Abstract：
:The integral membrane protein synaptophysin is one of the most abundant polypeptide components of synaptic vesicles. It is not essential for neurotransmission despite its abundance but is believed to modulate the efficiency of the synaptic vesicle cycle. Detailed behavioral analyses were therefore performed on synaptophysin knockout mice to test whether synaptophysin affects higher brain functions. We find that these animals are more exploratory than their wild type counterparts examining novel objects more closely and intensely in an enriched open field arena. We also detect impairments in learning and memory, most notably reduced object novelty recognition and reduced spatial learning. These deficits are unlikely caused by impaired vision, since all electroretinographic parameters measured were indistinguishable from those in wild type controls although an inverse optomotor reaction was observed. Taken together, our observations demonstrate functional consequences of synaptophysin depletion in a living organism.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Schmitt U,Tanimoto N,Seeliger M,Schaeffel F,Leube REdoi
10.1016/j.neuroscience.2009.04.046subject
Has Abstractpub_date
2009-08-18 00:00:00pages
234-43issue
2eissn
0306-4522issn
1873-7544pii
S0306-4522(09)00653-8journal_volume
162pub_type
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