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Tissue plasminogen activator in the bed nucleus of stria terminalis regulates acoustic startle.

Abstract：

:The bed nucleus of stria terminalis is a basal forebrain region involved in regulation of hormonal and behavioral responses to stress. In this report we demonstrate that bed nucleus of stria terminalis has a high and localized expression of tissue plasminogen activator, a serine protease with neuromodulatory properties and implicated in neuronal plasticity. Tissue plasminogen activator activity in the bed nucleus of stria terminalis is transiently increased in response to acute restraint stress or i.c.v. administration of a major stress mediator, corticotropin-releasing factor. We show that tissue plasminogen activator is important in bed nucleus of stria terminalis function using two criteria: 1, Neuronal activation in this region as measured by c-fos induction is reduced in tissue plasminogen activator-deficient mice; and 2, a bed nucleus of stria terminalis-dependent behavior, potentiation of acoustic startle by corticotropin-releasing factor, is attenuated in tissue plasminogen activator-deficient mice. These studies identify a novel site of tissue plasminogen activator expression in the mouse brain and demonstrate a functional role for this protease in the bed nucleus of stria terminalis.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Matys T,Pawlak R,Strickland S

doi

10.1016/j.neuroscience.2005.06.076

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

715-22

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(05)00727-X

journal_volume

135

pub_type

杂志文章

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