Abstract:
:Puberty is a critical period of development during which the reemergence of gonadotropin-releasing hormone secretion from the hypothalamus triggers a cascade of hormone-dependent processes. Maturation of specific brain regions including the prefrontal cortex occurs during this window, but the complex mechanisms underlying these dynamic changes are not well understood. Particularly, the potential involvement of epigenetics in this programming has been under-examined. The epigenome is known to guide earlier stages of development, and it is similarly poised to regulate vital pubertal-driven brain maturation. Further, as epigenetic machinery is highly environmentally responsive, its involvement may also lend this period of growth to greater vulnerability to external insults, resulting in reprogramming and increased disease risk. Importantly, neuropsychiatric diseases commonly present in individuals during or immediately following puberty, and environmental perturbations including stress may precipitate disease onset by disrupting the normal trajectory of pubertal brain development via epigenetic mechanisms. In this review, we discuss epigenetic processes involved in pubertal brain maturation, the potential points of derailment, and the importance of future studies for understanding this dynamic developmental window and gaining a better understanding of neuropsychiatric disease risk.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Morrison KE,Rodgers AB,Morgan CP,Bale TLdoi
10.1016/j.neuroscience.2013.11.014subject
Has Abstractpub_date
2014-04-04 00:00:00pages
17-24eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00954-8journal_volume
264pub_type
杂志文章,评审相关文献
NEUROSCIENCE文献大全abstract::Direct injections into the cerebroventricles have been extensively utilized in neurophysiological studies. Mapping the distribution of injectate after intracerebroventricular injection has been made only by post mortem analysis, and the dynamic distribution of injectate within the brain has not been well characterized...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00519-3
更新日期:1999-03-01 00:00:00
abstract::To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00611-3
更新日期:1999-01-01 00:00:00
abstract::The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, making this technique unsuitable for neurotrophin administration in a cl...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.11.057
更新日期:2008-03-27 00:00:00
abstract::Rapid eye movement sleep decreases between 10 and 30 days postnatally in the rat. The pedunculopontine nucleus is known to modulate waking and rapid eye movement sleep, and pedunculopontine nucleus neurons are thought to be hyperpolarized by noradrenergic input from the locus coeruleus. The goal of the study was to in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.04.045
更新日期:2006-08-25 00:00:00
abstract::Status epilepticus is a major medical emergency that results in significant alteration of neuronal function. Status epilepticus involves seizure activity recurring frequently enough to induce a sustained alteration in brain function. This study was initiated to investigate how status epilepticus affects the activity o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00462-5
更新日期:2000-01-01 00:00:00
abstract::Food restriction has been shown to be beneficial for a number of brain processes. In the current study, we characterized the impact of food restriction on hippocampal damage 70 days following ischemia. We assessed memory and cognitive flexibility of ad libitum fed (AL) and food-restricted (FR) animals using complex de...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.05.062
更新日期:2008-09-22 00:00:00
abstract::How seizures arise and recur in epilepsy is unknown. Recent genetic, pharmacological and electrophysiological data indicate a significant but undisclosed role for voltage-dependent calcium channels. Since the contribution such channels make to nerve function reflects the targeting of discrete subtypes to distinct cell...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00371-1
更新日期:1999-01-01 00:00:00
abstract::Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2020.04.038
更新日期:2020-12-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective degeneration and death of motoneurons in the spinal cord, brainstem and motor cortex which causes progressive muscle weakness and paralysis. Although the molecular mechanisms causing the disease remain unknown, excitotoxi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.10.060
更新日期:2009-02-18 00:00:00
abstract::Localized distension of the intestine evokes an ascending excitatory reflex and a descending inhibitory reflex in the circular muscle layer. The sequential activation of these two reflexes is believed to underlie the motor pattern of peristalsis, which is responsible for the co-ordinated propulsion of intestinal conte...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(96)00040-1
更新日期:1996-07-01 00:00:00
abstract::The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00568-5
更新日期:1999-01-01 00:00:00
abstract::Using an indirect immunofluorescence method the distribution of vasoactive intestinal peptide (VIP) immunoreactivity was studied in human foetus and newborn infant spinal cord and dorsal root ganglia. Further, for comparison some newborn infant brains were also investigated. Vasoactive intestinal peptide-like immunore...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90173-3
更新日期:1985-01-01 00:00:00
abstract::It has recently been demonstrated that alpha-bungarotoxin receptors, which behave as functional nicotinic receptors, are present in chick CNS. In this paper, we report the purification and characterization of a functional alpha-bungarotoxin receptor from chick cerebellum, a nervous tissue in which a clear inhibition o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90386-g
更新日期:1992-09-01 00:00:00
abstract::It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely with...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00067-s
更新日期:1995-05-01 00:00:00
abstract::The amygdalar basolateral nuclear complex (BLC) is a cortex-like structure that receives inputs from many cortical areas. It has long been assumed that cortico-amygdalar projections, as well as inter-areal intracortical connections, arise from cortical pyramidal cells. However, recent studies have shown that GABAergic...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.03.004
更新日期:2015-05-21 00:00:00
abstract::In rats anaesthetized with ketamine, rhythmic jaw-opening and jaw-closing movements were induced by palatal stimulation. The two masseter muscles (jaw-closing) and the four digastric muscles (jaw-opening) were fitted with electrodes, which could be used either for electrical stimulation or for recording electromyograp...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90273-3
更新日期:1986-10-01 00:00:00
abstract::Localization of luteotrophic hormone-releasing hormone (LHRH) was examined by immunocytochemistry in untreated male rats and rats that received an anterior hypothalamic deafferentation. Gonadotrophic function was assessed by examining testicular weight and morphology. All of the antisera used in this study were able t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)90012-4
更新日期:1982-01-01 00:00:00
abstract::The distribution of D1 dopamine receptors was studied autoradiographically in the basal ganglia of the cat, monkey and human. These receptor binding sites were labeled directly with the D1-selective antagonist [3H]SCH 23390, and ligand-binding assays were performed concurrently. Serial- or same-action analysis permitt...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90130-3
更新日期:1988-07-01 00:00:00
abstract::The interconnectivity between brain development and the immune system has become an area of interest for many neuroscientists. However, to date, a limited number of known immune mediators of the peripheral nervous system (PNS) have been found to influence the development of the central nervous system (CNS). FOXP3 is a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.06.032
更新日期:2020-08-21 00:00:00
abstract::Few studies have investigated whether neuronal function in the amygdaloid complex is necessary for the occurrence of the cardiovascular response to natural (unconditioned) environmental threats. In the present investigation in conscious unrestrained Sprague-Dawley rats we inactivated neuronal function in the amygdaloi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.10.008
更新日期:2013-01-03 00:00:00
abstract::We revealed the structural features of astrocytes by means of light microscopy, confocal laser scanning microscopy and high voltage electron microscopy, and estimated their numerical densities in the mouse hippocampus. The high voltage electron microscope examinations of Golgi-impregnated astrocytes clearly disclosed ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00041-6
更新日期:2002-01-01 00:00:00
abstract::Direct intracerebral administration of N-methyl-D-aspartate typically produces focal brain injury. (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-immi ne maleate (MK-801), a non-competitive N-methyl-D-aspartate antagonist, can protect against N-methyl-D-aspartate-mediated brain injury when administered sho...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90377-g
更新日期:1990-01-01 00:00:00
abstract::The levels of 5-hydroxytryptamine and tachykinin neuropeptides substance P, neurokinin A, neurokinin B and neuropeptide K were measured in the spinal cord of rats treated by intraventricular injection of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine. The spinal cord levels of 5-hydroxytryptamine as mea...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90231-c
更新日期:1991-01-01 00:00:00
abstract::Brainstem projections to hypoglossal motoneurons innervating the intrinsic and extrinsic muscles of the tongue were determined using the transneuronal transfer of Herpes simplex virus-1. Injections of Herpes simplex virus-1 into the intrinsic muscles of the anterior tongue, the geniohyoid and styloglossus muscles each...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00203-u
更新日期:1995-10-01 00:00:00
abstract::The anatomical distributions and affinity states of dopamine D1 and D2 receptors were compared in the rat central nervous system using quantitative autoradiography. [3H]SCH23390 and [3H]spiperone (in the presence of 100 nM mianserin) were used to label the D1 and D2 receptors, respectively. The densities of D1 and D2 ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90168-1
更新日期:1989-01-01 00:00:00
abstract::The uncrossed retinotectal projection of rats undergoes extensive axonal elimination and subsequent growth of axonal arbors in topographically appropriate territories within the first two/three postnatal weeks. Nitric oxide has been implicated in development and stabilization of synapses in the retinotectal pathway si...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.12.039
更新日期:2006-01-01 00:00:00
abstract::A previous study investigating potential adult hippocampal neurogenesis in microchiropteran bats failed to reveal a strong presence of this neural trait. As microchiropterans have a high field metabolic rate and a small body mass, it is possible that capture/handling stress may lead to a decrease in the detectable pre...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.07.063
更新日期:2014-09-26 00:00:00
abstract::The cerebellum, which controls coordinated and rapid movements, is a potential target for the deleterious effects of drugs of abuse including cannabis (i.e. marijuana, cannabinoids). Prenatal exposure to cannabinoids has been documented to cause abnormalities in motor and cognitive development, but the exact mechanism...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.10.031
更新日期:2011-01-13 00:00:00
abstract::Steroid hormones, especially estradiol, facilitate reproductive behaviors in male and female rodents and birds. In green anole lizards estradiol facilitates receptivity in females but, unlike in some other species, is not the activating hormone for courtship and copulatory behavior in males. Instead, testicular androg...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.02.060
更新日期:2009-05-19 00:00:00
abstract::In this study, using an in vitro superfusion technique for the first time, we provide direct neurochemical evidence of the transmitter role of dopamine at the level of lateral olivocochlear efferent fibres of the guinea-pig cochlea. Our results revealed that nerve terminals are able to take up and release dopamine upo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00461-8
更新日期:1999-04-01 00:00:00