronic administration of mu-opioid receptor agonists is known to produce adaptive changes within noradrenergic neurons of the locus coeruleus. Although mu-opioid receptors are densely expressed by locus coeruleus neurons, the effects of acute and chronic administration of agonists on the subcellular distribution of m...

journal_title：Neuroscience

authors： Van Bockstaele EJ,Commons KG

更新日期：2001-01-01 00:00:00

abstract：:Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...

journal_title：Neuroscience

authors： Ju G,Melander T,Ceccatelli S,Hökfelt T,Frey P

更新日期：1987-02-01 00:00:00

abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

journal_title：Neuroscience

authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

更新日期：1993-10-01 00:00:00

abstract：:In animal models of transients ischemia, selective vulnerability and delayed neuronal death in the hippocampus have been extensively described. However, little is known about selective damage in the neocortex and the thalamus, even though deficits in sensorimotor function are common in humans surviving hypoxic/ischemi...

journal_title：Neuroscience

authors： Lin CS,Polsky K,Nadler JV,Crain BJ

更新日期：1990-01-01 00:00:00

abstract：:The inhibitory neurotransmitter GABA is synthesized by glutamic acid decarboxylase (GAD), and two isoforms of this enzyme exist: GAD65 and GAD67. Immunocytochemical studies of the spinal cord have shown that whilst both are present in the dorsal horn, GAD67 is the predominant form in the ventral horn. The present stud...

journal_title：Neuroscience

authors： Mackie M,Hughes DI,Maxwell DJ,Tillakaratne NJ,Todd AJ

更新日期：2003-01-01 00:00:00

abstract：:Cultured neurons offer many advantages over a slice preparation for whole-cell patch-clamp studies, such as better control over the environment and space clamp control. However, heterogeneous cultures of neurons present problems in distinguishing the cell type from which recordings are made. The present study uses cor...

journal_title：Neuroscience

authors： Mynlieff M

更新日期：1999-01-01 00:00:00

abstract：:We have developed a stroke model involving middle cerebral artery occlusion in the rat which elicits changes in cardiac and autonomic variables that are similar to those observed clinically. It is likely that these neurogenic autonomic responses are mediated by changes in neurotransmitter systems subsequent to the str...

journal_title：Neuroscience

authors： Allen GV,Cheung RT,Cechetto DF

更新日期：1995-10-01 00:00:00

abstract：:Simvastatin is an HMG-CoA reductase inhibitor commonly used in the clinic to treat hypercholesterolemia. In addition, simvastatin has been shown to cross the blood-brain barrier and pleiotropic effects of simvastatin have been reported including anti-inflammatory properties, enhancement of neurite outgrowth, and memor...

journal_title：Neuroscience

authors： Métais C,Hughes B,Herron CE

更新日期：2015-04-16 00:00:00

abstract：:Serotonin induces 'spontaneous' (non-electrically evoked) excitatory postsynaptic currents in layer V pyramidal neurons in the prefrontal cortex. This is likely due to a serotonin2A receptor-mediated focal release of glutamate onto apical dendrites. In addition, activation of the serotonin2A receptor selectively enhan...

journal_title：Neuroscience

authors： Stutzmann GE,Marek GJ,Aghajanian GK

更新日期：2001-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

journal_title：Neuroscience

authors： van Vliet EA,Aronica E,Gorter JA

更新日期：2014-09-26 00:00:00

abstract：:The neurochemical and behavioural recovery following unilateral and bilateral lesions of the nucleus basalis was investigated in adult male Wistar rats 20 days and 6 months after surgery. The lesions were made by stereotaxic injections of ibotenic acid. Twenty days after surgery there was a statistically significant c...

journal_title：Neuroscience

authors： Casamenti F,Di Patre PL,Bartolini L,Pepeu G

更新日期：1988-01-01 00:00:00

abstract：:Homer is a postsynaptic density (PSD) scaffold protein that is involved in synaptic plasticity, calcium signaling and neurological disorders. Here, we use pre-embedding immunogold electron microscopy to illustrate the differential localization of three Homer gene products (Homer 1, 2, and 3) in different regions of th...

journal_title：Neuroscience

authors： Tao-Cheng JH,Thein S,Yang Y,Reese TS,Gallant PE

更新日期：2014-04-25 00:00:00

abstract：:Neurotrophic factors are known to promote neuronal survival during development and after acute brain injury. Recent data suggest that some neuropeptides also exhibit neurotrophic activities, as shown for the pituitary adenylate cyclase activating polypeptide, which increases the survival of various neuronal population...

journal_title：Neuroscience

authors： Skoglösa Y,Lewén A,Takei N,Hillered L,Lindholm D

更新日期：1999-04-01 00:00:00

abstract：:Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...

journal_title：Neuroscience

authors： Mychasiuk R,Hehar H,Ma I,Kolb B,Esser MJ

更新日期：2015-03-12 00:00:00

abstract：:Mast cells are known for their participation in immediate and, more recently, delayed hypersensitivity reactions. They have been found in the meninges and certain brain areas where they are strictly perivascular, in close apposition to neurons, and they are activated by direct nerve stimulation or by neuropeptides. In...

journal_title：Neuroscience

authors： Theoharides TC,Dimitriadou V,Letourneau R,Rozniecki JJ,Vliagoftis H,Boucher W

更新日期：1993-12-01 00:00:00

abstract：:Hippocampal cholinergic neurostimulating peptide, an undecapeptide originally isolated from the hippocampus of young rats, enhances acetylcholine synthesis in rat medial septal nucleus in vitro. Hippocampal cholinergic neurostimulating peptide is derived from the N-terminal region of its 21-kmol.wt precursor protein. ...

journal_title：Neuroscience

authors： Iwase T,Ojika K,Matsukawa N,Nishino H,Yamamoto T,Okada H,Fujimori O,Ueda R

更新日期：2001-01-01 00:00:00

abstract：:Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibite...

journal_title：Neuroscience

authors： Ruddy KL,Jaspers E,Keller M,Wenderoth N

更新日期：2016-10-01 00:00:00

abstract：:The expression of voltage-gated sodium channels is regulated at multiple levels, and in this study we addressed the potential for alternative splicing of the Na(v)1.2, Na(v)1.3, Na(v)1.6 and Na(v)1.7 mRNAs. We isolated novel mRNA isoforms of Na(v)1.2 and Na(v)1.3 from adult mouse and rat dorsal root ganglia (DRG), Na(...

journal_title：Neuroscience

authors： Kerr NC,Holmes FE,Wynick D

更新日期：2008-08-26 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00