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Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro.

Abstract：

:The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, making this technique unsuitable for neurotrophin administration in a clinical setting. Cell- and gene-based therapies are potential therapeutic options. This study investigated whether Schwann cells which were genetically modified to over-express the neurotrophins brain-derived neurotrophic factor (BDNF) or neurotrophin 3 (Ntf3, formerly NT-3) could support SGN survival in an in vitro model of deafness. Co-culture of either BDNF over-expressing Schwann cells or Ntf3 over-expressing Schwann cells with SGNs from early postnatal rats significantly enhanced neuronal survival in comparison to both control Schwann cells and conventional recombinant neurotrophin proteins. Transplantation of neurotrophin over-expressing Schwann cells into the cochlea may provide an alternative means of delivering neurotrophic factors to the deaf cochlea for therapeutic purposes.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Pettingill LN,Minter RL,Shepherd RK

doi

10.1016/j.neuroscience.2007.11.057

subject

Has Abstract

pub_date

2008-03-27 00:00:00

pages

821-8

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(07)01528-X

journal_volume

152

pub_type

杂志文章

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