Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia.

abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

journal_title：Neuroscience

authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

更新日期：2009-06-16 00:00:00

abstract：:We previously reported that the novel antidepressant-like effect of tipepidine may be produced at least partly through the activation of mesolimbic dopamine (DA) neurons via inhibiting G protein-coupled inwardly rectifying potassium (GIRK) channels. In this study, we investigated the action of tipepidine on DA D2 rece...

journal_title：Neuroscience

authors： Hamasaki R,Shirasaki T,Soeda F,Takahama K

更新日期：2013-11-12 00:00:00

abstract：:Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood. It is known that vascular endothelial growth factor A (VEGF) has neuroprotective effects. The objective of this study was to evaluate the role of the ...

journal_title：Neuroscience

authors： Feng Y,Rhodes PG,Bhatt AJ

更新日期：2011-04-14 00:00:00

abstract：:Gonadal hormones are known to influence the regulation of emotional responses and affective states. Whereas fluctuations in progesterone and estradiol are associated with increased vulnerability for mood disorders, testosterone is mainly associated with social dominance, aggressive, and antisocial behavior. Here, we r...

journal_title：Neuroscience

authors： van Wingen GA,Ossewaarde L,Bäckström T,Hermans EJ,Fernández G

更新日期：2011-09-15 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：:In the present study, we analysed the distribution and cellular localization of metabotropic glutamate receptors (1alpha, 2/3, 5) in parabrachial and Kölliker-Fuse nuclei using subtype-specific antisera. Immunolabelling revealed that different nuclei express different sets of metabotropic glutamate receptors. Metabotr...

journal_title：Neuroscience

authors： Guthmann A,Herbert H

更新日期：1999-03-01 00:00:00

abstract：:Presenilin-1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. To probe the functions of PS1 on neuronal resistance to oxidative stress, we pharmacologically examined the death signals in PS1-deficient neurons induced by oxidative stress. Because the death of primarily cult...

journal_title：Neuroscience

authors： Nakajima M,Shirasawa T

更新日期：2004-01-01 00:00:00

abstract：:The effect of muscarinic agonists on the spontaneous release of [3H]GABA was investigated in vitro on rat substantia nigra slices. Acetylcholine (5 x 10(-5) M) in the presence of eserine (5 x 10(-5) M) induced a 12.3% increase of the spontaneous release of [3H]GABA. Similarly, carbachol (5 x 10(-4) M) enhanced by 9% t...

journal_title：Neuroscience

authors： Kayadjanian N,Gioanni H,Ménetrey A,Besson MJ

更新日期：1994-12-01 00:00:00

abstract：:The piriform cortex (PC) is the largest region of the mammalian olfactory cortex with strong connections to other limbic structures, including the amygdala, hippocampus, and entorhinal cortex. In addition to its functional importance in the classification of olfactory stimuli, the PC has been implicated in the study o...

journal_title：Neuroscience

authors： Freichel C,Potschka H,Ebert U,Brandt C,Löscher W

更新日期：2006-09-15 00:00:00

abstract：:A study has been made at the ultrastructural level of the effects of denervation and axotomy on the synapse population of the rat superior cervical ganglion. Superior cervical ganglia were subjected unilaterally to acute (survival, 48 h) or chronic preganglionic denervation (survival, 41-189 days) by cutting the cervi...

journal_title：Neuroscience

authors： Ramsay DA,Matthews MR

更新日期：1985-12-01 00:00:00

abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

journal_title：Neuroscience

authors： van den Pol AN,Spencer DD

更新日期：2000-01-01 00:00:00

abstract：:Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...

journal_title：Neuroscience

authors： Ambrosini S,Sarchielli E,Comeglio P,Porfirio B,Gallina P,Morelli A,Vannelli GB

更新日期：2015-03-19 00:00:00

abstract：:According to the simulation theory, the internal simulation of a movement (imagined movement, IM) and its execution (actual movement, AM) are based on the same motor representations. The brain uses these representations for controlling action. The specific objective of this study was to investigate the updating proces...

journal_title：Neuroscience

authors： Chabeauti PY,Assaiante C,Vaugoyeau M

更新日期：2012-10-11 00:00:00

abstract：:8-oxoguanine DNA glycosylase and Kin17 are proteins widely distributed and phylogenetically conserved in the CNS. 8-oxoguanine DNA glycosylase is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine present in DNA damaged by oxidative stress. Kin17 protein is involved in DNA repair and illegitimate recombination ...

journal_title：Neuroscience

authors： Araneda S,Pelloux S,Radicella JP,Angulo J,Kitahama K,Gysling K,Forray MI

更新日期：2005-01-01 00:00:00

abstract：:Cannabinoid receptor activation has been shown to modulate both neurotransmission (CB(1)) and neuroinflammatory (CB(2)) responses. There are conflicting reports in the literature describing the influence of cannabinoid receptor activation on ischemic/reperfusion injury. The goal of this study was to evaluate how chang...

journal_title：Neuroscience

authors： Zhang M,Martin BR,Adler MW,Razdan RK,Ganea D,Tuma RF

更新日期：2008-03-27 00:00:00

abstract：:The goal of the present experiments was to examine the relationships of the zona incerta with two structures associated with visuomotor behavior, the superior colliculus and pretectum. The experiments were carried out in the cat, a species commonly used in studies of visuomotor integration, and utilized wheat germ agg...

journal_title：Neuroscience

authors： May PJ,Sun W,Hall WC

更新日期：1997-04-01 00:00:00

abstract：:Solid pieces of cerebellar primordia taken from 12-day-old C57BL embryos were implanted into the cerebellar parenchyma of 3- to 4-month-old "Purkinje cell degeneration" mutant mice and analysed 2-3 months later. Purkinje cell replacement was followed by means of immunocytochemistry with antisera against either cyclic ...

journal_title：Neuroscience

authors： Sotelo C,Alvarado-Mallart RM

更新日期：1987-01-01 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, and immunohistochemistry. Fluorogold (FG) retrogra...

journal_title：Neuroscience

authors： Takeda M,Kadoi J,Takahashi M,Nasu M,Matsumoto S

更新日期：2007-09-07 00:00:00

abstract：:Studies in humans have documented that acute acid infusion into the esophagus leads to decrease in threshold for sensations to mechanical distension of the esophagus. It is not known whether acid infusion leads to sensitization of brainstem neurons receiving synaptic input from vagal afferent fibers innervating the es...

journal_title：Neuroscience

authors： Medda BK,Sengupta JN,Lang IM,Shaker R

更新日期：2005-01-01 00:00:00

abstract：:The projections of the nucleus of the diagonal band of Broca and of the substantia innominata to the cerebral cortex were studied in the rat, using the anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase. Following diagonal band injections, fibers were observed ascending in the septum...

journal_title：Neuroscience

authors： Lamour Y,Dutar P,Jobert A

更新日期：1984-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder for which there is currently no effective treatment. Studies indicate that enhancing autophagy in mouse models of neurodegenerative disease can ameliorate the behavioral symptoms and pathological damage associated with the accumulation of pathol...

journal_title：Neuroscience

authors： Li Y,Guo Y,Wang X,Yu X,Duan W,Hong K,Wang J,Han H,Li C

更新日期：2015-07-09 00:00:00

abstract：:Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels. In the vertebrate brain pannexins have been found in neurons...

journal_title：Neuroscience

authors： Zoidl G,Petrasch-Parwez E,Ray A,Meier C,Bunse S,Habbes HW,Dahl G,Dermietzel R

更新日期：2007-04-25 00:00:00

abstract：:Updating the position of an earth-fixed target during whole-body rotation seems to rely on cognitive processes such as the utilization of external feedback. According to perceptual learning models, improvement in performance can also occur without external feedback. The aim of this study was to assess spatial updating...

journal_title：Neuroscience

authors： Mackrous I,Simoneau M

更新日期：2015-08-06 00:00:00

abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

journal_title：Neuroscience

authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

更新日期：1989-01-01 00:00:00

abstract：:GABA immunoreactivity was studied in the optic tectum of the frog, Rana esculenta, by postembedding immunohistochemical methods at the light and electron microscopic levels. Nearly one-third of the total population of tectal cells appeared to be GABA-immunoreactive. The proportion of stained neurons was highest in lay...

journal_title：Neuroscience

authors： Antal M

更新日期：1991-01-01 00:00:00

abstract：:The coordinate representation of the sense of limb orientation was investigated psychophysically by asking subjects to match the orientation of the arm or of the forearm in several different coordinate representations. Movement of all degrees of freedom of one arm was permitted while movement of the other limb was res...

journal_title：Neuroscience

authors： Soechting JF,Ross B

更新日期：1984-10-01 00:00:00

abstract：:Botulinum toxin is an agent that is typically encountered in two settings: as an agent that can cause disease (e.g. botulism), and as an agent that can be used to treat disease (i.e., a variety of neurologic disorders). In both cases it would be advantageous to develop a sound understanding of the mechanisms by which ...

journal_title：Neuroscience

authors： Joshi SG,Elias M,Singh A,Al-Saleem FH,Ancharski D,Nasser Z,Takahashi T,Simpson LL

更新日期：2011-04-14 00:00:00

abstract：:Recent studies have demonstrated that astrocytes express a variety of ion channels and neurotransmitter receptors and can modulate the activity of neurons. Since a single astrocyte makes tight contacts with many neighboring neuronal cells, they can provide efficient and wide modulation of neuronal networks. Here, we p...

journal_title：Neuroscience

authors： Yamazaki Y,Hozumi Y,Kaneko K,Li J,Fujii S,Miyakawa H,Kudo Y,Kato H

更新日期：2005-01-01 00:00:00

abstract：:There is increasing evidence that a subset of midbrain dopamine (DA) neurons uses glutamate as a co-transmitter and expresses vesicular glutamate transporter (VGLUT) 2, one of the three vesicular glutamate transporters. In the present study, double in situ hybridization was used to examine tyrosine hydroxylase (TH) an...

journal_title：Neuroscience

authors： Dal Bo G,Bérubé-Carrière N,Mendez JA,Leo D,Riad M,Descarries L,Lévesque D,Trudeau LE

更新日期：2008-09-22 00:00:00