当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice.

Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice.

Abstract：

:Characterization of the expression pattern of connexins in neural tissue is a necessary prerequisite for understanding the functional relevance of the corresponding gap junction channels in brain. Here we describe the cell type-specific expression of connexin45 in the CNS and the spatiotemporal expression pattern from embryonic day 19.5 to adult brain using a recently described connexin45 LacZ-reporter mouse. The connexin45 gene is highly expressed during embryogenesis and up to 2 weeks after birth in nearly all brain regions. Afterward its expression is restricted to the thalamus, the CA3 region of hippocampus and the cerebellum. In adult mouse brain, the pattern of LacZ-staining in combination with the analysis of different neuronal and glial marker proteins strongly suggests that connexin45 is expressed in neurons, but presumably not in astrocytes or mature oligodendrocytes. Expression of the LacZ/connexin45 reporter gene in subsets of neurons, such as cerebral cortical, hippocampal and thalamic neurons as well as basket and stellate cells of cerebellum should be corroborated by functional investigations of connexin45 protein in electrical synapses. Based on its expression pattern during development, we suggest that the connexin45-containing gap junction channels have a rather ubiquitous role during brain development and may contribute to functional specification in certain subsets of neurons in the adult brain.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Maxeiner S,Krüger O,Schilling K,Traub O,Urschel S,Willecke K

doi

10.1016/s0306-4522(03)00077-0

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

689-700

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306452203000770

journal_volume

119

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.

    abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.059

    authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

    更新日期：2009-06-16 00:00:00

  • Daily spinal cord stimulation suppresses autotomy behavior in rats following peripheral deafferentation.

    abstract：:Autotomy in experimental animals following peripheral nerve section has been interpreted as a sign of pain corresponding to the chronic pain observed in patients with extensive nerve lesions. Such pain may be alleviated by spinal cord stimulation. In the present study, the effect of such stimulation, via chronically i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00288-6

    authors： Gao XX,Ren B,Linderoth B,Meyerson BA

    更新日期：1996-11-01 00:00:00

  • Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice.

    abstract：:Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurologica...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.09.027

    authors： Lin XH,Ye XJ,Li QF,Gong Z,Cao X,Li JH,Zhao ST,Sun XD,He XS,Xuan AG

    更新日期：2020-11-10 00:00:00

  • Alternative Splicing and the Intracellular Domain Mediate TM-agrin's Ability to Differentially Regulate the Density of Excitatory and Inhibitory Synapse-like Specializations in Developing CNS Neurons.

    abstract：:Agrin is a multi-domain protein best known for its essential function during formation of the neuromuscular junction. Alternative mRNA splicing at sites named y and z in the C-terminal part of agrin regulates its interaction with a receptor complex consisting of the agrin-binding low-density lipoprotein receptor-relat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.09.011

    authors： Handara G,Kröger S

    更新日期：2019-11-01 00:00:00

  • Neuronal and glial elements of fetal neostriatal grafts in the adult neostriatum.

    abstract：:The cellular components of striatal grafts into the host striatum of rats were studied using [3H]thymidine autoradiography, histochemistry, immunocytochemistry and Golgi-staining. Autoradiography revealed that a layer of glial cells, somas smaller than 8 microns in diameter, stained positive with glial fibrillary acid...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90350-3

    authors： Zhou FC,Buchwald N,Hull C,Towle A

    更新日期：1989-01-01 00:00:00

  • Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.

    abstract：:Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.03.043

    authors： Lam YW,Sherman SM

    更新日期：2013-07-09 00:00:00

  • Auditory Brainstem Changes in Timing may Underlie Hyperacusis in a Salicylate-induced Acute Rat Model.

    abstract：:Hyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system thes...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.11.038

    authors： Duron J,Monconduit L,Avan P

    更新日期：2020-02-01 00:00:00

  • Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected].

    abstract：:During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.03.050

    authors： Pooler AM,Guez DH,Benedictus R,Wurtman RJ

    更新日期：2005-01-01 00:00:00

  • Gö6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation.

    abstract：:Microglial responses to endotoxin, including the synthesis of inflammatory factors, contribute to gliosis and neuron degeneration in cultured brain tissue. We have previously shown that Gö6976, a protein kinase C (PKC) inhibitor, suppressed the lipopolysaccharide (LPS)-induced production of inflammatory factors in mic...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00356-1

    authors： Jeohn GH,Cooper CL,Jang KJ,Liu B,Lee DS,Kim HC,Hong JS

    更新日期：2002-01-01 00:00:00

  • Binocular matching in monkey visual cortex: single cell responses to correlated and uncorrelated dynamic random dot stereograms.

    abstract：:This paper presents results obtained from experiments performed on two behaving monkeys (Macaca mulatta) viewing correlated and uncorrelated dynamic random dot stereograms. Extracellular single unit activity was recorded from areas V1 and V2. We found that cells sensitive to correlated stereograms (38%) were also sens...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90540-v

    authors： Gonzalez F,Krause F,Perez R,Alonso JM,Acuña C

    更新日期：1993-02-01 00:00:00

  • Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes.

    abstract：:Inflammatory and degenerative pathophysiological processes within the CNS are important causes of human disease. Astrocytes appear to modulate these reactions and are a major source of inflammatory mediators, e.g. extracellular adenine nucleotides, in nervous tissues. Actions following extracellular nucleotides bindin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.039

    authors： Wink MR,Braganhol E,Tamajusuku AS,Lenz G,Zerbini LF,Libermann TA,Sévigny J,Battastini AM,Robson SC

    更新日期：2006-01-01 00:00:00

  • Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle.

    abstract：:Nervous system formation integrates control of cellular proliferation and differentiation and is mediated by multipotent neural progenitor cells that become progressively restricted in their developmental potential before they give rise to differentiated neurons and glial cells. Evidence from different experimental sy...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.050

    authors： Spella M,Britz O,Kotantaki P,Lygerou Z,Nishitani H,Ramsay RG,Flordellis C,Guillemot F,Mantamadiotis T,Taraviras S

    更新日期：2007-06-29 00:00:00

  • Sex- and afferent-specific differences in histamine receptor expression in vagal afferents of rats: A potential mechanism for sexual dimorphism in prevalence and severity of asthma.

    abstract：:The incidence of asthma is more common in boys than in girls during the childhood, and more common in premenopausal female than age-matched males. Our previous study demonstrated a gender difference in histamine-mediated neuroexcitability in nodose ganglia neurons (NGNs), highlighting a possibility of histamine-mediat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.06.049

    authors： Li JN,Li XL,He J,Wang JX,Zhao M,Liang XB,Zhao SY,Ma MN,Liu Y,Wang YB,Chen H,Qiao GF,Li BY

    更新日期：2015-09-10 00:00:00

  • Long-term changes of ionotropic glutamate and GABA receptors after unilateral permanent focal cerebral ischemia in the mouse brain.

    abstract：:Long-term hyperexcitability was found after unilateral, permanent middle cerebral artery occlusion in exofocal neocortical areas of the adult mouse [Mittmann et al. (1998) Neuroscience 85, 15-27]. The aim of the present study was to test the hypothesis in an identical paradigm of ischemia. whether alterations in the d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00656-8

    authors： Qü M,Mittmann T,Luhmann HJ,Schleicher A,Zilles K

    更新日期：1998-07-01 00:00:00

  • Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity.

    abstract：:We examined the organization of spinal networks controlling locomotion in the isolated spinal cord of the neonatal rat, and in this study we provide the first demonstration of plateau and bursting mechanisms in mammalian interneurons that show locomotor-related activity. Using tight-seal whole-cell recordings, we char...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00250-3

    authors： Kiehn O,Johnson BR,Raastad M

    更新日期：1996-11-01 00:00:00

  • A Single Session of Aerobic Exercise Mediates Plasticity-Related Phosphorylation in both the Rat Motor Cortex and Hippocampus.

    abstract：:A single session of aerobic exercise may offer one means to "prime" motor regions to be more receptive to the acquisition of a motor skill; however, the mechanisms whereby this priming may occur are not clear. One possible explanation may be related to the post-translational modification of plasticity-related receptor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.05.051

    authors： Thacker JS,Xu Y,Tang C,Tupling AR,Staines WR,Mielke JG

    更新日期：2019-08-01 00:00:00

  • Some inhibitory neurons in the spinal cord develop c-fos-immunoreactivity after noxious stimulation.

    abstract：:In order to determine which types of spinal neuron produce c-fos in response to noxious stimulation, we have combined pre-embedding detection of c-fos-like immunoreactivity with post-embedding immunocytochemistry using antibodies against GABA and glycine, 2 h after subcutaneous injection of formalin into a hindpaw of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90525-8

    authors： Todd AJ,Spike RC,Brodbelt AR,Price RF,Shehab SA

    更新日期：1994-12-01 00:00:00

  • Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat.

    abstract：:It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.05.029

    authors： Machado ML,Lelong-Boulouard V,Smith PF,Freret T,Philoxene B,Denise P,Besnard S

    更新日期：2012-08-30 00:00:00

  • Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice.

    abstract：:Previous findings, mainly in in vitro systems, have shown that the density of vesicles and the synaptic efficacy at excitatory synapses are reduced in the absence of synapsins, despite the fact that transgenic mice lacking synapsins develop an epileptic phenotype. Here we study glutamate receptors by quantitative immu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.056

    authors： Gylterud Owe S,Bogen IL,Walaas SI,Storm-Mathisen J,Bergersen LH

    更新日期：2005-01-01 00:00:00

  • Formalin-induced changes in adrenocorticotropic hormone and corticosterone plasma levels and hippocampal choline acetyltransferase activity in male and female rats.

    abstract：:Formalin (10%) induces higher levels of licking and flexing in female than in male rats, as shown in the present study. In order to ascertain the neural and hormonal modifications that accompany these behavioural differences, we determined the activity of choline acetyltransferase in the hippocampus and the levels of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00232-1

    authors： Aloisi AM,Albonetti ME,Carli G

    更新日期：1996-10-01 00:00:00

  • Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.

    abstract：:Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR). Previously proposed explanations suggest that this lack of internalization could either lead to prolonged signaling and associated compensatory changes in downstream signaling systems, or tha...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.021

    authors： Walwyn WM,Wei W,Xie CW,Chiu K,Kieffer BL,Evans CJ,Maidment NT

    更新日期：2006-10-13 00:00:00

  • Selective gastric projections of nitric oxide synthase-containing vagal brainstem neurons.

    abstract：:Nitric oxide has been proposed to act as an intercellular messenger in central brainstem circuits controlling gastrointestinal motility. In particular, a subpopulation of preganglionic vagal neurons of the dorsal motor nucleus of the vagus have been shown to be reduced nicotinamide adenine dinucleotide phosphate(NADPH...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00586-7

    authors： Zheng ZL,Rogers RC,Travagli RA

    更新日期：1999-05-01 00:00:00

  • Deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson's disease.

    abstract：OBJECTIVES:The aim of this study was to investigate whether an objective measure of freezing of gait (FOG) using a validated alternating stepping in place (SIP) task, is related to executive and/or visuospatial cognitive impairment in Parkinson's disease (PD). METHODS:We studied prospectively 30 PD subjects with the U...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.007

    authors： Nantel J,McDonald JC,Tan S,Bronte-Stewart H

    更新日期：2012-09-27 00:00:00

  • Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy.

    abstract：:Diabetic peripheral neuropathy is a common complication of diabetes mellitus, and a significant proportion of individuals suffer debilitating pain that significantly affects their quality of life. Unfortunately, symptomatic treatment options have limited efficacy, and often carry significant risk of systemic adverse e...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.10.065

    authors： Katz NK,Ryals JM,Wright DE

    更新日期：2015-01-29 00:00:00

  • Unintentional force changes in cyclical tasks performed by an abundant system: Empirical observations and a dynamical model.

    abstract：:The study explored unintentional force changes elicited by removing visual feedback during cyclical, two-finger isometric force production tasks. Subjects performed two types of tasks at 1Hz, paced by an auditory metronome. One - Force task - required cyclical changes in total force while maintaining the sharing, defi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.03.022

    authors： Reschechtko S,Hasanbarani F,Akulin VM,Latash ML

    更新日期：2017-05-14 00:00:00

  • The Interaction Between Contactin and Amyloid Precursor Protein and Its Role in Alzheimer's Disease.

    abstract：:Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia. As the world population ages even modest advances in therapies and preventative strategies would be of benefit. The specific physiological function of the amyloid precursor protein (APP) remains unclear despite strong genetic and...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2019.10.006

    authors： Bamford RA,Widagdo J,Takamura N,Eve M,Anggono V,Oguro-Ando A

    更新日期：2020-01-01 00:00:00

  • Identification of dynorphin a from zebrafish: a comparative study with mammalian dynorphin A.

    abstract：:We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.09.028

    authors： Gonzalez-Nuñez V,Marrón Fernández de Velasco E,Arsequell G,Valencia G,Rodríguez RE

    更新日期：2007-01-19 00:00:00

  • Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment.

    abstract：:The anxiolytic diazepam selectively inhibits psychological stress-induced autonomic and behavioral responses without causing noticeable suppression of other central performances. This pharmacological property of diazepam led us to the idea that neurons that exhibit diazepam-sensitive, psychological stress-induced acti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.04.047

    authors： Lkhagvasuren B,Oka T,Nakamura Y,Hayashi H,Sudo N,Nakamura K

    更新日期：2014-07-11 00:00:00

  • Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo.

    abstract：:GABA neurones in the dorsal raphe nucleus (DRN) influence ascending 5-hydroxytryptamine (5-HT) neurones but are not physiologically or anatomically characterised. Here, in vivo juxtacellular labelling methods in urethane-anaesthetised rats were used to establish the neurochemical and morphological identity of a fast-f...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00518-9

    authors： Allers KA,Sharp T

    更新日期：2003-01-01 00:00:00

  • GABA(B) receptors at glutamatergic synapses in the rat striatum.

    abstract：:Although multiple effects of GABA(B) receptor activation on synaptic transmission in the striatum have been described, the precise locations of the receptors mediating these effects have not been determined. To address this issue, we carried out pre-embedding immunogold electron microscopy in the rat using antibodies ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.07.013

    authors： Lacey CJ,Boyes J,Gerlach O,Chen L,Magill PJ,Bolam JP

    更新日期：2005-01-01 00:00:00