Abstract：
:Alterations in axon-dendrite polarity impair functional recovery in the developing CNS after hypoxia-ischemia (HI) injury. PTEN (phosphatase and tensin homolog deleted on chromosome 10) signaling pathway mediates the formation of neuronal polarity. However, its role in cerebral HI injury is not fully understood. In this study, we investigated the role of PTEN pathway in regulation of axon-dendrite polarity using an oxygen-glucose deprivation (OGD) model with rat cortical neurons. We found that the activity of PTEN and glycogen synthase kinase 3β (GSK-3β) was increased after OGD, along with the decrease of the activity in protein kinase B (Akt) and collapsin response mediator protein-2 (CRMP-2). Pretreatment with bpv, a potent inhibitor of PTEN, caused a decrease of the activity in PTEN and GSK-3β, and a significant increase of the activity in Akt and CRMP-2. Simultaneously, the morphological polarity of neurons was maintained and neuronal apoptosis was reduced. Moreover, inhibition of PTEN rescued vesicle recycling in axons. These findings suggested that the PTEN/Akt/GSK-3β/CRMP-2 pathway is involved in the regulation of axon-dendrite polarity, providing a novel route for protecting neurons following neonatal HI.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Zhao J,Qu Y,Wu J,Cao M,Ferriero DM,Zhang L,Mu Ddoi
10.1016/j.neuroscience.2013.02.046subject
Has Abstractpub_date
2013-05-15 00:00:00pages
242-51eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00187-5journal_volume
238pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Transcranial magnetic stimulation (TMS) has opened important perspectives on the pathophysiological bases and potential targets of treatment strategies for idiopathic Parkinson's disease (IPD). Studies have been mainly focusing on motor cortical inhibitory phenomena. However, differences in patients and methods caused...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.08.033
更新日期：2007-11-30 00:00:00
abstract：:The projections of the nucleus of the diagonal band of Broca and of the substantia innominata to the cerebral cortex were studied in the rat, using the anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase. Following diagonal band injections, fibers were observed ascending in the septum...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(84)90061-7
更新日期：1984-06-01 00:00:00
abstract：:Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2005.06.015
更新日期：2006-01-01 00:00:00
abstract：:The present study was designed to investigate the roles of different subtypes of opioid receptors in ventrolateral orbital cortex (VLO) opioid-evoked antinociception in formalin test by using an automatic detection system for recording the nociceptive behavior (agitation) and a manual method for detecting the duration...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.04.013
更新日期：2004-01-01 00:00:00
abstract：:We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20). In control conditions, carbachol reduced the amplitude of evoked synaptic responses (n...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00338-2
更新日期：1998-02-01 00:00:00
abstract：:Intrauterine growth restriction is a risk factor for neurological and behavioural deficits in children although the precise underlying biological correlate for this is unclear. The present study shows that animals with intrauterine growth restriction, induced by a period of reduced placental blood flow during the seco...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00271-2
更新日期：2000-01-01 00:00:00
abstract：:Although neurogenesis in the hippocampus is critical for improvement of depressive behaviors and cognitive functions in neurodegeneration disorders, there is no therapeutic agent available to promote neurogenesis in adult brain following brain ischemic injury. Here we found that i.p. administration of bis(1-oxy-2-pyri...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2008.05.056
更新日期：2008-08-26 00:00:00
abstract：:The present study utilized an in vitro preparation of the rabbit carotid body, with tissue catecholamine stores labeled by incubation with 3H-tyrosine. The goal was to characterize pharmacologically the voltage-dependent Ca2+ channels present in the type I (glomus) cells of this arterial chemoreceptor organ, and to el...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90260-9
更新日期：1992-01-01 00:00:00
abstract：:The interaction between the dopaminergic and glutamatergic systems governs normal behavior and is perturbed in many psychiatric disorders including schizophrenia. Hypofunction of the D1 family of receptors, to which the D(1) and D(5) subtypes belong, is a typical feature of schizophrenia. Here we have used confocal li...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.08.052
更新日期：2009-12-01 00:00:00
abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90343-e
更新日期：1993-09-01 00:00:00
abstract：:In the present study we have investigated the possible role of gap junctions in the induction and manifestation of 4-aminopyridine-induced acute seizure activity both at the primary focus and at the mirror focus in anaesthetized rats by combining electrophysiological, pharmacological and molecular biological technique...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00533-x
更新日期：2002-01-01 00:00:00
abstract：:Rates of cerebral glucose utilization were measured by means of the autoradiographic 2-deoxy-D[1-14C]glucose technique in the rat brain in order to determine the metabolic effects of unilateral intranigral application of the GABAA agonist muscimol upon the substantia nigra and its targets. Intranigral injection of 1.5...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90204-f
更新日期：1992-10-01 00:00:00
abstract：:Identification of novel molecules that can induce neuronal differentiation of embryonic stem (ES) cells is essential for deciphering the molecular mechanisms of early development and for exploring cell therapy approaches. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.09.062
更新日期：2011-12-29 00:00:00
abstract：:In a previous study it has been demonstrated that fear conditioning is associated with a long-lasting potentiation of parallel fiber to Purkinje cell synaptic transmission in vermal lobules V and VI. Since modifications of intrinsic membrane properties have been suggested to mediate some forms of memory processes, we ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.02.040
更新日期：2006-07-07 00:00:00
abstract：:Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2020.04.038
更新日期：2020-12-01 00:00:00
abstract：:I.c.v. injection of L-ornithine has been shown to have sedative and hypnotic effects on neonatal chicks exposed to acute stressful conditions. To clarify the mechanism, we conducted three experiments under strengthened stressful conditions with corticotropin-releasing factor (CRF). In Experiment 1, the effect of i.c.v...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.10.076
更新日期：2011-01-13 00:00:00
abstract：:The extracellular matrix is a complex network of macromolecules including glycoproteins, polysaccharides and proteoglycans. Tenascin-R and chondroitin sulfate proteoglycans are essential components of hippocampal extracellular matrix co-localised in perineuronal nets on interneurons. Mutant mice deficient in expressio...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00082-3
更新日期：2001-01-01 00:00:00
abstract：:In the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the Na+-dependent glutamate transporter, which was activated by extracellular K+. Glutamate transport current was measured by a conventional whole-cell patch recording mode under voltage-clamp co...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00036-6
更新日期：1999-01-01 00:00:00
abstract：:Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. In the present study, the possibility that Arc would be specifically upregulated in rats during the acquisition of a quickly...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00605-4
更新日期：2002-01-01 00:00:00
abstract：:The bed nucleus of stria terminalis is a basal forebrain region involved in regulation of hormonal and behavioral responses to stress. In this report we demonstrate that bed nucleus of stria terminalis has a high and localized expression of tissue plasminogen activator, a serine protease with neuromodulatory propertie...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.06.076
更新日期：2005-01-01 00:00:00
abstract：:A study has been made at the ultrastructural level of the effects of denervation and axotomy on the synapse population of the rat superior cervical ganglion. Superior cervical ganglia were subjected unilaterally to acute (survival, 48 h) or chronic preganglionic denervation (survival, 41-189 days) by cutting the cervi...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(85)90112-5
更新日期：1985-12-01 00:00:00
abstract：:Whole-cell voltage-clamp recordings were made from acutely dissociated neurons obtained from the embryonic chick ciliary ganglion. Recording pipettes were filled with salines containing 120 mM CsCl or 120 mM tetraethylammonium-Cl. Application of depolarizing voltage commands evoked L-type Ca2+ currents and, at voltage...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90086-4
更新日期：1991-01-01 00:00:00
abstract：:In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(84)90204-5
更新日期：1984-04-01 00:00:00
abstract：:Neurotrophic factors, including basic fibroblast growth factor (FGF-2) and brain-derived neurotrophic factor (BDNF) are known to be affected by exposure to stressful experiences. Here, we examine the effects of behaviorally controllable (escapable tailshock, ES) or uncontrollable (inescapable tailshock, IS) stress on ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.11.026
更新日期：2007-02-23 00:00:00
abstract：:Inflammatory and degenerative pathophysiological processes within the CNS are important causes of human disease. Astrocytes appear to modulate these reactions and are a major source of inflammatory mediators, e.g. extracellular adenine nucleotides, in nervous tissues. Actions following extracellular nucleotides bindin...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.11.039
更新日期：2006-01-01 00:00:00
abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90304-4
更新日期：1983-06-01 00:00:00
abstract：:Oxytocin regulates partner preference formation and alloparental behavior in the socially monogamous prairie vole (Microtus ochrogaster) by activating oxytocin receptors in the nucleus accumbens of females. Mating facilitates partner preference formation, and oxytocin-immunoreactive fibers in the nucleus accumbens hav...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.05.055
更新日期：2009-09-15 00:00:00
abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00568-0
更新日期：2000-01-01 00:00:00
abstract：:Sleep is strongly implicated in learning, especially in the reprocessing of recently acquired memory. Children with intellectual disability (ID) tend to have sleep-wake disturbances, which may contribute to the pathophysiology of the disease. Given that sleep is partly controlled by the circadian clock, we decided to ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.08.066
更新日期：2015-11-12 00:00:00
abstract：:Neurotransmitter release and changes in the concentration of intracellular free calcium ([Ca++]i) were studied in cultured GABAergic cerebral cortical neurons, from mice, upon depolarization with either an unphysiologically high potassium concentration (55 mM) or the physiological excitatory neurotransmitter glutamate...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90592-4
更新日期：1993-06-01 00:00:00
