Abstract:
:Formalin (10%) induces higher levels of licking and flexing in female than in male rats, as shown in the present study. In order to ascertain the neural and hormonal modifications that accompany these behavioural differences, we determined the activity of choline acetyltransferase in the hippocampus and the levels of adrenocorticotropic hormone and corticosterone in the plasma. Two concentrations of formalin were used (50 microliters; 0.1% or 10%). Formalin was injected subcutaneously in the dorsal part of the hindpaw, and the animal's behaviour was then recorded for 60 min in a familiar open-field apparatus. Hippocampal choline acetyltransferase activity did not differ between the two genders in controls, while a significant gender difference was present in both formalin-injected groups, with higher levels in females than in males. This was the result of a decrease in males but not in females. In contrast, adrenocorticotropic hormone was increased by both formalin concentrations in females; corticosterone was not affected by treatment in either gender. Results are discussed in the light of the morphological and functional differences between the two genders in the hippocampus and in the hypothalamo-pituitary-adrenal axis.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Aloisi AM,Albonetti ME,Carli Gdoi
10.1016/0306-4522(96)00232-1subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1019-24issue
4eissn
0306-4522issn
1873-7544pii
0306-4522(96)00232-1journal_volume
74pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Cholecystokinin, substance P and methionine enkephalin all regulate the display of reproductive behaviour. Their expression is exquisitely regulated by estrogen in the limbic-hypothalamic circuit, a circuit that regulates the display of estrogen-sensitive female reproductive behavior. Relatively little is known, howev...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00072-9
更新日期:1997-09-01 00:00:00
abstract::We have shown that cortical acetylcholine modulates the balance between excitation and inhibition evoked in layer 5 pyramidal neurons of rat visual cortex [Lucas-Meunier E, Monier C, Amar M, Baux G, Frégnac Y, Fossier P (2009) Cereb Cortex 19:2411-2427]. Our aim is now to establish a functional basis for the role of t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.06.019
更新日期:2010-09-15 00:00:00
abstract::Dopaminergic mechanisms were analyzed in an isolated preparation of the turtle olfactory bulb. Field potentials were evoked by antidromic or orthodromic stimulation, and the effects determined of pharmacological manipulations of the bathing medium. In the presence of dopamine or a dopamine agonist, apomorphine, there ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(83)90005-2
更新日期:1983-04-01 00:00:00
abstract::Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study sought to provide insight into the cellular components of donor cell su...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00273-1
更新日期:2001-01-01 00:00:00
abstract::Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00160-x
更新日期:2003-01-01 00:00:00
abstract::Musculoskeletal pain conditions, particularly those associated with temporomandibular disorders (TMD) affect a large percentage of the population. Identifying mechanisms underlying hyperalgesia could contribute to the development of new treatment strategies for the management of TMD and other muscle pain conditions. I...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.11.015
更新日期:2013-03-01 00:00:00
abstract::The distribution of gene expression domains during development constitutes a novel tool for the identification of distinct brain regions. This is particularly useful in the brain of amphibians where cell migration is very limited and most neurons organize in a periventricular layer. Here we report the expression patte...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00326-3
更新日期:2002-01-01 00:00:00
abstract::Our previous studies have shown that selective inhibition of nitric oxide in the brain reduces pressor responses to activation of cardiac sympathetic afferents, thus suggesting that nitric oxide is involved in central regulation of cardiac-cardiovascular sympathoexcitatory reflexes. Central neural regions in which nit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00707-8
更新日期:2003-01-01 00:00:00
abstract::The study of the neural basis of predatory behavior has been largely neglected over the recent years. Using an ethologically based approach, we presently delineate the prosencephalic systems mobilized during predation by examining Fos immunoreactivity in rats performing insect hunting. These results were further compa...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.10.020
更新日期:2005-01-01 00:00:00
abstract::Small (SK) and intermediate (IK) conductance calcium-activated potassium channels are candidate ion channels for the regulation of excitability in nociceptive neurones. We have used unique peptide-directed antisera to describe the immunocytochemical distribution of the known isoforms of these ion channels in dorsal ro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.09.062
更新日期:2005-01-01 00:00:00
abstract::Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00139-a
更新日期:1995-09-01 00:00:00
abstract::The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90089-4
更新日期:1989-01-01 00:00:00
abstract::The cellular transcription factor Fos, product of the immediate early gene c-fos, is induced in secretory neurons of the hypothalamic paraventricular nucleus in response to stress. Recent evidence indicates that the paracrine-acting messenger molecule nitric oxide may be involved in the activation or regulation of c-f...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00590-8
更新日期:1997-04-01 00:00:00
abstract::Sleep mechanisms and synaptic plasticity are thought to interact to regulate homeostasis and memory formation. However, the influences of molecules that mediate synaptic plasticity on sleep are not well understood. In this study we demonstrate that mice lacking Rab3 interacting molecule 1 alpha (RIM1 alpha) (Rim1 alph...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.03.047
更新日期:2008-06-23 00:00:00
abstract::It has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of GABA both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia. The object of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00090-6
更新日期:1998-11-01 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.07.013
更新日期:2013-10-10 00:00:00
abstract::Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.12.073
更新日期:2015-03-19 00:00:00
abstract::Dopamine (DA) axons and receptors have recently been identified in the primate thalamus, including the mediodorsal thalamic nucleus (MD). In order to determine whether the DA innervation of the primate MD shares the anatomical features of the mesocortical or nigrostriatal DA projections, we performed tract-tracing and...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.08.056
更新日期:2006-12-28 00:00:00
abstract::Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule. The SNr receives one of the highest densit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.10.005
更新日期:2010-01-13 00:00:00
abstract::Aberrant activation of the developing immune system can have long-term negative consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia, the brain's resident immune cells, which could contribute to the lifelong deficits in learning and memory observed in humans with Fetal Alcohol Spectr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.03.033
更新日期:2016-06-02 00:00:00
abstract::In rats anaesthetized with ketamine, rhythmic jaw-opening and jaw-closing movements were induced by palatal stimulation. The two masseter muscles (jaw-closing) and the four digastric muscles (jaw-opening) were fitted with electrodes, which could be used either for electrical stimulation or for recording electromyograp...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90273-3
更新日期:1986-10-01 00:00:00
abstract::Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number an...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00060-v
更新日期:1995-07-01 00:00:00
abstract::In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.08.055
更新日期:2015-01-22 00:00:00
abstract::In the European rabbit (Oryctolagus cuniculus) nursing acts as a strong non-photic synchronizer of circadian rhythmicity in the newborn young. Rabbits only nurse for a few minutes once every 24 h and previous studies have shown that the pups, blind at birth, display endogenous circadian rhythms in behavior and physiol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.09.020
更新日期:2007-01-19 00:00:00
abstract::The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.08.051
更新日期:2015-10-29 00:00:00
abstract::We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00613-6
更新日期:1997-05-01 00:00:00
abstract::Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00010-g
更新日期:1995-08-01 00:00:00
abstract::Brain injury-derived neurotrophic peptide is a 13-amino acid peptide derived from a 15,000 mol. wt neurotrophic factor released from sites of mechanical injury in neonatal rat brain. This peptide promotes survival of septal cholinergic neurons and mesencephalic dopaminergic neurons, and protects hippocampal neurons fr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00136-6
更新日期:2000-01-01 00:00:00
abstract::Intraspecific confrontation has been used to study effect of depleting central serotonin on the adaptation of male rats to repeated social stress (social defeat). Four groups of adult male rats were used (serotonin depletion/sham: stressed; serotonin depletion/sham: non-stressed). Central serotonin was reduced (by 59-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00028-7
更新日期:1999-01-01 00:00:00
abstract::Central GABA(A) receptors mediate GABAergic phasic and tonic inhibition. While synaptic αβγ GABA(A) receptors primarily mediate phasic inhibition, extrasynaptic αβδ receptors play an important role in mediating tonic inhibition. Etomidate is a general anesthetic that produces its effects by enhancing GABA(A) receptor ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.05.051
更新日期:2015-08-06 00:00:00