当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Fetal neostriatal transplants in the rat: a light and electron microscopic Golgi study.

Fetal neostriatal transplants in the rat: a light and electron microscopic Golgi study.

Abstract：

:Fetal striatal neurons were transplanted into the ibotenic acid lesioned rat striatum. Three months after transplantation the grafted tissue was Golgi-impregnated and examined at the light microscopic level to determine the morphological characteristics of the transplanted neurons. Golgi-impregnated neurons were then gold-toned and examined at the electron microscopic level. The transplanted neurons were classified by both somatic size and somatic and dendritic morphology, which demonstrated that at least seven distinct cell types are present in striatal grafts. Type I large neurons had aspinous somata, sparsely spined dendrites, and indented nuclei, whereas type II large neurons displayed somatic spines, sparsely spined dendrites, and indented nuclei. Type I medium neurons exhibited aspinous somata and proximal dendrites, heavily spined distal dendrites, and unindented nuclei. Type II medium neurons had somatic spines, sparsely spined dendrites, and indented nuclei. Type III medium neurons had aspinous somata, poorly branched and sparsely spined dendrites, and indented nuclei, while type IV medium neurons had aspinous somata, highly branched and sparsely spined dendrites, and indented nuclei. Type V medium neurons displayed aspinous somata, varicose dendrites, and indented nuclei. These results demonstrate that transplanted fetal striatal neurons differentiate into morphologically and ultrastructurally distinct striatal cell types.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Helm GA,Palmer PE,Bennett JP Jr

doi

10.1016/0306-4522(90)90104-c

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

735-56

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(90)90104-C

journal_volume

37

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle.

    abstract：:Serotonergic systems are thought to play an important role in control of motor activity and emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a motor-eliciting stimulus in the presence or absence of induction of an acute fear state on serotonergic neurons in the dorsal raphe n...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.01.042

    authors： Spannuth BM,Hale MW,Evans AK,Lukkes JL,Campeau S,Lowry CA

    更新日期：2011-04-14 00:00:00

  • Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine.

    abstract：:In this study, we describe a model of opiate sensitization characterized by a brief schedule of treatment with repeated morphine administrations. In this model, we investigated the changes produced by repeated morphine treatment on dopamine transmission at the level of the two major terminal dopaminergic areas, the do...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00466-7

    authors： Cadoni C,Di Chiara G

    更新日期：1999-05-01 00:00:00

  • Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats.

    abstract：:An antisense oligodeoxynucleotide selective for the rat neuropeptide Y1 receptor gene was given into the left lateral ventricle in the experimental group of rats, whereas a missense oligodeoxynucleotide or saline was given in the control groups. Some rats were decapitated at 1-2h after the last injection of the oligod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00159-7

    authors： Cheung RT,Cechetto DF

    更新日期：2000-01-01 00:00:00

  • Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus.

    abstract：:Microglia, the innate immune cells of the brain, regulate brain development through many processes such as synaptic pruning, supporting cell genesis and phagocytosing living and dying cells. There are sex differences in these same developmental processes throughout the brain, thus microglia may contribute to brain sex...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.10.009

    authors： Nelson LH,Peketi P,Lenz KM

    更新日期：2021-01-15 00:00:00

  • Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms.

    abstract：:Prolonged seizures (status epilepticus) induced by kainic acid activate programmed cell death mechanisms, and it is believed that kainic acid-induced status epilepticus induces neuronal apoptosis. In order to test this hypothesis, adult rats were subjected to 3-h kainic acid-induced seizures, with 24- or 72-h recovery...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00085-3

    authors： Fujikawa DG,Shinmei SS,Cai B

    更新日期：2000-01-01 00:00:00

  • KATP-channels play a minor role in the protective hypoxic shut-down of cerebellar activity in eider ducks (Somateria mollissima).

    abstract：:Eider duck (Somateria mollissima) cerebellar neurons are highly tolerant toward hypoxia in vitro, which in part is due to a hypoxia-induced depression of their spontaneous activity. We have studied whether this response involves ATP-sensitive potassium (KATP) channels, which are known to be involved in the hypoxic/isc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.10.046

    authors： Geiseler SJ,Ludvigsen S,Folkow LP

    更新日期：2015-01-22 00:00:00

  • Titration of synaptotagmin I expression differentially regulates release of norepinephrine and neuropeptide Y.

    abstract：:Synaptotagmin (syt) I is a Ca(2+) sensor that has been thought to trigger all vesicle secretion with similar mechanisms. However, given the calcium and stimulation requirements of small clear, and large dense core vesicles, we hypothesized that syt I expression differentially regulates vesicle release. Therefore, in t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.05.020

    authors： Papke JB,Moore-Dotson JM,Watson DJ,Wedell CD,French LR,Rendell SR,Harkins AB

    更新日期：2012-08-30 00:00:00

  • Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis.

    abstract：:The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.067

    authors： Francis AB,Pace TW,Ginsberg AB,Rubin BA,Spencer RL

    更新日期：2006-09-01 00:00:00

  • MK801-induced caspase-3 in the postnatal brain: inverse relationship with calcium binding proteins.

    abstract：:Age-dependent, neuronal apoptosis following N-methyl-D-aspartate receptor blockade has been linked to loss of calcium. To further explore this relationship, we examined expression of activated caspase-3, as well as the calcium binding proteins, calbindin-D 28K, calretinin and parvalbumin, following injection of vehicl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.05.019

    authors： Lema Tomé CM,Bauer C,Nottingham C,Smith C,Blackstone K,Brown L,Hlavaty C,Nelson C,Daker R,Sola R,Miller R,Bryan R,Turner CP

    更新日期：2006-09-01 00:00:00

  • Specificity of attachment and neurite outgrowth of dissociated basal forebrain cholinergic neurons seeded on to organotypic slice cultures of forebrain.

    abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00067-5

    authors： Robertson RT,Baratta J,Kageyama GH,Ha DH,Yu J

    更新日期：1997-10-01 00:00:00

  • Regulation of 1,4,5-IP3, 1,3,4,5-IP4 and IP6 binding sites following entorhinal cortex lesions in rat brain.

    abstract：:A lesion of the entorhinal cortex produces a loss of more than 80% of the synapses in the outer molecular layer of the hippocampus in the rat. However, this synaptic loss is transient. Beginning a few days after denervation, new synapses are formed, virtually replacing the lost inputs within two months. Synaptic remod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90434-0

    authors： Parent A,Poirier J,Baccichet A,Quirion R

    更新日期：1994-08-01 00:00:00

  • Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

    abstract：:Here we studied the role of peripheral adenosine A(2A) receptors in mechanical hyperalgesia during inflammation using mice lacking the A(2A) receptors. Unilateral s.c. administration of the local inflammatory agent λ-carrageenan induced profound mechanical hyperalgesia 24 h after administration in the ipsilateral hind...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.07.045

    authors： Li L,Hao JX,Fredholm BB,Schulte G,Wiesenfeld-Hallin Z,Xu XJ

    更新日期：2010-10-27 00:00:00

  • Plasmalemmal appositions between cholinergic and non-cholinergic neurons in rat caudate-putamen nuclei.

    abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90341-k

    authors： Pickel VM,Chan J

    更新日期：1991-01-01 00:00:00

  • Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia.

    abstract：:The hypoxia-dependent activation of nitroheterocyclic drugs by cellular nitroreductases leads to the formation of intracellular adducts between the drugs and cellular macromolecules. Because this covalent binding is maximal in the absence of oxygen, detection of bound adducts provides an assay for estimating the degre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00377-7

    authors： Bergeron M,Evans SM,Sharp FR,Koch CJ,Lord EM,Ferriero DM

    更新日期：1999-01-01 00:00:00

  • Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation.

    abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90173-5

    authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

    更新日期：1989-01-01 00:00:00

  • The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy.

    abstract：:Sensory neurons mediate diabetic peripheral neuropathy. Using a mouse model of diabetic peripheral neuropathy (BKS.Cg-m+/+Lepr(db)/J (db/db) mice) and cultured dorsal root ganglion (DRG) neurons, the present study showed that hyperglycemia downregulated miR-146a expression and elevated interleukin-1 receptor-activated...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.057

    authors： Wang L,Chopp M,Szalad A,Zhang Y,Wang X,Zhang RL,Liu XS,Jia L,Zhang ZG

    更新日期：2014-02-14 00:00:00

  • Expression of alpha3, beta3 and gamma1 GABA(A) receptor subunit messenger RNAs in visual cortex and lateral geniculate nucleus of normal and monocularly deprived monkeys.

    abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00140-7

    authors： Huntsman MM,Jones EG

    更新日期：1998-11-01 00:00:00

  • Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.

    abstract：:Ascorbate is an antioxidant vitamin that is found in high concentrations in the brain which seems to have neuroprotective properties in some experimental models of excitotoxic neurological disorders, including convulsive behavior and reactive species-related damage. In this study we tested whether ascorbate (30, 100 o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.07.012

    authors： Schneider Oliveira M,Flávia Furian A,Freire Royes LF,Rechia Fighera M,de Carvalho Myskiw J,Gindri Fiorenza N,Mello CF

    更新日期：2004-01-01 00:00:00

  • Modulation of respiratory activity by locomotion in lampreys.

    abstract：:In vertebrates, locomotion is associated with changes in respiratory activity, but the neural mechanisms by which this occurs remain unknown. We began examining this in lampreys using a semi-intact preparation of young adult Petromyzon marinus, in which respiratory and locomotor behaviors can be recorded simultaneousl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.10.019

    authors： Gravel J,Brocard F,Gariépy JF,Lund JP,Dubuc R

    更新日期：2007-02-09 00:00:00

  • Long-term potentiation during whole-cell recording in rat hippocampal slices.

    abstract：:Factors involved in the production of long-term potentiation in the CA1 region of rat hippocampal slices were examined using whole-cell voltage clamp recordings. The pairing of postsynaptic membrane depolarization with tetanic stimulation produced a reliable long-lasting enhancement of synaptic currents provided that ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90282-k

    authors： Kato K,Clifford DB,Zorumski CF

    更新日期：1993-03-01 00:00:00

  • Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices.

    abstract：:The effects of steady iontophoretic applications of serotonin on the spontaneous discharge and on the excitatory responses induced in deep cerebellar nuclei neurons by iontophoretic pulse applications of L-glutamate, L-aspartate, N-methyl-D,L-aspartate and quisqualate were studied in rat cerebellar slices maintained i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90072-8

    authors： Gardette R,Krupa M,Crepel F

    更新日期：1987-11-01 00:00:00

  • Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice.

    abstract：:Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.01.011

    authors： Tao K,Ichikawa J,Matsuki N,Ikegaya Y,Koyama R

    更新日期：2016-03-24 00:00:00

  • Ventral tegmental area neurons are either excited or inhibited by cocaine's actions in the peripheral nervous system.

    abstract：:Cocaine's multiple pharmacological substrates are ubiquitously present in the peripheral and central nervous system. Thus, upon its administration, cocaine acts in the periphery before directly acting in the brain. We determined whether cocaine alters ventral tegmental area (VTA) neuronal activity via its peripheral a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.01.026

    authors： Mejías-Aponte CA,Kiyatkin EA

    更新日期：2012-04-05 00:00:00

  • Nuclear factor-kappa β regulates Notch signaling in production of proinflammatory cytokines and nitric oxide in murine BV-2 microglial cells.

    abstract：:Microglial cells exhibit Notch-1 signaling expression which is enhanced upon activation. We reported previously that enhanced Notch-1 expression in activated microglia modulates production of proinflammatory cytokines and nitric oxide (NO). Furthermore, Notch-1 modulates transcription factor nuclear factor-kappa B (NF...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.060

    authors： Cao Q,Kaur C,Wu CY,Lu J,Ling EA

    更新日期：2011-09-29 00:00:00

  • Prostaglandin E2 in the medial preoptic area produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla.

    abstract：:Prostaglandin E2 (PGE2) produced in the medial preoptic region (MPO) in response to immune signals is generally accepted to play a major role in triggering the illness response, a complex of physiological and behavioral changes induced by infection or injury. Hyperalgesia is now thought to be an important component of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.06.050

    authors： Heinricher MM,Neubert MJ,Martenson ME,Gonçalves L

    更新日期：2004-01-01 00:00:00

  • Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and col

    abstract：:The bladder and distal colon are innervated by lumbar splanchnic (LSN) and pelvic nerves (PN) whose axons arise from dorsal root ganglia (DRG) neurons at thoracolumbar (TL) and lumbosacral (LS) spinal levels, respectively. In an attempt to understand the molecular basis of differences between LSN and PN mechanosensiti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.049

    authors： La JH,Schwartz ES,Gebhart GF

    更新日期：2011-07-14 00:00:00

  • Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.

    abstract：:The piriform cortex (PC) is the largest region of the mammalian olfactory cortex with strong connections to other limbic structures, including the amygdala, hippocampus, and entorhinal cortex. In addition to its functional importance in the classification of olfactory stimuli, the PC has been implicated in the study o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.05.040

    authors： Freichel C,Potschka H,Ebert U,Brandt C,Löscher W

    更新日期：2006-09-15 00:00:00

  • Prenatal ethanol exposure alters immune capacity and noradrenergic synaptic transmission in lymphoid organs of the adult mouse.

    abstract：:Clinical and experimental evidence indicates that exposure to alcohol in utero is associated with altered immune capacity. The mechanisms underlying such abnormalities are not clear. However, the suggestion that reciprocal interactions between the immune and the nervous systems are necessary for a competent immune res...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90133-o

    authors： Gottesfeld Z,Christie R,Felten DL,LeGrue SJ

    更新日期：1990-01-01 00:00:00

  • Electrophysiological study of auditory development.

    abstract：:Cortical auditory evoked potential (CAEP) testing, a non-invasive technique, is widely employed to study auditory brain development. The aim of this study was to investigate the development of the auditory electrophysiological signal without addressing specific abilities such as speech or music discrimination. We were...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.07.066

    authors： Lippé S,Martinez-Montes E,Arcand C,Lassonde M

    更新日期：2009-12-15 00:00:00

  • Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group.

    abstract：:Considerable evidence suggests that a dysfunction of the dopamine and serotonin (5-hydroxytryptamine or 5-HT) neurotransmitter systems contributes to a diverse range of pathological conditions including schizophrenia, depression and drug abuse. Recent electrophysiological and behavioral studies suggest that 5-HT modul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00593-0

    authors： Nocjar C,Roth BL,Pehek EA

    更新日期：2002-01-01 00:00:00