Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures.

abstract：:DNA repair is one of the most essential systems for maintaining the inherited nucleotide sequence of genomic DNA over time. Repair of DNA damage would be particularly important in neurons, because these cells are among the longest-living cells in the body. MSH2 is one of the proteins which are involved in the recognit...

journal_title：Neuroscience

authors： Belloni M,Uberti D,Rizzini C,Ferrari-Toninelli G,Rizzonelli P,Jiricny J,Spano P,Memo M

更新日期：1999-01-01 00:00:00

abstract：:The purpose of the present study was to verify our assumption that rhythmic respiratory activity may be regulated by endogenous hydrogen sulfide (H(2)S) in the medullary slices of neonatal rats. We found that a moderate concentration of donor of H(2)S, NaHS, mainly induced diphasic respiratory responses indicated by c...

journal_title：Neuroscience

authors： Hu H,Shi Y,Chen Q,Yang W,Zhou H,Chen L,Tang Y,Zheng Y

更新日期：2008-10-28 00:00:00

abstract：:Levels of the pro-inflammatory cytokine interleukin-1beta are known to be elevated in patients with chronic disorders such as Alzheimer's disease. We have investigated the effects of interleukin-1beta on long-term potentiation and N-methyl-D-aspartate receptor-mediated field potentials in the rat dentate gyrus in vitr...

journal_title：Neuroscience

authors： Coogan AN,O'Neill LA,O'Connor JJ

更新日期：1999-01-01 00:00:00

abstract：:The effect of intracranial microdialysis on brain glucose metabolism in control and kainic acid-treated rats was assessed by semi-quantitative [14C]2-deoxyglucose autoradiography. A dialysis fiber loop was implanted into the piriform cortex or a horizontal Vita fiber into the hippocampus, and 24 h later, fibers were p...

journal_title：Neuroscience

authors： Chastain JE Jr,Samson F,Nelson SR,Pazdernik TL

更新日期：1990-01-01 00:00:00

abstract：:Following a Pavlovian pairing procedure, alcohol-paired cues come to elicit behavioral responses that lead to alcohol consumption. Here we used an optogenetic approach to activate basolateral amygdala (BLA) axonal terminals targeting the shell of nucleus accumbens (AcbSh) and investigated a possible influence over cue...

journal_title：Neuroscience

authors： Millan EZ,Kim HA,Janak PH

更新日期：2017-09-30 00:00:00

abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

journal_title：Neuroscience

authors： Yamamoto Y,Carter CS,Cushing BS

更新日期：2006-01-01 00:00:00

abstract：:Since mild thermal stress seems to exert neuroprotection via induction of heat-shock protein 70 kDa (hsp70), we tested whether hsp70 would preserve striatal bioelectrical activity under conditions of mitochondrial impairment. Corticostriatal slices from rats that had undergone mild thermal stress were exposed to eithe...

journal_title：Neuroscience

authors： Tantucci M,Mariucci G,Taha E,Spaccatini C,Tozzi A,Luchetti E,Calabresi P,Ambrosini MV

更新日期：2009-10-20 00:00:00

abstract：:The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase (BACE1) and γ-secretase complex. However, extrac...

journal_title：Neuroscience

authors： Cai Y,Xue ZQ,Zhang XM,Li MB,Wang H,Luo XG,Cai H,Yan XX

更新日期：2012-07-26 00:00:00

abstract：:Neurons of the efferent vestibular system were investigated in the cat using retrograde axonal transport of horseradish peroxidase and fluorescent retrograde double labelling techniques. The number of efferent neurons was clearly higher than previously reported. A three dimensional reconstruction of the location of th...

journal_title：Neuroscience

authors： Dechesne C,Raymond J,Sans A

更新日期：1984-04-01 00:00:00

abstract：:Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR). Previously proposed explanations suggest that this lack of internalization could either lead to prolonged signaling and associated compensatory changes in downstream signaling systems, or tha...

journal_title：Neuroscience

authors： Walwyn WM,Wei W,Xie CW,Chiu K,Kieffer BL,Evans CJ,Maidment NT

更新日期：2006-10-13 00:00:00

abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

journal_title：Neuroscience

authors： Clarke PG,Nussbaumer JC

更新日期：1987-12-01 00:00:00

abstract：:Cannabinoid receptor type 1 (CB1)-dependent signaling in the brain is known to modulate food intake. Recent evidence has actually shown that CB1 can both inhibit and stimulate food intake in fasting/refeeding conditions, depending on the specific neuronal circuits involved. However, the exact brain sites where this bi...

journal_title：Neuroscience

authors： Soria-Gómez E,Massa F,Bellocchio L,Rueda-Orozco PE,Ciofi P,Cota D,Oliet SH,Prospéro-García O,Marsicano G

更新日期：2014-03-28 00:00:00

abstract：:Organophosphates (OPs) pose a constant threat to human health due to their widespread use as pesticides and their potential employment in military and terrorist attacks. The acute toxicity of OPs has been extensively studied; however, the consequences of prolonged or repeated exposure to levels of OPs that produce no ...

journal_title：Neuroscience

authors： Terry AV Jr,Buccafusco JJ,Gearhart DA,Beck WD,Middlemore-Risher ML,Truan JN,Schwarz GM,Xu M,Bartlett MG,Kutiyanawala A,Pillai A

更新日期：2011-03-10 00:00:00

abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...

journal_title：Neuroscience

authors： Ugrumov MV,Popov AP,Vladimirov SV,Kasmambetova S,Novodjilova AP,Tramu G

更新日期：1994-01-01 00:00:00

abstract：:In rodents, reproductively relevant pheromonal cues are detected by receptors in the vomeronasal organ, which in turn transmit this information centrally via the accessory olfactory bulb, the medial nucleus of the amygdala, the posterior medial bed nucleus of the stria terminalis and the medial preoptic area. In the r...

journal_title：Neuroscience

authors： Bressler SC,Baum MJ

更新日期：1996-04-01 00:00:00

abstract：:Similarities in cellular morphology, afferentation, efferentation, and neurotransmitter content between the internal and external parts of the pallidum and the substantia nigra pars reticulata have long been noted. Here we present evidence that the globus pallidus, entopedunucular nucleus and substantia nigra pars ret...

journal_title：Neuroscience

authors： Sousa R,Hrinya Tannery N,Lafer EM

更新日期：1990-01-01 00:00:00

abstract：:Cranial parasympathetic outflow is mediated through the sphenopalatine ganglion (SPG). The present study was performed to examine the expression of the parasympathetic signaling transmitters and their receptors in human and rat SPG. Indirect immunofluorescence technique was used for the demonstration of vasoactive int...

journal_title：Neuroscience

authors： Csati A,Tajti J,Kuris A,Tuka B,Edvinsson L,Warfvinge K

更新日期：2012-01-27 00:00:00

abstract：:Many of the different morphological types of interneurons in mammalian neocortex are presumed to be inhibitory, but to date, conclusive functional data have been lacking. Using paired intracellular recordings in slices of adult rat somatosensory cortex, we present a sparsely spiny, burst firing interneuron that elicit...

journal_title：Neuroscience

authors： Deuchars J,Thomson AM

更新日期：1995-04-01 00:00:00

abstract：:We revealed the structural features of astrocytes by means of light microscopy, confocal laser scanning microscopy and high voltage electron microscopy, and estimated their numerical densities in the mouse hippocampus. The high voltage electron microscope examinations of Golgi-impregnated astrocytes clearly disclosed ...

journal_title：Neuroscience

authors： Ogata K,Kosaka T

更新日期：2002-01-01 00:00:00

abstract：:The circadian rhythms of mammals are generated by the circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Its intrinsic period is entrained to a 24 h cycle by external cues, mainly by light. Light impinging on the SCN at night causes either advancing or delaying phase shifts of the circad...

journal_title：Neuroscience

authors： Bendová Z,Sumová A,Mikkelsen JD

更新日期：2009-03-17 00:00:00

abstract：:Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia...

journal_title：Neuroscience

authors： Kakae M,Miyanohara J,Morishima M,Nagayasu K,Mori Y,Shirakawa H,Kaneko S

更新日期：2019-06-01 00:00:00

abstract：:There is increasing evidence indicating that estrogen replacement therapy produces neuroprotective actions but has undesirable side effects on the reproductive system. Raloxifene is a selective estrogen receptor modulator that exerts estrogen agonist action in the brain while acting as an estrogen antagonist in the re...

journal_title：Neuroscience

authors： Huang Y,Huang YL,Lai B,Zheng P,Zhu YC,Yao T

更新日期：2007-06-29 00:00:00

abstract：:Long non-coding RNA MALAT1 was previously revealed to express abnormally in animal and cellular models of stroke, suggesting its indispensable role in stroke. The aims of the present study were to further investigate the functions of MALAT1 and to elucidate the underlying molecular mechanisms. Oxygen glucose deprivati...

journal_title：Neuroscience

authors： Gao C,Zhang CC,Yang HX,Hao YN

更新日期：2020-05-21 00:00:00

abstract：:In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

journal_title：Neuroscience

authors： Ko AR,Kim JY,Hyun HW,Kim JE

更新日期：2015-10-29 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

journal_title：Neuroscience

authors： Song C,Merali Z,Anisman H

更新日期：1999-01-01 00:00:00

abstract：:A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may not only limit tran...

journal_title：Neuroscience

authors： McMenamin MM,Byrnes AP,Charlton HM,Coffin RS,Latchman DS,Wood MJ

更新日期：1998-04-01 00:00:00

abstract：:Transient global ischemia results in delayed selective neuronal death of hippocampal CA1 pyramidal cells. Glucocorticoids increase and adrenalectomy decreases the rate of neuronal death; however, they also produce changes in brain temperature, serum glucose and adrenocorticotropic hormone levels. In order to understan...

journal_title：Neuroscience

authors： Antonawich FJ,Miller G,Rigsby DC,Davis JN

更新日期：1999-01-01 00:00:00

abstract：:The results of a previous experiment suggest that the cell bodies of many jaw closing muscle spindle afferents in the trigeminal mesencephalic nucleus of the rabbit are phasically inhibited during fictive mastication. The aim of this study was to investigate one possible neurotransmitter system that could be involved ...

journal_title：Neuroscience

authors： Kolta A,Dubuc R,Lund JP

更新日期：1993-04-01 00:00:00

abstract：:Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner. Therefore, using the lithium-pilocarpine status epilepticus model, we performed a detailed in situ hybridization ti...

journal_title：Neuroscience

authors： Rosell DR,Nacher J,Akama KT,McEwen BS

更新日期：2003-01-01 00:00:00

abstract：:Apolipoprotein E isoforms affect the risk of developing Alzheimer's disease. Apolipoprotein E-associated risk may be related to its binding to and clearance by cell surface receptors, including members of the low-density lipoprotein receptor family. We examined the brain expression of the most recently identified memb...

journal_title：Neuroscience

authors： Clatworthy AE,Stockinger W,Christie RH,Schneider WJ,Nimpf J,Hyman BT,Rebeck GW

更新日期：1999-03-01 00:00:00